Danio rerio

0 known processes

apex2

APEX nuclease (apurinic/apyrimidinic endonuclease) 2

(Aliases: MGC55889,zgc:55889)

apex2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
reflex GO:0060004 2 0.150
regulation of cell shape GO:0008360 1 0.122
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.121
sensory perception of chemical stimulus GO:0007606 3 0.089
regulation of multicellular organism growth GO:0040014 4 0.083
single organism organelle organization GO:1902589 199 0.070
signal transduction GO:0007165 455 0.066
neural precursor cell proliferation GO:0061351 20 0.066
regulation of protein targeting GO:1903533 2 0.064
response to nutrient GO:0007584 3 0.064
aging GO:0007568 2 0.063
larval development GO:0002164 2 0.058
neuroblast proliferation GO:0007405 2 0.054
multicellular organism growth GO:0035264 4 0.054
regulation of response to stimulus GO:0048583 269 0.052
growth GO:0040007 174 0.050
cell morphogenesis GO:0000902 289 0.050
maintenance of location GO:0051235 4 0.049
regulation of cellular metabolic process GO:0031323 320 0.047
histone phosphorylation GO:0016572 2 0.047
stem cell division GO:0017145 1 0.045
regulation of protein transport GO:0051223 3 0.044
organelle organization GO:0006996 227 0.044
digestive tract development GO:0048565 265 0.044
enzyme linked receptor protein signaling pathway GO:0007167 106 0.044
regulation of synapse organization GO:0050807 3 0.042
response to carbohydrate GO:0009743 3 0.042
ubiquitin dependent protein catabolic process GO:0006511 3 0.042
chemosensory behavior GO:0007635 1 0.042
negative regulation of response to stimulus GO:0048585 104 0.041
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.041
heart development GO:0007507 313 0.041
regulation of nucleotide catabolic process GO:0030811 2 0.040
cellular component morphogenesis GO:0032989 336 0.040
regulation of gene expression GO:0010468 265 0.039
phagocytosis GO:0006909 3 0.038
morphogenesis of an epithelium GO:0002009 333 0.038
establishment of protein localization to organelle GO:0072594 4 0.037
tube morphogenesis GO:0035239 349 0.036
response to chemical GO:0042221 320 0.036
digestive system development GO:0055123 289 0.036
spindle assembly GO:0051225 2 0.035
angiogenesis GO:0001525 158 0.035
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.035
regulation of protein localization to nucleus GO:1900180 2 0.035
stem cell proliferation GO:0072089 4 0.035
meiotic cell cycle process GO:1903046 3 0.035
localization of cell GO:0051674 244 0.034
regulation of primary metabolic process GO:0080090 311 0.034
regulation of cytoplasmic transport GO:1903649 4 0.034
phosphate containing compound metabolic process GO:0006796 108 0.033
peptidyl serine phosphorylation GO:0018105 1 0.033
regulation of purine nucleotide catabolic process GO:0033121 2 0.033
nucleocytoplasmic transport GO:0006913 4 0.033
positive regulation of cellular catabolic process GO:0031331 3 0.033
guanosine containing compound catabolic process GO:1901069 2 0.032
meiosis i GO:0007127 1 0.032
cellular aromatic compound metabolic process GO:0006725 295 0.031
gtp catabolic process GO:0006184 2 0.031
regulation of signal transduction GO:0009966 225 0.031
macromolecular complex subunit organization GO:0043933 74 0.031
digestive tract morphogenesis GO:0048546 231 0.031
cytoskeleton dependent cytokinesis GO:0061640 3 0.030
cellular response to biotic stimulus GO:0071216 3 0.030
positive regulation of transport GO:0051050 2 0.030
centrosome organization GO:0051297 1 0.030
regulation of establishment of protein localization GO:0070201 4 0.030
blood vessel morphogenesis GO:0048514 216 0.030
heterocycle metabolic process GO:0046483 290 0.029
regulation of protein import into nucleus GO:0042306 2 0.029
nitrogen compound metabolic process GO:0006807 319 0.029
cytokinetic process GO:0032506 2 0.029
single organism localization GO:1902578 225 0.029
regulation of organelle assembly GO:1902115 4 0.029
positive regulation of catabolic process GO:0009896 4 0.029
regulation of nucleocytoplasmic transport GO:0046822 2 0.029
chromosome organization involved in meiosis GO:0070192 1 0.028
generation of neurons GO:0048699 385 0.028
phosphorus metabolic process GO:0006793 109 0.028
centrosome cycle GO:0007098 1 0.028
