Danio rerio

0 known processes

ogdh

oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide)

(Aliases: MGC73296,im:7045267,wu:fa06d01,zgc:73296,wu:fb98a04)

ogdh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 2 0.318
Worm
larval development GO:0002164 2 0.267
Worm
cellular respiration GO:0045333 3 0.144
vasculature development GO:0001944 278 0.127
single organism localization GO:1902578 225 0.115
positive regulation of biological process GO:0048518 253 0.113
oxoacid metabolic process GO:0043436 31 0.109
multicellular organism growth GO:0035264 4 0.098
blood vessel development GO:0001568 246 0.089
organic acid metabolic process GO:0006082 31 0.086
specification of symmetry GO:0009799 204 0.069
blood vessel morphogenesis GO:0048514 216 0.068
regulation of multicellular organism growth GO:0040014 4 0.067
coenzyme biosynthetic process GO:0009108 2 0.067
determination of left right symmetry GO:0007368 179 0.062
embryo development ending in birth or egg hatching GO:0009792 271 0.061
Worm
tube morphogenesis GO:0035239 349 0.061
negative regulation of biological process GO:0048519 304 0.059
carboxylic acid metabolic process GO:0019752 22 0.059
small molecule metabolic process GO:0044281 77 0.058
cellular amine metabolic process GO:0044106 2 0.058
rna metabolic process GO:0016070 219 0.055
single organism metabolic process GO:0044710 217 0.055
locomotion GO:0040011 313 0.055
positive regulation of catabolic process GO:0009896 4 0.054
signal transduction GO:0007165 455 0.053
pyruvate metabolic process GO:0006090 1 0.052
transmembrane transport GO:0055085 120 0.051
regulation of gene expression GO:0010468 265 0.051
morphogenesis of an epithelium GO:0002009 333 0.050
cation transport GO:0006812 81 0.049
mitochondrion organization GO:0007005 4 0.048
cellular component movement GO:0006928 335 0.048
growth GO:0040007 174 0.048
carboxylic acid catabolic process GO:0046395 3 0.047
maintenance of location GO:0051235 4 0.047
cellular macromolecule metabolic process GO:0044260 391 0.044
positive regulation of transport GO:0051050 2 0.043
cell surface receptor signaling pathway GO:0007166 325 0.042
nucleobase containing compound metabolic process GO:0006139 274 0.041
phagocytosis GO:0006909 3 0.041
regeneration GO:0031099 91 0.040
response to external stimulus GO:0009605 264 0.039
dicarboxylic acid metabolic process GO:0043648 1 0.039
organonitrogen compound metabolic process GO:1901564 74 0.038
amine metabolic process GO:0009308 2 0.038
localization of cell GO:0051674 244 0.038
establishment of localization GO:0051234 244 0.037
cell migration GO:0016477 237 0.037
oxidation reduction process GO:0055114 41 0.036
regulation of macromolecule metabolic process GO:0060255 317 0.036
stem cell proliferation GO:0072089 4 0.036
response to chemical GO:0042221 320 0.036
ion transport GO:0006811 114 0.035
organic cyclic compound metabolic process GO:1901360 301 0.035
organic cyclic compound biosynthetic process GO:1901362 223 0.035
gene expression GO:0010467 252 0.035
thioester biosynthetic process GO:0035384 1 0.035
transport GO:0006810 220 0.035
alpha amino acid metabolic process GO:1901605 3 0.034
macromolecule biosynthetic process GO:0009059 227 0.034
regulation of nitrogen compound metabolic process GO:0051171 251 0.034
regulation of metabolic process GO:0019222 359 0.033
cellular nitrogen compound metabolic process GO:0034641 290 0.033
regulation of cell shape GO:0008360 1 0.033
organic substance biosynthetic process GO:1901576 289 0.033
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.032
cellular component assembly GO:0022607 170 0.032
nuclear transport GO:0051169 4 0.031
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.031
positive regulation of cellular catabolic process GO:0031331 3 0.030
ion transmembrane transport GO:0034220 91 0.030
spermatid development GO:0007286 2 0.029
regulation of primary metabolic process GO:0080090 311 0.029
regulation of multicellular organismal process GO:0051239 277 0.029
cation transmembrane transport GO:0098655 65 0.028
negative regulation of heart contraction GO:0045822 2 0.028
inorganic cation transmembrane transport GO:0098662 50 0.028
regulation of reproductive process GO:2000241 4 0.028
cellular aromatic compound metabolic process GO:0006725 295 0.028
