Danio rerio

0 known processes

sort1a

sortilin 1a

(Aliases: sort1,zgc:85953)

sort1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.174
sensory organ development GO:0007423 393 0.153
localization of cell GO:0051674 244 0.112
cellular component movement GO:0006928 335 0.092
striated muscle tissue development GO:0014706 110 0.089
digestive tract development GO:0048565 265 0.080
generation of neurons GO:0048699 385 0.078
regulation of multicellular organismal process GO:0051239 277 0.076
digestive system development GO:0055123 289 0.074
tube morphogenesis GO:0035239 349 0.072
digestive tract morphogenesis GO:0048546 231 0.071
system process GO:0003008 185 0.067
central nervous system development GO:0007417 387 0.066
regulation of reproductive process GO:2000241 4 0.064
negative regulation of cellular process GO:0048523 283 0.062
regulation of synapse organization GO:0050807 3 0.062
response to external stimulus GO:0009605 264 0.061
chemotaxis GO:0006935 104 0.058
regulation of signal transduction GO:0009966 225 0.057
cell projection organization GO:0030030 284 0.053
positive regulation of biological process GO:0048518 253 0.053
maintenance of location GO:0051235 4 0.052
camera type eye development GO:0043010 222 0.051
aging GO:0007568 2 0.051
taxis GO:0042330 109 0.050
regulation of biological quality GO:0065008 263 0.048
regulation of synapse assembly GO:0051963 3 0.048
hemopoiesis GO:0030097 183 0.046
stem cell maintenance GO:0019827 4 0.045
chemosensory behavior GO:0007635 1 0.044
regulation of multicellular organism growth GO:0040014 4 0.044
lipid storage GO:0019915 1 0.044
cell migration GO:0016477 237 0.042
locomotion GO:0040011 313 0.041
renal system development GO:0072001 94 0.041
regulation of response to stimulus GO:0048583 269 0.041
response to chemical GO:0042221 320 0.040
Mouse
regulation of developmental process GO:0050793 247 0.040
single organism localization GO:1902578 225 0.039
Mouse
olfactory lobe development GO:0021988 4 0.039
single organism cell adhesion GO:0098602 29 0.038
single organismal cell cell adhesion GO:0016337 29 0.037
regulation of cell communication GO:0010646 232 0.037
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.036
endosomal transport GO:0016197 2 0.036
gastrulation GO:0007369 208 0.036
cell substrate adhesion GO:0031589 4 0.036
negative regulation of synapse assembly GO:0051964 2 0.035
signal transduction GO:0007165 455 0.035
notochord development GO:0030903 54 0.035
blood vessel development GO:0001568 246 0.034
gland development GO:0048732 143 0.034
single organism metabolic process GO:0044710 217 0.034
positive regulation of blood circulation GO:1903524 2 0.034
positive regulation of transport GO:0051050 2 0.034
morphogenesis of an epithelium GO:0002009 333 0.033
spermatid development GO:0007286 2 0.033
axon guidance GO:0007411 86 0.033
neuron development GO:0048666 262 0.032
mitochondrion organization GO:0007005 4 0.031
angiogenesis GO:0001525 158 0.031
neurological system process GO:0050877 62 0.031
cognition GO:0050890 1 0.031
cell motility GO:0048870 244 0.031
response to stress GO:0006950 263 0.031
cortical cytoskeleton organization GO:0030865 1 0.030
biological adhesion GO:0022610 40 0.030
protein homooligomerization GO:0051260 3 0.030
positive regulation of cell cycle GO:0045787 3 0.030
stem cell division GO:0017145 1 0.029
olfactory bulb development GO:0021772 4 0.029
spermatid differentiation GO:0048515 2 0.029
small molecule metabolic process GO:0044281 77 0.029
regulation of multicellular organismal development GO:2000026 223 0.029
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.028
positive regulation of cellular component biogenesis GO:0044089 3 0.028
meiotic nuclear division GO:0007126 4 0.028
regionalization GO:0003002 274 0.028
regulation of signaling GO:0023051 235 0.027
synaptic growth at neuromuscular junction GO:0051124 2 0.027
eye development GO:0001654 277 0.027
heart development GO:0007507 313 0.027
muscle structure development GO:0061061 196 0.027
Mouse
