Danio rerio

0 known processes

ror2

receptor tyrosine kinase-like orphan receptor 2

ror2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
determination of heart left right asymmetry GO:0061371 117 0.814
heart development GO:0007507 313 0.363
determination of left right symmetry GO:0007368 179 0.300
positive regulation of cell cycle GO:0045787 3 0.271
cellular modified amino acid metabolic process GO:0006575 3 0.266
single organism organelle organization GO:1902589 199 0.233
head development GO:0060322 303 0.181
determination of bilateral symmetry GO:0009855 204 0.176
digestive system development GO:0055123 289 0.172
pronephros morphogenesis GO:0072114 14 0.165
regulation of multicellular organism growth GO:0040014 4 0.147
cell surface receptor signaling pathway GO:0007166 325 0.137
ameboidal type cell migration GO:0001667 143 0.135
convergent extension GO:0060026 118 0.127
negative regulation of biological process GO:0048519 304 0.125
chordate embryonic development GO:0043009 271 0.123
mesenchyme development GO:0060485 127 0.117
hematopoietic or lymphoid organ development GO:0048534 191 0.112
embryonic organ development GO:0048568 381 0.109
positive regulation of cell division GO:0051781 2 0.107
sensory organ development GO:0007423 393 0.104
cellular protein catabolic process GO:0044257 4 0.104
embryonic heart tube morphogenesis GO:0003143 108 0.099
digestive tract development GO:0048565 265 0.096
positive regulation of cellular component biogenesis GO:0044089 3 0.094
morphogenesis of an epithelium GO:0002009 333 0.094
stem cell differentiation GO:0048863 117 0.094
positive regulation of map kinase activity GO:0043406 3 0.092
wnt signaling pathway GO:0016055 80 0.092
epithelial tube morphogenesis GO:0060562 148 0.088
cognition GO:0050890 1 0.081
multicellular organism growth GO:0035264 4 0.072
convergent extension involved in gastrulation GO:0060027 71 0.071
digestive tract morphogenesis GO:0048546 231 0.071
cellular amide metabolic process GO:0043603 4 0.071
myeloid cell development GO:0061515 32 0.071
regulation of establishment of planar polarity GO:0090175 4 0.070
tube morphogenesis GO:0035239 349 0.069
central nervous system development GO:0007417 387 0.069
somatic stem cell maintenance GO:0035019 1 0.069
ectodermal placode morphogenesis GO:0071697 32 0.067
sulfur compound metabolic process GO:0006790 13 0.066
blood circulation GO:0008015 87 0.066
cellular component movement GO:0006928 335 0.064
adult behavior GO:0030534 2 0.063
regulation of synapse organization GO:0050807 3 0.061
positive regulation of oocyte development GO:0060282 1 0.061
embryonic organ morphogenesis GO:0048562 274 0.059
mesenchymal cell development GO:0014031 78 0.058
germ line stem cell division GO:0042078 1 0.058
cellular response to biotic stimulus GO:0071216 3 0.057
g1 s transition of mitotic cell cycle GO:0000082 1 0.056
negative regulation of cellular process GO:0048523 283 0.056
circulatory system process GO:0003013 87 0.055
cell morphogenesis GO:0000902 289 0.055
embryonic heart tube development GO:0035050 133 0.053
lateral line system development GO:0048925 76 0.052
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.052
ubiquitin dependent protein catabolic process GO:0006511 3 0.052
protein targeting to nucleus GO:0044744 3 0.051
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.050
immune system development GO:0002520 191 0.049
nuclear transport GO:0051169 4 0.049
heart contraction GO:0060047 71 0.048
cell cycle g1 s phase transition GO:0044843 1 0.047
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.045
periodic partitioning GO:0007365 1 0.044
locomotor rhythm GO:0045475 3 0.044
modification dependent protein catabolic process GO:0019941 3 0.043
erythrocyte homeostasis GO:0034101 55 0.042
proteasomal protein catabolic process GO:0010498 2 0.042
