Danio rerio

68 known processes

apex1

APEX nuclease (multifunctional DNA repair enzyme) 1

(Aliases: apex1a,wu:fc13d11,MGC113976,zgc:66204,hm:zehn1532)

apex1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nucleobase containing compound metabolic process GO:0006139 274 0.707
Human Worm Fly
cellular aromatic compound metabolic process GO:0006725 295 0.575
Human Worm Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.501
heterocycle metabolic process GO:0046483 290 0.475
Human Worm Fly
cellular macromolecule metabolic process GO:0044260 391 0.449
Human Worm Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.432
Human
regulation of nitrogen compound metabolic process GO:0051171 251 0.394
Human
regulation of metabolic process GO:0019222 359 0.369
single organism organelle organization GO:1902589 199 0.367
cellular nitrogen compound biosynthetic process GO:0044271 218 0.363
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.322
Human
nucleic acid templated transcription GO:0097659 181 0.320
nitrogen compound metabolic process GO:0006807 319 0.302
Human Worm Fly
biosynthetic process GO:0009058 294 0.273
regulation of rna biosynthetic process GO:2001141 213 0.253
Human
positive regulation of chromatin modification GO:1903310 1 0.239
regulation of cellular metabolic process GO:0031323 320 0.235
Human
positive regulation of cellular process GO:0048522 201 0.222
Human
cell morphogenesis GO:0000902 289 0.220
organelle organization GO:0006996 227 0.217
organic substance biosynthetic process GO:1901576 289 0.217
rna biosynthetic process GO:0032774 181 0.212
nucleobase containing compound biosynthetic process GO:0034654 205 0.211
mitotic cell cycle GO:0000278 64 0.207
nucleic acid metabolic process GO:0090304 244 0.203
Human Worm Fly
purine nucleoside monophosphate catabolic process GO:0009128 4 0.194
single organism metabolic process GO:0044710 217 0.189
Human Worm
regulation of macromolecule biosynthetic process GO:0010556 225 0.178
Human
organic cyclic compound metabolic process GO:1901360 301 0.175
Human Worm Fly
regulation of transcription dna templated GO:0006355 213 0.173
negative regulation of ras protein signal transduction GO:0046580 1 0.164
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.160
Human
muscle structure development GO:0061061 196 0.154
response to stress GO:0006950 263 0.144
Human Worm Fly
regulation of biosynthetic process GO:0009889 250 0.139
Human
organic cyclic compound biosynthetic process GO:1901362 223 0.134
rna metabolic process GO:0016070 219 0.133
heterocycle biosynthetic process GO:0018130 215 0.133
transcription from rna polymerase ii promoter GO:0006366 80 0.130
negative regulation of biological process GO:0048519 304 0.127
ribonucleoside monophosphate catabolic process GO:0009158 4 0.126
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.121
transcription dna templated GO:0006351 181 0.121
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.116
Human
macromolecule biosynthetic process GO:0009059 227 0.116
cytoskeleton organization GO:0007010 96 0.111
regulation of multicellular organism growth GO:0040014 4 0.107
cytokinesis GO:0000910 3 0.107
protein acetylation GO:0006473 2 0.107
cellular nitrogen compound metabolic process GO:0034641 290 0.105
Human Worm Fly
cellular component morphogenesis GO:0032989 336 0.104
digestive tract morphogenesis GO:0048546 231 0.102
regulation of gene expression GO:0010468 265 0.100
response to chemical GO:0042221 320 0.098
negative regulation of rna metabolic process GO:0051253 48 0.098
negative regulation of cellular process GO:0048523 283 0.095
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.092
small molecule metabolic process GO:0044281 77 0.092
regulation of cellular biosynthetic process GO:0031326 245 0.091
Human
cell projection organization GO:0030030 284 0.090
positive regulation of metabolic process GO:0009893 108 0.087
spindle assembly GO:0051225 2 0.081
regulation of rna metabolic process GO:0051252 224 0.080
