Danio rerio

59 known processes

mdkb

midkine-related growth factor b

(Aliases: mdk,fj33b02,wu:fj48a12,wu:fb79b05,fj48a12,mdk2,fb79b05,plei2,cb518,wu:fj33b02)

mdkb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
head development GO:0060322 303 0.852
astrocyte differentiation GO:0048708 1 0.836
central nervous system development GO:0007417 387 0.813
brain development GO:0007420 293 0.723
generation of neurons GO:0048699 385 0.706
neuron differentiation GO:0030182 353 0.654
chordate embryonic development GO:0043009 271 0.583
cell projection morphogenesis GO:0048858 244 0.570
gene expression GO:0010467 252 0.545
Mouse
locomotory behavior GO:0007626 34 0.442
brain morphogenesis GO:0048854 18 0.442
morphogenesis of an epithelium GO:0002009 333 0.382
Zebrafish
endodermal cell fate determination GO:0007493 2 0.376
cellular macromolecule biosynthetic process GO:0034645 224 0.323
Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.320
Mouse
epithelial cell differentiation GO:0030855 116 0.310
regulation of developmental process GO:0050793 247 0.302
eye morphogenesis GO:0048592 144 0.294
sensory organ development GO:0007423 393 0.279
embryonic organ development GO:0048568 381 0.256
cellular response to prostaglandin stimulus GO:0071379 3 0.246
response to prostaglandin GO:0034694 5 0.224
cell proliferation in hindbrain GO:0021534 4 0.223
regulation of multicellular organismal development GO:2000026 223 0.215
pancreas development GO:0031016 84 0.206
response to radiation GO:0009314 51 0.186
signal transduction GO:0007165 455 0.185
cellular component morphogenesis GO:0032989 336 0.178
negative regulation of cellular process GO:0048523 283 0.172
Mouse
central nervous system myelination GO:0022010 2 0.170
adult behavior GO:0030534 2 0.159
embryonic skeletal system development GO:0048706 97 0.158
hindbrain development GO:0030902 91 0.158
Mouse
negative regulation of cell communication GO:0010648 96 0.155
embryo development ending in birth or egg hatching GO:0009792 271 0.152
neural tube development GO:0021915 62 0.148
Zebrafish
extracellular structure organization GO:0043062 27 0.139
response to wounding GO:0009611 116 0.133
Mouse
maintenance of location GO:0051235 4 0.133
cellular biosynthetic process GO:0044249 286 0.130
Mouse
hormone secretion GO:0046879 2 0.129
cerebellar granular layer development GO:0021681 3 0.127
Mouse
forebrain anterior posterior pattern specification GO:0021797 3 0.126
cellular nitrogen compound biosynthetic process GO:0044271 218 0.119
Mouse
sensory organ morphogenesis GO:0090596 200 0.117
heterocycle biosynthetic process GO:0018130 215 0.111
Mouse
regulation of hormone secretion GO:0046883 2 0.105
larval development GO:0002164 2 0.104
cell proliferation in forebrain GO:0021846 3 0.100
regulation of neuron migration GO:2001222 2 0.100
camera type eye morphogenesis GO:0048593 108 0.098
single organism behavior GO:0044708 24 0.098
Mouse
regulation of apoptotic process GO:0042981 98 0.095
Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.094
Mouse
neuroepithelial cell differentiation GO:0060563 26 0.088
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.087
Mouse
peripheral nervous system neuron differentiation GO:0048934 28 0.086
neuron projection development GO:0031175 180 0.086
embryonic organ morphogenesis GO:0048562 274 0.084
anterior commissure morphogenesis GO:0021960 3 0.081
rna biosynthetic process GO:0032774 181 0.080
Mouse
response to chemical GO:0042221 320 0.077
skeletal system morphogenesis GO:0048705 102 0.073
cell surface receptor signaling pathway GO:0007166 325 0.071
cellular response to fatty acid GO:0071398 3 0.070
aging GO:0007568 2 0.069
neural tube formation GO:0001841 16 0.069
Zebrafish
anatomical structure arrangement GO:0048532 2 0.068
