Danio rerio

0 known processes

gnaz

guanine nucleotide binding protein (G protein), alpha z polypeptide

gnaz biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cell cell adhesion mediated by cadherin GO:2000048 2 0.406
establishment of endothelial barrier GO:0061028 3 0.175
detection of visible light GO:0009584 12 0.149
hematopoietic or lymphoid organ development GO:0048534 191 0.098
g protein coupled receptor signaling pathway GO:0007186 74 0.094
guanosine containing compound catabolic process GO:1901069 2 0.094
guanosine containing compound metabolic process GO:1901068 4 0.092
regulation of cell cell adhesion mediated by cadherin GO:2000047 5 0.090
signal transduction GO:0007165 455 0.089
axon ensheathment in central nervous system GO:0032291 2 0.084
nucleocytoplasmic transport GO:0006913 4 0.082
regulation of nucleoside metabolic process GO:0009118 2 0.081
regulation of gtp catabolic process GO:0033124 2 0.081
detection of light stimulus GO:0009583 12 0.079
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.077
ameboidal type cell migration GO:0001667 143 0.074
negative regulation of biological process GO:0048519 304 0.070
actomyosin structure organization GO:0031032 53 0.068
cortical cytoskeleton organization GO:0030865 1 0.067
cortical actin cytoskeleton organization GO:0030866 1 0.066
regulation of metabolic process GO:0019222 359 0.066
gastrulation GO:0007369 208 0.065
response to radiation GO:0009314 51 0.064
inositol lipid mediated signaling GO:0048017 2 0.064
response to external stimulus GO:0009605 264 0.060
regulation of nucleotide catabolic process GO:0030811 2 0.058
central nervous system development GO:0007417 387 0.058
morphogenesis of an epithelium GO:0002009 333 0.056
gtp catabolic process GO:0006184 2 0.055
negative regulation of cellular process GO:0048523 283 0.055
gtp metabolic process GO:0046039 4 0.055
multicellular organismal signaling GO:0035637 22 0.054
cellular component morphogenesis GO:0032989 336 0.053
larval development GO:0002164 2 0.053
cell morphogenesis GO:0000902 289 0.049
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.048
heart development GO:0007507 313 0.047
regulation of cell shape GO:0008360 1 0.047
system process GO:0003008 185 0.047
cell cell adhesion mediated by cadherin GO:0044331 5 0.045
unidimensional cell growth GO:0009826 5 0.045
regulation of gtpase activity GO:0043087 2 0.045
cellular component movement GO:0006928 335 0.044
visual perception GO:0007601 17 0.043
sensory perception of chemical stimulus GO:0007606 3 0.042
cell surface receptor signaling pathway GO:0007166 325 0.042
regulation of purine nucleotide catabolic process GO:0033121 2 0.041
single organism membrane fusion GO:0044801 2 0.041
small gtpase mediated signal transduction GO:0007264 8 0.040
organelle fusion GO:0048284 3 0.039
organonitrogen compound metabolic process GO:1901564 74 0.039
developmental growth involved in morphogenesis GO:0060560 86 0.039
cell motility GO:0048870 244 0.039
digestive tract morphogenesis GO:0048546 231 0.039
establishment of blood brain barrier GO:0060856 2 0.038
response to abiotic stimulus GO:0009628 122 0.038
convergent extension GO:0060026 118 0.038
regulation of nucleocytoplasmic transport GO:0046822 2 0.038
tube morphogenesis GO:0035239 349 0.038
actin filament based process GO:0030029 64 0.037
rho protein signal transduction GO:0007266 5 0.037
single organismal cell cell adhesion GO:0016337 29 0.037
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.036
regulation of establishment of protein localization GO:0070201 4 0.036
cognition GO:0050890 1 0.036
immune system development GO:0002520 191 0.036
hemopoiesis GO:0030097 183 0.036
nuclear transport GO:0051169 4 0.036
axon ensheathment GO:0008366 18 0.036
epiboly GO:0090504 41 0.036
regulation of protein transport GO:0051223 3 0.035
regulation of cytoplasmic transport GO:1903649 4 0.035
