Danio rerio

0 known processes

fh

fumarate hydratase

(Aliases: zf-e152,zgc:77498,zgc:66253,ns:zf-e152,Fh1,MGC66253)

fh biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 0.078
larval development GO:0002164 2 0.074
regulation of multicellular organism growth GO:0040014 4 0.065
locomotion GO:0040011 313 0.063
aging GO:0007568 2 0.063
nuclear transport GO:0051169 4 0.062
digestive system development GO:0055123 289 0.061
cellular carbohydrate metabolic process GO:0044262 4 0.054
vasculature development GO:0001944 278 0.050
nucleocytoplasmic transport GO:0006913 4 0.049
regulation of multicellular organismal process GO:0051239 277 0.046
cellular aromatic compound metabolic process GO:0006725 295 0.044
localization of cell GO:0051674 244 0.043
digestive tract development GO:0048565 265 0.043
multicellular organism growth GO:0035264 4 0.042
system process GO:0003008 185 0.042
alpha amino acid metabolic process GO:1901605 3 0.042
regulation of macromolecule metabolic process GO:0060255 317 0.042
signal transduction GO:0007165 455 0.041
immune system development GO:0002520 191 0.041
response to drug GO:0042493 3 0.040
negative regulation of neural precursor cell proliferation GO:2000178 1 0.040
biosynthetic process GO:0009058 294 0.039
regulation of cellular metabolic process GO:0031323 320 0.039
cell substrate adhesion GO:0031589 4 0.039
cognition GO:0050890 1 0.039
maintenance of location GO:0051235 4 0.038
gastrulation GO:0007369 208 0.038
protein localization to nucleus GO:0034504 3 0.037
phagocytosis GO:0006909 3 0.037
stem cell proliferation GO:0072089 4 0.036
regulation of biological quality GO:0065008 263 0.035
negative regulation of biological process GO:0048519 304 0.035
nitrogen compound metabolic process GO:0006807 319 0.035
regulation of establishment of protein localization GO:0070201 4 0.034
negative regulation of cellular process GO:0048523 283 0.034
cellular nitrogen compound metabolic process GO:0034641 290 0.033
tube morphogenesis GO:0035239 349 0.032
brain development GO:0007420 293 0.032
cellular macromolecule metabolic process GO:0044260 391 0.032
cell surface receptor signaling pathway GO:0007166 325 0.032
heterocycle metabolic process GO:0046483 290 0.031
regulation of developmental process GO:0050793 247 0.031
regulation of nitrogen compound metabolic process GO:0051171 251 0.031
cellular nitrogen compound biosynthetic process GO:0044271 218 0.030
stem cell maintenance GO:0019827 4 0.030
establishment of protein localization to organelle GO:0072594 4 0.030
organic cyclic compound metabolic process GO:1901360 301 0.030
lymphocyte proliferation GO:0046651 1 0.030
positive regulation of transport GO:0051050 2 0.029
cell morphogenesis GO:0000902 289 0.029
blood vessel development GO:0001568 246 0.029
amine metabolic process GO:0009308 2 0.029
regulation of neural precursor cell proliferation GO:2000177 3 0.029
cellular component movement GO:0006928 335 0.028
cellular macromolecule biosynthetic process GO:0034645 224 0.028
regulation of protein transport GO:0051223 3 0.028
protein import into nucleus GO:0006606 3 0.028
regulation of cytokine production GO:0001817 3 0.028
digestive tract morphogenesis GO:0048546 231 0.028
response to carbohydrate GO:0009743 3 0.028
cell motility GO:0048870 244 0.027
negative regulation of response to stimulus GO:0048585 104 0.027
embryo development ending in birth or egg hatching GO:0009792 271 0.027
morphogenesis of an epithelium GO:0002009 333 0.027
single organism localization GO:1902578 225 0.027
establishment of localization GO:0051234 244 0.027
response to chemical GO:0042221 320 0.027
response to abiotic stimulus GO:0009628 122 0.027
rna metabolic process GO:0016070 219 0.026
negative regulation of protein phosphorylation GO:0001933 4 0.026
oxoacid metabolic process GO:0043436 31 0.026
immune system process GO:0002376 241 0.026
carbohydrate biosynthetic process GO:0016051 1 0.026
single organism nuclear import GO:1902593 3 0.026
response to monosaccharide GO:0034284 3 0.026
protein targeting to nucleus GO:0044744 3 0.026
aromatic compound biosynthetic process GO:0019438 217 0.026
organic substance biosynthetic process GO:1901576 289 0.025
regulation of cytoplasmic transport GO:1903649 4 0.025
nucleic acid metabolic process GO:0090304 244 0.025
regulation of protein localization to nucleus GO:1900180 2 0.025
cell migration GO:0016477 237 0.025
protein import GO:0017038 3 0.025
