Danio rerio

13 known processes

pklr

pyruvate kinase, liver and RBC

(Aliases: wu:fd15e01,wu:fi37e08)

pklr biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
morphogenesis of an epithelium GO:0002009 333 0.282
aging GO:0007568 2 0.181
cellular macromolecule metabolic process GO:0044260 391 0.141
regulation of wound healing GO:0061041 2 0.115
cellular protein catabolic process GO:0044257 4 0.103
response to biotic stimulus GO:0009607 97 0.079
gene expression GO:0010467 252 0.073
negative regulation of biological process GO:0048519 304 0.073
localization of cell GO:0051674 244 0.071
organic acid metabolic process GO:0006082 31 0.071
response to external stimulus GO:0009605 264 0.067
cell motility GO:0048870 244 0.067
negative regulation of protein processing GO:0010955 10 0.066
organic heteropentacyclic compound metabolic process GO:1901376 1 0.066
muscle structure development GO:0061061 196 0.065
regulation of biological quality GO:0065008 263 0.064
regulation of transcription dna templated GO:0006355 213 0.063
negative regulation of cellular process GO:0048523 283 0.059
cellular response to chemical stimulus GO:0070887 157 0.057
larval development GO:0002164 2 0.056
regulation of blood coagulation GO:0030193 1 0.056
renal tubule morphogenesis GO:0061333 1 0.056
developmental growth GO:0048589 166 0.055
regulation of gene expression GO:0010468 265 0.053
negative regulation of endopeptidase activity GO:0010951 10 0.050
killing of cells in other organism involved in symbiotic interaction GO:0051883 1 0.050
positive regulation of response to stimulus GO:0048584 80 0.050
maintenance of location GO:0051235 4 0.049
cellular ketone metabolic process GO:0042180 11 0.048
growth GO:0040007 174 0.047
mycotoxin metabolic process GO:0043385 1 0.047
regulation of signal transduction GO:0009966 225 0.046
regulation of cellular metabolic process GO:0031323 320 0.044
neuron differentiation GO:0030182 353 0.044
modification dependent macromolecule catabolic process GO:0043632 3 0.043
response to organic substance GO:0010033 153 0.041
positive regulation of wound healing GO:0090303 1 0.040
response to organic cyclic compound GO:0014070 51 0.039
regulation of response to stimulus GO:0048583 269 0.038
single organism metabolic process GO:0044710 217 0.038
tube morphogenesis GO:0035239 349 0.038
system process GO:0003008 185 0.037
digestive tract development GO:0048565 265 0.037
response to lipid GO:0033993 60 0.037
head development GO:0060322 303 0.036
regulation of primary metabolic process GO:0080090 311 0.036
heart looping GO:0001947 94 0.036
regulation of cell substrate adhesion GO:0010810 1 0.035
lipid storage GO:0019915 1 0.034
regulation of protein catabolic process GO:0042176 1 0.034
cellular response to external stimulus GO:0071496 2 0.033
response to endogenous stimulus GO:0009719 83 0.033
cellular component morphogenesis GO:0032989 336 0.033
regulation of hemostasis GO:1900046 1 0.033
digestive system development GO:0055123 289 0.033
cellular amino acid metabolic process GO:0006520 7 0.032
protein metabolic process GO:0019538 183 0.032
cellular response to hormone stimulus GO:0032870 39 0.032
central nervous system development GO:0007417 387 0.031
cellular response to estrogen stimulus GO:0071391 24 0.031
regulation of protein maturation GO:1903317 10 0.031
cellular component movement GO:0006928 335 0.031
ether metabolic process GO:0018904 1 0.030
organic acid catabolic process GO:0016054 3 0.030
ameboidal type cell migration GO:0001667 143 0.030
regulation of metal ion transport GO:0010959 4 0.030
proteolysis GO:0006508 38 0.030
regulation of tube size GO:0035150 2 0.030
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.029
regulation of blood vessel size GO:0050880 2 0.029
circulatory system process GO:0003013 87 0.029
transcription dna templated GO:0006351 181 0.028
response to chemical GO:0042221 320 0.028
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.028
positive regulation of transport GO:0051050 2 0.028
lipid oxidation GO:0034440 1 0.028
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.027
heterocycle metabolic process GO:0046483 290 0.027
negative regulation of cellular metabolic process GO:0031324 77 0.027
cellular response to starvation GO:0009267 1 0.027
cellular response to steroid hormone stimulus GO:0071383 31 0.027
meiotic nuclear division GO:0007126 4 0.026
lipid catabolic process GO:0016042 4 0.026
response to wounding GO:0009611 116 0.026
positive regulation of signaling GO:0023056 56 0.026
regulation of multicellular organismal process GO:0051239 277 0.026
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.025
proteasomal protein catabolic process GO:0010498 2 0.025