cellular amino acid metabolic process GO:0006520 7 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
regulation of epithelial cell proliferation GO:0050678 3 0.027
regulation of cellular amine metabolic process GO:0033238 0 0.026
immune system process GO:0002376 241 0.026
negative regulation of protein phosphorylation GO:0001933 4 0.026
positive regulation of cellular process GO:0048522 201 0.026
embryonic organ development GO:0048568 381 0.026
organelle organization GO:0006996 227 0.025
synaptic growth at neuromuscular junction GO:0051124 2 0.025
cellular response to extracellular stimulus GO:0031668 2 0.025
negative regulation of protein kinase activity GO:0006469 4 0.025
atp synthesis coupled electron transport GO:0042773 1 0.025
heterocycle metabolic process GO:0046483 290 0.024
cellular nitrogen compound biosynthetic process GO:0044271 218 0.024
macromolecular complex assembly GO:0065003 35 0.024
cellular lipid catabolic process GO:0044242 3 0.024
regulation of establishment of protein localization GO:0070201 4 0.024
response to stress GO:0006950 263 0.023
death GO:0016265 121 0.023
phagocytosis engulfment GO:0006911 1 0.023
regulation of rna metabolic process GO:0051252 224 0.023
regulation of multicellular organismal development GO:2000026 223 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
striated muscle cell development GO:0055002 108 0.023
modification dependent protein catabolic process GO:0019941 3 0.023
angiogenesis GO:0001525 158 0.023
protein import into nucleus GO:0006606 3 0.023
lipid storage GO:0019915 1 0.022
single organism nuclear import GO:1902593 3 0.022
nucleobase containing compound biosynthetic process GO:0034654 205 0.022
positive regulation of cell adhesion GO:0045785 1 0.022
cell projection organization GO:0030030 284 0.022
digestive tract development GO:0048565 265 0.022
regulation of neural precursor cell proliferation GO:2000177 3 0.022
muscle structure development GO:0061061 196 0.022
cell motility GO:0048870 244 0.022
taxis GO:0042330 109 0.021
regulation of metal ion transport GO:0010959 4 0.021
programmed cell death GO:0012501 119 0.021
cellular biosynthetic process GO:0044249 286 0.021
negative regulation of kinase activity GO:0033673 4 0.021
establishment of protein localization to organelle GO:0072594 4 0.021
regulation of protein transport GO:0051223 3 0.021
positive regulation of muscle cell differentiation GO:0051149 1 0.021
amino acid transport GO:0006865 2 0.021
somatic muscle development GO:0007525 4 0.020
nucleic acid transport GO:0050657 2 0.020
oocyte maturation GO:0001556 4 0.020
biosynthetic process GO:0009058 294 0.020
nitrogen compound metabolic process GO:0006807 319 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.020
nucleocytoplasmic transport GO:0006913 4 0.020
cellular carbohydrate metabolic process GO:0044262 4 0.020
cellular response to nutrient levels GO:0031669 2 0.019
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.019
multicellular organismal metabolic process GO:0044236 2 0.019
nucleic acid metabolic process GO:0090304 244 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.019
positive regulation of cell activation GO:0050867 1 0.019
eye development GO:0001654 277 0.019
regulation of protein targeting GO:1903533 2 0.019
positive regulation of translation GO:0045727 1 0.019
cellular protein metabolic process GO:0044267 129 0.019
response to wounding GO:0009611 116 0.019
regulation of stem cell differentiation GO:2000736 4 0.019
protein complex disassembly GO:0043241 1 0.019
adult behavior GO:0030534 2 0.019
neurotransmitter transport GO:0006836 2 0.019
spermatid differentiation GO:0048515 2 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.019
nucleoside monophosphate catabolic process GO:0009125 4 0.019
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.019
cellular component morphogenesis GO:0032989 336 0.019
determination of bilateral symmetry GO:0009855 204 0.019
cell death GO:0008219 121 0.019
digestive tract morphogenesis GO:0048546 231 0.018
protein polymerization GO:0051258 4 0.018
single organism transport GO:0044765 206 0.018
modification dependent macromolecule catabolic process GO:0043632 3 0.018
regulation of developmental process GO:0050793 247 0.018
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.018