regulation of rho protein signal transduction GO:0035023 2 0.027
regulation of nitrogen compound metabolic process GO:0051171 251 0.027
microtubule organizing center organization GO:0031023 1 0.027
nuclear import GO:0051170 3 0.027
modification dependent macromolecule catabolic process GO:0043632 3 0.027
cellular component movement GO:0006928 335 0.027
cytoskeleton organization GO:0007010 96 0.026
cell motility GO:0048870 244 0.026
regulation of intracellular protein transport GO:0033157 3 0.026
regulation of gtp catabolic process GO:0033124 2 0.026
cell migration involved in gastrulation GO:0042074 79 0.026
regulation of nucleoside metabolic process GO:0009118 2 0.025
protein localization to microtubule cytoskeleton GO:0072698 1 0.025
regulation of biological quality GO:0065008 263 0.025
response to hydrogen peroxide GO:0042542 3 0.025
embryonic organ development GO:0048568 381 0.025
single organism metabolic process GO:0044710 217 0.025
positive regulation of muscle cell differentiation GO:0051149 1 0.025
meiotic nuclear division GO:0007126 4 0.025
biosynthetic process GO:0009058 294 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.025
regulation of binding GO:0051098 3 0.024
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.024
nucleobase containing compound metabolic process GO:0006139 274 0.024
regulation of dna templated transcription in response to stress GO:0043620 0 0.024
transport GO:0006810 220 0.024
response to glucose GO:0009749 3 0.024
vasculature development GO:0001944 278 0.024
regulation of mrna splicing via spliceosome GO:0048024 3 0.024
actin filament polymerization GO:0030041 2 0.024
gtp metabolic process GO:0046039 4 0.024
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.023
synaptic growth at neuromuscular junction GO:0051124 2 0.023
response to stress GO:0006950 263 0.023
positive regulation of cell cycle GO:0045787 3 0.023
establishment of localization GO:0051234 244 0.023
gene expression GO:0010467 252 0.023
protein polymerization GO:0051258 4 0.023
protein import GO:0017038 3 0.022
response to hexose GO:0009746 3 0.022
response to external stimulus GO:0009605 264 0.022
protein metabolic process GO:0019538 183 0.022
cellular protein catabolic process GO:0044257 4 0.022
organic cyclic compound metabolic process GO:1901360 301 0.022
regulation of macromolecule metabolic process GO:0060255 317 0.022
negative regulation of cytoplasmic transport GO:1903650 2 0.022
cellular carbohydrate metabolic process GO:0044262 4 0.022
regulation of metabolic process GO:0019222 359 0.022
regulation of developmental process GO:0050793 247 0.022
mitotic dna integrity checkpoint GO:0044774 4 0.022
i kappab kinase nf kappab signaling GO:0007249 4 0.022
regulation of dna replication GO:0006275 3 0.022
nucleic acid metabolic process GO:0090304 244 0.022
extrinsic apoptotic signaling pathway GO:0097191 3 0.021
regulation of mrna processing GO:0050684 3 0.021
cell part morphogenesis GO:0032990 246 0.021
lipid storage GO:0019915 1 0.021
sequestering of metal ion GO:0051238 3 0.021
cellular response to lipopolysaccharide GO:0071222 3 0.021
positive regulation of cellular component biogenesis GO:0044089 3 0.021
cellular response to external stimulus GO:0071496 2 0.021
nuclear transport GO:0051169 4 0.021
cellular nitrogen compound metabolic process GO:0034641 290 0.021
protein import into nucleus GO:0006606 3 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.020
heart process GO:0003015 71 0.020
ameboidal type cell migration GO:0001667 143 0.020
axon extension GO:0048675 45 0.020
protein localization to nucleus GO:0034504 3 0.020
proteasomal protein catabolic process GO:0010498 2 0.020
response to monosaccharide GO:0034284 3 0.020
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.019
single organism membrane fusion GO:0044801 2 0.019
positive regulation of nucleoside metabolic process GO:0045979 1 0.019
heart morphogenesis GO:0003007 156 0.019
atp catabolic process GO:0006200 4 0.019
positive regulation of gtp catabolic process GO:0033126 1 0.019
regulation of macromolecule biosynthetic process GO:0010556 225 0.019
lipid oxidation GO:0034440 1 0.019
single organism nuclear import GO:1902593 3 0.019