neuron differentiation GO:0030182 353 0.027
kidney development GO:0001822 92 0.027
neuroblast proliferation GO:0007405 2 0.026
cellular component biogenesis GO:0044085 178 0.026
cortical actin cytoskeleton organization GO:0030866 1 0.025
regulation of metabolic process GO:0019222 359 0.025
organonitrogen compound metabolic process GO:1901564 74 0.024
vasculature development GO:0001944 278 0.024
atp catabolic process GO:0006200 4 0.024
muscle organ development GO:0007517 101 0.024
organic acid metabolic process GO:0006082 31 0.024
adult behavior GO:0030534 2 0.024
muscle cell development GO:0055001 115 0.024
lateral inhibition GO:0046331 1 0.023
multicellular organism growth GO:0035264 4 0.023
negative regulation of protein phosphorylation GO:0001933 4 0.023
dorsal ventral pattern formation GO:0009953 125 0.023
guanosine containing compound metabolic process GO:1901068 4 0.023
synaptic vesicle localization GO:0097479 1 0.023
cellular amine metabolic process GO:0044106 2 0.023
response to wounding GO:0009611 116 0.023
embryo development ending in birth or egg hatching GO:0009792 271 0.023
fertilization GO:0009566 3 0.023
regulation of establishment of protein localization GO:0070201 4 0.023
embryonic organ development GO:0048568 381 0.023
transport GO:0006810 220 0.022
Mouse
phagocytosis GO:0006909 3 0.022
regulation of cell activation GO:0050865 1 0.022
organic substance biosynthetic process GO:1901576 289 0.022
meiotic cell cycle process GO:1903046 3 0.022
cell surface receptor signaling pathway GO:0007166 325 0.021
regulation of cytokine production GO:0001817 3 0.021
regulation of localization GO:0032879 104 0.021
cell part morphogenesis GO:0032990 246 0.021
leukocyte proliferation GO:0070661 1 0.021
exocytosis GO:0006887 1 0.021
cartilage development GO:0051216 96 0.021
gtp catabolic process GO:0006184 2 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
muscle tissue development GO:0060537 110 0.021
amine metabolic process GO:0009308 2 0.021
negative regulation of reproductive process GO:2000242 3 0.020
anterior posterior pattern specification GO:0009952 152 0.020
cellular component morphogenesis GO:0032989 336 0.020
regulation of muscle contraction GO:0006937 3 0.020
actin filament polymerization GO:0030041 2 0.020
axon development GO:0061564 166 0.020
cellular response to chemical stimulus GO:0070887 157 0.020
developmental growth GO:0048589 166 0.020
regulation of erk1 and erk2 cascade GO:0070372 4 0.020
regulation of cell shape GO:0008360 1 0.020
cell adhesion GO:0007155 40 0.020
regulation of blood vessel size GO:0050880 2 0.020
regulation of stem cell proliferation GO:0072091 2 0.020
neuronal action potential GO:0019228 18 0.020
adherens junction organization GO:0034332 4 0.020
positive regulation of reproductive process GO:2000243 2 0.019
negative regulation of biological process GO:0048519 304 0.019
mesoderm development GO:0007498 88 0.019
synaptic vesicle transport GO:0048489 1 0.019
compound eye development GO:0048749 2 0.019
establishment of synaptic vesicle localization GO:0097480 1 0.019
cellular component assembly GO:0022607 170 0.019
myotube differentiation GO:0014902 45 0.019
Mouse
guanosine containing compound catabolic process GO:1901069 2 0.019
nucleoside monophosphate catabolic process GO:0009125 4 0.019
actin polymerization or depolymerization GO:0008154 2 0.019
nucleocytoplasmic transport GO:0006913 4 0.019
positive regulation of cytoskeleton organization GO:0051495 3 0.019
cell matrix adhesion GO:0007160 4 0.018
immune system development GO:0002520 191 0.018
positive regulation of secretion GO:0051047 1 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
determination of left right symmetry GO:0007368 179 0.018
stem cell proliferation GO:0072089 4 0.018
negative regulation of macromolecule metabolic process GO:0010605 76 0.018
syncytium formation by plasma membrane fusion GO:0000768 12 0.018
immune system process GO:0002376 241 0.018
germ line stem cell maintenance GO:0030718 2 0.018
purine nucleoside monophosphate catabolic process GO:0009128 4 0.018
