Danio rerio

0 known processes

hpd

4-hydroxyphenylpyruvate dioxygenase

(Aliases: hpdb,zgc:92456)

hpd biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of multicellular organismal process GO:0051239 277 0.219
eye development GO:0001654 277 0.173
cell surface receptor signaling pathway GO:0007166 325 0.146
sensory organ development GO:0007423 393 0.144
skeletal system development GO:0001501 181 0.141
regulation of cell differentiation GO:0045595 142 0.107
digestive tract morphogenesis GO:0048546 231 0.104
morphogenesis of an epithelium GO:0002009 333 0.099
regulation of developmental process GO:0050793 247 0.095
signal transduction GO:0007165 455 0.095
regulation of signal transduction GO:0009966 225 0.090
regulation of response to stimulus GO:0048583 269 0.088
regulation of multicellular organismal development GO:2000026 223 0.088
negative regulation of response to stimulus GO:0048585 104 0.080
generation of neurons GO:0048699 385 0.079
regulation of reproductive process GO:2000241 4 0.077
cell substrate adhesion GO:0031589 4 0.076
heart development GO:0007507 313 0.073
regulation of cell shape GO:0008360 1 0.072
regulation of neurogenesis GO:0050767 87 0.071
cell migration GO:0016477 237 0.069
larval development GO:0002164 2 0.068
positive regulation of transport GO:0051050 2 0.066
vasculature development GO:0001944 278 0.065
regulation of hormone secretion GO:0046883 2 0.065
regulation of stem cell differentiation GO:2000736 4 0.061
tube morphogenesis GO:0035239 349 0.061
regulation of neuron differentiation GO:0045664 56 0.059
regulation of cell development GO:0060284 100 0.058
cellular component movement GO:0006928 335 0.057
protein localization to nucleus GO:0034504 3 0.056
locomotion GO:0040011 313 0.055
positive regulation of cell differentiation GO:0045597 30 0.055
regulation of signaling GO:0023051 235 0.055
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.054
organic substance biosynthetic process GO:1901576 289 0.052
cell motility GO:0048870 244 0.048
cartilage development GO:0051216 96 0.047
biological adhesion GO:0022610 40 0.047
digestive tract development GO:0048565 265 0.046
ameboidal type cell migration GO:0001667 143 0.045
regulation of nervous system development GO:0051960 90 0.045
regulation of cell substrate adhesion GO:0010810 1 0.044
cell fate commitment GO:0045165 99 0.043
localization of cell GO:0051674 244 0.042
specification of symmetry GO:0009799 204 0.042
regulation of anatomical structure morphogenesis GO:0022603 130 0.041
cell fate specification GO:0001708 68 0.040
cell morphogenesis involved in differentiation GO:0000904 195 0.040
hormone transport GO:0009914 2 0.040
regulation of synapse assembly GO:0051963 3 0.039
positive regulation of developmental process GO:0051094 50 0.039
regulation of cellular biosynthetic process GO:0031326 245 0.039
hematopoietic or lymphoid organ development GO:0048534 191 0.039
regulation of establishment of protein localization GO:0070201 4 0.039
cell part morphogenesis GO:0032990 246 0.038
negative regulation of cellular process GO:0048523 283 0.038
nuclear transport GO:0051169 4 0.038
gastrulation GO:0007369 208 0.038
regulation of cell communication GO:0010646 232 0.038
cell adhesion GO:0007155 40 0.038
nucleocytoplasmic transport GO:0006913 4 0.037
negative regulation of biological process GO:0048519 304 0.036
biosynthetic process GO:0009058 294 0.036
peptide transport GO:0015833 1 0.036
regulation of intracellular protein transport GO:0033157 3 0.035
nucleic acid metabolic process GO:0090304 244 0.035
multicellular organism growth GO:0035264 4 0.035
regulation of gene expression GO:0010468 265 0.035
digestive system development GO:0055123 289 0.034
nucleobase containing compound biosynthetic process GO:0034654 205 0.034
regulation of locomotion GO:0040012 55 0.034
protein import GO:0017038 3 0.034
positive regulation of stress activated mapk cascade GO:0032874 3 0.034
hormone secretion GO:0046879 2 0.033
cellular nitrogen compound biosynthetic process GO:0044271 218 0.033
regulation of biosynthetic process GO:0009889 250 0.033
nucleic acid templated transcription GO:0097659 181 0.033
positive regulation of cell adhesion GO:0045785 1 0.033