Human
covalent chromatin modification GO:0016569 20 0.080
neuron development GO:0048666 262 0.079
positive regulation of histone modification GO:0031058 1 0.078
chromosome organization GO:0051276 31 0.077
generation of neurons GO:0048699 385 0.077
positive regulation of cell cycle GO:0045787 3 0.076
regulation of primary metabolic process GO:0080090 311 0.074
Human
purine containing compound metabolic process GO:0072521 29 0.074
protein complex localization GO:0031503 1 0.072
cellular component assembly GO:0022607 170 0.072
gene expression GO:0010467 252 0.072
regulation of developmental process GO:0050793 247 0.071
embryonic digestive tract development GO:0048566 4 0.070
positive regulation of cellular metabolic process GO:0031325 94 0.069
Human
cell part morphogenesis GO:0032990 246 0.068
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.068
positive regulation of biosynthetic process GO:0009891 68 0.067
adult behavior GO:0030534 2 0.066
nuclear transport GO:0051169 4 0.066
negative regulation of biosynthetic process GO:0009890 55 0.066
positive regulation of dna metabolic process GO:0051054 1 0.066
Human
embryonic digestive tract morphogenesis GO:0048557 3 0.063
cell cycle g2 m phase transition GO:0044839 4 0.063
cell projection morphogenesis GO:0048858 244 0.062
positive regulation of transport GO:0051050 2 0.062
negative regulation of transcription dna templated GO:0045892 45 0.062
cell cycle GO:0007049 93 0.061
digestive system development GO:0055123 289 0.060
internal peptidyl lysine acetylation GO:0018393 2 0.060
regulation of macromolecule metabolic process GO:0060255 317 0.059
cell cycle process GO:0022402 53 0.058
embryonic organ development GO:0048568 381 0.058
histone modification GO:0016570 20 0.056
negative regulation of macromolecule metabolic process GO:0010605 76 0.056
organonitrogen compound metabolic process GO:1901564 74 0.054
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.054
definitive hemopoiesis GO:0060216 18 0.054
negative regulation of metabolic process GO:0009892 86 0.054
peptidyl lysine acetylation GO:0018394 2 0.053
multicellular organism growth GO:0035264 4 0.053
dna metabolic process GO:0006259 27 0.051
Human Worm Fly
regulation of biological quality GO:0065008 263 0.050
Human Mouse
peptidyl lysine methylation GO:0018022 3 0.050
striated muscle cell differentiation GO:0051146 129 0.050
organelle fission GO:0048285 23 0.050
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.049
regulation of dna metabolic process GO:0051052 11 0.048
Human
aromatic compound biosynthetic process GO:0019438 217 0.048
positive regulation of chromosome organization GO:2001252 1 0.045
nucleoside monophosphate catabolic process GO:0009125 4 0.044
phosphorus metabolic process GO:0006793 109 0.044
larval development GO:0002164 2 0.044
Worm
protein acylation GO:0043543 3 0.044
negative regulation of cellular biosynthetic process GO:0031327 55 0.043
negative regulation of nucleic acid templated transcription GO:1903507 45 0.042
chemosensory behavior GO:0007635 1 0.042
aging GO:0007568 2 0.042
regulation of cell death GO:0010941 103 0.041
regulation of histone methylation GO:0031060 3 0.041
ribonucleotide metabolic process GO:0009259 27 0.040
cellular biosynthetic process GO:0044249 286 0.040
positive regulation of nucleic acid templated transcription GO:1903508 57 0.039
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.039
mitotic cell cycle process GO:1903047 48 0.039
muscle cell development GO:0055001 115 0.039
positive regulation of biological process GO:0048518 253 0.038
regulation of protein complex assembly GO:0043254 3 0.037
cellular response to stress GO:0033554 62 0.037
Human Worm Fly
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.037
cell death GO:0008219 121 0.037
double strand break repair GO:0006302 3 0.036
regulation of circadian rhythm GO:0042752 4 0.036
eye development GO:0001654 277 0.036