regulation of protein transport GO:0051223 3 0.018
protein acetylation GO:0006473 2 0.018
protein localization to plasma membrane GO:0072659 1 0.018
neuron projection morphogenesis GO:0048812 161 0.018
negative regulation of small gtpase mediated signal transduction GO:0051058 1 0.018
positive regulation of cell adhesion GO:0045785 1 0.018
response to alkaloid GO:0043279 2 0.018
positive regulation of cell activation GO:0050867 1 0.018
regulation of cellular amine metabolic process GO:0033238 0 0.017
regulation of protein complex assembly GO:0043254 3 0.017
lymphocyte proliferation GO:0046651 1 0.017
single fertilization GO:0007338 3 0.017
neuron projection guidance GO:0097485 86 0.017
single organism nuclear import GO:1902593 3 0.017
mononuclear cell proliferation GO:0032943 1 0.017
positive regulation of cellular process GO:0048522 201 0.017
organelle organization GO:0006996 227 0.017
Mouse
response to carbohydrate GO:0009743 3 0.017
actin filament based process GO:0030029 64 0.017
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.017
regulation of syncytium formation by plasma membrane fusion GO:0060142 2 0.017
rna localization GO:0006403 4 0.017
internal protein amino acid acetylation GO:0006475 2 0.017
regulation of binding GO:0051098 3 0.016
single organism organelle organization GO:1902589 199 0.016
positive regulation of cytokine production GO:0001819 2 0.016
response to organic substance GO:0010033 153 0.016
Mouse
positive regulation of secretion by cell GO:1903532 1 0.016
membrane fusion GO:0061025 2 0.016
regulation of neurological system process GO:0031644 2 0.016
erk1 and erk2 cascade GO:0070371 4 0.016
oxoacid metabolic process GO:0043436 31 0.016
death GO:0016265 121 0.016
female sex differentiation GO:0046660 4 0.016
gtp metabolic process GO:0046039 4 0.016
embryonic organ morphogenesis GO:0048562 274 0.016
multi organism process GO:0051704 134 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.016
positive regulation of catabolic process GO:0009896 4 0.016
blood vessel morphogenesis GO:0048514 216 0.016
regulation of protein polymerization GO:0032271 2 0.016
signal transduction in absence of ligand GO:0038034 1 0.016
response to abiotic stimulus GO:0009628 122 0.016
axonogenesis GO:0007409 152 0.016
protein import into nucleus GO:0006606 3 0.015
actin cytoskeleton organization GO:0030036 63 0.015
striated muscle cell development GO:0055002 108 0.015
cell morphogenesis GO:0000902 289 0.015
single organism membrane fusion GO:0044801 2 0.015
nuclear transport GO:0051169 4 0.015
regulation of cellular metabolic process GO:0031323 320 0.015
extracellular structure organization GO:0043062 27 0.015
cellular macromolecule metabolic process GO:0044260 391 0.015
heart morphogenesis GO:0003007 156 0.015
smooth muscle contraction GO:0006939 2 0.015
regulation of intracellular protein transport GO:0033157 3 0.015
establishment of protein localization to organelle GO:0072594 4 0.015
protein polymerization GO:0051258 4 0.015
forebrain cell migration GO:0021885 1 0.015
phosphorus metabolic process GO:0006793 109 0.015
establishment of protein localization to plasma membrane GO:0090002 1 0.015
regulation of protein catabolic process GO:0042176 1 0.015
cellular extravasation GO:0045123 1 0.015
cytoskeleton dependent cytokinesis GO:0061640 3 0.015
cell projection morphogenesis GO:0048858 244 0.015
regulation of inflammatory response GO:0050727 2 0.014
camera type eye morphogenesis GO:0048593 108 0.014
nuclear import GO:0051170 3 0.014
cytoskeleton organization GO:0007010 96 0.014
blood circulation GO:0008015 87 0.014
intracellular receptor signaling pathway GO:0030522 30 0.014
protein targeting to nucleus GO:0044744 3 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
multicellular organismal response to stress GO:0033555 2 0.014
striated muscle cell differentiation GO:0051146 129 0.014
Mouse
nitrogen compound metabolic process GO:0006807 319 0.014
protein localization to nucleus GO:0034504 3 0.014
