Danio rerio

20 known processes

hpx

hemopexin

(Aliases: wu:fi17f11,wu:fi19a10)

hpx biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
immune system process GO:0002376 241 0.490
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.218
Mouse
negative regulation of biological process GO:0048519 304 0.169
organic cyclic compound metabolic process GO:1901360 301 0.152
Mouse
aging GO:0007568 2 0.150
larval development GO:0002164 2 0.116
biosynthetic process GO:0009058 294 0.114
single organism metabolic process GO:0044710 217 0.110
Mouse
macromolecule biosynthetic process GO:0009059 227 0.106
regulation of transcription dna templated GO:0006355 213 0.096
regulation of metabolic process GO:0019222 359 0.092
Mouse
organic substance biosynthetic process GO:1901576 289 0.086
response to stress GO:0006950 263 0.084
Mouse
regulation of multicellular organismal process GO:0051239 277 0.084
camera type eye development GO:0043010 222 0.081
positive regulation of cellular component biogenesis GO:0044089 3 0.075
nitrogen compound metabolic process GO:0006807 319 0.068
Mouse
negative regulation of cellular process GO:0048523 283 0.063
signal transduction GO:0007165 455 0.063
Mouse
regulation of cell death GO:0010941 103 0.056
regulation of establishment of protein localization GO:0070201 4 0.055
cell surface receptor signaling pathway GO:0007166 325 0.053
Mouse
nucleic acid templated transcription GO:0097659 181 0.051
organonitrogen compound metabolic process GO:1901564 74 0.050
Mouse
rna biosynthetic process GO:0032774 181 0.050
regulation of macromolecule metabolic process GO:0060255 317 0.049
Mouse
positive regulation of cellular process GO:0048522 201 0.048
Mouse
response to biotic stimulus GO:0009607 97 0.047
cellular aromatic compound metabolic process GO:0006725 295 0.047
Mouse
gene expression GO:0010467 252 0.047
regulation of dna replication GO:0006275 3 0.046
regulation of protein complex assembly GO:0043254 3 0.045
regulation of biosynthetic process GO:0009889 250 0.044
ear development GO:0043583 127 0.043
positive regulation of blood circulation GO:1903524 2 0.043
extrinsic apoptotic signaling pathway GO:0097191 3 0.042
regulation of nitrogen compound metabolic process GO:0051171 251 0.042
cell death GO:0008219 121 0.042
cellular biosynthetic process GO:0044249 286 0.042
skeletal system development GO:0001501 181 0.042
cell substrate adhesion GO:0031589 4 0.041
response to wounding GO:0009611 116 0.041
regulation of cellular ketone metabolic process GO:0010565 7 0.040
regulation of multicellular organism growth GO:0040014 4 0.040
generation of neurons GO:0048699 385 0.040
heterocycle metabolic process GO:0046483 290 0.040
Mouse
regulation of primary metabolic process GO:0080090 311 0.040
Mouse
organic acid metabolic process GO:0006082 31 0.040
innate immune response GO:0045087 13 0.039
Mouse
cellular ketone metabolic process GO:0042180 11 0.039
stem cell proliferation GO:0072089 4 0.039
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.039
maintenance of location GO:0051235 4 0.038
multicellular organism growth GO:0035264 4 0.038
response to external stimulus GO:0009605 264 0.038
regulation of rna biosynthetic process GO:2001141 213 0.037
protein polymerization GO:0051258 4 0.037
regulation of binding GO:0051098 3 0.037
cellular nitrogen compound metabolic process GO:0034641 290 0.037
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.037
morphogenesis of an epithelium GO:0002009 333 0.037
carboxylic acid metabolic process GO:0019752 22 0.037
phosphorus metabolic process GO:0006793 109 0.036
Mouse
nucleic acid metabolic process GO:0090304 244 0.036
cellular response to xenobiotic stimulus GO:0071466 35 0.036
cell proliferation GO:0008283 80 0.036
response to other organism GO:0051707 97 0.035
death GO:0016265 121 0.035
embryonic organ development GO:0048568 381 0.035
small molecule metabolic process GO:0044281 77 0.035