negative regulation of gene expression GO:0010629 65 0.035
neuron projection morphogenesis GO:0048812 161 0.035
histone h3 k4 methylation GO:0051568 2 0.035
protein metabolic process GO:0019538 183 0.035
mitotic dna integrity checkpoint GO:0044774 4 0.035
multi organism process GO:0051704 134 0.034
digestive tract development GO:0048565 265 0.034
internal protein amino acid acetylation GO:0006475 2 0.034
regulation of programmed cell death GO:0043067 101 0.033
macromolecular complex subunit organization GO:0043933 74 0.033
cellular component biogenesis GO:0044085 178 0.033
regulation of nucleocytoplasmic transport GO:0046822 2 0.032
intracellular signal transduction GO:0035556 85 0.032
signal transduction GO:0007165 455 0.031
negative regulation of chromosome organization GO:2001251 1 0.031
regulation of cytoplasmic transport GO:1903649 4 0.031
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.031
positive regulation of cellular amine metabolic process GO:0033240 0 0.031
positive regulation of gene expression GO:0010628 71 0.031
behavior GO:0007610 74 0.030
dna catabolic process GO:0006308 1 0.030
Human Worm Fly
protein complex assembly GO:0006461 30 0.030
actin filament based process GO:0030029 64 0.030
regulation of signaling GO:0023051 235 0.029
atp catabolic process GO:0006200 4 0.029
muscle cell differentiation GO:0042692 139 0.029
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.029
death GO:0016265 121 0.029
nuclear export GO:0051168 1 0.029
cellular protein complex assembly GO:0043623 19 0.028
neuron differentiation GO:0030182 353 0.028
nuclear envelope organization GO:0006998 2 0.028
amine metabolic process GO:0009308 2 0.028
mitotic dna damage checkpoint GO:0044773 4 0.028
system process GO:0003008 185 0.028
regulation of multicellular organismal development GO:2000026 223 0.028
mitotic cytokinesis GO:0000281 3 0.028
chromatin organization GO:0006325 22 0.028
nucleobase containing small molecule metabolic process GO:0055086 32 0.027
cellular protein metabolic process GO:0044267 129 0.027
regulation of cellular response to oxidative stress GO:1900407 2 0.027
phosphate containing compound metabolic process GO:0006796 108 0.027
microtubule based process GO:0007017 60 0.027
positive regulation of carbohydrate metabolic process GO:0045913 1 0.027
neurological system process GO:0050877 62 0.027
peptidyl lysine dimethylation GO:0018027 1 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.026
protein alkylation GO:0008213 13 0.026
i kappab kinase nf kappab signaling GO:0007249 4 0.026
regulation of chromatin organization GO:1902275 5 0.025
nuclear migration GO:0007097 3 0.025
negative regulation of cellular metabolic process GO:0031324 77 0.025
positive regulation of rna metabolic process GO:0051254 59 0.025
lipid storage GO:0019915 1 0.025
histone methylation GO:0016571 13 0.025
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.025
tube morphogenesis GO:0035239 349 0.025
organophosphate metabolic process GO:0019637 37 0.024
cell fate commitment GO:0045165 99 0.024
neuron projection development GO:0031175 180 0.024
protein modification process GO:0036211 100 0.024
cell morphogenesis involved in differentiation GO:0000904 195 0.024
positive regulation of cellular biosynthetic process GO:0031328 68 0.024
cellular amine metabolic process GO:0044106 2 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
cell proliferation GO:0008283 80 0.023
ribose phosphate metabolic process GO:0019693 27 0.023
ras protein signal transduction GO:0007265 7 0.023
macromolecule modification GO:0043412 111 0.023
Human
camera type eye development GO:0043010 222 0.022
exocrine pancreas development GO:0031017 28 0.022
peptidyl lysine trimethylation GO:0018023 1 0.022
retina morphogenesis in camera type eye GO:0060042 79 0.022
protein targeting to nucleus GO:0044744 3 0.022
protein localization GO:0008104 40 0.022
establishment of protein localization to organelle GO:0072594 4 0.021
developmental growth GO:0048589 166 0.021
