Danio rerio

0 known processes

pdia4

protein disulfide isomerase associated 4

(Aliases: zgc:136625,MGC136625,wu:fd20c07,zgc:113965,cai,MGC113965,zgc:77773,zgc:56014)

pdia4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.573
Worm
cellular response to topologically incorrect protein GO:0035967 2 0.449
Worm
response to topologically incorrect protein GO:0035966 2 0.418
Worm
cellular macromolecule metabolic process GO:0044260 391 0.354
Rat
cellular response to unfolded protein GO:0034620 2 0.351
Worm
er nucleus signaling pathway GO:0006984 2 0.330
Worm
larval development GO:0002164 2 0.319
endoplasmic reticulum unfolded protein response GO:0030968 2 0.270
Worm
modification dependent macromolecule catabolic process GO:0043632 3 0.251
response to endoplasmic reticulum stress GO:0034976 6 0.245
Worm
response to oxygen containing compound GO:1901700 55 0.233
modification dependent protein catabolic process GO:0019941 3 0.207
cellular protein catabolic process GO:0044257 4 0.197
response to organic substance GO:0010033 153 0.192
Worm
sensory organ development GO:0007423 393 0.185
response to stress GO:0006950 263 0.185
Worm
response to unfolded protein GO:0006986 2 0.182
Worm
response to chemical GO:0042221 320 0.179
Worm
aging GO:0007568 2 0.172
establishment of localization GO:0051234 244 0.169
cellular protein metabolic process GO:0044267 129 0.151
Rat
locomotion GO:0040011 313 0.141
cellular response to chemical stimulus GO:0070887 157 0.130
Worm
cellular component biogenesis GO:0044085 178 0.125
response to biotic stimulus GO:0009607 97 0.117
proteasomal protein catabolic process GO:0010498 2 0.105
cellular response to organic substance GO:0071310 105 0.101
Worm
response to abiotic stimulus GO:0009628 122 0.101
maintenance of location GO:0051235 4 0.097
cell death GO:0008219 121 0.097
protein n linked glycosylation GO:0006487 1 0.096
protein metabolic process GO:0019538 183 0.090
Rat
cellular response to extracellular stimulus GO:0031668 2 0.088
leukocyte proliferation GO:0070661 1 0.076
cellular component assembly GO:0022607 170 0.075
negative regulation of cellular process GO:0048523 283 0.071
programmed cell death GO:0012501 119 0.071
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.067
ubiquitin dependent protein catabolic process GO:0006511 3 0.063
regulation of muscle contraction GO:0006937 3 0.062
regulation of protein transport GO:0051223 3 0.060
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.058
response to temperature stimulus GO:0009266 15 0.057
cell substrate junction assembly GO:0007044 2 0.057
negative regulation of signal transduction GO:0009968 94 0.056
response to heat GO:0009408 6 0.056
regulation of protein ubiquitination GO:0031396 3 0.054
regulation of response to stimulus GO:0048583 269 0.054
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.052
extrinsic apoptotic signaling pathway GO:0097191 3 0.048
cell surface receptor signaling pathway GO:0007166 325 0.047
organonitrogen compound metabolic process GO:1901564 74 0.047
lipid storage GO:0019915 1 0.047
regulation of signal transduction GO:0009966 225 0.046
peptide transport GO:0015833 1 0.041
response to alcohol GO:0097305 14 0.040
regulation of signaling GO:0023051 235 0.040
transport GO:0006810 220 0.040
regulation of blood vessel size GO:0050880 2 0.039
cellular response to starvation GO:0009267 1 0.039
single organism localization GO:1902578 225 0.038
stem cell maintenance GO:0019827 4 0.037
inner ear development GO:0048839 126 0.037
negative regulation of cellular catabolic process GO:0031330 3 0.035
embryo development ending in birth or egg hatching GO:0009792 271 0.035
Worm
cellular response to nutrient levels GO:0031669 2 0.035
amide transport GO:0042886 12 0.035
regulation of biological quality GO:0065008 263 0.034
response to hypoxia GO:0001666 25 0.034
positive regulation of apoptotic signaling pathway GO:2001235 1 0.033
positive regulation of transport GO:0051050 2 0.033
positive regulation of secretion by cell GO:1903532 1 0.031
i kappab kinase nf kappab signaling GO:0007249 4 0.030
regulation of nucleoside metabolic process GO:0009118 2 0.029
regulation of nucleotide catabolic process GO:0030811 2 0.029
response to ethanol GO:0045471 6 0.028
regulation of multicellular organismal process GO:0051239 277 0.028
Worm
cellular response to external stimulus GO:0071496 2 0.028
membrane lipid metabolic process GO:0006643 10 0.028
regulation of localization GO:0032879 104 0.028
ear development GO:0043583 127 0.028
establishment of protein localization to organelle GO:0072594 4 0.028
system process GO:0003008 185 0.028
membrane lipid biosynthetic process GO:0046467 2 0.027
