Danio rerio

0 known processes

ldlr

low density lipoprotein receptor

ldlr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.077
response to chemical GO:0042221 320 0.059
regulation of biological quality GO:0065008 263 0.059
positive regulation of cellular catabolic process GO:0031331 3 0.057
regulation of metabolic process GO:0019222 359 0.050
maintenance of location GO:0051235 4 0.048
signal transduction GO:0007165 455 0.047
regulation of primary metabolic process GO:0080090 311 0.047
response to drug GO:0042493 3 0.047
positive regulation of catabolic process GO:0009896 4 0.046
positive regulation of transport GO:0051050 2 0.044
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.044
regulation of nitrogen compound metabolic process GO:0051171 251 0.044
cellular macromolecule metabolic process GO:0044260 391 0.043
regulation of macromolecule metabolic process GO:0060255 317 0.042
embryonic organ development GO:0048568 381 0.041
nitrogen compound metabolic process GO:0006807 319 0.040
aging GO:0007568 2 0.040
cellular amine metabolic process GO:0044106 2 0.040
adult behavior GO:0030534 2 0.039
gene expression GO:0010467 252 0.039
cellular biosynthetic process GO:0044249 286 0.038
cellular nitrogen compound metabolic process GO:0034641 290 0.038
lipid storage GO:0019915 1 0.038
biosynthetic process GO:0009058 294 0.037
regulation of signaling GO:0023051 235 0.037
small molecule metabolic process GO:0044281 77 0.036
transmembrane transport GO:0055085 120 0.036
amine metabolic process GO:0009308 2 0.036
organic cyclic compound metabolic process GO:1901360 301 0.036
regulation of multicellular organism growth GO:0040014 4 0.035
regulation of cellular amino acid metabolic process GO:0006521 0 0.035
regulation of protein catabolic process GO:0042176 1 0.035
regulation of cellular metabolic process GO:0031323 320 0.035
cell surface receptor signaling pathway GO:0007166 325 0.034
aromatic compound biosynthetic process GO:0019438 217 0.034
establishment of protein localization to organelle GO:0072594 4 0.034
regulation of gene expression GO:0010468 265 0.034
regulation of cellular amine metabolic process GO:0033238 0 0.034
organic substance biosynthetic process GO:1901576 289 0.033
organic cyclic compound biosynthetic process GO:1901362 223 0.033
tube morphogenesis GO:0035239 349 0.033
cellular ketone metabolic process GO:0042180 11 0.032
nucleic acid templated transcription GO:0097659 181 0.032
rna biosynthetic process GO:0032774 181 0.032
response to vitamin GO:0033273 3 0.032
response to external stimulus GO:0009605 264 0.032
cellular response to nutrient levels GO:0031669 2 0.032
central nervous system development GO:0007417 387 0.032
regulation of cell communication GO:0010646 232 0.032
cation transmembrane transport GO:0098655 65 0.032
transcription from rna polymerase ii promoter GO:0006366 80 0.032
regulation of cellular ketone metabolic process GO:0010565 7 0.031
ion transmembrane transport GO:0034220 91 0.031
establishment of localization GO:0051234 244 0.031
cellular response to external stimulus GO:0071496 2 0.031
heterocycle metabolic process GO:0046483 290 0.030
cellular macromolecule biosynthetic process GO:0034645 224 0.030
regulation of protein complex assembly GO:0043254 3 0.030
response to nutrient GO:0007584 3 0.029
regulation of signal transduction GO:0009966 225 0.029
regulation of cytokine production GO:0001817 3 0.029
heterocycle biosynthetic process GO:0018130 215 0.029
cellular aromatic compound metabolic process GO:0006725 295 0.029
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.029
single organism metabolic process GO:0044710 217 0.029
multicellular organism growth GO:0035264 4 0.029
regulation of tube size GO:0035150 2 0.028
organonitrogen compound metabolic process GO:1901564 74 0.028
response to stress GO:0006950 263 0.028
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.028
regulation of biosynthetic process GO:0009889 250 0.028
digestive system development GO:0055123 289 0.028
transcription dna templated GO:0006351 181 0.027
regulation of rna metabolic process GO:0051252 224 0.027
regulation of macromolecule biosynthetic process GO:0010556 225 0.027
cellular component movement GO:0006928 335 0.027
regulation of response to stimulus GO:0048583 269 0.027
