Danio rerio

14 known processes

f2

coagulation factor II (thrombin)

(Aliases: wu:fd42e09,wu:fd59d01,wu:fb57c10,zgc:66319)

f2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
response to stress GO:0006950 263 0.090
positive regulation of transport GO:0051050 2 0.076
Human
regulation of establishment of protein localization GO:0070201 4 0.067
larval development GO:0002164 2 0.066
localization of cell GO:0051674 244 0.064
regulation of protein transport GO:0051223 3 0.059
regulation of biological quality GO:0065008 263 0.053
gene expression GO:0010467 252 0.051
Human Mouse
cell migration GO:0016477 237 0.051
cellular component movement GO:0006928 335 0.050
nuclear transport GO:0051169 4 0.048
cellular response to lipopolysaccharide GO:0071222 3 0.047
signal transduction GO:0007165 455 0.045
Human Mouse
regulation of cellular metabolic process GO:0031323 320 0.044
Human
morphogenesis of an epithelium GO:0002009 333 0.043
protein import GO:0017038 3 0.043
establishment of protein localization to organelle GO:0072594 4 0.042
positive regulation of secretion by cell GO:1903532 1 0.042
nucleocytoplasmic transport GO:0006913 4 0.041
cell motility GO:0048870 244 0.041
guanosine containing compound catabolic process GO:1901069 2 0.040
system process GO:0003008 185 0.040
aging GO:0007568 2 0.038
positive regulation of biological process GO:0048518 253 0.037
Human Mouse
digestive tract development GO:0048565 265 0.037
regulation of cytokine production GO:0001817 3 0.037
hepaticobiliary system development GO:0061008 98 0.037
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.036
tissue remodeling GO:0048771 4 0.036
immune system process GO:0002376 241 0.035
gtp catabolic process GO:0006184 2 0.035
maintenance of location GO:0051235 4 0.035
cellular nitrogen compound metabolic process GO:0034641 290 0.035
extrinsic apoptotic signaling pathway GO:0097191 3 0.035
cellular response to molecule of bacterial origin GO:0071219 3 0.035
positive regulation of cytokine production GO:0001819 2 0.034
response to chemical GO:0042221 320 0.034
mitochondrion organization GO:0007005 4 0.034
regulation of cell substrate adhesion GO:0010810 1 0.034
regulation of nitrogen compound metabolic process GO:0051171 251 0.033
proteasomal protein catabolic process GO:0010498 2 0.033
blood circulation GO:0008015 87 0.033
tube morphogenesis GO:0035239 349 0.033
cellular response to estrogen stimulus GO:0071391 24 0.033
protein secretion GO:0009306 1 0.033
negative regulation of cellular process GO:0048523 283 0.033
Human
positive regulation of catabolic process GO:0009896 4 0.032
protein import into nucleus GO:0006606 3 0.032
positive regulation of cell cycle GO:0045787 3 0.032
regulation of macromolecule metabolic process GO:0060255 317 0.031
Human Mouse
cellular protein catabolic process GO:0044257 4 0.031
regulation of primary metabolic process GO:0080090 311 0.031
Human
positive regulation of cellular process GO:0048522 201 0.031
Human Mouse
response to wounding GO:0009611 116 0.031
regulation of gene expression GO:0010468 265 0.030
Human Mouse
locomotion GO:0040011 313 0.030
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.030
negative regulation of biological process GO:0048519 304 0.030
Human
organic cyclic compound metabolic process GO:1901360 301 0.029
regulation of multicellular organismal process GO:0051239 277 0.029
Human
single organism nuclear import GO:1902593 3 0.029
heart contraction GO:0060047 71 0.029
positive regulation of cellular component biogenesis GO:0044089 3 0.028
regulation of cytoplasmic transport GO:1903649 4 0.028
Human
meiotic nuclear division GO:0007126 4 0.028
lipid storage GO:0019915 1 0.028
gtp metabolic process GO:0046039 4 0.028
protein localization to nucleus GO:0034504 3 0.028
embryonic organ development GO:0048568 381 0.028
cellular amino acid metabolic process GO:0006520 7 0.027
digestive system development GO:0055123 289 0.027
nuclear import GO:0051170 3 0.027
homeostatic process GO:0042592 142 0.027
Human
rna biosynthetic process GO:0032774 181 0.027
liver development GO:0001889 96 0.027
cell substrate adhesion GO:0031589 4 0.026
regulation of nucleocytoplasmic transport GO:0046822 2 0.026
negative regulation of protein phosphorylation GO:0001933 4 0.025
synaptic transmission cholinergic GO:0007271 4 0.025
neurotransmitter transport GO:0006836 2 0.025
guanosine containing compound metabolic process GO:1901068 4 0.025
positive regulation of cellular catabolic process GO:0031331 3 0.025
organic cyclic compound biosynthetic process GO:1901362 223 0.025
exocytosis GO:0006887 1 0.025
regulation of hormone secretion GO:0046883 2 0.025
heterocycle metabolic process GO:0046483 290 0.025
regulation of intracellular protein transport GO:0033157 3 0.025