cellular response to stress GO:0033554 62 0.067
axis elongation involved in somitogenesis GO:0090245 2 0.067
lipid storage GO:0019915 1 0.067
dopaminergic neuron differentiation GO:0071542 14 0.066
hormone transport GO:0009914 2 0.066
blood vessel development GO:0001568 246 0.064
positive regulation of neuron migration GO:2001224 2 0.063
growth GO:0040007 174 0.063
macromolecule biosynthetic process GO:0009059 227 0.063
Mouse
regulation of biological quality GO:0065008 263 0.062
rna metabolic process GO:0016070 219 0.061
Mouse
carbohydrate homeostasis GO:0033500 1 0.061
regulation of cellular metabolic process GO:0031323 320 0.059
Mouse
positive regulation of transcription dna templated GO:0045893 57 0.059
Mouse
negative regulation of epithelial cell proliferation GO:0050680 1 0.058
response to biotic stimulus GO:0009607 97 0.058
forebrain dorsal ventral pattern formation GO:0021798 1 0.058
metencephalon development GO:0022037 27 0.058
Mouse
ectodermal placode morphogenesis GO:0071697 32 0.057
intra s dna damage checkpoint GO:0031573 1 0.057
embryonic skeletal system morphogenesis GO:0048704 93 0.056
positive regulation of cytokine production GO:0001819 2 0.056
axon development GO:0061564 166 0.055
cellular homeostasis GO:0019725 26 0.055
regulation of metabolic process GO:0019222 359 0.054
Mouse
eye development GO:0001654 277 0.054
camera type eye development GO:0043010 222 0.053
retinal pigment epithelium development GO:0003406 8 0.053
response to stress GO:0006950 263 0.053
Mouse
negative regulation of signaling GO:0023057 96 0.052
negative regulation of biological process GO:0048519 304 0.051
Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.051
Mouse
positive regulation of macromolecule metabolic process GO:0010604 93 0.051
Mouse
posterior lateral line system development GO:0048915 46 0.050
circadian regulation of gene expression GO:0032922 8 0.050
regeneration GO:0031099 91 0.049
taxis GO:0042330 109 0.049
regulation of cytokine production GO:0001817 3 0.048
melanocyte differentiation GO:0030318 26 0.048
regulation of intracellular protein transport GO:0033157 3 0.048
peptide transport GO:0015833 1 0.048
epithelial cell development GO:0002064 42 0.047
protein stabilization GO:0050821 2 0.045
spermatid differentiation GO:0048515 2 0.045
neuron projection morphogenesis GO:0048812 161 0.045
regulation of nitrogen compound metabolic process GO:0051171 251 0.044
Mouse
positive regulation of developmental process GO:0051094 50 0.044
post embryonic morphogenesis GO:0009886 4 0.044
heart development GO:0007507 313 0.043
innervation GO:0060384 3 0.043
developmental pigmentation GO:0048066 48 0.043
negative regulation of gliogenesis GO:0014014 1 0.043
nucleic acid metabolic process GO:0090304 244 0.041
Mouse
forebrain regionalization GO:0021871 4 0.041
cellular response to chemical stimulus GO:0070887 157 0.041
retinal ganglion cell axon guidance GO:0031290 35 0.041
epiboly GO:0090504 41 0.040
regulation of catalytic activity GO:0050790 55 0.040
negative regulation of protein transport GO:0051224 3 0.039
forebrain development GO:0030900 96 0.039
Mouse
wnt signaling pathway GO:0016055 80 0.038
positive regulation of transport GO:0051050 2 0.038
system process GO:0003008 185 0.038
Mouse
negative regulation of multicellular organismal process GO:0051241 69 0.038
otic vesicle morphogenesis GO:0071600 34 0.038
regulation of multicellular organism growth GO:0040014 4 0.037
cellular macromolecule metabolic process GO:0044260 391 0.037
Mouse
organic cyclic compound metabolic process GO:1901360 301 0.036
Mouse
regulation of protein transport GO:0051223 3 0.036
retina development in camera type eye GO:0060041 146 0.036
regulation of establishment of protein localization GO:0070201 4 0.035
determination of left right symmetry GO:0007368 179 0.035