regulation of intracellular protein transport GO:0033157 3 0.035
positive regulation of cellular catabolic process GO:0031331 3 0.035
nitrogen compound metabolic process GO:0006807 319 0.034
detection of stimulus GO:0051606 29 0.034
actin filament organization GO:0007015 15 0.034
regulation of primary metabolic process GO:0080090 311 0.033
cell growth GO:0016049 57 0.033
regulation of synaptic plasticity GO:0048167 1 0.033
synaptic growth at neuromuscular junction GO:0051124 2 0.033
small molecule metabolic process GO:0044281 77 0.032
cell migration involved in heart development GO:0060973 22 0.032
response to drug GO:0042493 3 0.032
vasculature development GO:0001944 278 0.032
detection of abiotic stimulus GO:0009582 24 0.032
single organism organelle organization GO:1902589 199 0.032
positive regulation of catabolic process GO:0009896 4 0.031
regulation of biological quality GO:0065008 263 0.031
transmission of nerve impulse GO:0019226 19 0.031
membrane fusion GO:0061025 2 0.030
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.030
detection of light stimulus involved in sensory perception GO:0050962 7 0.030
actin cytoskeleton organization GO:0030036 63 0.030
aging GO:0007568 2 0.030
maintenance of location GO:0051235 4 0.030
response to light stimulus GO:0009416 46 0.029
gastrulation with mouth forming second GO:0001702 44 0.029
localization of cell GO:0051674 244 0.029
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.029
developmental growth GO:0048589 166 0.029
nuclear export GO:0051168 1 0.029
phosphorus metabolic process GO:0006793 109 0.029
regulation of nitrogen compound metabolic process GO:0051171 251 0.028
positive regulation of cellular component biogenesis GO:0044089 3 0.028
astrocyte differentiation GO:0048708 1 0.028
regulation of cellular metabolic process GO:0031323 320 0.027
ras protein signal transduction GO:0007265 7 0.027
cell migration involved in gastrulation GO:0042074 79 0.027
digestive tract development GO:0048565 265 0.026
proteasomal protein catabolic process GO:0010498 2 0.026
blood vessel morphogenesis GO:0048514 216 0.026
neurological system process GO:0050877 62 0.026
actin filament based movement GO:0030048 1 0.026
protein localization to plasma membrane GO:0072659 1 0.026
digestive system development GO:0055123 289 0.025
morphogenesis of an epithelial sheet GO:0002011 49 0.025
negative regulation of protein phosphorylation GO:0001933 4 0.025
rna localization GO:0006403 4 0.025
angiogenesis GO:0001525 158 0.024
blood vessel development GO:0001568 246 0.024
neuroblast proliferation GO:0007405 2 0.024
immune system process GO:0002376 241 0.024
positive regulation of cytoskeleton organization GO:0051495 3 0.024
regulation of protein complex assembly GO:0043254 3 0.024
stem cell proliferation GO:0072089 4 0.024
ribonucleoside monophosphate catabolic process GO:0009158 4 0.024
detection of external stimulus GO:0009581 24 0.023
actin mediated cell contraction GO:0070252 1 0.023
modification dependent protein catabolic process GO:0019941 3 0.023
cellular component biogenesis GO:0044085 178 0.023
action potential GO:0001508 19 0.023
response to chemical GO:0042221 320 0.023
nucleobase containing compound metabolic process GO:0006139 274 0.023
locomotion GO:0040011 313 0.022
negative regulation of protein kinase activity GO:0006469 4 0.022
stem cell division GO:0017145 1 0.022
cellular component assembly GO:0022607 170 0.022
muscle structure development GO:0061061 196 0.022
neuronal action potential GO:0019228 18 0.022
mitochondrion organization GO:0007005 4 0.021
establishment of endothelial blood brain barrier GO:0014045 2 0.021
actin filament bundle organization GO:0061572 6 0.021
sequestering of calcium ion GO:0051208 3 0.021
cellular response to oxygen levels GO:0071453 1 0.021
carbohydrate derivative metabolic process GO:1901135 61 0.021