cellular response to extracellular stimulus GO:0031668 2 0.025
phagocytosis GO:0006909 3 0.024
nucleobase containing compound metabolic process GO:0006139 274 0.024
embryonic organ morphogenesis GO:0048562 274 0.024
response to external stimulus GO:0009605 264 0.024
Human Rat
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
negative regulation of response to stimulus GO:0048585 104 0.024
Human
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.024
Human
cellular response to nutrient levels GO:0031669 2 0.024
response to organic substance GO:0010033 153 0.024
angiogenesis GO:0001525 158 0.024
cognition GO:0050890 1 0.024
regulation of signal transduction GO:0009966 225 0.024
Human Mouse
regulation of response to stimulus GO:0048583 269 0.023
Human Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
Human
cellular aromatic compound metabolic process GO:0006725 295 0.023
regulation of protein localization to nucleus GO:1900180 2 0.023
regulation of metabolic process GO:0019222 359 0.023
Human Mouse
peptide transport GO:0015833 1 0.023
regulation of protein import into nucleus GO:0042306 2 0.023
regulation of protein catabolic process GO:0042176 1 0.023
regulation of meiotic cell cycle GO:0051445 1 0.023
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.022
blood vessel development GO:0001568 246 0.022
regulation of multicellular organismal development GO:2000026 223 0.022
Human
cellular response to biotic stimulus GO:0071216 3 0.022
regulation of inflammatory response GO:0050727 2 0.022
heterocycle biosynthetic process GO:0018130 215 0.022
regulation of cellular amine metabolic process GO:0033238 0 0.021
regulation of protein targeting GO:1903533 2 0.021
positive regulation of secretion GO:0051047 1 0.021
regulation of developmental process GO:0050793 247 0.021
Human Mouse
ubiquitin dependent protein catabolic process GO:0006511 3 0.021
circulatory system process GO:0003013 87 0.021
rna localization GO:0006403 4 0.021
sequestering of metal ion GO:0051238 3 0.021
rna metabolic process GO:0016070 219 0.020
regulation of epithelial cell proliferation GO:0050678 3 0.020
negative regulation of protein transport GO:0051224 3 0.020
biosynthetic process GO:0009058 294 0.020
Human
triglyceride homeostasis GO:0070328 2 0.020
amine metabolic process GO:0009308 2 0.020
cellular response to organic substance GO:0071310 105 0.020
regulation of protein complex assembly GO:0043254 3 0.020
single organism transport GO:0044765 206 0.020
Human
phosphate containing compound metabolic process GO:0006796 108 0.020
Human
secondary metabolic process GO:0019748 3 0.020
regulation of nucleoside metabolic process GO:0009118 2 0.020
gastrulation GO:0007369 208 0.020
nucleobase containing compound biosynthetic process GO:0034654 205 0.020
macromolecule biosynthetic process GO:0009059 227 0.020
Human
negative regulation of protein kinase activity GO:0006469 4 0.020
cellular response to external stimulus GO:0071496 2 0.019
Rat
positive regulation of metabolic process GO:0009893 108 0.019
Human
organonitrogen compound metabolic process GO:1901564 74 0.019
nucleic acid templated transcription GO:0097659 181 0.019
modification dependent macromolecule catabolic process GO:0043632 3 0.019
heart morphogenesis GO:0003007 156 0.019
regulation of multicellular organism growth GO:0040014 4 0.019
neurotransmitter secretion GO:0007269 2 0.019
regulation of neural precursor cell proliferation GO:2000177 3 0.019
determination of bilateral symmetry GO:0009855 204 0.019
transport GO:0006810 220 0.019
Human
modification dependent protein catabolic process GO:0019941 3 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.019
multicellular organism growth GO:0035264 4 0.018
female sex differentiation GO:0046660 4 0.018
negative regulation of catabolic process GO:0009895 3 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.018
organic substance biosynthetic process GO:1901576 289 0.018
Human
adult behavior GO:0030534 2 0.018
regulation of tube size GO:0035150 2 0.018
cellular amine metabolic process GO:0044106 2 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.018
regulation of cell differentiation GO:0045595 142 0.018
Human
sensory organ development GO:0007423 393 0.018
retina development in camera type eye GO:0060041 146 0.017
negative regulation of signal transduction GO:0009968 94 0.017
regulation of blood vessel size GO:0050880 2 0.017
establishment of localization GO:0051234 244 0.017
Human
female gonad development GO:0008585 4 0.017
cell matrix adhesion GO:0007160 4 0.017
heart looping GO:0001947 94 0.017
heart development GO:0007507 313 0.017
central nervous system development GO:0007417 387 0.017
Human