negative regulation of cellular process GO:0048523 283 0.027
protein import GO:0017038 3 0.027
nucleobase containing compound metabolic process GO:0006139 274 0.027
response to organic substance GO:0010033 153 0.026
cellular amino acid metabolic process GO:0006520 7 0.026
phagocytosis GO:0006909 3 0.026
determination of bilateral symmetry GO:0009855 204 0.026
rna metabolic process GO:0016070 219 0.026
organic acid metabolic process GO:0006082 31 0.026
embryonic organ morphogenesis GO:0048562 274 0.026
regionalization GO:0003002 274 0.026
gtp metabolic process GO:0046039 4 0.025
single organism transport GO:0044765 206 0.025
cellular carbohydrate metabolic process GO:0044262 4 0.025
carbohydrate biosynthetic process GO:0016051 1 0.025
cellular nitrogen compound biosynthetic process GO:0044271 218 0.025
regulation of rna biosynthetic process GO:2001141 213 0.025
regulation of transcription dna templated GO:0006355 213 0.025
positive regulation of cytokine production GO:0001819 2 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
macromolecule biosynthetic process GO:0009059 227 0.024
regulation of synaptic plasticity GO:0048167 1 0.024
regulation of inflammatory response GO:0050727 2 0.024
cellular response to extracellular stimulus GO:0031668 2 0.024
nucleobase containing compound biosynthetic process GO:0034654 205 0.024
positive regulation of cellular component biogenesis GO:0044089 3 0.024
positive regulation of cell cycle GO:0045787 3 0.024
transport GO:0006810 220 0.024
regulation of cellular biosynthetic process GO:0031326 245 0.023
vasculature development GO:0001944 278 0.023
regulation of blood vessel size GO:0050880 2 0.023
guanosine containing compound metabolic process GO:1901068 4 0.023
oxoacid metabolic process GO:0043436 31 0.023
cellular response to starvation GO:0009267 1 0.023
autophagy GO:0006914 4 0.023
regulation of binding GO:0051098 3 0.023
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.023
specification of symmetry GO:0009799 204 0.023
regulation of muscle contraction GO:0006937 3 0.023
brain development GO:0007420 293 0.022
gtp catabolic process GO:0006184 2 0.022
nuclear transport GO:0051169 4 0.022
cognition GO:0050890 1 0.022
regulation of reactive oxygen species metabolic process GO:2000377 2 0.022
positive regulation of blood circulation GO:1903524 2 0.022
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.022
synaptic transmission cholinergic GO:0007271 4 0.022
regulation of ph GO:0006885 3 0.021
regulation of nucleoside metabolic process GO:0009118 2 0.021
regulation of nucleotide catabolic process GO:0030811 2 0.021
regulation of transmembrane transporter activity GO:0022898 2 0.021
regulation of developmental process GO:0050793 247 0.021
negative regulation of biological process GO:0048519 304 0.021
muscle structure development GO:0061061 196 0.021
single organism localization GO:1902578 225 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.021
fatty acid transport GO:0015908 1 0.021
regulation of multicellular organismal process GO:0051239 277 0.021
regulation of carbohydrate metabolic process GO:0006109 4 0.021
stem cell proliferation GO:0072089 4 0.021
carboxylic acid metabolic process GO:0019752 22 0.021
regulation of ion transmembrane transporter activity GO:0032412 2 0.021
guanosine containing compound catabolic process GO:1901069 2 0.020
response to carbohydrate GO:0009743 3 0.020
nucleic acid metabolic process GO:0090304 244 0.020
tissue remodeling GO:0048771 4 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
regulation of nucleic acid templated transcription GO:1903506 213 0.020
positive regulation of biological process GO:0048518 253 0.020
dorsal ventral pattern formation GO:0009953 125 0.020
synaptic growth at neuromuscular junction GO:0051124 2 0.020
generation of neurons GO:0048699 385 0.020
hormone secretion GO:0046879 2 0.020
g1 s transition of mitotic cell cycle GO:0000082 1 0.020
cell motility GO:0048870 244 0.019
protein targeting to nucleus GO:0044744 3 0.019
protein localization to nucleus GO:0034504 3 0.019
negative regulation of protein kinase activity GO:0006469 4 0.019
regulation of wound healing GO:0061041 2 0.019
cellular component morphogenesis GO:0032989 336 0.019
protein localization to plasma membrane GO:0072659 1 0.019