nuclear import GO:0051170 3 0.033
regulation of synapse organization GO:0050807 3 0.032
lateral inhibition GO:0046331 1 0.032
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.032
organelle assembly GO:0070925 110 0.032
embryonic organ morphogenesis GO:0048562 274 0.032
regulation of nucleocytoplasmic transport GO:0046822 2 0.032
cellular component biogenesis GO:0044085 178 0.032
organic cyclic compound biosynthetic process GO:1901362 223 0.031
positive regulation of biological process GO:0048518 253 0.031
convergent extension GO:0060026 118 0.031
blood vessel morphogenesis GO:0048514 216 0.031
cognition GO:0050890 1 0.031
macromolecule biosynthetic process GO:0009059 227 0.030
epithelial cell migration GO:0010631 25 0.030
cellular macromolecule biosynthetic process GO:0034645 224 0.029
head development GO:0060322 303 0.029
regulation of primary metabolic process GO:0080090 311 0.029
positive regulation of cellular process GO:0048522 201 0.028
immune system process GO:0002376 241 0.028
chordate embryonic development GO:0043009 271 0.028
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.028
muscle tissue development GO:0060537 110 0.028
angiogenesis GO:0001525 158 0.028
formation of primary germ layer GO:0001704 62 0.028
positive regulation of cell substrate adhesion GO:0010811 1 0.027
small molecule catabolic process GO:0044282 3 0.027
neuron differentiation GO:0030182 353 0.027
cell morphogenesis GO:0000902 289 0.027
regulation of protein transport GO:0051223 3 0.027
regulation of protein targeting GO:1903533 2 0.027
embryonic organ development GO:0048568 381 0.027
glucose homeostasis GO:0042593 1 0.026
mesenchymal cell development GO:0014031 78 0.026
regulation of cellular component movement GO:0051270 55 0.026
aging GO:0007568 2 0.026
Worm
regulation of multicellular organism growth GO:0040014 4 0.026
regulation of protein localization to nucleus GO:1900180 2 0.026
regulation of metabolic process GO:0019222 359 0.026
regulation of macromolecule biosynthetic process GO:0010556 225 0.025
developmental growth GO:0048589 166 0.025
protein targeting to nucleus GO:0044744 3 0.025
nitrogen compound metabolic process GO:0006807 319 0.025
gland development GO:0048732 143 0.025
cellular macromolecule metabolic process GO:0044260 391 0.024
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.024
stem cell maintenance GO:0019827 4 0.024
mesenchyme development GO:0060485 127 0.024
cellular nitrogen compound metabolic process GO:0034641 290 0.023
response to drug GO:0042493 3 0.023
negative regulation of synapse assembly GO:0051964 2 0.023
organic acid metabolic process GO:0006082 31 0.023
brain development GO:0007420 293 0.023
mononuclear cell proliferation GO:0032943 1 0.023
epithelium migration GO:0090132 25 0.023
single organism nuclear import GO:1902593 3 0.023
germ line stem cell maintenance GO:0030718 2 0.023
establishment of protein localization to organelle GO:0072594 4 0.022
sprouting angiogenesis GO:0002040 53 0.022
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.022
positive regulation of signal transduction GO:0009967 56 0.022
activation of mapk activity GO:0000187 3 0.022
blood vessel endothelial cell migration GO:0043534 18 0.022
positive regulation of locomotion GO:0040017 14 0.022
outflow tract morphogenesis GO:0003151 1 0.022
regulation of cell activation GO:0050865 1 0.022
eye morphogenesis GO:0048592 144 0.022
oxoacid metabolic process GO:0043436 31 0.021
positive regulation of jnk cascade GO:0046330 3 0.021
protein metabolic process GO:0019538 183 0.021
negative regulation of ras protein signal transduction GO:0046580 1 0.021
cellular response to organic substance GO:0071310 105 0.021
embryonic heart tube development GO:0035050 133 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
endothelial cell migration GO:0043542 19 0.021
cellular component morphogenesis GO:0032989 336 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
regionalization GO:0003002 274 0.020
connective tissue development GO:0061448 99 0.020
central nervous system development GO:0007417 387 0.020
transcription from rna polymerase ii promoter GO:0006366 80 0.020