cell substrate adhesion GO:0031589 4 0.025
regulation of macromolecule metabolic process GO:0060255 317 0.025
cellular response to endogenous stimulus GO:0071495 68 0.025
epithelial tube morphogenesis GO:0060562 148 0.024
multicellular organism growth GO:0035264 4 0.024
mesenchymal cell differentiation GO:0048762 87 0.024
locomotion GO:0040011 313 0.024
positive regulation of cellular amine metabolic process GO:0033240 0 0.024
cellular response to nutrient levels GO:0031669 2 0.024
pyruvate metabolic process GO:0006090 1 0.024
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
positive regulation of cell cycle GO:0045787 3 0.023
regulation of cytokine production GO:0001817 3 0.023
cellular response to organic substance GO:0071310 105 0.023
cell adhesion GO:0007155 40 0.023
blood coagulation fibrin clot formation GO:0072378 3 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.023
single organism organelle organization GO:1902589 199 0.022
hormone secretion GO:0046879 2 0.022
regulation of protein transport GO:0051223 3 0.022
tissue regeneration GO:0042246 74 0.022
brain development GO:0007420 293 0.022
regulation of establishment of protein localization GO:0070201 4 0.022
regulation of organ growth GO:0046620 3 0.022
cell migration GO:0016477 237 0.022
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.021
nucleic acid templated transcription GO:0097659 181 0.021
aflatoxin b1 metabolic process GO:0043390 1 0.021
extrinsic apoptotic signaling pathway GO:0097191 3 0.021
phagocytosis GO:0006909 3 0.021
cellular response to extracellular stimulus GO:0031668 2 0.021
small molecule catabolic process GO:0044282 3 0.020
negative regulation of multicellular organismal process GO:0051241 69 0.020
oxoacid metabolic process GO:0043436 31 0.020
glucose homeostasis GO:0042593 1 0.020
regulation of multicellular organism growth GO:0040014 4 0.020
immune system process GO:0002376 241 0.020
response to steroid hormone GO:0048545 35 0.019
regulation of signaling GO:0023051 235 0.019
positive regulation of cell communication GO:0010647 56 0.019
signal transduction GO:0007165 455 0.019
blood circulation GO:0008015 87 0.019
astrocyte differentiation GO:0048708 1 0.019
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.018
regulation of cellular amine metabolic process GO:0033238 0 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.018
rna biosynthetic process GO:0032774 181 0.018
positive regulation of cellular process GO:0048522 201 0.018
gastrulation GO:0007369 208 0.018
epithelial cell differentiation GO:0030855 116 0.018
interspecies interaction between organisms GO:0044419 4 0.018
cell morphogenesis GO:0000902 289 0.018
response to estrogen GO:0043627 27 0.018
amine metabolic process GO:0009308 2 0.018
mesenchyme development GO:0060485 127 0.018
regulation of coagulation GO:0050818 2 0.018
glucocorticoid metabolic process GO:0008211 2 0.017
cell matrix adhesion GO:0007160 4 0.017
blood coagulation GO:0007596 12 0.017
response to stress GO:0006950 263 0.017
translational initiation GO:0006413 3 0.017
aflatoxin metabolic process GO:0046222 1 0.017
regulation of protein processing GO:0070613 10 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
regulation of fatty acid metabolic process GO:0019217 1 0.017
protein secretion GO:0009306 1 0.017
epiboly GO:0090504 41 0.017
negative regulation of protein maturation GO:1903318 10 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.017
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.017
regulation of hormone secretion GO:0046883 2 0.016
spermatid differentiation GO:0048515 2 0.016
homeostatic process GO:0042592 142 0.016
negative regulation of gene expression GO:0010629 65 0.016
regulation of positive chemotaxis GO:0050926 4 0.016
oxidation reduction process GO:0055114 41 0.016
vitamin a metabolic process GO:0006776 1 0.016
negative regulation of proteolysis GO:0045861 10 0.016
cellular aromatic compound metabolic process GO:0006725 295 0.016
positive regulation of cytokine production GO:0001819 2 0.016
intracellular signal transduction GO:0035556 85 0.016
generation of neurons GO:0048699 385 0.016
regulation of hormone levels GO:0010817 21 0.015
fatty acid biosynthetic process GO:0006633 4 0.015
wound healing GO:0042060 90 0.015
regulation of cell shape GO:0008360 1 0.015
positive regulation of secretion GO:0051047 1 0.015
regeneration GO:0031099 91 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
coagulation GO:0050817 13 0.015
cellular component disassembly GO:0022411 1 0.015
negative regulation of peptidase activity GO:0010466 10 0.015
blood vessel development GO:0001568 246 0.015