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.042
sensory system development GO:0048880 76 0.040
heart looping GO:0001947 94 0.040
gene expression GO:0010467 252 0.040
cilium assembly GO:0042384 58 0.040
regulation of meiotic cell cycle GO:0051445 1 0.039
specification of symmetry GO:0009799 204 0.038
hemopoiesis GO:0030097 183 0.038
localization of cell GO:0051674 244 0.037
kupffer s vesicle development GO:0070121 50 0.036
cell motility GO:0048870 244 0.035
actin filament based movement GO:0030048 1 0.035
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.035
blood vessel development GO:0001568 246 0.035
response to stress GO:0006950 263 0.034
embryonic viscerocranium morphogenesis GO:0048703 52 0.034
regulation of heart contraction GO:0008016 32 0.034
non canonical wnt signaling pathway GO:0035567 13 0.034
gastrulation GO:0007369 208 0.034
cell migration GO:0016477 237 0.033
establishment of protein localization to organelle GO:0072594 4 0.033
neural crest cell development GO:0014032 62 0.033
myeloid cell differentiation GO:0030099 86 0.033
regulation of canonical wnt signaling pathway GO:0060828 34 0.032
segment polarity determination GO:0007367 1 0.032
peripheral nervous system development GO:0007422 55 0.032
regulation of wnt signaling pathway GO:0030111 53 0.032
segmentation GO:0035282 97 0.031
regulation of apoptotic process GO:0042981 98 0.031
modification dependent macromolecule catabolic process GO:0043632 3 0.031
vasculature development GO:0001944 278 0.031
positive regulation of cellular amine metabolic process GO:0033240 0 0.031
regulation of erk1 and erk2 cascade GO:0070372 4 0.030
brain development GO:0007420 293 0.030
regulation of blood circulation GO:1903522 32 0.030
protein polymerization GO:0051258 4 0.030
cytoskeleton organization GO:0007010 96 0.030
regulation of epithelial cell proliferation GO:0050678 3 0.030
cytokinesis GO:0000910 3 0.029
regulation of synapse assembly GO:0051963 3 0.029
single organism nuclear import GO:1902593 3 0.029
regulation of cellular protein catabolic process GO:1903362 1 0.029
protein import GO:0017038 3 0.029
neuromast development GO:0048884 46 0.029
lipid metabolic process GO:0006629 52 0.028
neural crest cell differentiation GO:0014033 72 0.028
regulation of cellular amine metabolic process GO:0033238 0 0.028
heart morphogenesis GO:0003007 156 0.027
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.027
positive regulation of protein kinase b signaling GO:0051897 1 0.027
positive regulation of striated muscle cell differentiation GO:0051155 1 0.027
cellular pigmentation GO:0033059 30 0.026
organelle organization GO:0006996 227 0.026
protein complex disassembly GO:0043241 1 0.026
cellular component morphogenesis GO:0032989 336 0.026
mesenchymal cell differentiation GO:0048762 87 0.026
cell projection assembly GO:0030031 64 0.026
adherens junction organization GO:0034332 4 0.025
cell projection organization GO:0030030 284 0.025
embryonic cranial skeleton morphogenesis GO:0048701 90 0.024
nuclear import GO:0051170 3 0.024
regulation of biological quality GO:0065008 263 0.024
regulation of organelle assembly GO:1902115 4 0.024
macromolecular complex disassembly GO:0032984 1 0.024
neuron differentiation GO:0030182 353 0.024
response to hexose GO:0009746 3 0.024
pigmentation GO:0043473 85 0.024
cilium organization GO:0044782 71 0.023
regulation of chromosome segregation GO:0051983 1 0.023
stem cell maintenance GO:0019827 4 0.023
signal transduction GO:0007165 455 0.023
organelle fusion GO:0048284 3 0.023
positive regulation of apoptotic signaling pathway GO:2001235 1 0.023
cellular amino acid metabolic process GO:0006520 7 0.023
multicellular organismal signaling GO:0035637 22 0.022
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.022