positive regulation of blood circulation GO:1903524 2 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.017
single organism metabolic process GO:0044710 217 0.017
Human
single organism localization GO:1902578 225 0.017
Human
camera type eye development GO:0043010 222 0.017
proteolysis GO:0006508 38 0.017
Human Mouse Rat
mitochondrial transport GO:0006839 2 0.017
regulation of cell activation GO:0050865 1 0.017
regulation of macromolecule biosynthetic process GO:0010556 225 0.017
Human
embryonic skeletal system development GO:0048706 97 0.016
growth GO:0040007 174 0.016
Mouse
hormone secretion GO:0046879 2 0.016
leukocyte proliferation GO:0070661 1 0.016
negative regulation of cellular catabolic process GO:0031330 3 0.016
transcription dna templated GO:0006351 181 0.016
embryonic heart tube morphogenesis GO:0003143 108 0.016
cellular response to starvation GO:0009267 1 0.016
regulation of synapse organization GO:0050807 3 0.016
ear development GO:0043583 127 0.016
epithelial cell differentiation GO:0030855 116 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
b cell activation GO:0042113 2 0.016
myeloid cell differentiation GO:0030099 86 0.016
cellular ketone metabolic process GO:0042180 11 0.016
regulation of rna biosynthetic process GO:2001141 213 0.016
neuron differentiation GO:0030182 353 0.016
protein metabolic process GO:0019538 183 0.016
Human Mouse Rat
response to nutrient GO:0007584 3 0.016
response to uv GO:0009411 3 0.016
negative regulation of cytoplasmic transport GO:1903650 2 0.015
cytokinesis GO:0000910 3 0.015
regulation of biosynthetic process GO:0009889 250 0.015
Human
response to topologically incorrect protein GO:0035966 2 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
eye development GO:0001654 277 0.015
regulation of nervous system development GO:0051960 90 0.015
Human
negative regulation of gene expression GO:0010629 65 0.015
Human
germ cell migration GO:0008354 8 0.015
digestive tract morphogenesis GO:0048546 231 0.015
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.015
cell cycle arrest GO:0007050 1 0.015
negative regulation of kinase activity GO:0033673 4 0.015
regulation of cell death GO:0010941 103 0.015
immune system development GO:0002520 191 0.015
cellular response to chemical stimulus GO:0070887 157 0.015
hormone transport GO:0009914 2 0.015
gland development GO:0048732 143 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
vasculature development GO:0001944 278 0.014
vasculogenesis GO:0001570 41 0.014
nucleic acid metabolic process GO:0090304 244 0.014
cellular response to lipid GO:0071396 39 0.014
cellular component assembly GO:0022607 170 0.014
regulation of gtpase activity GO:0043087 2 0.014
protein targeting to nucleus GO:0044744 3 0.014
programmed cell death GO:0012501 119 0.014
nitrogen compound metabolic process GO:0006807 319 0.014
skeletal system development GO:0001501 181 0.014
phosphorus metabolic process GO:0006793 109 0.014
Human
positive regulation of dna metabolic process GO:0051054 1 0.014
convergent extension GO:0060026 118 0.014
antimicrobial humoral response GO:0019730 2 0.014
development of primary female sexual characteristics GO:0046545 4 0.014
stem cell division GO:0017145 1 0.014
endocrine process GO:0050886 2 0.014
head development GO:0060322 303 0.014
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
Human
protein polymerization GO:0051258 4 0.013
ameboidal type cell migration GO:0001667 143 0.013
regulation of transcription dna templated GO:0006355 213 0.013
regulation of programmed cell death GO:0043067 101 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
lymphocyte proliferation GO:0046651 1 0.013
response to amino acid GO:0043200 2 0.013
glucose homeostasis GO:0042593 1 0.013
negative regulation of defense response GO:0031348 2 0.013
blood vessel morphogenesis GO:0048514 216 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
sensory organ morphogenesis GO:0090596 200 0.013
intracellular mrna localization GO:0008298 1 0.013
organelle organization GO:0006996 227 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
regulation of synapse assembly GO:0051963 3 0.013
negative regulation of metabolic process GO:0009892 86 0.013
Human
regulation of protein polymerization GO:0032271 2 0.012
regulation of reactive oxygen species metabolic process GO:2000377 2 0.012
Human
regulation of cellular ketone metabolic process GO:0010565 7 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
er nucleus signaling pathway GO:0006984 2 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
regulation of protein metabolic process GO:0051246 56 0.012
Human
positive regulation of cell activation GO:0050867 1 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
regulation of organ growth GO:0046620 3 0.012
