Danio rerio

18 known processes

loxl2a

lysyl oxidase-like 2a

loxl2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
blood vessel morphogenesis GO:0048514 216 0.164
vasculature development GO:0001944 278 0.140
embryonic organ development GO:0048568 381 0.107
Zebrafish
tube morphogenesis GO:0035239 349 0.078
regulation of cellular metabolic process GO:0031323 320 0.076
amine metabolic process GO:0009308 2 0.066
cellular nitrogen compound biosynthetic process GO:0044271 218 0.063
cellular macromolecule metabolic process GO:0044260 391 0.059
cellular amine metabolic process GO:0044106 2 0.059
regulation of nitrogen compound metabolic process GO:0051171 251 0.056
central nervous system development GO:0007417 387 0.054
biosynthetic process GO:0009058 294 0.053
heterocycle biosynthetic process GO:0018130 215 0.053
regulation of metabolic process GO:0019222 359 0.052
regulation of macromolecule metabolic process GO:0060255 317 0.052
rna biosynthetic process GO:0032774 181 0.051
transcription dna templated GO:0006351 181 0.050
cell projection morphogenesis GO:0048858 244 0.049
regulation of macromolecule biosynthetic process GO:0010556 225 0.049
regulation of cellular amino acid metabolic process GO:0006521 0 0.048
heart development GO:0007507 313 0.048
skeletal system development GO:0001501 181 0.047
Zebrafish
cell motility GO:0048870 244 0.047
nucleic acid templated transcription GO:0097659 181 0.046
rna metabolic process GO:0016070 219 0.046
oxoacid metabolic process GO:0043436 31 0.046
blood vessel development GO:0001568 246 0.045
nitrogen compound metabolic process GO:0006807 319 0.045
angiogenesis GO:0001525 158 0.045
regulation of rna biosynthetic process GO:2001141 213 0.044
heart morphogenesis GO:0003007 156 0.044
cellular component movement GO:0006928 335 0.043
response to stress GO:0006950 263 0.043
aging GO:0007568 2 0.043
regionalization GO:0003002 274 0.043
cellular nitrogen compound metabolic process GO:0034641 290 0.042
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.042
regulation of cellular biosynthetic process GO:0031326 245 0.041
positive regulation of transport GO:0051050 2 0.041
development of primary female sexual characteristics GO:0046545 4 0.040
regulation of cellular amine metabolic process GO:0033238 0 0.039
regulation of primary metabolic process GO:0080090 311 0.039
positive regulation of cellular component biogenesis GO:0044089 3 0.039
cell substrate adhesion GO:0031589 4 0.039
embryonic organ morphogenesis GO:0048562 274 0.039
Zebrafish
negative regulation of kinase activity GO:0033673 4 0.039
cellular response to nutrient levels GO:0031669 2 0.038
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.037
regulation of organ growth GO:0046620 3 0.037
eye development GO:0001654 277 0.036
positive regulation of cellular process GO:0048522 201 0.036
regulation of cellular ketone metabolic process GO:0010565 7 0.035
larval development GO:0002164 2 0.035
cell projection organization GO:0030030 284 0.034
macromolecule biosynthetic process GO:0009059 227 0.034
organic cyclic compound metabolic process GO:1901360 301 0.033
negative regulation of protein phosphorylation GO:0001933 4 0.033
digestive tract development GO:0048565 265 0.033
cellular response to external stimulus GO:0071496 2 0.032
organic substance biosynthetic process GO:1901576 289 0.032
somite development GO:0061053 96 0.032
sensory organ development GO:0007423 393 0.032
female sex differentiation GO:0046660 4 0.031
phagocytosis GO:0006909 3 0.031
positive regulation of biological process GO:0048518 253 0.031
digestive tract morphogenesis GO:0048546 231 0.030
regulation of gene expression GO:0010468 265 0.030
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.030
cellular amino acid metabolic process GO:0006520 7 0.030
regulation of nucleic acid templated transcription GO:1903506 213 0.030
nucleic acid metabolic process GO:0090304 244 0.029
locomotion GO:0040011 313 0.029
maintenance of location GO:0051235 4 0.029
positive regulation of cellular amine metabolic process GO:0033240 0 0.029
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.029
cellular component morphogenesis GO:0032989 336 0.029
localization of cell GO:0051674 244 0.029
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.029
negative regulation of protein kinase activity GO:0006469 4 0.029
regulation of biosynthetic process GO:0009889 250 0.028
aromatic compound biosynthetic process GO:0019438 217 0.028
regulation of cytokine production GO:0001817 3 0.028
sprouting angiogenesis GO:0002040 53 0.028
transcription from rna polymerase ii promoter GO:0006366 80 0.028
female gonad development GO:0008585 4 0.028
gastrulation GO:0007369 208 0.028