actin filament polymerization GO:0030041 2 0.022
actin polymerization or depolymerization GO:0008154 2 0.022
regionalization GO:0003002 274 0.022
regulation of protein ubiquitination GO:0031396 3 0.022
regulation of establishment of protein localization GO:0070201 4 0.022
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.022
system process GO:0003008 185 0.022
regulation of wound healing GO:0061041 2 0.022
ear development GO:0043583 127 0.022
cellular component disassembly GO:0022411 1 0.021
neural plate anterior posterior regionalization GO:0021999 8 0.021
activation of mapk activity GO:0000187 3 0.021
mitotic cell cycle GO:0000278 64 0.021
neural crest cell migration GO:0001755 42 0.021
positive regulation of protein complex assembly GO:0031334 2 0.021
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.021
lymph vessel morphogenesis GO:0036303 25 0.021
death GO:0016265 121 0.021
regulation of signaling GO:0023051 235 0.020
canonical wnt signaling pathway GO:0060070 48 0.020
protein modification process GO:0036211 100 0.020
antimicrobial humoral response GO:0019730 2 0.020
response to drug GO:0042493 3 0.020
inner ear development GO:0048839 126 0.020
cellular nitrogen compound metabolic process GO:0034641 290 0.020
regulation of metabolic process GO:0019222 359 0.020
protein metabolic process GO:0019538 183 0.020
protein localization to nucleus GO:0034504 3 0.020
enzyme linked receptor protein signaling pathway GO:0007167 106 0.019
positive regulation of transport GO:0051050 2 0.019
regulation of reproductive process GO:2000241 4 0.019
epidermal cell fate specification GO:0009957 4 0.019
regulation of protein catabolic process GO:0042176 1 0.019
heterocycle biosynthetic process GO:0018130 215 0.019
programmed cell death GO:0012501 119 0.019
intracellular signal transduction GO:0035556 85 0.019
regulation of muscle contraction GO:0006937 3 0.019
phosphate containing compound metabolic process GO:0006796 108 0.019
positive regulation of catabolic process GO:0009896 4 0.019
amine metabolic process GO:0009308 2 0.019
single organism metabolic process GO:0044710 217 0.019
stem cell development GO:0048864 82 0.019
gtp catabolic process GO:0006184 2 0.019
regulation of programmed cell death GO:0043067 101 0.019
axon ensheathment in central nervous system GO:0032291 2 0.018
specification of organ identity GO:0010092 2 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
sprouting angiogenesis GO:0002040 53 0.018
dorsal ventral pattern formation GO:0009953 125 0.018
sequestering of metal ion GO:0051238 3 0.018
action potential GO:0001508 19 0.018
entrainment of circadian clock by photoperiod GO:0043153 1 0.018
developmental growth GO:0048589 166 0.018
skeletal system morphogenesis GO:0048705 102 0.018
erythrocyte differentiation GO:0030218 54 0.018
nuclear export GO:0051168 1 0.018
endocrine process GO:0050886 2 0.018
neuron development GO:0048666 262 0.018
determination of ventral identity GO:0048264 21 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
water homeostasis GO:0030104 4 0.017
regulation of hormone secretion GO:0046883 2 0.017
cell part morphogenesis GO:0032990 246 0.017
locomotion GO:0040011 313 0.017
angiogenesis GO:0001525 158 0.017
wnt signaling pathway planar cell polarity pathway GO:0060071 4 0.017
regulation of response to stimulus GO:0048583 269 0.017
cellular macromolecule metabolic process GO:0044260 391 0.017
generation of neurons GO:0048699 385 0.017
negative regulation of nuclear division GO:0051784 3 0.016
positive regulation of lipid metabolic process GO:0045834 1 0.016
regulation of signal transduction GO:0009966 225 0.016
cellular amine metabolic process GO:0044106 2 0.016
g protein coupled receptor signaling pathway GO:0007186 74 0.016
regulation of developmental process GO:0050793 247 0.016