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.019
inositol lipid mediated signaling GO:0048017 2 0.018
cell projection morphogenesis GO:0048858 244 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
regulation of cell activation GO:0050865 1 0.018
protein secretion GO:0009306 1 0.018
negative regulation of catabolic process GO:0009895 3 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
positive regulation of cellular process GO:0048522 201 0.018
negative regulation of kinase activity GO:0033673 4 0.018
digestive tract development GO:0048565 265 0.018
locomotion GO:0040011 313 0.018
cellular response to xenobiotic stimulus GO:0071466 35 0.018
regulation of gtp catabolic process GO:0033124 2 0.018
stem cell maintenance GO:0019827 4 0.018
regulation of striated muscle contraction GO:0006942 2 0.018
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.018
positive regulation of secretion GO:0051047 1 0.017
regulation of protein transport GO:0051223 3 0.017
smooth muscle contraction GO:0006939 2 0.017
small molecule catabolic process GO:0044282 3 0.017
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
cellular component biogenesis GO:0044085 178 0.017
localization of cell GO:0051674 244 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
muscle cell development GO:0055001 115 0.017
neuron differentiation GO:0030182 353 0.017
protein import into nucleus GO:0006606 3 0.017
regulation of metal ion transport GO:0010959 4 0.017
sodium ion transmembrane transport GO:0035725 21 0.017
blood vessel development GO:0001568 246 0.017
response to corticosteroid GO:0031960 1 0.017
system process GO:0003008 185 0.017
organelle organization GO:0006996 227 0.017
heart looping GO:0001947 94 0.017
membrane fusion GO:0061025 2 0.016
nucleocytoplasmic transport GO:0006913 4 0.016
digestive tract morphogenesis GO:0048546 231 0.016
protein metabolic process GO:0019538 183 0.016
regulation of anatomical structure morphogenesis GO:0022603 130 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
multicellular organismal metabolic process GO:0044236 2 0.016
single organism organelle organization GO:1902589 199 0.016
nuclear import GO:0051170 3 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
positive regulation of nucleotide catabolic process GO:0030813 1 0.016
single organism nuclear import GO:1902593 3 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
regulation of cytoplasmic transport GO:1903649 4 0.016
cellular response to organic substance GO:0071310 105 0.016
head development GO:0060322 303 0.016
response to endogenous stimulus GO:0009719 83 0.016
protein polymerization GO:0051258 4 0.016
cell migration GO:0016477 237 0.015
homeostatic process GO:0042592 142 0.015
determination of left right symmetry GO:0007368 179 0.015
regulation of reproductive process GO:2000241 4 0.015
mitochondrion organization GO:0007005 4 0.015
inorganic ion transmembrane transport GO:0098660 57 0.015
regulation of gtpase activity GO:0043087 2 0.015
negative regulation of mapk cascade GO:0043409 4 0.015
morphogenesis of an epithelium GO:0002009 333 0.015
regulation of multicellular organismal development GO:2000026 223 0.015
programmed cell death GO:0012501 119 0.015
inorganic cation transmembrane transport GO:0098662 50 0.015
germ line stem cell division GO:0042078 1 0.015
developmental programmed cell death GO:0010623 4 0.015
immune system process GO:0002376 241 0.015
monovalent inorganic cation transport GO:0015672 42 0.015
response to xenobiotic stimulus GO:0009410 45 0.015
wound healing GO:0042060 90 0.015
regulation of cellular protein catabolic process GO:1903362 1 0.015
positive regulation of gtp catabolic process GO:0033126 1 0.015
negative regulation of cytokine production GO:0001818 1 0.015
circulatory system process GO:0003013 87 0.015
cellular component assembly GO:0022607 170 0.015
complement activation GO:0006956 3 0.015
female sex differentiation GO:0046660 4 0.014
hormone transport GO:0009914 2 0.014
establishment of protein localization to plasma membrane GO:0090002 1 0.014
sensory organ morphogenesis GO:0090596 200 0.014
atp catabolic process GO:0006200 4 0.014
positive regulation of gtpase activity GO:0043547 1 0.014
blood vessel morphogenesis GO:0048514 216 0.014
embryo development ending in birth or egg hatching GO:0009792 271 0.014