regulation of cell death GO:0010941 103 0.027
protein import GO:0017038 3 0.026
cellular protein modification process GO:0006464 100 0.026
ameboidal type cell migration GO:0001667 143 0.026
regulation of response to biotic stimulus GO:0002831 2 0.025
gland development GO:0048732 143 0.025
brain development GO:0007420 293 0.025
response to external biotic stimulus GO:0043207 97 0.025
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.024
macromolecule modification GO:0043412 111 0.024
response to endogenous stimulus GO:0009719 83 0.024
multicellular organism growth GO:0035264 4 0.024
Worm
positive regulation of catabolic process GO:0009896 4 0.024
regulation of establishment of protein localization GO:0070201 4 0.024
biosynthetic process GO:0009058 294 0.024
exocytosis GO:0006887 1 0.023
cellular response to stress GO:0033554 62 0.023
Worm
specification of symmetry GO:0009799 204 0.023
negative regulation of biological process GO:0048519 304 0.023
response to bacterium GO:0009617 58 0.023
negative regulation of cell communication GO:0010648 96 0.023
regulation of multicellular organism growth GO:0040014 4 0.022
Worm
multicellular organismal reproductive process GO:0048609 35 0.022
regulation of systemic arterial blood pressure GO:0003073 1 0.022
positive regulation of cytokine production GO:0001819 2 0.021
single organism organelle organization GO:1902589 199 0.021
regulation of gtpase activity GO:0043087 2 0.021
collagen metabolic process GO:0032963 2 0.021
regulation of blood pressure GO:0008217 1 0.021
regulation of cytokine production GO:0001817 3 0.021
regulation of tube size GO:0035150 2 0.021
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.021
amine metabolic process GO:0009308 2 0.021
regulation of cell shape GO:0008360 1 0.021
response to other organism GO:0051707 97 0.021
muscle cell migration GO:0014812 4 0.021
response to oxygen levels GO:0070482 25 0.020
death GO:0016265 121 0.020
gtp metabolic process GO:0046039 4 0.020
apoptotic process GO:0006915 116 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
head development GO:0060322 303 0.020
regulation of purine nucleotide catabolic process GO:0033121 2 0.019
regulation of protein catabolic process GO:0042176 1 0.019
immune system process GO:0002376 241 0.019
cell motility GO:0048870 244 0.018
macromolecule localization GO:0033036 54 0.018
determination of left right symmetry GO:0007368 179 0.018
nucleocytoplasmic transport GO:0006913 4 0.018
response to external stimulus GO:0009605 264 0.018
negative regulation of catabolic process GO:0009895 3 0.018
regulation of cell activation GO:0050865 1 0.018
endodermal digestive tract morphogenesis GO:0061031 2 0.018
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.018
autophagy GO:0006914 4 0.018
response to glucose GO:0009749 3 0.017
response to decreased oxygen levels GO:0036293 25 0.017
response to wounding GO:0009611 116 0.017
protein secretion GO:0009306 1 0.017
positive regulation of secretion GO:0051047 1 0.017
cell aging GO:0007569 2 0.017
cellular biosynthetic process GO:0044249 286 0.017
cellular modified amino acid metabolic process GO:0006575 3 0.017
hepaticobiliary system development GO:0061008 98 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
regulation of developmental process GO:0050793 247 0.016
Worm
single organism transport GO:0044765 206 0.016
regulation of hormone levels GO:0010817 21 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
regulation of nucleocytoplasmic transport GO:0046822 2 0.016
female sex differentiation GO:0046660 4 0.016
multi organism process GO:0051704 134 0.016
regulation of binding GO:0051098 3 0.016
cellular response to lipopolysaccharide GO:0071222 3 0.016
nuclear transport GO:0051169 4 0.016
response to drug GO:0042493 3 0.016
cell migration GO:0016477 237 0.016
cell morphogenesis GO:0000902 289 0.016
positive regulation of cell activation GO:0050867 1 0.016
cellular nitrogen compound metabolic process GO:0034641 290 0.015
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.015
tube morphogenesis GO:0035239 349 0.015
regulation of nuclease activity GO:0032069 1 0.015
peptide metabolic process GO:0006518 1 0.015
nitrogen compound metabolic process GO:0006807 319 0.015
ovulation cycle GO:0042698 2 0.015
digestive system development GO:0055123 289 0.015
nuclear import GO:0051170 3 0.015
female gonad development GO:0008585 4 0.014
multicellular organismal macromolecule metabolic process GO:0044259 2 0.014
production of molecular mediator of immune response GO:0002440 2 0.014
nuclear export GO:0051168 1 0.014
reactive oxygen species biosynthetic process GO:1903409 1 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