regulation of cell communication GO:0010646 232 0.034
blood vessel morphogenesis GO:0048514 216 0.034
developmental growth GO:0048589 166 0.034
regulation of cell differentiation GO:0045595 142 0.034
neuromuscular process GO:0050905 7 0.033
regulation of response to stimulus GO:0048583 269 0.033
Mouse
heart morphogenesis GO:0003007 156 0.033
forebrain midbrain boundary formation GO:0021905 1 0.032
endodermal digestive tract morphogenesis GO:0061031 2 0.032
positive regulation of secretion GO:0051047 1 0.031
aromatic compound biosynthetic process GO:0019438 217 0.031
Mouse
glucose homeostasis GO:0042593 1 0.031
behavior GO:0007610 74 0.031
Mouse
regulation of gene expression GO:0010468 265 0.030
Mouse
midbrain development GO:0030901 28 0.030
cell part morphogenesis GO:0032990 246 0.030
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.030
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.030
appendage development GO:0048736 80 0.030
mononuclear cell proliferation GO:0032943 1 0.029
regulation of cell activation GO:0050865 1 0.029
epithelial tube morphogenesis GO:0060562 148 0.029
Zebrafish
homeostatic process GO:0042592 142 0.029
neuroblast proliferation GO:0007405 2 0.029
regulation of inner ear receptor cell differentiation GO:2000980 1 0.028
regulation of insulin like growth factor receptor signaling pathway GO:0043567 1 0.028
response to endogenous stimulus GO:0009719 83 0.028
anterior posterior pattern specification GO:0009952 152 0.027
retinoic acid receptor signaling pathway GO:0048384 16 0.027
negative regulation of cytokine production GO:0001818 1 0.027
glial cell differentiation GO:0010001 42 0.027
negative regulation of developmental process GO:0051093 65 0.027
single organism transport GO:0044765 206 0.027
intracellular signal transduction GO:0035556 85 0.027
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.026
organic substance biosynthetic process GO:1901576 289 0.026
Mouse
cellular amine metabolic process GO:0044106 2 0.026
cellular response to lipid GO:0071396 39 0.026
single organism metabolic process GO:0044710 217 0.025
chemical homeostasis GO:0048878 49 0.025
ectodermal placode formation GO:0060788 26 0.024
response to external stimulus GO:0009605 264 0.024
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.024
Mouse
transcription dna templated GO:0006351 181 0.024
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 106 0.024
macromolecule modification GO:0043412 111 0.024
regulation of canonical wnt signaling pathway GO:0060828 34 0.024
water homeostasis GO:0030104 4 0.024
regulation of cellular protein metabolic process GO:0032268 52 0.023
cell cycle g1 s phase transition GO:0044843 1 0.023
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.023
cell proliferation GO:0008283 80 0.023
chondrocyte development GO:0002063 4 0.023
startle response GO:0001964 4 0.023
peripheral nervous system development GO:0007422 55 0.023
regulation of glial cell differentiation GO:0045685 4 0.023
cell proliferation in midbrain GO:0033278 4 0.023
regulation of transcription involved in cell fate commitment GO:0060850 1 0.023
organic substance transport GO:0071702 58 0.023
ribose phosphate metabolic process GO:0019693 27 0.023
regulation of nucleoside metabolic process GO:0009118 2 0.023
negative regulation of signal transduction GO:0009968 94 0.023
regulation of molecular function GO:0065009 70 0.023
ectodermal placode development GO:0071696 37 0.023
olfactory lobe development GO:0021988 4 0.022
hindbrain morphogenesis GO:0021575 22 0.022
regulation of macromolecule biosynthetic process GO:0010556 225 0.022
Mouse
regulation of rna metabolic process GO:0051252 224 0.022
Mouse
rostrocaudal neural tube patterning GO:0021903 29 0.022
abducens nucleus development GO:0021742 2 0.022