regulation of rna biosynthetic process GO:2001141 213 0.020
release of sequestered calcium ion into cytosol GO:0051209 3 0.020
regulation of rna metabolic process GO:0051252 224 0.020
positive regulation of cellular component biogenesis GO:0044089 3 0.020
developmental growth involved in morphogenesis GO:0060560 86 0.020
single organism metabolic process GO:0044710 217 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
regulation of macromolecule metabolic process GO:0060255 317 0.020
sensory perception of chemical stimulus GO:0007606 3 0.020
negative regulation of chemotaxis GO:0050922 4 0.019
extrinsic apoptotic signaling pathway GO:0097191 3 0.019
carbohydrate homeostasis GO:0033500 1 0.019
positive regulation of multicellular organismal process GO:0051240 52 0.019
lymphocyte proliferation GO:0046651 1 0.019
carboxylic acid metabolic process GO:0019752 22 0.019
tissue migration GO:0090130 37 0.019
axonogenesis GO:0007409 152 0.019
mesenchymal cell differentiation GO:0048762 87 0.019
response to glucose GO:0009749 3 0.019
extracellular structure organization GO:0043062 27 0.019
regulation of cell motility GO:2000145 46 0.019
response to carbohydrate GO:0009743 3 0.018
cellular aromatic compound metabolic process GO:0006725 295 0.018
transcription dna templated GO:0006351 181 0.018
regulation of sequestering of calcium ion GO:0051282 4 0.018
camera type eye development GO:0043010 222 0.018
negative regulation of sequestering of calcium ion GO:0051283 4 0.018
aromatic compound biosynthetic process GO:0019438 217 0.018
negative regulation of catabolic process GO:0009895 3 0.018
positive regulation of cell development GO:0010720 25 0.018
response to hexose GO:0009746 3 0.018
amine metabolic process GO:0009308 2 0.018
nucleobase containing compound metabolic process GO:0006139 274 0.018
single organism localization GO:1902578 225 0.018
rna biosynthetic process GO:0032774 181 0.018
negative chemotaxis GO:0050919 1 0.018
positive regulation of response to stimulus GO:0048584 80 0.017
mesodermal cell differentiation GO:0048333 21 0.017
response to organic substance GO:0010033 153 0.017
stem cell proliferation GO:0072089 4 0.017
positive regulation of synapse assembly GO:0051965 1 0.017
positive regulation of secretion GO:0051047 1 0.017
forebrain cell migration GO:0021885 1 0.017
negative regulation of cell differentiation GO:0045596 46 0.017
cell cycle g1 s phase transition GO:0044843 1 0.017
regulation of erk1 and erk2 cascade GO:0070372 4 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
protein polymerization GO:0051258 4 0.017
response to monosaccharide GO:0034284 3 0.017
stem cell development GO:0048864 82 0.017
striated muscle cell development GO:0055002 108 0.017
regulation of transcription dna templated GO:0006355 213 0.017
internal peptidyl lysine acetylation GO:0018393 2 0.017
regulation of protein catabolic process GO:0042176 1 0.017
sequestering of metal ion GO:0051238 3 0.017
establishment of organelle localization GO:0051656 45 0.016
cell matrix adhesion GO:0007160 4 0.016
regulation of behavior GO:0050795 24 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.016
chemotaxis GO:0006935 104 0.016
regulation of rho protein signal transduction GO:0035023 2 0.016
blood vessel development GO:0001568 246 0.016
stem cell differentiation GO:0048863 117 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
cellular protein metabolic process GO:0044267 129 0.016
heterocycle biosynthetic process GO:0018130 215 0.016
endocrine system development GO:0035270 65 0.016
programmed cell death GO:0012501 119 0.016
regulation of biomineral tissue development GO:0070167 2 0.016
hard palate development GO:0060022 4 0.016
production of molecular mediator of immune response GO:0002440 2 0.015
negative regulation of signaling GO:0023057 96 0.015
regulation of cellular component organization GO:0051128 86 0.015
regulation of dendrite development GO:0050773 3 0.015
endosomal transport GO:0016197 2 0.015
negative regulation of multicellular organismal process GO:0051241 69 0.015
rna metabolic process GO:0016070 219 0.015
positive regulation of nervous system development GO:0051962 25 0.015