organic cyclic compound biosynthetic process GO:1901362 223 0.027
epithelial tube morphogenesis GO:0060562 148 0.027
gene expression GO:0010467 252 0.027
developmental growth GO:0048589 166 0.026
gland development GO:0048732 143 0.026
forebrain development GO:0030900 96 0.026
regulation of multicellular organismal process GO:0051239 277 0.026
modification dependent protein catabolic process GO:0019941 3 0.025
extrinsic apoptotic signaling pathway GO:0097191 3 0.025
camera type eye development GO:0043010 222 0.025
tissue remodeling GO:0048771 4 0.025
negative regulation of cellular process GO:0048523 283 0.025
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.025
ameboidal type cell migration GO:0001667 143 0.025
negative regulation of biological process GO:0048519 304 0.024
cellular biosynthetic process GO:0044249 286 0.024
regulation of dendrite development GO:0050773 3 0.024
regulation of transcription dna templated GO:0006355 213 0.024
nucleobase containing compound biosynthetic process GO:0034654 205 0.024
synaptic transmission cholinergic GO:0007271 4 0.024
positive regulation of epithelial cell migration GO:0010634 2 0.023
protein import GO:0017038 3 0.023
axonogenesis GO:0007409 152 0.023
organelle organization GO:0006996 227 0.023
mitochondrion organization GO:0007005 4 0.023
carboxylic acid metabolic process GO:0019752 22 0.023
cell morphogenesis GO:0000902 289 0.023
regulation of epithelial cell proliferation GO:0050678 3 0.023
cellular aromatic compound metabolic process GO:0006725 295 0.023
regulation of erk1 and erk2 cascade GO:0070372 4 0.023
brain development GO:0007420 293 0.023
system process GO:0003008 185 0.023
meiotic nuclear division GO:0007126 4 0.022
morphogenesis of an epithelium GO:0002009 333 0.022
cell surface receptor signaling pathway GO:0007166 325 0.022
nucleobase containing compound metabolic process GO:0006139 274 0.022
regulation of rna metabolic process GO:0051252 224 0.022
regulation of developmental process GO:0050793 247 0.022
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.022
cell part morphogenesis GO:0032990 246 0.022
response to nutrient GO:0007584 3 0.021
adult behavior GO:0030534 2 0.021
response to external stimulus GO:0009605 264 0.021
lipid storage GO:0019915 1 0.021
cellular response to extracellular stimulus GO:0031668 2 0.020
neuron differentiation GO:0030182 353 0.020
i kappab kinase nf kappab signaling GO:0007249 4 0.020
hepaticobiliary system development GO:0061008 98 0.020
inner ear development GO:0048839 126 0.020
regulation of dna replication GO:0006275 3 0.020
regulation of binding GO:0051098 3 0.020
connective tissue development GO:0061448 99 0.020
Zebrafish
sensory organ morphogenesis GO:0090596 200 0.020
negative regulation of programmed cell death GO:0043069 58 0.020
regulation of organelle assembly GO:1902115 4 0.020
positive regulation of endothelial cell migration GO:0010595 2 0.020
homeostatic process GO:0042592 142 0.020
head development GO:0060322 303 0.020
retina development in camera type eye GO:0060041 146 0.019
regulation of cell differentiation GO:0045595 142 0.019
cellular response to starvation GO:0009267 1 0.019
response to drug GO:0042493 3 0.019
regulation of anatomical structure morphogenesis GO:0022603 130 0.019
cell morphogenesis involved in differentiation GO:0000904 195 0.019
regulation of reproductive process GO:2000241 4 0.019
neuron projection morphogenesis GO:0048812 161 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.019
generation of neurons GO:0048699 385 0.019
programmed cell death GO:0012501 119 0.019
liver development GO:0001889 96 0.019
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.019
cartilage development GO:0051216 96 0.019
Zebrafish
enzyme linked receptor protein signaling pathway GO:0007167 106 0.019
stem cell proliferation GO:0072089 4 0.019
regulation of blood vessel size GO:0050880 2 0.018
cell matrix adhesion GO:0007160 4 0.018
regulation of cell death GO:0010941 103 0.018
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.018
cell migration GO:0016477 237 0.018
organic acid metabolic process GO:0006082 31 0.018
cellular ketone metabolic process GO:0042180 11 0.018
positive regulation of cell adhesion GO:0045785 1 0.018
nuclear transport GO:0051169 4 0.018
negative regulation of map kinase activity GO:0043407 2 0.018
chordate embryonic development GO:0043009 271 0.018
Zebrafish
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.017
anterior posterior pattern specification GO:0009952 152 0.017
membrane fusion GO:0061025 2 0.017
response to carbohydrate GO:0009743 3 0.017
immune system development GO:0002520 191 0.017
developmental growth involved in morphogenesis GO:0060560 86 0.017