cell projection morphogenesis GO:0048858 244 0.019
alternative mrna splicing via spliceosome GO:0000380 1 0.019
cellular response to radiation GO:0071478 4 0.019
blood vessel development GO:0001568 246 0.019
spindle assembly involved in mitosis GO:0090307 1 0.019
regulation of signaling GO:0023051 235 0.019
cellular response to reactive oxygen species GO:0034614 2 0.019
cytokinesis GO:0000910 3 0.019
hepaticobiliary system development GO:0061008 98 0.019
mitotic nuclear division GO:0007067 18 0.019
modification dependent protein catabolic process GO:0019941 3 0.018
cellular response to extracellular stimulus GO:0031668 2 0.018
negative regulation of mapk cascade GO:0043409 4 0.018
cellular component disassembly GO:0022411 1 0.018
regulation of synapse assembly GO:0051963 3 0.018
sensory perception of touch GO:0050975 2 0.018
macromolecule modification GO:0043412 111 0.018
amine metabolic process GO:0009308 2 0.018
actin polymerization or depolymerization GO:0008154 2 0.018
positive regulation of myeloid cell differentiation GO:0045639 2 0.018
response to biotic stimulus GO:0009607 97 0.018
regulation of gtpase activity GO:0043087 2 0.018
developmental growth GO:0048589 166 0.018
heterocycle biosynthetic process GO:0018130 215 0.018
cellular component assembly GO:0022607 170 0.018
protein acylation GO:0043543 3 0.018
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
protein targeting to nucleus GO:0044744 3 0.017
fatty acid oxidation GO:0019395 1 0.017
small molecule metabolic process GO:0044281 77 0.017
negative regulation of synapse assembly GO:0051964 2 0.017
cellular amine metabolic process GO:0044106 2 0.017
female meiotic division GO:0007143 2 0.017
regulation of nucleic acid templated transcription GO:1903506 213 0.017
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.017
positive regulation of nucleotide catabolic process GO:0030813 1 0.017
purine nucleoside monophosphate catabolic process GO:0009128 4 0.017
macromolecular complex disassembly GO:0032984 1 0.017
mitochondrion organization GO:0007005 4 0.017
oxoacid metabolic process GO:0043436 31 0.017
spermatid development GO:0007286 2 0.017
cell migration GO:0016477 237 0.017
cell aggregation GO:0098743 3 0.017
regulation of bmp signaling pathway GO:0030510 39 0.017
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.017
regulation of multicellular organismal process GO:0051239 277 0.017
mitotic cell cycle process GO:1903047 48 0.017
negative regulation of apoptotic process GO:0043066 55 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
regulation of anatomical structure morphogenesis GO:0022603 130 0.016
membrane fusion GO:0061025 2 0.016
regulation of cell cycle GO:0051726 52 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
cell cycle GO:0007049 93 0.016
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.016
positive regulation of gtpase activity GO:0043547 1 0.016
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.016
circulatory system process GO:0003013 87 0.016
system process GO:0003008 185 0.016
actin filament organization GO:0007015 15 0.016
regulation of biosynthetic process GO:0009889 250 0.016
negative regulation of cell death GO:0060548 60 0.016
neuron differentiation GO:0030182 353 0.016
convergent extension GO:0060026 118 0.016
specification of symmetry GO:0009799 204 0.016
regulation of cellular amine metabolic process GO:0033238 0 0.016
death GO:0016265 121 0.016
nucleoside monophosphate catabolic process GO:0009125 4 0.015
cell adhesion GO:0007155 40 0.015
apoptotic process GO:0006915 116 0.015
neuron projection morphogenesis GO:0048812 161 0.015
response to growth factor GO:0070848 39 0.015
protein acetylation GO:0006473 2 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
negative regulation of cellular process GO:0048523 283 0.015
actin cytoskeleton organization GO:0030036 63 0.015
regulation of protein binding GO:0043393 3 0.015
secondary metabolic process GO:0019748 3 0.015
rna metabolic process GO:0016070 219 0.014
organelle fusion GO:0048284 3 0.014
regulation of phosphorus metabolic process GO:0051174 43 0.014
g2 dna damage checkpoint GO:0031572 3 0.014
primary neural tube formation GO:0014020 1 0.014
peptidyl lysine acetylation GO:0018394 2 0.014