photoreceptor cell development GO:0042461 40 0.021
regulation of cell communication GO:0010646 232 0.021
protein localization to nucleus GO:0034504 3 0.021
rna transport GO:0050658 2 0.021
regulation of dna replication GO:0006275 3 0.021
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.021
sensory organ morphogenesis GO:0090596 200 0.021
protein homooligomerization GO:0051260 3 0.020
locomotion GO:0040011 313 0.020
histone h3 k9 methylation GO:0051567 5 0.020
convergent extension involved in gastrulation GO:0060027 71 0.020
liver development GO:0001889 96 0.020
negative regulation of myeloid cell differentiation GO:0045638 1 0.020
muscle organ development GO:0007517 101 0.020
hemopoiesis GO:0030097 183 0.019
g2 m transition of mitotic cell cycle GO:0000086 4 0.019
cellular macromolecule localization GO:0070727 21 0.019
positive regulation of rna biosynthetic process GO:1902680 57 0.019
hematopoietic or lymphoid organ development GO:0048534 191 0.019
retina development in camera type eye GO:0060041 146 0.019
response to corticosteroid GO:0031960 1 0.019
chromatin modification GO:0016568 21 0.018
regulation of binding GO:0051098 3 0.018
protein complex subunit organization GO:0071822 46 0.018
regulation of multicellular organismal process GO:0051239 277 0.018
cellular ketone metabolic process GO:0042180 11 0.018
response to nutrient GO:0007584 3 0.018
nucleus organization GO:0006997 7 0.018
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.018
transport GO:0006810 220 0.018
regulation of myotube differentiation GO:0010830 2 0.018
mitotic nuclear division GO:0007067 18 0.018
regulation of signal transduction GO:0009966 225 0.018
cellular component movement GO:0006928 335 0.018
immune system process GO:0002376 241 0.017
regulation of cellular amine metabolic process GO:0033238 0 0.017
regulation of chromosome segregation GO:0051983 1 0.017
cytoskeleton dependent cytokinesis GO:0061640 3 0.017
cellular protein modification process GO:0006464 100 0.017
apoptotic process GO:0006915 116 0.017
spindle assembly involved in mitosis GO:0090307 1 0.017
sensory organ development GO:0007423 393 0.017
determination of bilateral symmetry GO:0009855 204 0.017
immune system development GO:0002520 191 0.017
telomere organization GO:0032200 1 0.017
alternative mrna splicing via spliceosome GO:0000380 1 0.017
regulation of intracellular signal transduction GO:1902531 57 0.017
positive regulation of macromolecule metabolic process GO:0010604 93 0.016
fertilization GO:0009566 3 0.016
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.016
negative regulation of chromatin modification GO:1903309 1 0.016
regulation of translational initiation GO:0006446 1 0.016
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.016
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
morphogenesis of an epithelium GO:0002009 333 0.016
mitochondrion organization GO:0007005 4 0.016
cellular response to oxygen levels GO:0071453 1 0.016
heart morphogenesis GO:0003007 156 0.016
macromolecular complex assembly GO:0065003 35 0.015
muscle tissue development GO:0060537 110 0.015
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.015
skeletal muscle tissue development GO:0007519 67 0.015
single organism reproductive process GO:0044702 40 0.015
meiotic nuclear division GO:0007126 4 0.015
camera type eye morphogenesis GO:0048593 108 0.015
cellular macromolecular complex assembly GO:0034622 24 0.015
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.015
cellular protein complex localization GO:0034629 1 0.015
cellular carbohydrate metabolic process GO:0044262 4 0.015
protein complex biogenesis GO:0070271 30 0.014
programmed cell death GO:0012501 119 0.014
axon development GO:0061564 166 0.014
cell migration GO:0016477 237 0.014
growth GO:0040007 174 0.014
regulation of cell shape GO:0008360 1 0.014
regulation of microtubule cytoskeleton organization GO:0070507 3 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