ectodermal placode development GO:0071696 37 0.016
cellular response to organic substance GO:0071310 105 0.016
ensheathment of neurons GO:0007272 18 0.016
regulation of carbohydrate metabolic process GO:0006109 4 0.016
rna biosynthetic process GO:0032774 181 0.016
urogenital system development GO:0001655 97 0.016
embryonic skeletal system morphogenesis GO:0048704 93 0.016
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
nucleocytoplasmic transport GO:0006913 4 0.015
lateral inhibition GO:0046331 1 0.015
lipid homeostasis GO:0055088 3 0.015
sodium ion import GO:0097369 3 0.015
regulation of organ morphogenesis GO:2000027 35 0.015
protein polyubiquitination GO:0000209 4 0.015
b cell differentiation GO:0030183 1 0.015
establishment of pigment granule localization GO:0051905 22 0.015
otic vesicle development GO:0071599 42 0.015
hormone transport GO:0009914 2 0.015
cell projection morphogenesis GO:0048858 244 0.015
hormone secretion GO:0046879 2 0.015
positive regulation of stress activated mapk cascade GO:0032874 3 0.015
fin regeneration GO:0031101 51 0.015
regulation of glial cell differentiation GO:0045685 4 0.014
oxoacid metabolic process GO:0043436 31 0.014
positive regulation of cellular process GO:0048522 201 0.014
cellular protein modification process GO:0006464 100 0.014
regulation of protein complex disassembly GO:0043244 1 0.014
negative regulation of wnt signaling pathway GO:0030178 30 0.014
transcription dna templated GO:0006351 181 0.014
regulation of cellular component organization GO:0051128 86 0.014
cilium morphogenesis GO:0060271 85 0.014
response to carbohydrate GO:0009743 3 0.014
regulation of response to extracellular stimulus GO:0032104 1 0.014
regulation of cell shape GO:0008360 1 0.014
regulation of cell activation GO:0050865 1 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
megakaryocyte differentiation GO:0030219 1 0.014
response to monosaccharide GO:0034284 3 0.014
leukocyte mediated immunity GO:0002443 6 0.013
neuromast deposition GO:0048885 9 0.013
protein depolymerization GO:0051261 1 0.013
hard palate development GO:0060022 4 0.013
myotube differentiation GO:0014902 45 0.013
regulation of cellular ketone metabolic process GO:0010565 7 0.013
guanosine containing compound catabolic process GO:1901069 2 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
regulation of mitotic cell cycle GO:0007346 25 0.013
response to organic substance GO:0010033 153 0.013
keratinocyte differentiation GO:0030216 0 0.013
positive regulation of cell death GO:0010942 29 0.013
regulation of cell projection assembly GO:0060491 4 0.013
pigment granule localization GO:0051875 25 0.013
regulation of cell communication GO:0010646 232 0.013
negative regulation of epithelial cell proliferation GO:0050680 1 0.013
regulation of blood pressure GO:0008217 1 0.013
melanosome localization GO:0032400 21 0.013
regeneration GO:0031099 91 0.013
regulation of oocyte development GO:0060281 3 0.013
anterior head development GO:0097065 2 0.013
otic placode formation GO:0043049 23 0.012
small molecule metabolic process GO:0044281 77 0.012
maintenance of location GO:0051235 4 0.012
positive regulation of muscle tissue development GO:1901863 1 0.012
gas transport GO:0015669 3 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
regulation of cytokine production GO:0001817 3 0.012
regulation of nitrogen compound metabolic process GO:0051171 251 0.012
regulation of protein depolymerization GO:1901879 1 0.012
liver development GO:0001889 96 0.012
tissue remodeling GO:0048771 4 0.012
regulation of cell death GO:0010941 103 0.012
lipid storage GO:0019915 1 0.012
protein modification by small protein conjugation GO:0032446 13 0.012
organelle localization GO:0051640 49 0.012
kidney development GO:0001822 92 0.012
cellular component assembly GO:0022607 170 0.012