regulation of skeletal muscle tissue development GO:0048641 4 0.021
modification dependent macromolecule catabolic process GO:0043632 3 0.020
single organism cell adhesion GO:0098602 29 0.020
positive regulation of gtpase activity GO:0043547 1 0.020
establishment of localization GO:0051234 244 0.020
apical junction assembly GO:0043297 1 0.020
phototransduction GO:0007602 2 0.020
regulation of developmental process GO:0050793 247 0.020
single organism metabolic process GO:0044710 217 0.020
regulation of multicellular organism growth GO:0040014 4 0.020
mechanosensory behavior GO:0007638 2 0.020
cell substrate adhesion GO:0031589 4 0.020
regulation of multicellular organismal process GO:0051239 277 0.019
regulation of reproductive process GO:2000241 4 0.019
single organism localization GO:1902578 225 0.019
cellular aromatic compound metabolic process GO:0006725 295 0.019
regulation of metal ion transport GO:0010959 4 0.019
regulation of cell cell adhesion GO:0022407 13 0.019
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.019
exocytosis GO:0006887 1 0.019
cytoskeleton organization GO:0007010 96 0.019
regulation of protein catabolic process GO:0042176 1 0.019
heterocycle metabolic process GO:0046483 290 0.019
endoderm development GO:0007492 49 0.019
organelle organization GO:0006996 227 0.018
cell migration GO:0016477 237 0.018
establishment of protein localization to plasma membrane GO:0090002 1 0.018
regulation of inflammatory response GO:0050727 2 0.018
carbohydrate homeostasis GO:0033500 1 0.018
cellular response to decreased oxygen levels GO:0036294 1 0.018
positive regulation of nucleotide catabolic process GO:0030813 1 0.018
nucleobase containing small molecule metabolic process GO:0055086 32 0.018
multicellular organism growth GO:0035264 4 0.018
intracellular signal transduction GO:0035556 85 0.018
sequestering of metal ion GO:0051238 3 0.018
gas transport GO:0015669 3 0.018
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
negative regulation of sequestering of calcium ion GO:0051283 4 0.017
embryonic limb morphogenesis GO:0030326 2 0.017
cellular component disassembly GO:0022411 1 0.017
positive regulation of transport GO:0051050 2 0.017
carbon dioxide transport GO:0015670 3 0.017
response to hydrogen peroxide GO:0042542 3 0.017
regulation of membrane potential GO:0042391 23 0.017
nucleoside monophosphate catabolic process GO:0009125 4 0.017
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.017
sensory perception of light stimulus GO:0050953 19 0.017
cellular response to lipopolysaccharide GO:0071222 3 0.017
atp catabolic process GO:0006200 4 0.017
b cell activation GO:0042113 2 0.017
detection of stimulus involved in sensory perception GO:0050906 21 0.017
regulation of cytokine production GO:0001817 3 0.017
sensory perception GO:0007600 39 0.017
negative regulation of kinase activity GO:0033673 4 0.017
transport GO:0006810 220 0.017
detection of light stimulus involved in visual perception GO:0050908 7 0.017
regulation of binding GO:0051098 3 0.017
positive regulation of nucleoside metabolic process GO:0045979 1 0.017
regulation of dendrite development GO:0050773 3 0.016
regulation of cellular ketone metabolic process GO:0010565 7 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.016
cellular protein catabolic process GO:0044257 4 0.016
regulation of actin filament based process GO:0032970 9 0.016
response to glucocorticoid GO:0051384 1 0.016
cellular response to hypoxia GO:0071456 1 0.016
cellular response to biotic stimulus GO:0071216 3 0.016
negative regulation of synapse assembly GO:0051964 2 0.016
epithelial cell differentiation GO:0030855 116 0.016
regulation of organelle organization GO:0033043 29 0.016
regulation of anatomical structure morphogenesis GO:0022603 130 0.016
growth GO:0040007 174 0.016
regulation of cellular protein catabolic process GO:1903362 1 0.015