positive regulation of catabolic process GO:0009896 4 0.025
inositol lipid mediated signaling GO:0048017 2 0.025
positive regulation of biological process GO:0048518 253 0.025
ameboidal type cell migration GO:0001667 143 0.025
growth GO:0040007 174 0.025
cell matrix adhesion GO:0007160 4 0.025
regulation of rna metabolic process GO:0051252 224 0.024
leukocyte proliferation GO:0070661 1 0.024
cellular amine metabolic process GO:0044106 2 0.023
regulation of cell substrate adhesion GO:0010810 1 0.023
transport GO:0006810 220 0.023
organic cyclic compound biosynthetic process GO:1901362 223 0.023
response to hexose GO:0009746 3 0.023
generation of neurons GO:0048699 385 0.023
neuroblast proliferation GO:0007405 2 0.023
organic acid metabolic process GO:0006082 31 0.023
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
single organism metabolic process GO:0044710 217 0.022
gastrulation with mouth forming second GO:0001702 44 0.022
small molecule catabolic process GO:0044282 3 0.022
programmed cell death GO:0012501 119 0.022
rna biosynthetic process GO:0032774 181 0.022
death GO:0016265 121 0.022
carboxylic acid catabolic process GO:0046395 3 0.021
regulation of metabolic process GO:0019222 359 0.021
heart development GO:0007507 313 0.021
negative regulation of cytokine production GO:0001818 1 0.021
lipid storage GO:0019915 1 0.021
regulation of protein catabolic process GO:0042176 1 0.021
regulation of nucleocytoplasmic transport GO:0046822 2 0.021
mononuclear cell proliferation GO:0032943 1 0.021
regulation of gene expression GO:0010468 265 0.021
protein acylation GO:0043543 3 0.021
regulation of cell differentiation GO:0045595 142 0.021
meiotic nuclear division GO:0007126 4 0.021
synaptic growth at neuromuscular junction GO:0051124 2 0.021
cellular response to nutrient levels GO:0031669 2 0.021
regulation of rna biosynthetic process GO:2001141 213 0.020
cellular component morphogenesis GO:0032989 336 0.020
protein acetylation GO:0006473 2 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
intracellular signal transduction GO:0035556 85 0.020
cell projection morphogenesis GO:0048858 244 0.020
amino acid transport GO:0006865 2 0.020
negative regulation of catabolic process GO:0009895 3 0.019
chordate embryonic development GO:0043009 271 0.019
mitochondrion organization GO:0007005 4 0.019
regulation of mrna processing GO:0050684 3 0.019
transcription from rna polymerase ii promoter GO:0006366 80 0.019
nuclear import GO:0051170 3 0.019
regulation of multicellular organismal development GO:2000026 223 0.019
nucleobase containing compound biosynthetic process GO:0034654 205 0.019
cell morphogenesis involved in differentiation GO:0000904 195 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.019
negative regulation of signaling GO:0023057 96 0.019
regulation of cellular biosynthetic process GO:0031326 245 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
neuron differentiation GO:0030182 353 0.019
adherens junction organization GO:0034332 4 0.019
regionalization GO:0003002 274 0.018
response to glucose GO:0009749 3 0.018
cellular response to starvation GO:0009267 1 0.018
ion transmembrane transport GO:0034220 91 0.018
organic acid catabolic process GO:0016054 3 0.018
regulation of anatomical structure morphogenesis GO:0022603 130 0.018
regulation of primary metabolic process GO:0080090 311 0.018
single organism transport GO:0044765 206 0.018
regulation of cell activation GO:0050865 1 0.018
nucleobase containing compound metabolic process GO:0006139 274 0.018
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.018
regulation of cell shape GO:0008360 1 0.018
gene expression GO:0010467 252 0.018
regulation of cell communication GO:0010646 232 0.018
regulation of response to stimulus GO:0048583 269 0.018
determination of bilateral symmetry GO:0009855 204 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
pericardium development GO:0060039 1 0.017
female sex differentiation GO:0046660 4 0.017
head development GO:0060322 303 0.017
positive regulation of cell cycle GO:0045787 3 0.017
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
multicellular organismal metabolic process GO:0044236 2 0.017
sensory organ development GO:0007423 393 0.017
regulation of intracellular protein transport GO:0033157 3 0.017
zymogen activation GO:0031638 3 0.017
negative regulation of cell communication GO:0010648 96 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