nephron epithelium morphogenesis GO:0072088 1 0.012
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.012
developmental growth GO:0048589 166 0.012
regulation of cell projection assembly GO:0060491 4 0.012
neuron projection development GO:0031175 180 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
cellular component disassembly GO:0022411 1 0.012
epidermis development GO:0008544 48 0.012
cellular component biogenesis GO:0044085 178 0.012
specification of symmetry GO:0009799 204 0.012
mitotic dna integrity checkpoint GO:0044774 4 0.012
negative regulation of protein maturation GO:1903318 10 0.012
Human
response to monosaccharide GO:0034284 3 0.012
embryonic heart tube development GO:0035050 133 0.012
positive regulation of cell division GO:0051781 2 0.012
regeneration GO:0031099 91 0.012
regulation of binding GO:0051098 3 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
regulation of calcium ion transport GO:0051924 2 0.012
Human
wound healing GO:0042060 90 0.012
cellular response to organic cyclic compound GO:0071407 38 0.012
positive regulation of protein complex assembly GO:0031334 2 0.011
carbohydrate biosynthetic process GO:0016051 1 0.011
mitotic dna damage checkpoint GO:0044773 4 0.011
sensory perception of chemical stimulus GO:0007606 3 0.011
determination of heart left right asymmetry GO:0061371 117 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
response to unfolded protein GO:0006986 2 0.011
regulation of bone remodeling GO:0046850 2 0.011
positive regulation of immune effector process GO:0002699 3 0.011
neuron development GO:0048666 262 0.011
death GO:0016265 121 0.011
apoptotic process GO:0006915 116 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.011
regulation of reproductive process GO:2000241 4 0.011
cellular response to hypoxia GO:0071456 1 0.011
neuroblast proliferation GO:0007405 2 0.011
ovulation cycle process GO:0022602 2 0.011
response to hydrogen peroxide GO:0042542 3 0.011
transcription from rna polymerase ii promoter GO:0006366 80 0.011
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.011
developmental pigmentation GO:0048066 48 0.011
regulation of cellular component organization GO:0051128 86 0.011
Mouse
stem cell proliferation GO:0072089 4 0.011
response to glucose GO:0009749 3 0.011
cellular response to steroid hormone stimulus GO:0071383 31 0.011
ion homeostasis GO:0050801 41 0.011
Human
post embryonic morphogenesis GO:0009886 4 0.011
negative regulation of proteolysis GO:0045861 10 0.011
Human
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
spermatid differentiation GO:0048515 2 0.011
astrocyte differentiation GO:0048708 1 0.011
Human
organelle assembly GO:0070925 110 0.011
positive regulation of chromatin modification GO:1903310 1 0.011
zymogen activation GO:0031638 3 0.011
mononuclear cell proliferation GO:0032943 1 0.011
regulation of cell communication GO:0010646 232 0.011
Human Mouse
response to carbohydrate GO:0009743 3 0.011
negative regulation of cell death GO:0060548 60 0.011
peptidyl serine modification GO:0018209 2 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
negative regulation of intracellular transport GO:0032387 3 0.010
endoplasmic reticulum unfolded protein response GO:0030968 2 0.010
regulation of dendrite development GO:0050773 3 0.010
dna catabolic process GO:0006308 1 0.010
cellular response to reactive oxygen species GO:0034614 2 0.010
organic acid metabolic process GO:0006082 31 0.010
regulation of localization GO:0032879 104 0.010
Human
membrane invagination GO:0010324 1 0.010
cell part morphogenesis GO:0032990 246 0.010
inner ear development GO:0048839 126 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
regulation of nucleotide catabolic process GO:0030811 2 0.010
autophagy GO:0006914 4 0.010
regulation of exocytosis GO:0017157 1 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
peptidyl serine phosphorylation GO:0018105 1 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
negative regulation of epithelial cell proliferation GO:0050680 1 0.010
cellular response to oxygen levels GO:0071453 1 0.010
multicellular organismal response to stress GO:0033555 2 0.010
otic vesicle development GO:0071599 42 0.010
negative regulation of chromosome organization GO:2001251 1 0.010
negative regulation of mapk cascade GO:0043409 4 0.010
regulation of cellular biosynthetic process GO:0031326 245 0.010

f2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.039
Human
immune system disease DOID:2914 0 0.021
Human
hematopoietic system disease DOID:74 0 0.019
Human
disease of metabolism DOID:0014667 0 0.016
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
organ system cancer DOID:0050686 0 0.012
nervous system disease DOID:863 0 0.011