establishment of localization GO:0051234 244 0.017
single organism nuclear import GO:1902593 3 0.017
sensory perception of chemical stimulus GO:0007606 3 0.017
regulation of cellular component movement GO:0051270 55 0.017
cardiac atrium development GO:0003230 4 0.017
organonitrogen compound metabolic process GO:1901564 74 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
protein secretion GO:0009306 1 0.017
regulation of biological quality GO:0065008 263 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
convergent extension GO:0060026 118 0.016
regulation of mesenchymal cell proliferation GO:0010464 1 0.016
regulation of protein transport GO:0051223 3 0.016
regulation of cell shape GO:0008360 1 0.016
dorsal ventral pattern formation GO:0009953 125 0.016
response to corticosteroid GO:0031960 1 0.016
axon development GO:0061564 166 0.016
hypothalamus cell differentiation GO:0021979 4 0.016
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.016
regulation of reactive oxygen species metabolic process GO:2000377 2 0.016
regulation of response to stimulus GO:0048583 269 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
regulation of protein complex assembly GO:0043254 3 0.016
regulation of autophagy GO:0010506 3 0.016
hematopoietic or lymphoid organ development GO:0048534 191 0.016
death GO:0016265 121 0.016
regulation of dendrite morphogenesis GO:0048814 3 0.016
regulation of endothelial cell proliferation GO:0001936 1 0.016
apoptotic process GO:0006915 116 0.016
cellular macromolecule biosynthetic process GO:0034645 224 0.016
somatic stem cell maintenance GO:0035019 1 0.016
nucleocytoplasmic transport GO:0006913 4 0.016
cellular protein metabolic process GO:0044267 129 0.016
peptidyl serine phosphorylation GO:0018105 1 0.016
multicellular organism growth GO:0035264 4 0.016
heterocycle metabolic process GO:0046483 290 0.016
positive regulation of cytoskeleton organization GO:0051495 3 0.016
regulation of stem cell proliferation GO:0072091 2 0.016
tissue migration GO:0090130 37 0.015
regulation of heart growth GO:0060420 2 0.015
dendrite guidance GO:0070983 0 0.015
immune system process GO:0002376 241 0.015
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.015
cellular response to radiation GO:0071478 4 0.015
response to hexose GO:0009746 3 0.015
determination of bilateral symmetry GO:0009855 204 0.015
growth GO:0040007 174 0.015
digestive system development GO:0055123 289 0.015
response to chemical GO:0042221 320 0.015
regulation of cytoplasmic transport GO:1903649 4 0.015
stem cell differentiation GO:0048863 117 0.015
muscle cell differentiation GO:0042692 139 0.015
single organism transport GO:0044765 206 0.015
mitotic dna integrity checkpoint GO:0044774 4 0.015
microtubule organizing center organization GO:0031023 1 0.015
cytokinesis GO:0000910 3 0.015
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.015
protein metabolic process GO:0019538 183 0.015
signal transduction GO:0007165 455 0.015
inositol lipid mediated signaling GO:0048017 2 0.015
ear development GO:0043583 127 0.015
regulation of programmed cell death GO:0043067 101 0.015
embryo development ending in birth or egg hatching GO:0009792 271 0.015
Zebrafish
positive regulation of multicellular organismal process GO:0051240 52 0.015
carbohydrate homeostasis GO:0033500 1 0.014
regulation of jak stat cascade GO:0046425 3 0.014
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
regulation of systemic arterial blood pressure GO:0003073 1 0.014
notochord development GO:0030903 54 0.014
Zebrafish
regulation of locomotion GO:0040012 55 0.014
negative regulation of signaling GO:0023057 96 0.014
negative regulation of apoptotic process GO:0043066 55 0.014
positive regulation of stem cell proliferation GO:2000648 1 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
transport GO:0006810 220 0.014
regulation of tube size GO:0035150 2 0.014
positive regulation of catabolic process GO:0009896 4 0.014
protein localization to nucleus GO:0034504 3 0.014
carbon dioxide transport GO:0015670 3 0.014
bmp signaling pathway GO:0030509 52 0.014
regulation of metal ion transport GO:0010959 4 0.014
kidney development GO:0001822 92 0.014
autophagy GO:0006914 4 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
stem cell maintenance GO:0019827 4 0.013
regulation of cell substrate adhesion GO:0010810 1 0.013
collagen fibril organization GO:0030199 1 0.013
regulation of apoptotic process GO:0042981 98 0.013
response to glucocorticoid GO:0051384 1 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
neural crest cell migration GO:0001755 42 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