regulation of nucleocytoplasmic transport GO:0046822 2 0.018
regulation of biosynthetic process GO:0009889 250 0.018
cellular component biogenesis GO:0044085 178 0.018
protein methylation GO:0006479 13 0.018
single organism biosynthetic process GO:0044711 71 0.018
organic acid catabolic process GO:0016054 3 0.018
protein import GO:0017038 3 0.018
nuclear import GO:0051170 3 0.018
positive regulation of metabolic process GO:0009893 108 0.017
purine nucleoside triphosphate biosynthetic process GO:0009145 2 0.017
i kappab kinase nf kappab signaling GO:0007249 4 0.017
alcohol biosynthetic process GO:0046165 2 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
positive regulation of cellular amine metabolic process GO:0033240 0 0.017
electron transport chain GO:0022900 2 0.017
transcription dna templated GO:0006351 181 0.017
macromolecular complex subunit organization GO:0043933 74 0.017
cell substrate adhesion GO:0031589 4 0.017
tissue remodeling GO:0048771 4 0.017
positive regulation of transcription elongation from rna polymerase ii promoter GO:0032968 1 0.016
cellular ketone metabolic process GO:0042180 11 0.016
meiotic nuclear division GO:0007126 4 0.016
chordate embryonic development GO:0043009 271 0.016
developmental growth GO:0048589 166 0.016
branched chain amino acid metabolic process GO:0009081 1 0.016
protein acylation GO:0043543 3 0.016
sensory organ development GO:0007423 393 0.016
negative regulation of catabolic process GO:0009895 3 0.016
regulation of signaling GO:0023051 235 0.016
response to drug GO:0042493 3 0.016
embryonic hemopoiesis GO:0035162 53 0.016
negative regulation of cellular process GO:0048523 283 0.016
regulation of protein catabolic process GO:0042176 1 0.016
cofactor biosynthetic process GO:0051188 10 0.016
oxidative phosphorylation GO:0006119 1 0.016
mononuclear cell proliferation GO:0032943 1 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.016
cellular response to stress GO:0033554 62 0.016
tissue regeneration GO:0042246 74 0.016
apoptotic process GO:0006915 116 0.016
cognition GO:0050890 1 0.016
insulin like growth factor receptor signaling pathway GO:0048009 4 0.016
macromolecular complex disassembly GO:0032984 1 0.016
inorganic ion transmembrane transport GO:0098660 57 0.015
fatty acid beta oxidation GO:0006635 1 0.015
regulation of dna templated transcription in response to stress GO:0043620 0 0.015
heart development GO:0007507 313 0.015
metal ion transport GO:0030001 58 0.015
skeletal system development GO:0001501 181 0.015
regulation of fatty acid metabolic process GO:0019217 1 0.015
calcium mediated signaling GO:0019722 2 0.015
protein targeting to nucleus GO:0044744 3 0.015
lipid oxidation GO:0034440 1 0.015
meiotic cell cycle process GO:1903046 3 0.015
energy reserve metabolic process GO:0006112 2 0.015
determination of heart left right asymmetry GO:0061371 117 0.015
heterocycle biosynthetic process GO:0018130 215 0.015
cellular response to starvation GO:0009267 1 0.015
cellular response to external stimulus GO:0071496 2 0.015
regulation of intracellular ph GO:0051453 1 0.015
regulation of rna biosynthetic process GO:2001141 213 0.015
negative regulation of macromolecule metabolic process GO:0010605 76 0.015
cellular response to unfolded protein GO:0034620 2 0.015
positive regulation of epithelial cell migration GO:0010634 2 0.015
organophosphate biosynthetic process GO:0090407 23 0.015
response to external biotic stimulus GO:0043207 97 0.015
ubiquitin dependent protein catabolic process GO:0006511 3 0.015
single organism organelle organization GO:1902589 199 0.014
regulation of cell death GO:0010941 103 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
rna transport GO:0050658 2 0.014
aromatic compound biosynthetic process GO:0019438 217 0.014
generation of neurons GO:0048699 385 0.014
positive regulation of cell cycle GO:0045787 3 0.014
neuron projection development GO:0031175 180 0.014
system process GO:0003008 185 0.014
embryonic heart tube development GO:0035050 133 0.014
regulation of receptor activity GO:0010469 2 0.014
regulation of programmed cell death GO:0043067 101 0.014
regulation of anatomical structure morphogenesis GO:0022603 130 0.014
enzyme linked receptor protein signaling pathway GO:0007167 106 0.014
chemosensory behavior GO:0007635 1 0.014