regulation of biological quality GO:0065008 263 0.035
regulation of nucleic acid templated transcription GO:1903506 213 0.035
regulation of response to stimulus GO:0048583 269 0.035
Mouse
regulation of cytokine production GO:0001817 3 0.035
regeneration GO:0031099 91 0.035
regulation of multicellular organismal development GO:2000026 223 0.034
regulation of apoptotic process GO:0042981 98 0.034
phosphate containing compound metabolic process GO:0006796 108 0.034
Mouse
cellular protein catabolic process GO:0044257 4 0.034
apoptotic process GO:0006915 116 0.033
nucleobase containing compound metabolic process GO:0006139 274 0.033
nucleobase containing compound biosynthetic process GO:0034654 205 0.033
circulatory system process GO:0003013 87 0.032
positive regulation of metabolic process GO:0009893 108 0.032
Mouse
developmental growth GO:0048589 166 0.032
defense response GO:0006952 47 0.032
Mouse
regulation of programmed cell death GO:0043067 101 0.032
digestive tract morphogenesis GO:0048546 231 0.032
response to glucocorticoid GO:0051384 1 0.031
system process GO:0003008 185 0.031
cellular amide metabolic process GO:0043603 4 0.031
leukocyte homeostasis GO:0001776 2 0.031
transcription dna templated GO:0006351 181 0.030
embryonic organ morphogenesis GO:0048562 274 0.030
locomotion GO:0040011 313 0.030
regulation of gene expression GO:0010468 265 0.030
regulation of cellular biosynthetic process GO:0031326 245 0.030
transport GO:0006810 220 0.030
regulation of inflammatory response GO:0050727 2 0.030
cellular amine metabolic process GO:0044106 2 0.030
negative regulation of apoptotic process GO:0043066 55 0.029
fatty acid biosynthetic process GO:0006633 4 0.029
transmembrane transport GO:0055085 120 0.029
positive regulation of biological process GO:0048518 253 0.029
Mouse
multi organism process GO:0051704 134 0.028
regulation of cell activation GO:0050865 1 0.028
regulation of protein transport GO:0051223 3 0.028
post embryonic organ development GO:0048569 4 0.028
regulation of rna metabolic process GO:0051252 224 0.028
regulation of blood pressure GO:0008217 1 0.028
ovulation cycle process GO:0022602 2 0.028
sensory organ development GO:0007423 393 0.028
retina development in camera type eye GO:0060041 146 0.028
oxoacid metabolic process GO:0043436 31 0.027
regulation of macromolecule biosynthetic process GO:0010556 225 0.027
neurotransmitter transport GO:0006836 2 0.027
positive regulation of protein complex assembly GO:0031334 2 0.027
regulation of neurogenesis GO:0050767 87 0.027
tube morphogenesis GO:0035239 349 0.027
programmed cell death GO:0012501 119 0.027
secondary metabolic process GO:0019748 3 0.026
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.026
neurological system process GO:0050877 62 0.026
nephron tubule morphogenesis GO:0072078 1 0.026
lipid storage GO:0019915 1 0.026
positive regulation of transport GO:0051050 2 0.026
immune effector process GO:0002252 23 0.026
Mouse
positive regulation of catabolic process GO:0009896 4 0.026
negative regulation of gene expression GO:0010629 65 0.025
fertilization GO:0009566 3 0.025
regionalization GO:0003002 274 0.025
cellular macromolecule biosynthetic process GO:0034645 224 0.025
transcription from rna polymerase ii promoter GO:0006366 80 0.025
response to xenobiotic stimulus GO:0009410 45 0.025
hemopoiesis GO:0030097 183 0.025
homeostatic process GO:0042592 142 0.024
development of primary female sexual characteristics GO:0046545 4 0.024
regulation of signaling GO:0023051 235 0.024
Mouse
intracellular signal transduction GO:0035556 85 0.024
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.024
heterocycle biosynthetic process GO:0018130 215 0.024
hepaticobiliary system development GO:0061008 98 0.024
cognition GO:0050890 1 0.024
aromatic compound biosynthetic process GO:0019438 217 0.024
cell projection morphogenesis GO:0048858 244 0.024
phagocytosis GO:0006909 3 0.023
negative regulation of cell death GO:0060548 60 0.023