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.015
neural crest cell development GO:0014032 62 0.015
fat soluble vitamin metabolic process GO:0006775 4 0.015
heart development GO:0007507 313 0.015
cellular biosynthetic process GO:0044249 286 0.015
stem cell differentiation GO:0048863 117 0.015
cytoskeleton organization GO:0007010 96 0.015
negative regulation of sequestering of calcium ion GO:0051283 4 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
multi organism process GO:0051704 134 0.014
cellular nitrogen compound metabolic process GO:0034641 290 0.014
regulation of immune system process GO:0002682 34 0.014
carboxylic acid metabolic process GO:0019752 22 0.014
biological adhesion GO:0022610 40 0.014
regulation of localization GO:0032879 104 0.014
synaptic growth at neuromuscular junction GO:0051124 2 0.014
regulation of developmental process GO:0050793 247 0.014
regulation of jak stat cascade GO:0046425 3 0.014
response to nutrient GO:0007584 3 0.014
protein polymerization GO:0051258 4 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
regulation of intracellular signal transduction GO:1902531 57 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
cell surface receptor signaling pathway GO:0007166 325 0.014
regulation of proteolysis GO:0030162 24 0.014
endocrine system development GO:0035270 65 0.014
heart morphogenesis GO:0003007 156 0.014
embryonic organ development GO:0048568 381 0.014
regulation of metabolic process GO:0019222 359 0.014
positive regulation of biological process GO:0048518 253 0.013
rna metabolic process GO:0016070 219 0.013
cellular catabolic process GO:0044248 27 0.013
transport GO:0006810 220 0.013
muscle cell differentiation GO:0042692 139 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
positive regulation of cellular component biogenesis GO:0044089 3 0.013
cellular component biogenesis GO:0044085 178 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
negative regulation of metabolic process GO:0009892 86 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
nephron morphogenesis GO:0072028 2 0.013
otic vesicle development GO:0071599 42 0.013
mesenchymal cell development GO:0014031 78 0.013
regulation of biosynthetic process GO:0009889 250 0.012
female gonad development GO:0008585 4 0.012
hormone transport GO:0009914 2 0.012
muscle organ development GO:0007517 101 0.012
regionalization GO:0003002 274 0.012
small molecule metabolic process GO:0044281 77 0.012
regulation of neurogenesis GO:0050767 87 0.012
vasculature development GO:0001944 278 0.012
carboxylic acid catabolic process GO:0046395 3 0.012
regulation of nervous system development GO:0051960 90 0.012
sensory organ development GO:0007423 393 0.012
embryonic heart tube morphogenesis GO:0003143 108 0.012
negative regulation of dna metabolic process GO:0051053 4 0.012
response to carbohydrate GO:0009743 3 0.012
cellular amine metabolic process GO:0044106 2 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
chemosensory behavior GO:0007635 1 0.012
heart contraction GO:0060047 71 0.012
adherens junction organization GO:0034332 4 0.011
regulation of stem cell proliferation GO:0072091 2 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
cation transport GO:0006812 81 0.011
response to hormone GO:0009725 48 0.011
epithelial cell development GO:0002064 42 0.011
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.011
organic cyclic compound metabolic process GO:1901360 301 0.011
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.011
secondary metabolic process GO:0019748 3 0.011
nucleic acid metabolic process GO:0090304 244 0.011
extracellular matrix organization GO:0030198 27 0.011
taxis GO:0042330 109 0.011
regulation of cell development GO:0060284 100 0.011
negative regulation of multi organism process GO:0043901 3 0.011
angiogenesis GO:0001525 158 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
neural crest cell migration GO:0001755 42 0.011
regulation of protein ubiquitination GO:0031396 3 0.010
carbohydrate homeostasis GO:0033500 1 0.010
regulation of cell activation GO:0050865 1 0.010
protein maturation GO:0051604 12 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
positive regulation of cellular catabolic process GO:0031331 3 0.010
triglyceride homeostasis GO:0070328 2 0.010
development of primary female sexual characteristics GO:0046545 4 0.010
inner ear development GO:0048839 126 0.010
muscle tissue development GO:0060537 110 0.010

pklr disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.130
immune system disease DOID:2914 0 0.021
disease of metabolism DOID:0014667 0 0.015
hematopoietic system disease DOID:74 0 0.011
cardiovascular system disease DOID:1287 0 0.010