immune system development GO:0002520 191 0.015
g protein coupled receptor signaling pathway GO:0007186 74 0.015
regulation of dna replication GO:0006275 3 0.015
regulation of programmed cell death GO:0043067 101 0.015
response to stress GO:0006950 263 0.015
defense response to fungus GO:0050832 2 0.015
protein acylation GO:0043543 3 0.015
response to nutrient GO:0007584 3 0.015
multicellular organismal metabolic process GO:0044236 2 0.015
response to growth factor GO:0070848 39 0.015
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.014
phagocytosis GO:0006909 3 0.014
negative regulation of developmental process GO:0051093 65 0.014
signal transduction in absence of ligand GO:0038034 1 0.014
multicellular organismal macromolecule metabolic process GO:0044259 2 0.014
cellular component assembly GO:0022607 170 0.014
gene expression GO:0010467 252 0.014
cellular biosynthetic process GO:0044249 286 0.014
embryo development ending in birth or egg hatching GO:0009792 271 0.014
positive regulation of secretion by cell GO:1903532 1 0.014
immunoglobulin mediated immune response GO:0016064 3 0.014
regulation of blood vessel size GO:0050880 2 0.014
positive regulation of cell communication GO:0010647 56 0.014
taxis GO:0042330 109 0.014
embryonic skeletal system development GO:0048706 97 0.014
regulation of localization GO:0032879 104 0.014
maintenance of location GO:0051235 4 0.014
behavior GO:0007610 74 0.014
neuron projection guidance GO:0097485 86 0.014
regulation of cellular response to growth factor stimulus GO:0090287 35 0.014
ear development GO:0043583 127 0.014
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.014
regulation of apoptotic process GO:0042981 98 0.014
synaptic growth at neuromuscular junction GO:0051124 2 0.013
regulation of cellular amine metabolic process GO:0033238 0 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
homeostatic process GO:0042592 142 0.013
response to external stimulus GO:0009605 264 0.013
negative regulation of cell communication GO:0010648 96 0.013
response to vitamin GO:0033273 3 0.013
heterocycle metabolic process GO:0046483 290 0.013
regulation of binding GO:0051098 3 0.013
positive regulation of rna metabolic process GO:0051254 59 0.013
skeletal muscle organ development GO:0060538 78 0.013
regulation of biological quality GO:0065008 263 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.013
cellular response to endogenous stimulus GO:0071495 68 0.013
response to chemical GO:0042221 320 0.013
kupffer s vesicle development GO:0070121 50 0.013
apoptotic process GO:0006915 116 0.013
response to corticosteroid GO:0031960 1 0.013
regulation of cellular amino acid metabolic process GO:0006521 0 0.013
positive regulation of protein complex assembly GO:0031334 2 0.013
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.013
b cell mediated immunity GO:0019724 3 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
protein localization to plasma membrane GO:0072659 1 0.013
multi organism cellular process GO:0044764 2 0.013
neuron projection extension GO:1990138 45 0.013
proteasomal protein catabolic process GO:0010498 2 0.012
regulation of protein complex assembly GO:0043254 3 0.012
negative regulation of dna metabolic process GO:0051053 4 0.012
sequestering of calcium ion GO:0051208 3 0.012
negative regulation of rho protein signal transduction GO:0035024 1 0.012
post embryonic organ development GO:0048569 4 0.012
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.012
cellular amine metabolic process GO:0044106 2 0.012
positive regulation of cell activation GO:0050867 1 0.012
organic cyclic compound metabolic process GO:1901360 301 0.012
multi organism process GO:0051704 134 0.012
regulation of canonical wnt signaling pathway GO:0060828 34 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
single organism transport GO:0044765 206 0.012
nuclear migration GO:0007097 3 0.012
regulation of cell migration GO:0030334 40 0.012
protein acetylation GO:0006473 2 0.012
regulation of nitrogen compound metabolic process GO:0051171 251 0.012
positive regulation of immune effector process GO:0002699 3 0.012
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.012