organic cyclic compound biosynthetic process GO:1901362 223 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.023
negative regulation of dna metabolic process GO:0051053 4 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
negative regulation of dna replication GO:0008156 2 0.023
mononuclear cell proliferation GO:0032943 1 0.023
meiotic nuclear division GO:0007126 4 0.022
response to chemical GO:0042221 320 0.022
wound healing GO:0042060 90 0.022
cellular amino acid metabolic process GO:0006520 7 0.022
response to bacterium GO:0009617 58 0.022
blood vessel development GO:0001568 246 0.022
mycotoxin metabolic process GO:0043385 1 0.022
cell part morphogenesis GO:0032990 246 0.022
vasculature development GO:0001944 278 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
lymphocyte proliferation GO:0046651 1 0.021
embryonic skeletal system development GO:0048706 97 0.021
regulation of molecular function GO:0065009 70 0.021
embryonic hemopoiesis GO:0035162 53 0.021
central nervous system neuron differentiation GO:0021953 74 0.021
glucose homeostasis GO:0042593 1 0.021
nuclear transport GO:0051169 4 0.020
blood circulation GO:0008015 87 0.020
gastrulation GO:0007369 208 0.020
cellular modified amino acid metabolic process GO:0006575 3 0.020
liver development GO:0001889 96 0.020
nephron morphogenesis GO:0072028 2 0.020
establishment of localization GO:0051234 244 0.020
regulation of stem cell differentiation GO:2000736 4 0.020
immune response GO:0006955 28 0.019
Mouse
rna metabolic process GO:0016070 219 0.019
positive regulation of cell cycle GO:0045787 3 0.019
antimicrobial humoral response GO:0019730 2 0.019
cellular component assembly GO:0022607 170 0.019
amine metabolic process GO:0009308 2 0.019
tissue regeneration GO:0042246 74 0.019
mitochondrion organization GO:0007005 4 0.019
cellular component disassembly GO:0022411 1 0.019
apoptotic process involved in development GO:1902742 2 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.019
regulation of protein catabolic process GO:0042176 1 0.019
negative regulation of reproductive process GO:2000242 3 0.019
gland development GO:0048732 143 0.019
homeostasis of number of cells GO:0048872 62 0.018
embryonic skeletal joint development GO:0072498 3 0.018
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.018
regulation of cell development GO:0060284 100 0.018
monoamine transport GO:0015844 1 0.018
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
single organism localization GO:1902578 225 0.018
regulation of immune response GO:0050776 14 0.018
Mouse
growth GO:0040007 174 0.018
response to corticosteroid GO:0031960 1 0.018
regulation of reproductive process GO:2000241 4 0.018
dna templated transcription initiation GO:0006352 1 0.018
response to external biotic stimulus GO:0043207 97 0.018
regulation of signal transduction GO:0009966 225 0.018
Mouse
cellular component morphogenesis GO:0032989 336 0.018
phagocytosis engulfment GO:0006911 1 0.017
positive regulation of secretion by cell GO:1903532 1 0.017
spermatid development GO:0007286 2 0.017
protein metabolic process GO:0019538 183 0.017
Mouse
embryonic digestive tract morphogenesis GO:0048557 3 0.017
membrane invagination GO:0010324 1 0.017
response to organic cyclic compound GO:0014070 51 0.017
catechol containing compound metabolic process GO:0009712 2 0.017
response to drug GO:0042493 3 0.017
cellular protein metabolic process GO:0044267 129 0.016
Mouse
cell morphogenesis involved in differentiation GO:0000904 195 0.016
cell morphogenesis GO:0000902 289 0.016
sequestering of metal ion GO:0051238 3 0.016
angiogenesis GO:0001525 158 0.016
negative regulation of macromolecule metabolic process GO:0010605 76 0.016
modification dependent macromolecule catabolic process GO:0043632 3 0.016
regulation of systemic arterial blood pressure GO:0003073 1 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.016