post embryonic organ development GO:0048569 4 0.014
gastrulation GO:0007369 208 0.014
cellular protein catabolic process GO:0044257 4 0.014
response to alkaloid GO:0043279 2 0.014
development of primary female sexual characteristics GO:0046545 4 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
actin filament based movement GO:0030048 1 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
blood circulation GO:0008015 87 0.014
regulation of transporter activity GO:0032409 2 0.014
protein dephosphorylation GO:0006470 3 0.014
stem cell division GO:0017145 1 0.014
b cell activation GO:0042113 2 0.014
negative regulation of cellular metabolic process GO:0031324 77 0.014
negative regulation of signal transduction GO:0009968 94 0.014
growth GO:0040007 174 0.014
positive regulation of stress activated mapk cascade GO:0032874 3 0.014
peptide transport GO:0015833 1 0.014
long chain fatty acid metabolic process GO:0001676 1 0.013
gland development GO:0048732 143 0.013
cartilage development GO:0051216 96 0.013
female gonad development GO:0008585 4 0.013
negative regulation of defense response GO:0031348 2 0.013
neuron neuron synaptic transmission GO:0007270 1 0.013
intracellular signal transduction GO:0035556 85 0.013
inorganic anion transport GO:0015698 25 0.013
camera type eye development GO:0043010 222 0.013
cellular component disassembly GO:0022411 1 0.013
g protein coupled receptor signaling pathway GO:0007186 74 0.013
response to glucocorticoid GO:0051384 1 0.013
bmp signaling pathway GO:0030509 52 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
organelle fusion GO:0048284 3 0.013
regulation of dendrite development GO:0050773 3 0.013
modification dependent protein catabolic process GO:0019941 3 0.013
skeletal system morphogenesis GO:0048705 102 0.013
actin mediated cell contraction GO:0070252 1 0.013
response to oxygen containing compound GO:1901700 55 0.013
response to uv GO:0009411 3 0.013
eye development GO:0001654 277 0.013
lipid oxidation GO:0034440 1 0.013
regulation of neurotransmitter transport GO:0051588 1 0.013
connective tissue development GO:0061448 99 0.013
response to wounding GO:0009611 116 0.013
developmental growth GO:0048589 166 0.013
protein stabilization GO:0050821 2 0.013
response to hydrogen peroxide GO:0042542 3 0.013
regulation of erk1 and erk2 cascade GO:0070372 4 0.013
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.013
response to transition metal nanoparticle GO:1990267 28 0.013
chordate embryonic development GO:0043009 271 0.013
carbohydrate homeostasis GO:0033500 1 0.013
ion transport GO:0006811 114 0.013
single organism membrane fusion GO:0044801 2 0.013
response to amino acid GO:0043200 2 0.013
negative regulation of metabolic process GO:0009892 86 0.013
response to external biotic stimulus GO:0043207 97 0.013
organelle assembly GO:0070925 110 0.013
regulation of organ growth GO:0046620 3 0.013
response to monosaccharide GO:0034284 3 0.013
response to topologically incorrect protein GO:0035966 2 0.013
regulation of localization GO:0032879 104 0.013
sleep GO:0030431 1 0.013
positive regulation of map kinase activity GO:0043406 3 0.013
embryonic heart tube morphogenesis GO:0003143 108 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
striated muscle cell differentiation GO:0051146 129 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
cell cell recognition GO:0009988 1 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
regulation of cell differentiation GO:0045595 142 0.012
cell part morphogenesis GO:0032990 246 0.012
regulation of apoptotic process GO:0042981 98 0.012
gas transport GO:0015669 3 0.012
cellular response to oxygen levels GO:0071453 1 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
regulation of sodium ion transport GO:0002028 2 0.012
response to hexose GO:0009746 3 0.012
regulation of jak stat cascade GO:0046425 3 0.012
mesenchyme development GO:0060485 127 0.012
striated muscle cell development GO:0055002 108 0.012
cellular response to radiation GO:0071478 4 0.012
regulation of cell shape GO:0008360 1 0.012
angiogenesis GO:0001525 158 0.012
cation transport GO:0006812 81 0.012
trabecula morphogenesis GO:0061383 2 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