axon development GO:0061564 166 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
organic acid catabolic process GO:0016054 3 0.012
leukocyte proliferation GO:0070661 1 0.011
positive regulation of macromolecule metabolic process GO:0010604 93 0.011
synaptic target recognition GO:0008039 1 0.011
cell adhesion mediated by integrin GO:0033627 1 0.011
response to abiotic stimulus GO:0009628 122 0.011
regulation of cell morphogenesis GO:0022604 42 0.011
cellular ketone metabolic process GO:0042180 11 0.011
striated muscle cell differentiation GO:0051146 129 0.011
muscle cell migration GO:0014812 4 0.011
positive regulation of cytokine production GO:0001819 2 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
phenol containing compound biosynthetic process GO:0046189 4 0.011
protein dephosphorylation GO:0006470 3 0.011
axon extension GO:0048675 45 0.011
regulation of glucose transport GO:0010827 1 0.011
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.011
cellular response to nutrient levels GO:0031669 2 0.011
cellular transition metal ion homeostasis GO:0046916 3 0.011
response to endogenous stimulus GO:0009719 83 0.011
positive regulation of multi organism process GO:0043902 3 0.011
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.011
myeloid cell differentiation GO:0030099 86 0.011
rna localization GO:0006403 4 0.011
regulation of bone mineralization GO:0030500 2 0.011
positive regulation of transcription dna templated GO:0045893 57 0.011
muscle cell differentiation GO:0042692 139 0.011
negative regulation of cytokine production GO:0001818 1 0.011
larval heart development GO:0007508 2 0.011
determination of bilateral symmetry GO:0009855 204 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
pathway restricted smad protein phosphorylation GO:0060389 1 0.011
establishment of blood brain barrier GO:0060856 2 0.011
negative regulation of cellular component movement GO:0051271 18 0.011
positive regulation of rna biosynthetic process GO:1902680 57 0.011
positive regulation of neuron differentiation GO:0045666 12 0.011
protein complex subunit organization GO:0071822 46 0.011
regulation of organelle assembly GO:1902115 4 0.011
exocrine system development GO:0035272 28 0.011
positive regulation of reproductive process GO:2000243 2 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
atp catabolic process GO:0006200 4 0.010
collagen metabolic process GO:0032963 2 0.010
positive regulation of catabolic process GO:0009896 4 0.010
viral process GO:0016032 1 0.010
negative regulation of programmed cell death GO:0043069 58 0.010
epithelial to mesenchymal transition GO:0001837 21 0.010
glial cell migration GO:0008347 3 0.010
cell projection morphogenesis GO:0048858 244 0.010
negative regulation of neurogenesis GO:0050768 20 0.010
regulation of calcium ion transport GO:0051924 2 0.010
organelle organization GO:0006996 227 0.010
internal protein amino acid acetylation GO:0006475 2 0.010
cell death GO:0008219 121 0.010
cellular protein catabolic process GO:0044257 4 0.010
response to glucocorticoid GO:0051384 1 0.010
notochord development GO:0030903 54 0.010
cell migration involved in heart development GO:0060973 22 0.010
b cell activation GO:0042113 2 0.010
cellular response to oxygen levels GO:0071453 1 0.010
cellular response to external stimulus GO:0071496 2 0.010
negative regulation of myeloid cell differentiation GO:0045638 1 0.010
positive regulation of cytoskeleton organization GO:0051495 3 0.010
cellular response to growth factor stimulus GO:0071363 39 0.010
myofibril assembly GO:0030239 48 0.010
positive regulation of biosynthetic process GO:0009891 68 0.010

hpd disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.051
musculoskeletal system disease DOID:17 0 0.040
nervous system disease DOID:863 0 0.023
cardiovascular system disease DOID:1287 0 0.020
connective tissue disease DOID:65 0 0.015
bone disease DOID:0080001 0 0.014
sensory system disease DOID:0050155 0 0.012
eye and adnexa disease DOID:1492 0 0.012
eye disease DOID:5614 0 0.012
myopathy DOID:423 0 0.011
muscular disease DOID:0080000 0 0.011
muscle tissue disease DOID:66 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011