central nervous system development GO:0007417 387 0.014
regulation of programmed cell death GO:0043067 101 0.014
gtp catabolic process GO:0006184 2 0.014
response to cold GO:0009409 4 0.014
reproduction GO:0000003 40 0.014
Worm
organic substance catabolic process GO:1901575 28 0.014
reproductive process GO:0022414 40 0.014
negative regulation of response to stimulus GO:0048585 104 0.014
response to lipid GO:0033993 60 0.014
mononuclear cell proliferation GO:0032943 1 0.014
positive regulation of macromolecule metabolic process GO:0010604 93 0.014
regulation of neurotransmitter secretion GO:0046928 1 0.013
cellular amide metabolic process GO:0043603 4 0.013
regulation of molecular function GO:0065009 70 0.013
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.013
pronephros development GO:0048793 69 0.013
kidney development GO:0001822 92 0.013
very long chain fatty acid metabolic process GO:0000038 4 0.013
pigmentation GO:0043473 85 0.013
regulation of exocytosis GO:0017157 1 0.013
positive regulation of blood circulation GO:1903524 2 0.013
cellular amine metabolic process GO:0044106 2 0.013
lipid digestion GO:0044241 3 0.013
regulation of cell communication GO:0010646 232 0.013
regulation of multicellular organismal development GO:2000026 223 0.013
smooth muscle contraction GO:0006939 2 0.013
reactive nitrogen species metabolic process GO:2001057 0 0.013
sister chromatid cohesion GO:0007062 2 0.012
phagocytosis GO:0006909 3 0.012
protein modification process GO:0036211 100 0.012
cellular catabolic process GO:0044248 27 0.012
cellular response to biotic stimulus GO:0071216 3 0.012
nitric oxide biosynthetic process GO:0006809 2 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
single organism metabolic process GO:0044710 217 0.012
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.012
negative regulation of programmed cell death GO:0043069 58 0.012
proteolysis GO:0006508 38 0.012
organic substance transport GO:0071702 58 0.012
digestive tract development GO:0048565 265 0.012
ovulation cycle process GO:0022602 2 0.012
neurotransmitter transport GO:0006836 2 0.012
organic substance biosynthetic process GO:1901576 289 0.012
homeostatic process GO:0042592 142 0.012
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.012
defense response GO:0006952 47 0.012
organelle organization GO:0006996 227 0.012
single organism biosynthetic process GO:0044711 71 0.011
superoxide metabolic process GO:0006801 2 0.011
regulation of protein binding GO:0043393 3 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
axon ensheathment in central nervous system GO:0032291 2 0.011
lymphocyte proliferation GO:0046651 1 0.011
cellular localization GO:0051641 97 0.011
golgi vesicle transport GO:0048193 3 0.011
determination of bilateral symmetry GO:0009855 204 0.011
regulation of inflammatory response GO:0050727 2 0.011
natural killer cell mediated cytotoxicity GO:0042267 1 0.011
protein import into nucleus GO:0006606 3 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
regulation of metabolic process GO:0019222 359 0.011
negative regulation of signaling GO:0023057 96 0.011
liver development GO:0001889 96 0.011
catabolic process GO:0009056 32 0.011
negative regulation of cytoplasmic transport GO:1903650 2 0.011
antimicrobial humoral response GO:0019730 2 0.011
regulation of autophagy GO:0010506 3 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
b cell activation GO:0042113 2 0.011
cellular response to oxygen radical GO:0071450 2 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
urogenital system development GO:0001655 97 0.011
negative regulation of chromosome organization GO:2001251 1 0.011
extracellular matrix organization GO:0030198 27 0.011
renal system development GO:0072001 94 0.011
negative regulation of multicellular organismal process GO:0051241 69 0.011
developmental growth GO:0048589 166 0.010
Worm
body morphogenesis GO:0010171 16 0.010
regulation of leukocyte mediated immunity GO:0002703 1 0.010
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.010
positive regulation of cellular amine metabolic process GO:0033240 0 0.010
guanosine containing compound metabolic process GO:1901068 4 0.010
response to glucocorticoid GO:0051384 1 0.010
skeletal system development GO:0001501 181 0.010
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.010

pdia4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.062
auditory system disease DOID:2742 0 0.015
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.015
nonsyndromic deafness DOID:0050563 0 0.015
sensory system disease DOID:0050155 0 0.015
nervous system disease DOID:863 0 0.015