regulation of cell death GO:0010941 103 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
cell morphogenesis GO:0000902 289 0.012
cellular lipid catabolic process GO:0044242 3 0.012
negative regulation of cell communication GO:0010648 96 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
apoptotic process GO:0006915 116 0.012
regulation of membrane potential GO:0042391 23 0.012
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
regulation of protein targeting GO:1903533 2 0.012
multi organism process GO:0051704 134 0.011
muscle cell differentiation GO:0042692 139 0.011
mononuclear cell proliferation GO:0032943 1 0.011
negative regulation of signaling GO:0023057 96 0.011
endocrine process GO:0050886 2 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
carbon dioxide transport GO:0015670 3 0.011
heart development GO:0007507 313 0.011
regulation of autophagy GO:0010506 3 0.011
regulation of circadian rhythm GO:0042752 4 0.011
sensory perception of chemical stimulus GO:0007606 3 0.011
cellular amide metabolic process GO:0043603 4 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
response to glucose GO:0009749 3 0.011
cell projection organization GO:0030030 284 0.011
microtubule polymerization or depolymerization GO:0031109 3 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
regulation of epithelial cell proliferation GO:0050678 3 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.011
mesenchymal cell differentiation GO:0048762 87 0.011
cell substrate adhesion GO:0031589 4 0.011
epithelial tube morphogenesis GO:0060562 148 0.011
leukocyte proliferation GO:0070661 1 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
regulation of cellular component movement GO:0051270 55 0.011
positive regulation of heart contraction GO:0045823 2 0.011
notochord development GO:0030903 54 0.011
reactive oxygen species biosynthetic process GO:1903409 1 0.011
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.011
peptide metabolic process GO:0006518 1 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
alcohol biosynthetic process GO:0046165 2 0.011
astrocyte differentiation GO:0048708 1 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
phosphatidylinositol mediated signaling GO:0048015 2 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
protein homooligomerization GO:0051260 3 0.011
regulation of programmed cell death GO:0043067 101 0.011
nuclear migration GO:0007097 3 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
embryonic skeletal system morphogenesis GO:0048704 93 0.011
cellular protein metabolic process GO:0044267 129 0.011
cellular response to reactive oxygen species GO:0034614 2 0.011
action potential GO:0001508 19 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
cellular response to lipopolysaccharide GO:0071222 3 0.011
embryonic skeletal system development GO:0048706 97 0.011
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.011
regulation of blood pressure GO:0008217 1 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
positive regulation of protein complex assembly GO:0031334 2 0.010
water transport GO:0006833 15 0.010
sensory organ development GO:0007423 393 0.010
regulation of stem cell differentiation GO:2000736 4 0.010
g2 m transition of mitotic cell cycle GO:0000086 4 0.010
mitotic dna damage checkpoint GO:0044773 4 0.010
axon ensheathment in central nervous system GO:0032291 2 0.010
protein complex disassembly GO:0043241 1 0.010
macromolecular complex disassembly GO:0032984 1 0.010
regulation of glucose transport GO:0010827 1 0.010
regulation of system process GO:0044057 40 0.010
cell morphogenesis involved in differentiation GO:0000904 195 0.010
peptidyl lysine acetylation GO:0018394 2 0.010
death GO:0016265 121 0.010
lipid homeostasis GO:0055088 3 0.010
cellular aldehyde metabolic process GO:0006081 4 0.010

ldlr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.037
nervous system disease DOID:863 0 0.017
cancer DOID:162 0 0.016
disease of cellular proliferation DOID:14566 0 0.016
organ system cancer DOID:0050686 0 0.016
musculoskeletal system disease DOID:17 0 0.015
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
disease of metabolism DOID:0014667 0 0.011
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011
myopathy DOID:423 0 0.010
cardiovascular system disease DOID:1287 0 0.010