negative regulation of i kappab kinase nf kappab signaling GO:0043124 1 0.014
negative regulation of nuclear division GO:0051784 3 0.014
gastrulation with mouth forming second GO:0001702 44 0.014
regulation of cellular ketone metabolic process GO:0010565 7 0.014
gastrulation GO:0007369 208 0.014
mesodermal cell differentiation GO:0048333 21 0.014
regulation of reproductive process GO:2000241 4 0.014
regulation of erk1 and erk2 cascade GO:0070372 4 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
organic substance biosynthetic process GO:1901576 289 0.014
regulation of cellular biosynthetic process GO:0031326 245 0.014
cellular response to nutrient levels GO:0031669 2 0.014
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.014
retina development in camera type eye GO:0060041 146 0.014
cell fate commitment GO:0045165 99 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
phagocytosis engulfment GO:0006911 1 0.014
locomotion GO:0040011 313 0.014
cellular macromolecule metabolic process GO:0044260 391 0.014
cell aging GO:0007569 2 0.014
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.014
cellular biosynthetic process GO:0044249 286 0.014
regulation of microtubule cytoskeleton organization GO:0070507 3 0.014
endosomal transport GO:0016197 2 0.013
regulation of cytokine production GO:0001817 3 0.013
organelle localization GO:0051640 49 0.013
regulation of programmed cell death GO:0043067 101 0.013
regulation of protein complex assembly GO:0043254 3 0.013
cilium morphogenesis GO:0060271 85 0.013
regulation of protein complex disassembly GO:0043244 1 0.013
protein complex subunit organization GO:0071822 46 0.013
peptide transport GO:0015833 1 0.013
biological adhesion GO:0022610 40 0.013
regulation of cell communication GO:0010646 232 0.013
membrane invagination GO:0010324 1 0.013
regulation of dendrite development GO:0050773 3 0.013
protein secretion GO:0009306 1 0.013
organic acid metabolic process GO:0006082 31 0.013
defense response to fungus GO:0050832 2 0.013
protein complex disassembly GO:0043241 1 0.013
golgi vesicle transport GO:0048193 3 0.013
negative regulation of protein phosphorylation GO:0001933 4 0.013
negative regulation of programmed cell death GO:0043069 58 0.013
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.013
regulation of rna metabolic process GO:0051252 224 0.013
mitotic g2 dna damage checkpoint GO:0007095 3 0.013
positive regulation of cellular process GO:0048522 201 0.013
cell projection organization GO:0030030 284 0.013
regulation of oocyte development GO:0060281 3 0.013
protein localization to plasma membrane GO:0072659 1 0.013
chromosome organization GO:0051276 31 0.013
antimicrobial humoral response GO:0019730 2 0.013
cell substrate adhesion GO:0031589 4 0.013
mesoderm morphogenesis GO:0048332 51 0.013
translational initiation GO:0006413 3 0.012
cellular respiration GO:0045333 3 0.012
meiotic chromosome segregation GO:0045132 3 0.012
cellular amide metabolic process GO:0043603 4 0.012
actin filament based process GO:0030029 64 0.012
cognition GO:0050890 1 0.012
immune system process GO:0002376 241 0.012
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.012
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.012
regulation of cell activation GO:0050865 1 0.012
negative regulation of cell communication GO:0010648 96 0.012
positive regulation of developmental process GO:0051094 50 0.012
regulation of developmental growth GO:0048638 38 0.012
tube closure GO:0060606 1 0.012
cellular localization GO:0051641 97 0.012
positive regulation of biological process GO:0048518 253 0.012
meiotic spindle organization GO:0000212 1 0.012
behavior GO:0007610 74 0.012
regulation of cell morphogenesis GO:0022604 42 0.012
response to inorganic substance GO:0010035 38 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
cellular response to organic substance GO:0071310 105 0.012
negative regulation of stress activated mapk cascade GO:0032873 1 0.012
nuclear division GO:0000280 23 0.012
mitotic g2 m transition checkpoint GO:0044818 3 0.012
cation homeostasis GO:0055080 33 0.012
osteoclast differentiation GO:0030316 1 0.012
positive regulation of protein complex assembly GO:0031334 2 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