positive regulation of cellular process GO:0048522 201 0.017
hemopoiesis GO:0030097 183 0.017
regulation of stem cell differentiation GO:2000736 4 0.016
blood vessel morphogenesis GO:0048514 216 0.016
angiogenesis GO:0001525 158 0.016
developmental growth GO:0048589 166 0.016
protein metabolic process GO:0019538 183 0.016
wound healing GO:0042060 90 0.016
macromolecule biosynthetic process GO:0009059 227 0.016
cell cycle g1 s phase transition GO:0044843 1 0.016
negative regulation of ras protein signal transduction GO:0046580 1 0.016
small molecule metabolic process GO:0044281 77 0.016
mitochondrial transport GO:0006839 2 0.016
convergent extension GO:0060026 118 0.016
muscle structure development GO:0061061 196 0.016
modification dependent macromolecule catabolic process GO:0043632 3 0.016
embryonic organ development GO:0048568 381 0.016
cellular ketone metabolic process GO:0042180 11 0.016
cellular biosynthetic process GO:0044249 286 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
regulation of rho protein signal transduction GO:0035023 2 0.016
positive regulation of secretion GO:0051047 1 0.016
regulation of gtp catabolic process GO:0033124 2 0.016
extrinsic apoptotic signaling pathway GO:0097191 3 0.016
internal protein amino acid acetylation GO:0006475 2 0.015
cell projection organization GO:0030030 284 0.015
regulation of macromolecule biosynthetic process GO:0010556 225 0.015
peptide transport GO:0015833 1 0.015
organonitrogen compound metabolic process GO:1901564 74 0.015
female gonad development GO:0008585 4 0.015
nucleic acid templated transcription GO:0097659 181 0.015
energy reserve metabolic process GO:0006112 2 0.015
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
morphogenesis of an epithelial sheet GO:0002011 49 0.015
regulation of transcription dna templated GO:0006355 213 0.015
positive regulation of cytokine production GO:0001819 2 0.015
regulation of signaling GO:0023051 235 0.015
adult behavior GO:0030534 2 0.015
transcription dna templated GO:0006351 181 0.015
regulation of protein import into nucleus GO:0042306 2 0.015
positive regulation of cell adhesion GO:0045785 1 0.015
proteasomal protein catabolic process GO:0010498 2 0.015
transmembrane transport GO:0055085 120 0.015
regulation of binding GO:0051098 3 0.015
cell cycle arrest GO:0007050 1 0.015
regulation of biosynthetic process GO:0009889 250 0.015
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.015
peptidyl lysine acetylation GO:0018394 2 0.014
cellular component disassembly GO:0022411 1 0.014
cellular respiration GO:0045333 3 0.014
negative regulation of cellular metabolic process GO:0031324 77 0.014
regulation of inflammatory response GO:0050727 2 0.014
positive regulation of secretion by cell GO:1903532 1 0.014
regulation of tube size GO:0035150 2 0.014
single organism biosynthetic process GO:0044711 71 0.014
regulation of gtpase activity GO:0043087 2 0.014
regulation of nucleotide catabolic process GO:0030811 2 0.014
negative regulation of defense response GO:0031348 2 0.014
enzyme linked receptor protein signaling pathway GO:0007167 106 0.014
tissue regeneration GO:0042246 74 0.014
determination of left right symmetry GO:0007368 179 0.014
negative regulation of signal transduction GO:0009968 94 0.014
response to external stimulus GO:0009605 264 0.014
regulation of cell death GO:0010941 103 0.014
cell adhesion GO:0007155 40 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
eye development GO:0001654 277 0.013
regulation of signal transduction GO:0009966 225 0.013
hormone transport GO:0009914 2 0.013
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.013
cell part morphogenesis GO:0032990 246 0.013
cellular protein catabolic process GO:0044257 4 0.013
camera type eye development GO:0043010 222 0.013
l amino acid transport GO:0015807 1 0.013
neuron development GO:0048666 262 0.013
regulation of apoptotic process GO:0042981 98 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
b cell mediated immunity GO:0019724 3 0.013
g1 s transition of mitotic cell cycle GO:0000082 1 0.013
ear development GO:0043583 127 0.013
axonogenesis GO:0007409 152 0.013
development of primary female sexual characteristics GO:0046545 4 0.013
negative regulation of rna splicing GO:0033119 1 0.013
response to wounding GO:0009611 116 0.013
positive regulation of metabolic process GO:0009893 108 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