regulation of dna recombination GO:0000018 2 0.014
regulation of organelle organization GO:0033043 29 0.014
positive regulation of transcription dna templated GO:0045893 57 0.014
mitotic g2 dna damage checkpoint GO:0007095 3 0.014
nucleocytoplasmic transport GO:0006913 4 0.014
segmentation GO:0035282 97 0.014
regulation of histone h3 k9 methylation GO:0051570 2 0.014
response to abiotic stimulus GO:0009628 122 0.014
cell division GO:0051301 20 0.014
oxoacid metabolic process GO:0043436 31 0.014
regulation of cell differentiation GO:0045595 142 0.013
axonogenesis GO:0007409 152 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
striated muscle tissue development GO:0014706 110 0.013
pancreas development GO:0031016 84 0.013
cognition GO:0050890 1 0.013
protein import into nucleus GO:0006606 3 0.013
negative regulation of dna metabolic process GO:0051053 4 0.013
negative regulation of dna replication GO:0008156 2 0.013
mrna metabolic process GO:0016071 20 0.013
adherens junction organization GO:0034332 4 0.013
regulation of cellular component organization GO:0051128 86 0.013
negative regulation of rna biosynthetic process GO:1902679 45 0.013
nucleic acid transport GO:0050657 2 0.013
positive regulation of cytoskeleton organization GO:0051495 3 0.013
cell substrate adhesion GO:0031589 4 0.013
protein import GO:0017038 3 0.013
energy reserve metabolic process GO:0006112 2 0.013
negative regulation of rna splicing GO:0033119 1 0.013
protein polymerization GO:0051258 4 0.013
regulation of histone modification GO:0031056 5 0.013
cellular localization GO:0051641 97 0.012
proteasomal protein catabolic process GO:0010498 2 0.012
cell aging GO:0007569 2 0.012
regulation of cell cycle GO:0051726 52 0.012
regionalization GO:0003002 274 0.012
protein stabilization GO:0050821 2 0.012
positive regulation of rna splicing GO:0033120 1 0.012
organelle assembly GO:0070925 110 0.012
epidermal cell fate specification GO:0009957 4 0.012
microtubule organizing center organization GO:0031023 1 0.012
organism emergence from protective structure GO:0071684 4 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
response to amphetamine GO:0001975 1 0.012
recombinational repair GO:0000725 1 0.012
cellular response to hypoxia GO:0071456 1 0.011
synaptic growth at neuromuscular junction GO:0051124 2 0.011
phosphorylation GO:0016310 69 0.011
lateral inhibition GO:0046331 1 0.011
regulation of response to stimulus GO:0048583 269 0.011
Human
negative regulation of signal transduction GO:0009968 94 0.011
regulation of cellular protein metabolic process GO:0032268 52 0.011
regulation of chromatin modification GO:1903308 5 0.011
multi organism reproductive process GO:0044703 36 0.011
regulation of protein transport GO:0051223 3 0.011
response to drug GO:0042493 3 0.011
response to glucocorticoid GO:0051384 1 0.011
anterior posterior pattern specification GO:0009952 152 0.011
purine ribonucleotide metabolic process GO:0009150 27 0.010
regulation of anatomical structure morphogenesis GO:0022603 130 0.010
immunoglobulin mediated immune response GO:0016064 3 0.010
negative regulation of cellular catabolic process GO:0031330 3 0.010
dna templated transcription elongation GO:0006354 3 0.010
regulation of cell cycle process GO:0010564 20 0.010
tissue regeneration GO:0042246 74 0.010
guanosine containing compound metabolic process GO:1901068 4 0.010
regulation of glial cell differentiation GO:0045685 4 0.010
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.010
cellular response to external stimulus GO:0071496 2 0.010
cell surface receptor signaling pathway GO:0007166 325 0.010

apex1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.036
disease of cellular proliferation DOID:14566 0 0.036
organ system cancer DOID:0050686 0 0.035
disease of metabolism DOID:0014667 0 0.025
sensory system disease DOID:0050155 0 0.015
disease of anatomical entity DOID:7 0 0.015
nervous system disease DOID:863 0 0.015