homeostatic process GO:0042592 142 0.014
regulation of cell activation GO:0050865 1 0.014
negative regulation of metabolic process GO:0009892 86 0.014
multi organism cellular process GO:0044764 2 0.014
brain development GO:0007420 293 0.014
leukocyte proliferation GO:0070661 1 0.014
neurotransmitter secretion GO:0007269 2 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.014
purine nucleoside monophosphate catabolic process GO:0009128 4 0.014
protein dephosphorylation GO:0006470 3 0.013
negative regulation of multicellular organismal process GO:0051241 69 0.013
response to unfolded protein GO:0006986 2 0.013
peptidyl threonine phosphorylation GO:0018107 1 0.013
monovalent inorganic cation transport GO:0015672 42 0.013
cofactor metabolic process GO:0051186 15 0.013
posttranscriptional gene silencing by rna GO:0035194 3 0.013
regulation of oocyte development GO:0060281 3 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
multi organism process GO:0051704 134 0.013
cellular component maintenance GO:0043954 3 0.013
regulation of protein localization to nucleus GO:1900180 2 0.013
branching morphogenesis of a nerve GO:0048755 4 0.013
nucleic acid templated transcription GO:0097659 181 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
negative regulation of cytokine production GO:0001818 1 0.013
fatty acid oxidation GO:0019395 1 0.013
carbohydrate biosynthetic process GO:0016051 1 0.013
epithelial cell morphogenesis GO:0003382 2 0.013
negative regulation of cytoplasmic transport GO:1903650 2 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
lymphocyte proliferation GO:0046651 1 0.013
regulation of muscle contraction GO:0006937 3 0.013
regulation of signal transduction GO:0009966 225 0.013
monocarboxylic acid catabolic process GO:0072329 3 0.013
central nervous system development GO:0007417 387 0.013
regulation of cell migration GO:0030334 40 0.013
heart morphogenesis GO:0003007 156 0.013
positive regulation of protein polymerization GO:0032273 2 0.013
regulation of erk1 and erk2 cascade GO:0070372 4 0.013
regulation of mrna catabolic process GO:0061013 3 0.013
heart looping GO:0001947 94 0.013
nuclear export GO:0051168 1 0.013
specification of organ axis polarity GO:0010084 2 0.013
regulation of dna replication GO:0006275 3 0.013
wound healing GO:0042060 90 0.013
regulation of protein polymerization GO:0032271 2 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
phosphorus metabolic process GO:0006793 109 0.012
rna biosynthetic process GO:0032774 181 0.012
sprouting angiogenesis GO:0002040 53 0.012
receptor internalization GO:0031623 2 0.012
gtp metabolic process GO:0046039 4 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
organelle assembly GO:0070925 110 0.012
protein acetylation GO:0006473 2 0.012
establishment of rna localization GO:0051236 3 0.012
embryonic organ morphogenesis GO:0048562 274 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.012
thioester metabolic process GO:0035383 1 0.012
lipid catabolic process GO:0016042 4 0.012
regulation of cell substrate adhesion GO:0010810 1 0.012
regulation of cell maturation GO:1903429 1 0.012
regulation of mrna processing GO:0050684 3 0.012
carbohydrate homeostasis GO:0033500 1 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
cell morphogenesis GO:0000902 289 0.012
regulation of cardiac muscle contraction GO:0055117 2 0.012
regulation of neuron projection development GO:0010975 40 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
respiratory electron transport chain GO:0022904 2 0.012
positive regulation of dna metabolic process GO:0051054 1 0.012
chemotaxis GO:0006935 104 0.012
peptidyl serine phosphorylation GO:0018105 1 0.012
negative regulation of blood circulation GO:1903523 2 0.012
stem cell maintenance GO:0019827 4 0.012
tube closure GO:0060606 1 0.012
extracellular matrix organization GO:0030198 27 0.012
purine ribonucleoside triphosphate biosynthetic process GO:0009206 2 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
skeletal system morphogenesis GO:0048705 102 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
intracellular signal transduction GO:0035556 85 0.011
regulation of cellular component organization GO:0051128 86 0.011
response to vitamin GO:0033273 3 0.011