b cell activation GO:0042113 2 0.013
regulation of cell development GO:0060284 100 0.013
response to stress GO:0006950 263 0.013
regulation of muscle contraction GO:0006937 3 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
anterior posterior pattern specification GO:0009952 152 0.013
cellular component biogenesis GO:0044085 178 0.013
cellular response to oxygen levels GO:0071453 1 0.013
heterocycle biosynthetic process GO:0018130 215 0.012
establishment of localization in cell GO:0051649 77 0.012
tissue remodeling GO:0048771 4 0.012
cellular component assembly GO:0022607 170 0.012
gtp metabolic process GO:0046039 4 0.012
regulation of carbohydrate metabolic process GO:0006109 4 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
regulation of blood vessel size GO:0050880 2 0.012
rna localization GO:0006403 4 0.012
negative regulation of kinase activity GO:0033673 4 0.012
dorsal motor nucleus of vagus nerve development GO:0021744 4 0.012
cellular response to external stimulus GO:0071496 2 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
astrocyte differentiation GO:0048708 1 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
cell fate commitment GO:0045165 99 0.012
positive regulation of cell activation GO:0050867 1 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
negative regulation of macromolecule metabolic process GO:0010605 76 0.012
gtp catabolic process GO:0006184 2 0.012
centrosome organization GO:0051297 1 0.012
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.012
multi organism cellular process GO:0044764 2 0.012
organelle organization GO:0006996 227 0.012
cellular modified amino acid metabolic process GO:0006575 3 0.011
single organism organelle organization GO:1902589 199 0.011
cell death GO:0008219 121 0.011
macromolecule modification GO:0043412 111 0.011
neuronal action potential GO:0019228 18 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
axon development GO:0061564 166 0.011
action potential GO:0001508 19 0.011
chemotaxis GO:0006935 104 0.011
neurological system process GO:0050877 62 0.011
protein stabilization GO:0050821 2 0.011
oxidative phosphorylation GO:0006119 1 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
epiboly GO:0090504 41 0.011
production of molecular mediator of immune response GO:0002440 2 0.011
homeostatic process GO:0042592 142 0.011
response to alkaloid GO:0043279 2 0.011
gliogenesis GO:0042063 45 0.011
embryonic organ morphogenesis GO:0048562 274 0.011
gland development GO:0048732 143 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
regulation of neurogenesis GO:0050767 87 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
carbohydrate homeostasis GO:0033500 1 0.011
forebrain development GO:0030900 96 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
germ line stem cell maintenance GO:0030718 2 0.010
sensory perception of chemical stimulus GO:0007606 3 0.010
skeletal system development GO:0001501 181 0.010
cellular localization GO:0051641 97 0.010
circulatory system process GO:0003013 87 0.010
negative regulation of sequestering of calcium ion GO:0051283 4 0.010
rna 3 end processing GO:0031123 2 0.010
liver development GO:0001889 96 0.010
hematopoietic or lymphoid organ development GO:0048534 191 0.010
connective tissue development GO:0061448 99 0.010
hormone secretion GO:0046879 2 0.010
nucleobase containing compound transport GO:0015931 2 0.010
regulation of programmed cell death GO:0043067 101 0.010
multicellular organismal signaling GO:0035637 22 0.010
meiotic cell cycle process GO:1903046 3 0.010
apoptotic process GO:0006915 116 0.010
nucleic acid transport GO:0050657 2 0.010
somatic muscle development GO:0007525 4 0.010
guanosine containing compound metabolic process GO:1901068 4 0.010
regulation of transmembrane transporter activity GO:0022898 2 0.010
neuron projection development GO:0031175 180 0.010
regulation of hormone secretion GO:0046883 2 0.010

fh disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.082
disease of metabolism DOID:0014667 0 0.022
inherited metabolic disorder DOID:655 0 0.022
nervous system disease DOID:863 0 0.020
sensory system disease DOID:0050155 0 0.013
eye and adnexa disease DOID:1492 0 0.013
cancer DOID:162 0 0.012
disease of cellular proliferation DOID:14566 0 0.012
muscular disease DOID:0080000 0 0.012
musculoskeletal system disease DOID:17 0 0.012
muscle tissue disease DOID:66 0 0.012
myopathy DOID:423 0 0.011