pronephros development GO:0048793 69 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.013
regulation of cell matrix adhesion GO:0001952 1 0.013
ventricular cardiac muscle tissue development GO:0003229 3 0.013
cell death GO:0008219 121 0.013
eye morphogenesis GO:0048592 144 0.013
negative regulation of macromolecule metabolic process GO:0010605 76 0.013
regeneration GO:0031099 91 0.013
regulation of signal transduction GO:0009966 225 0.013
small molecule metabolic process GO:0044281 77 0.012
skeletal muscle organ development GO:0060538 78 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
regulation of protein catabolic process GO:0042176 1 0.012
adherens junction organization GO:0034332 4 0.012
gas transport GO:0015669 3 0.012
cardiac cell fate commitment GO:0060911 1 0.012
mesenchymal cell development GO:0014031 78 0.012
cellular component assembly GO:0022607 170 0.012
regulation of multicellular organism growth GO:0040014 4 0.012
chemotaxis GO:0006935 104 0.012
synaptic target recognition GO:0008039 1 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
negative regulation of cell death GO:0060548 60 0.012
response to ketone GO:1901654 1 0.012
response to wounding GO:0009611 116 0.012
protein complex subunit organization GO:0071822 46 0.012
regulation of signaling GO:0023051 235 0.012
trabecula morphogenesis GO:0061383 2 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
regulation of cell activation GO:0050865 1 0.012
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.012
cardiac atrium morphogenesis GO:0003209 2 0.012
developmental cell growth GO:0048588 52 0.012
regulation of protein targeting GO:1903533 2 0.012
gtp catabolic process GO:0006184 2 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
ion transmembrane transport GO:0034220 91 0.012
negative regulation of cell communication GO:0010648 96 0.012
positive regulation of epithelial cell proliferation GO:0050679 1 0.012
blood vessel endothelial cell migration GO:0043534 18 0.012
specification of symmetry GO:0009799 204 0.012
organ regeneration GO:0031100 1 0.012
striated muscle tissue development GO:0014706 110 0.012
skeletal system morphogenesis GO:0048705 102 0.011
Zebrafish
regulation of cell communication GO:0010646 232 0.011
epithelium migration GO:0090132 25 0.011
mesenchyme development GO:0060485 127 0.011
protein import into nucleus GO:0006606 3 0.011
endosomal transport GO:0016197 2 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
regulation of behavior GO:0050795 24 0.011
neuron projection development GO:0031175 180 0.011
wnt signaling pathway GO:0016055 80 0.011
protein targeting to nucleus GO:0044744 3 0.011
segmentation GO:0035282 97 0.011
single organism membrane fusion GO:0044801 2 0.011
ovulation cycle process GO:0022602 2 0.011
post embryonic organ development GO:0048569 4 0.011
determination of left right symmetry GO:0007368 179 0.011
meiotic cell cycle process GO:1903046 3 0.011
peptide metabolic process GO:0006518 1 0.011
negative regulation of signal transduction GO:0009968 94 0.011
urogenital system development GO:0001655 97 0.011
response to monosaccharide GO:0034284 3 0.011
negative regulation of developmental process GO:0051093 65 0.011
response to biotic stimulus GO:0009607 97 0.011
positive regulation of endothelial cell proliferation GO:0001938 1 0.011
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.011
camera type eye morphogenesis GO:0048593 108 0.011
mesenchymal cell differentiation GO:0048762 87 0.011
nuclear import GO:0051170 3 0.011
regulation of nucleoside metabolic process GO:0009118 2 0.011
response to external biotic stimulus GO:0043207 97 0.011
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.010
positive regulation of cytokine production GO:0001819 2 0.010
erk1 and erk2 cascade GO:0070371 4 0.010
regulation of response to external stimulus GO:0032101 31 0.010
cellular protein modification process GO:0006464 100 0.010
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.010
stem cell division GO:0017145 1 0.010
positive regulation of secretion GO:0051047 1 0.010
cellular amide metabolic process GO:0043603 4 0.010
endocrine process GO:0050886 2 0.010
wound healing GO:0042060 90 0.010
lateral inhibition GO:0046331 1 0.010
positive regulation of cell substrate adhesion GO:0010811 1 0.010
g1 s transition of mitotic cell cycle GO:0000082 1 0.010
negative regulation of chemotaxis GO:0050922 4 0.010
positive regulation of cell cycle GO:0045787 3 0.010
regulation of calcium ion transport GO:0051924 2 0.010

loxl2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.043
musculoskeletal system disease DOID:17 0 0.021
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
nervous system disease DOID:863 0 0.013