cell cell adhesion involved in gastrulation GO:0070586 4 0.022
negative regulation of cell death GO:0060548 60 0.021
Mouse
positive regulation of cell differentiation GO:0045597 30 0.021
negative regulation of protein phosphorylation GO:0001933 4 0.021
cell morphogenesis involved in differentiation GO:0000904 195 0.021
extracellular matrix organization GO:0030198 27 0.021
photoreceptor cell differentiation GO:0046530 55 0.021
determination of heart left right asymmetry GO:0061371 117 0.020
regulation of multicellular organismal process GO:0051239 277 0.020
embryonic heart tube development GO:0035050 133 0.020
multicellular organismal water homeostasis GO:0050891 1 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.020
retinal cell programmed cell death GO:0046666 2 0.020
regulation of cell cycle GO:0051726 52 0.020
Zebrafish
response to vitamin GO:0033273 3 0.020
positive regulation of cell division GO:0051781 2 0.019
nucleocytoplasmic transport GO:0006913 4 0.019
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.019
tube closure GO:0060606 1 0.019
regulation of gtp catabolic process GO:0033124 2 0.019
regulation of binding GO:0051098 3 0.019
neural precursor cell proliferation GO:0061351 20 0.019
digestive system development GO:0055123 289 0.019
positive regulation of cell fate specification GO:0042660 1 0.019
peripheral nervous system neuron axonogenesis GO:0048936 13 0.019
gastrulation GO:0007369 208 0.019
neuron death GO:0070997 21 0.019
Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.019
Mouse
negative regulation of wnt signaling pathway GO:0030178 30 0.018
regulation of cell death GO:0010941 103 0.018
Mouse
positive regulation of axon extension involved in axon guidance GO:0048842 1 0.018
response to nutrient GO:0007584 3 0.018
regulation of eye photoreceptor cell development GO:0042478 2 0.018
negative regulation of map kinase activity GO:0043407 2 0.018
regulation of rna biosynthetic process GO:2001141 213 0.018
Mouse
regulation of localization GO:0032879 104 0.017
intracellular receptor signaling pathway GO:0030522 30 0.017
negative regulation of programmed cell death GO:0043069 58 0.017
Mouse
protein targeting to nucleus GO:0044744 3 0.017
iris morphogenesis GO:0061072 1 0.017
cerebellum development GO:0021549 17 0.017
Mouse
axonogenesis involved in innervation GO:0060385 1 0.017
pigmentation GO:0043473 85 0.017
positive regulation of biological process GO:0048518 253 0.017
ear development GO:0043583 127 0.017
cellular response to organic substance GO:0071310 105 0.017
dendrite guidance GO:0070983 0 0.017
regulation of wnt signaling pathway GO:0030111 53 0.017
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.017
regulation of cellular amine metabolic process GO:0033238 0 0.016
positive regulation of nucleic acid templated transcription GO:1903508 57 0.016
Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.016
Mouse
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
glial cell development GO:0021782 20 0.016
regulation of protein metabolic process GO:0051246 56 0.016
mesenchymal cell development GO:0014031 78 0.016
negative regulation of defense response GO:0031348 2 0.016
determination of pancreatic left right asymmetry GO:0035469 11 0.016
pigment cell differentiation GO:0050931 38 0.016
response to carbohydrate GO:0009743 3 0.016
angiogenesis GO:0001525 158 0.015
development of primary female sexual characteristics GO:0046545 4 0.015
regulation of retinoic acid receptor signaling pathway GO:0048385 5 0.015
cellular chemical homeostasis GO:0055082 17 0.015
specification of symmetry GO:0009799 204 0.015
response to hexose GO:0009746 3 0.015
response to light stimulus GO:0009416 46 0.015
protein phosphorylation GO:0006468 47 0.015