protein localization to nucleus GO:0034504 3 0.016
peptidyl serine modification GO:0018209 2 0.016
positive regulation of exocytosis GO:0045921 1 0.016
protein secretion GO:0009306 1 0.016
regulation of autophagy GO:0010506 3 0.015
negative regulation of catabolic process GO:0009895 3 0.015
leukocyte proliferation GO:0070661 1 0.015
cellular amino acid biosynthetic process GO:0008652 2 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
muscle cell differentiation GO:0042692 139 0.015
formation of primary germ layer GO:0001704 62 0.015
pigmentation GO:0043473 85 0.015
response to nutrient GO:0007584 3 0.015
cation transport GO:0006812 81 0.015
macromolecule modification GO:0043412 111 0.015
Mouse
cellular component biogenesis GO:0044085 178 0.015
cell projection organization GO:0030030 284 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
positive regulation of cell activation GO:0050867 1 0.015
erythrocyte development GO:0048821 24 0.015
neurotransmitter secretion GO:0007269 2 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.014
cellular response to external stimulus GO:0071496 2 0.014
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.014
negative regulation of programmed cell death GO:0043069 58 0.014
regulation of fatty acid metabolic process GO:0019217 1 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
Mouse
female sex differentiation GO:0046660 4 0.014
striated muscle cell differentiation GO:0051146 129 0.014
regulation of protein binding GO:0043393 3 0.014
negative regulation of cellular metabolic process GO:0031324 77 0.014
heart development GO:0007507 313 0.014
nuclear import GO:0051170 3 0.014
embryonic skeletal system morphogenesis GO:0048704 93 0.014
eye development GO:0001654 277 0.014
muscle structure development GO:0061061 196 0.014
small molecule biosynthetic process GO:0044283 16 0.014
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.014
digestive tract development GO:0048565 265 0.014
somatic muscle development GO:0007525 4 0.014
appendage morphogenesis GO:0035107 56 0.014
protein import into nucleus GO:0006606 3 0.014
ovulation cycle GO:0042698 2 0.014
regulation of jak stat cascade GO:0046425 3 0.014
Mouse
ion transport GO:0006811 114 0.014
phosphorylation GO:0016310 69 0.014
Mouse
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
hematopoietic or lymphoid organ development GO:0048534 191 0.014
heart looping GO:0001947 94 0.014
stem cell differentiation GO:0048863 117 0.014
positive regulation of secretion GO:0051047 1 0.014
aflatoxin metabolic process GO:0046222 1 0.014
dna metabolic process GO:0006259 27 0.014
regulation of blood vessel size GO:0050880 2 0.014
single fertilization GO:0007338 3 0.014
organelle assembly GO:0070925 110 0.013
appendage development GO:0048736 80 0.013
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.013
negative regulation of cellular catabolic process GO:0031330 3 0.013
inner ear development GO:0048839 126 0.013
single organism biosynthetic process GO:0044711 71 0.013
oocyte maturation GO:0001556 4 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
tissue remodeling GO:0048771 4 0.013
head development GO:0060322 303 0.013
protein targeting to nucleus GO:0044744 3 0.013
carbohydrate homeostasis GO:0033500 1 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
peptide transport GO:0015833 1 0.013
neuron projection development GO:0031175 180 0.013
wnt signaling pathway GO:0016055 80 0.013
positive regulation of cytoskeleton organization GO:0051495 3 0.013
regulation of developmental process GO:0050793 247 0.013
mesenchyme development GO:0060485 127 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
alcohol biosynthetic process GO:0046165 2 0.013
regulation of cellular protein catabolic process GO:1903362 1 0.013
positive regulation of dna metabolic process GO:0051054 1 0.012
proteasomal protein catabolic process GO:0010498 2 0.012
b cell activation GO:0042113 2 0.012