negative regulation of immune response GO:0050777 2 0.011
digestive system development GO:0055123 289 0.011
double strand break repair GO:0006302 3 0.011
nucleoside biosynthetic process GO:0009163 2 0.011
regulation of locomotion GO:0040012 55 0.011
methylation GO:0032259 22 0.011
fatty acid transport GO:0015908 1 0.011
muscle cell development GO:0055001 115 0.011
regulation of sodium ion transport GO:0002028 2 0.011
regulation of neurotransmitter transport GO:0051588 1 0.011
peptidyl serine modification GO:0018209 2 0.011
regulation of cellular component movement GO:0051270 55 0.011
small molecule catabolic process GO:0044282 3 0.011
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.011
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.011
protein localization to nucleus GO:0034504 3 0.011
interspecies interaction between organisms GO:0044419 4 0.011
positive regulation of blood circulation GO:1903524 2 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
regulation of myotube differentiation GO:0010830 2 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
catabolic process GO:0009056 32 0.011
sulfur compound biosynthetic process GO:0044272 9 0.011
neuron development GO:0048666 262 0.011
regulation of protein ubiquitination GO:0031396 3 0.011
centrosome organization GO:0051297 1 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
response to alkaloid GO:0043279 2 0.011
regulation of cellular biosynthetic process GO:0031326 245 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
skeletal muscle tissue development GO:0007519 67 0.011
er nucleus signaling pathway GO:0006984 2 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
sleep GO:0030431 1 0.011
fatty acid catabolic process GO:0009062 1 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
microtubule organizing center organization GO:0031023 1 0.011
regulation of transporter activity GO:0032409 2 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
positive regulation of cell substrate adhesion GO:0010811 1 0.011
positive regulation of stem cell proliferation GO:2000648 1 0.011
anion transport GO:0006820 38 0.011
response to abiotic stimulus GO:0009628 122 0.010
positive regulation of striated muscle cell differentiation GO:0051155 1 0.010
positive regulation of dna templated transcription elongation GO:0032786 1 0.010
actin filament polymerization GO:0030041 2 0.010
epithelial tube morphogenesis GO:0060562 148 0.010
primary neural tube formation GO:0014020 1 0.010
erythrocyte homeostasis GO:0034101 55 0.010
response to nutrient GO:0007584 3 0.010
germ cell development GO:0007281 22 0.010
adherens junction organization GO:0034332 4 0.010
purine ribonucleoside biosynthetic process GO:0046129 2 0.010
gene silencing GO:0016458 4 0.010
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.010
cellular response to organic substance GO:0071310 105 0.010
guanosine containing compound metabolic process GO:1901068 4 0.010
cell proliferation GO:0008283 80 0.010
g2 m transition of mitotic cell cycle GO:0000086 4 0.010
cellular response to decreased oxygen levels GO:0036294 1 0.010
axon development GO:0061564 166 0.010
negative regulation of apoptotic process GO:0043066 55 0.010
cellular protein catabolic process GO:0044257 4 0.010
positive regulation of striated muscle tissue development GO:0045844 1 0.010
guanosine containing compound catabolic process GO:1901069 2 0.010
dna templated transcription elongation GO:0006354 3 0.010
cellular amide metabolic process GO:0043603 4 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
negative regulation of multi organism process GO:0043901 3 0.010

ogdh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.079
inherited metabolic disorder DOID:655 0 0.079
disease of anatomical entity DOID:7 0 0.041
nervous system disease DOID:863 0 0.034
musculoskeletal system disease DOID:17 0 0.022
connective tissue disease DOID:65 0 0.019
bone disease DOID:0080001 0 0.014
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
cardiovascular system disease DOID:1287 0 0.011
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011
heart disease DOID:114 0 0.010
cardiomyopathy DOID:0050700 0 0.010
intrinsic cardiomyopathy DOID:0060036 0 0.010
central nervous system disease DOID:331 0 0.010
neurodegenerative disease DOID:1289 0 0.010