positive regulation of embryonic development GO:0040019 3 0.014
cognition GO:0050890 1 0.014
Mouse
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.014
positive regulation of metabolic process GO:0009893 108 0.014
Mouse
stem cell differentiation GO:0048863 117 0.014
positive regulation of secretion by cell GO:1903532 1 0.014
neuron development GO:0048666 262 0.014
negative regulation of response to stimulus GO:0048585 104 0.014
embryonic viscerocranium morphogenesis GO:0048703 52 0.014
mesenchymal cell differentiation GO:0048762 87 0.014
regulation of oligodendrocyte differentiation GO:0048713 1 0.014
nucleic acid templated transcription GO:0097659 181 0.014
Mouse
regulation of cytoplasmic transport GO:1903649 4 0.014
response to inorganic substance GO:0010035 38 0.014
collateral sprouting in absence of injury GO:0048669 4 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
cellular response to dna damage stimulus GO:0006974 24 0.013
response to metal ion GO:0010038 34 0.013
heart looping GO:0001947 94 0.013
regulation of gtpase activity GO:0043087 2 0.013
skeletal system development GO:0001501 181 0.013
phagocytosis GO:0006909 3 0.013
single organism intracellular transport GO:1902582 25 0.013
canonical wnt signaling pathway GO:0060070 48 0.013
regulation of signaling GO:0023051 235 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.013
Mouse
multicellular organism growth GO:0035264 4 0.013
response to oxygen containing compound GO:1901700 55 0.013
positive regulation of muscle tissue development GO:1901863 1 0.013
positive regulation of multicellular organismal process GO:0051240 52 0.013
positive regulation of rna metabolic process GO:0051254 59 0.013
Mouse
cell morphogenesis GO:0000902 289 0.013
cellular component assembly GO:0022607 170 0.012
telencephalon development GO:0021537 14 0.012
Mouse
carboxylic acid metabolic process GO:0019752 22 0.012
negative regulation of mapk cascade GO:0043409 4 0.012
regionalization GO:0003002 274 0.012
leukocyte proliferation GO:0070661 1 0.012
response to organic substance GO:0010033 153 0.012
posterior lateral line development GO:0048916 38 0.012
transmission of nerve impulse GO:0019226 19 0.012
regulation of transport GO:0051049 45 0.012
protein secretion GO:0009306 1 0.012
establishment of localization GO:0051234 244 0.011
neuroblast differentiation GO:0014016 1 0.011
primitive hemopoiesis GO:0060215 27 0.011
stem cell proliferation GO:0072089 4 0.011
regulation of biomineral tissue development GO:0070167 2 0.011
retina layer formation GO:0010842 24 0.011
negative regulation of intracellular protein transport GO:0090317 3 0.011
ribonucleotide metabolic process GO:0009259 27 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
endocrine hormone secretion GO:0060986 2 0.011
regulation of programmed cell death GO:0043067 101 0.011
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
mitotic cell cycle process GO:1903047 48 0.011
positive regulation of epithelial cell differentiation GO:0030858 2 0.011
transport GO:0006810 220 0.011
nuclear transport GO:0051169 4 0.010
oligodendrocyte differentiation GO:0048709 23 0.010
trigeminal nerve development GO:0021559 3 0.010
regulation of cellular amino acid metabolic process GO:0006521 0 0.010
mammillary body development GO:0021767 4 0.010
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.010
oxoacid metabolic process GO:0043436 31 0.010
regulation of inflammatory response GO:0050727 2 0.010

mdkb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.025
reproductive organ cancer DOID:193 0 0.013
female reproductive organ cancer DOID:120 0 0.013
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
organ system cancer DOID:0050686 0 0.013
physical disorder DOID:0080015 0 0.011
congenital nervous system abnormality DOID:2490 0 0.011