lipid catabolic process GO:0016042 4 0.012
regulation of cytoplasmic transport GO:1903649 4 0.012
negative regulation of blood circulation GO:1903523 2 0.012
regulation of wound healing GO:0061041 2 0.012
positive regulation of cytokine production GO:0001819 2 0.012
response to virus GO:0009615 21 0.012
response to abiotic stimulus GO:0009628 122 0.012
negative regulation of multi organism process GO:0043901 3 0.012
cellular lipid catabolic process GO:0044242 3 0.012
renal system development GO:0072001 94 0.012
catecholamine metabolic process GO:0006584 2 0.012
aflatoxin b1 metabolic process GO:0043390 1 0.012
organic substance transport GO:0071702 58 0.012
positive regulation of apoptotic signaling pathway GO:2001235 1 0.012
stem cell division GO:0017145 1 0.012
coagulation GO:0050817 13 0.012
negative regulation of metabolic process GO:0009892 86 0.012
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.012
negative regulation of biosynthetic process GO:0009890 55 0.012
cellular response to drug GO:0035690 1 0.012
toxin metabolic process GO:0009404 1 0.012
negative regulation of transcription dna templated GO:0045892 45 0.012
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
response to endogenous stimulus GO:0009719 83 0.011
erythrocyte differentiation GO:0030218 54 0.011
nucleoside monophosphate catabolic process GO:0009125 4 0.011
cellular response to radiation GO:0071478 4 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
ether metabolic process GO:0018904 1 0.011
skeletal system morphogenesis GO:0048705 102 0.011
single organism organelle organization GO:1902589 199 0.011
organelle organization GO:0006996 227 0.011
xenobiotic metabolic process GO:0006805 4 0.011
regulation of cell projection assembly GO:0060491 4 0.011
autophagy GO:0006914 4 0.011
cytokinesis GO:0000910 3 0.011
positive regulation of immune effector process GO:0002699 3 0.011
Mouse
protein activation cascade GO:0072376 6 0.011
glial cell proliferation GO:0014009 4 0.011
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.011
sequestering of calcium ion GO:0051208 3 0.011
erythrocyte homeostasis GO:0034101 55 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
digestive system development GO:0055123 289 0.011
hormone secretion GO:0046879 2 0.011
energy reserve metabolic process GO:0006112 2 0.011
response to light intensity GO:0009642 1 0.011
peptide metabolic process GO:0006518 1 0.011
cellular component movement GO:0006928 335 0.011
interspecies interaction between organisms GO:0044419 4 0.011
regulation of tube size GO:0035150 2 0.011
purine nucleoside monophosphate catabolic process GO:0009128 4 0.011
positive regulation of multi organism process GO:0043902 3 0.011
regulation of cell communication GO:0010646 232 0.010
Mouse
renal tubule morphogenesis GO:0061333 1 0.010
positive regulation of leukocyte migration GO:0002687 2 0.010
specification of organ identity GO:0010092 2 0.010
urogenital system development GO:0001655 97 0.010
post embryonic morphogenesis GO:0009886 4 0.010
exocytosis GO:0006887 1 0.010
muscle tissue development GO:0060537 110 0.010
atp catabolic process GO:0006200 4 0.010
negative regulation of multicellular organismal process GO:0051241 69 0.010
regulation of cellular metabolic process GO:0031323 320 0.010
Mouse
positive regulation of cellular metabolic process GO:0031325 94 0.010
Mouse
neuroblast proliferation GO:0007405 2 0.010
meiotic cell cycle process GO:1903046 3 0.010
cell matrix adhesion GO:0007160 4 0.010
fatty acid oxidation GO:0019395 1 0.010
regulation of neurotransmitter secretion GO:0046928 1 0.010

hpx disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.111
disease of metabolism DOID:0014667 0 0.037
immune system disease DOID:2914 0 0.020
nervous system disease DOID:863 0 0.016
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
cardiovascular system disease DOID:1287 0 0.013
organ system cancer DOID:0050686 0 0.012