calcium ion homeostasis GO:0055074 19 0.012
heart process GO:0003015 71 0.012
b cell activation GO:0042113 2 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
negative regulation of gliogenesis GO:0014014 1 0.011
regulation of nuclear division GO:0051783 9 0.011
cardiac muscle tissue morphogenesis GO:0055008 7 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
positive regulation of jnk cascade GO:0046330 3 0.011
organic acid metabolic process GO:0006082 31 0.011
regulation of protein transport GO:0051223 3 0.011
hepaticobiliary system development GO:0061008 98 0.011
regulation of binding GO:0051098 3 0.011
protein phosphorylation GO:0006468 47 0.011
regulation of behavior GO:0050795 24 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
mononuclear cell proliferation GO:0032943 1 0.011
camera type eye development GO:0043010 222 0.011
cilium movement involved in cell motility GO:0060294 3 0.011
vesicle localization GO:0051648 27 0.011
leukocyte proliferation GO:0070661 1 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
response to hormone GO:0009725 48 0.011
apoptotic process GO:0006915 116 0.011
gland development GO:0048732 143 0.011
chemical homeostasis GO:0048878 49 0.011
macroautophagy GO:0016236 1 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
cell death GO:0008219 121 0.011
positive regulation of gliogenesis GO:0014015 2 0.011
lateral line development GO:0048882 66 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
cellular protein metabolic process GO:0044267 129 0.011
positive regulation of exocytosis GO:0045921 1 0.011
biosynthetic process GO:0009058 294 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
pigment granule aggregation in cell center GO:0051877 8 0.011
negative regulation of catabolic process GO:0009895 3 0.011
regulation of cell migration GO:0030334 40 0.011
positive regulation of neuron death GO:1901216 1 0.011
cilium or flagellum dependent cell motility GO:0001539 4 0.011
negative regulation of catalytic activity GO:0043086 21 0.011
organic hydroxy compound transport GO:0015850 14 0.011
regulation of cardiac muscle contraction GO:0055117 2 0.010
neural plate regionalization GO:0060897 10 0.010
negative regulation of cellular component movement GO:0051271 18 0.010
regulation of multicellular organismal process GO:0051239 277 0.010
regulation of jun kinase activity GO:0043506 3 0.010
positive regulation of secretion GO:0051047 1 0.010
positive regulation of signaling GO:0023056 56 0.010
positive regulation of epithelial cell proliferation GO:0050679 1 0.010
tissue regeneration GO:0042246 74 0.010
glucose homeostasis GO:0042593 1 0.010
pronephros development GO:0048793 69 0.010
nucleic acid transport GO:0050657 2 0.010
regulation of establishment or maintenance of cell polarity GO:0032878 2 0.010
wound healing GO:0042060 90 0.010
cellular response to extracellular stimulus GO:0031668 2 0.010
somatic muscle development GO:0007525 4 0.010
cellular response to chemical stimulus GO:0070887 157 0.010
protein import into nucleus GO:0006606 3 0.010
blood vessel endothelial cell migration GO:0043534 18 0.010
positive regulation of immune effector process GO:0002699 3 0.010
carbohydrate homeostasis GO:0033500 1 0.010
regulation of endocrine process GO:0044060 2 0.010

ror2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.154
disease of cellular proliferation DOID:14566 0 0.154
disease of anatomical entity DOID:7 0 0.073
organ system cancer DOID:0050686 0 0.054
nervous system disease DOID:863 0 0.014
gastrointestinal system cancer DOID:3119 0 0.014
immune system disease DOID:2914 0 0.013
hematopoietic system disease DOID:74 0 0.013
large intestine cancer DOID:5672 0 0.013
intestinal cancer DOID:10155 0 0.013
disease of metabolism DOID:0014667 0 0.013
inherited metabolic disorder DOID:655 0 0.013