actin filament bundle assembly GO:0051017 6 0.015
adherens junction organization GO:0034332 4 0.015
response to corticosteroid GO:0031960 1 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
positive regulation of cell adhesion GO:0045785 1 0.015
stem cell maintenance GO:0019827 4 0.015
positive regulation of cell matrix adhesion GO:0001954 1 0.015
regulation of neuronal synaptic plasticity GO:0048168 1 0.015
regulation of cell communication GO:0010646 232 0.015
epithelial cell morphogenesis GO:0003382 2 0.015
generation of neurons GO:0048699 385 0.015
protein import GO:0017038 3 0.015
circulatory system process GO:0003013 87 0.015
cellular response to radiation GO:0071478 4 0.015
regulation of synapse organization GO:0050807 3 0.015
monovalent inorganic cation transport GO:0015672 42 0.015
macromolecular complex disassembly GO:0032984 1 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
striated muscle tissue development GO:0014706 110 0.014
protein heterooligomerization GO:0051291 1 0.014
negative regulation of mapk cascade GO:0043409 4 0.014
response to food GO:0032094 1 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.014
homeostatic process GO:0042592 142 0.014
regulation of synapse assembly GO:0051963 3 0.014
ribose phosphate metabolic process GO:0019693 27 0.014
protein complex disassembly GO:0043241 1 0.014
inorganic cation transmembrane transport GO:0098662 50 0.014
negative regulation of cell cell adhesion GO:0022408 6 0.014
gliogenesis GO:0042063 45 0.014
purine containing compound metabolic process GO:0072521 29 0.014
cell matrix adhesion GO:0007160 4 0.014
regulation of tube size GO:0035150 2 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
regulation of multicellular organismal development GO:2000026 223 0.014
cellular response to external stimulus GO:0071496 2 0.014
carbohydrate biosynthetic process GO:0016051 1 0.014
ribonucleotide metabolic process GO:0009259 27 0.014
regulation of gene expression GO:0010468 265 0.014
embryo development ending in birth or egg hatching GO:0009792 271 0.014
protein homooligomerization GO:0051260 3 0.014
response to wounding GO:0009611 116 0.014
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
regulation of cell activation GO:0050865 1 0.014
chemosensory behavior GO:0007635 1 0.014
lipid storage GO:0019915 1 0.014
regulation of dendrite morphogenesis GO:0048814 3 0.013
organic cyclic compound metabolic process GO:1901360 301 0.013
regulation of hydrolase activity GO:0051336 28 0.013
regulation of autophagy GO:0010506 3 0.013
transmembrane transport GO:0055085 120 0.013
response to stress GO:0006950 263 0.013
cellular response to nutrient levels GO:0031669 2 0.013
purine nucleotide metabolic process GO:0006163 27 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
purine nucleoside monophosphate catabolic process GO:0009128 4 0.013
calcium mediated signaling GO:0019722 2 0.013
macromolecular complex subunit organization GO:0043933 74 0.013
sleep GO:0030431 1 0.013
skeletal muscle organ development GO:0060538 78 0.013
glial cell differentiation GO:0010001 42 0.013
regulation of ras gtpase activity GO:0032318 2 0.013
peptidyl lysine acetylation GO:0018394 2 0.013
response to transition metal nanoparticle GO:1990267 28 0.013
sensory perception of smell GO:0007608 2 0.013
regulation of neural precursor cell proliferation GO:2000177 3 0.013
leukocyte proliferation GO:0070661 1 0.013
regulation of calcium ion transport GO:0051924 2 0.013
regulation of cell substrate adhesion GO:0010810 1 0.013
positive regulation of muscle organ development GO:0048636 1 0.013
positive regulation of cytokine production GO:0001819 2 0.013
cellular response to extracellular stimulus GO:0031668 2 0.013
glial cell development GO:0021782 20 0.012
establishment of protein localization to organelle GO:0072594 4 0.012