peptidyl serine modification GO:0018209 2 0.012
g1 s transition of mitotic cell cycle GO:0000082 1 0.012
hormone transport GO:0009914 2 0.012
negative regulation of immune response GO:0050777 2 0.012
cell cycle process GO:0022402 53 0.011
mitotic cell cycle embryonic GO:0045448 2 0.011
sprouting angiogenesis GO:0002040 53 0.011
phosphorylation GO:0016310 69 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
cell matrix adhesion GO:0007160 4 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
tissue remodeling GO:0048771 4 0.011
cellular response to endogenous stimulus GO:0071495 68 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
negative regulation of sequestering of calcium ion GO:0051283 4 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
protein polyubiquitination GO:0000209 4 0.011
dna catabolic process GO:0006308 1 0.011
nucleobase containing compound biosynthetic process GO:0034654 205 0.011
peptidyl threonine modification GO:0018210 1 0.011
developmental growth involved in morphogenesis GO:0060560 86 0.011
negative regulation of translation GO:0017148 1 0.011
positive regulation of multi organism process GO:0043902 3 0.011
thermosensory behavior GO:0040040 1 0.011
dorsal ventral pattern formation GO:0009953 125 0.011
organic cyclic compound biosynthetic process GO:1901362 223 0.011
cellular amino acid metabolic process GO:0006520 7 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
negative regulation of mitosis GO:0045839 3 0.011
embryonic heart tube development GO:0035050 133 0.011
intracellular signal transduction GO:0035556 85 0.011
cellular nitrogen compound biosynthetic process GO:0044271 218 0.011
adult behavior GO:0030534 2 0.011
mitotic dna damage checkpoint GO:0044773 4 0.011
positive regulation of cell adhesion GO:0045785 1 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
negative regulation of multi organism process GO:0043901 3 0.011
protein depolymerization GO:0051261 1 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
cellular transition metal ion homeostasis GO:0046916 3 0.011
regulation of ras gtpase activity GO:0032318 2 0.011
regulation of inflammatory response GO:0050727 2 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
negative regulation of protein transport GO:0051224 3 0.011
hormone secretion GO:0046879 2 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
regulation of phosphate metabolic process GO:0019220 43 0.011
positive regulation of ras gtpase activity GO:0032320 1 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
regulation of localization GO:0032879 104 0.011
nuclear export GO:0051168 1 0.011
nucleic acid templated transcription GO:0097659 181 0.010
negative regulation of jnk cascade GO:0046329 1 0.010
small gtpase mediated signal transduction GO:0007264 8 0.010
organism emergence from protective structure GO:0071684 4 0.010
mitotic cell cycle GO:0000278 64 0.010
single organism cellular localization GO:1902580 46 0.010
positive regulation of epithelial cell proliferation GO:0050679 1 0.010
histone modification GO:0016570 20 0.010
negative regulation of defense response GO:0031348 2 0.010
response to ionizing radiation GO:0010212 6 0.010
cartilage condensation GO:0001502 3 0.010
cellular response to starvation GO:0009267 1 0.010
positive regulation of cytokine production GO:0001819 2 0.010
spermatid differentiation GO:0048515 2 0.010
negative regulation of intracellular transport GO:0032387 3 0.010
response to organic substance GO:0010033 153 0.010
cell cycle arrest GO:0007050 1 0.010
sequestering of calcium ion GO:0051208 3 0.010
erythrocyte differentiation GO:0030218 54 0.010
response to bacterium GO:0009617 58 0.010
morphogenesis of an epithelial sheet GO:0002011 49 0.010
ovulation cycle GO:0042698 2 0.010
release of sequestered calcium ion into cytosol GO:0051209 3 0.010
macromolecule biosynthetic process GO:0009059 227 0.010

apex2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.019
disease of cellular proliferation DOID:14566 0 0.017
disease of metabolism DOID:0014667 0 0.014
lysosomal storage disease DOID:3211 0 0.014
inherited metabolic disorder DOID:655 0 0.014
nervous system disease DOID:863 0 0.013
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.011