macromolecule biosynthetic process GO:0009059 227 0.012
inorganic ion transmembrane transport GO:0098660 57 0.012
cell morphogenesis involved in differentiation GO:0000904 195 0.012
signal transduction in absence of ligand GO:0038034 1 0.012
muscle organ development GO:0007517 101 0.012
regulation of transporter activity GO:0032409 2 0.012
phagocytosis GO:0006909 3 0.012
positive regulation of biological process GO:0048518 253 0.012
nucleotide metabolic process GO:0009117 28 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.012
skeletal muscle tissue development GO:0007519 67 0.012
inorganic anion transport GO:0015698 25 0.012
cell substrate junction assembly GO:0007044 2 0.012
single organism transport GO:0044765 206 0.012
internal peptidyl lysine acetylation GO:0018393 2 0.012
regulation of signal transduction GO:0009966 225 0.012
hormone secretion GO:0046879 2 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
ion transmembrane transport GO:0034220 91 0.012
cation transmembrane transport GO:0098655 65 0.012
cellular nitrogen compound metabolic process GO:0034641 290 0.012
response to organic substance GO:0010033 153 0.011
cellular localization GO:0051641 97 0.011
positive regulation of cell substrate adhesion GO:0010811 1 0.011
wnt signaling pathway GO:0016055 80 0.011
regulation of rho protein signal transduction GO:0035023 2 0.011
response to carbohydrate GO:0009743 3 0.011
cytoplasm organization GO:0007028 4 0.011
regulation of muscle contraction GO:0006937 3 0.011
regulation of circadian rhythm GO:0042752 4 0.011
neurotransmitter transport GO:0006836 2 0.011
protein polymerization GO:0051258 4 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
regulation of blood vessel size GO:0050880 2 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
regulation of localization GO:0032879 104 0.011
adult behavior GO:0030534 2 0.011
regulation of organ growth GO:0046620 3 0.011
response to uv GO:0009411 3 0.011
biological adhesion GO:0022610 40 0.011
epithelial cell development GO:0002064 42 0.011
protein localization to nucleus GO:0034504 3 0.011
negative regulation of cell adhesion GO:0007162 6 0.011
amine metabolic process GO:0009308 2 0.011
cellular response to starvation GO:0009267 1 0.011
cytoskeleton dependent cytokinesis GO:0061640 3 0.011
somatic muscle development GO:0007525 4 0.011
protein acetylation GO:0006473 2 0.011
sensory perception of pain GO:0019233 1 0.010
tissue remodeling GO:0048771 4 0.010
cell adhesion GO:0007155 40 0.010
head development GO:0060322 303 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
positive regulation of dna metabolic process GO:0051054 1 0.010
cellular carbohydrate metabolic process GO:0044262 4 0.010
positive regulation of inflammatory response GO:0050729 1 0.010
regulation of actin cytoskeleton organization GO:0032956 8 0.010
protein dephosphorylation GO:0006470 3 0.010
synaptic vesicle transport GO:0048489 1 0.010
synaptic vesicle localization GO:0097479 1 0.010
negative regulation of defense response GO:0031348 2 0.010
hormone transport GO:0009914 2 0.010
regulation of reactive oxygen species metabolic process GO:2000377 2 0.010
cell part morphogenesis GO:0032990 246 0.010
cellular ketone metabolic process GO:0042180 11 0.010
regulation of cellular component organization GO:0051128 86 0.010
autophagy GO:0006914 4 0.010
regulation of signaling GO:0023051 235 0.010
single fertilization GO:0007338 3 0.010
negative regulation of catabolic process GO:0009895 3 0.010

gnaz disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.050
nervous system disease DOID:863 0 0.023
sensory system disease DOID:0050155 0 0.015
eye and adnexa disease DOID:1492 0 0.015
eye disease DOID:5614 0 0.015
cancer DOID:162 0 0.014
disease of cellular proliferation DOID:14566 0 0.014
organ system cancer DOID:0050686 0 0.012
retinal disease DOID:5679 0 0.010