cellular biosynthetic process GO:0044249 286 0.014
hematopoietic or lymphoid organ development GO:0048534 191 0.014
positive regulation of chromosome organization GO:2001252 1 0.014
pronephros development GO:0048793 69 0.014
cytoplasm organization GO:0007028 4 0.014
nucleic acid templated transcription GO:0097659 181 0.014
peptidyl lysine acetylation GO:0018394 2 0.014
regulation of oocyte development GO:0060281 3 0.014
negative regulation of ras protein signal transduction GO:0046580 1 0.014
negative regulation of signaling GO:0023057 96 0.014
ovulation cycle GO:0042698 2 0.014
regulation of synaptic plasticity GO:0048167 1 0.014
protein import GO:0017038 3 0.014
proteasomal protein catabolic process GO:0010498 2 0.013
cell death GO:0008219 121 0.013
ovulation cycle process GO:0022602 2 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
regulation of cell death GO:0010941 103 0.013
positive regulation of cell division GO:0051781 2 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
skeletal muscle tissue development GO:0007519 67 0.013
biosynthetic process GO:0009058 294 0.013
internal peptidyl lysine acetylation GO:0018393 2 0.013
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.013
positive regulation of protein complex assembly GO:0031334 2 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
protein metabolic process GO:0019538 183 0.013
negative regulation of signal transduction GO:0009968 94 0.013
cellular nitrogen compound metabolic process GO:0034641 290 0.013
programmed cell death GO:0012501 119 0.013
cellular component disassembly GO:0022411 1 0.013
positive regulation of immune effector process GO:0002699 3 0.013
regulation of protein localization to plasma membrane GO:1903076 1 0.013
response to uv GO:0009411 3 0.013
multicellular organismal signaling GO:0035637 22 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
small gtpase mediated signal transduction GO:0007264 8 0.013
forebrain development GO:0030900 96 0.013
cellular protein catabolic process GO:0044257 4 0.013
skeletal muscle organ development GO:0060538 78 0.013
urogenital system development GO:0001655 97 0.013
cellular response to external stimulus GO:0071496 2 0.013
regulation of apoptotic process GO:0042981 98 0.013
response to hexose GO:0009746 3 0.013
cellular response to lipopolysaccharide GO:0071222 3 0.012
macromolecule deacylation GO:0098732 3 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
cell cell signaling GO:0007267 52 0.012
development of primary female sexual characteristics GO:0046545 4 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
nucleobase containing compound transport GO:0015931 2 0.012
growth GO:0040007 174 0.012
regulation of cell adhesion GO:0030155 15 0.012
apoptotic process GO:0006915 116 0.012
regulation of tube size GO:0035150 2 0.012
lipid metabolic process GO:0006629 52 0.012
alcohol biosynthetic process GO:0046165 2 0.012
circulatory system process GO:0003013 87 0.012
spinal cord motor neuron differentiation GO:0021522 26 0.012
cell migration involved in gastrulation GO:0042074 79 0.012
peptidyl threonine modification GO:0018210 1 0.012
post embryonic organ development GO:0048569 4 0.012
regulation of epithelial cell proliferation GO:0050678 3 0.012
neuromuscular synaptic transmission GO:0007274 2 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
cellular carbohydrate metabolic process GO:0044262 4 0.012
positive regulation of cellular catabolic process GO:0031331 3 0.012
regulation of neurotransmitter transport GO:0051588 1 0.012
ras protein signal transduction GO:0007265 7 0.011
pole plasm assembly GO:0007315 4 0.011
response to nutrient GO:0007584 3 0.011
regulation of locomotion GO:0040012 55 0.011
regulation of cellular component movement GO:0051270 55 0.011
regulation of cell migration GO:0030334 40 0.011
protein acylation GO:0043543 3 0.011
myoblast fusion GO:0007520 10 0.011
glial cell migration GO:0008347 3 0.011
carbohydrate homeostasis GO:0033500 1 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
neuron remodeling GO:0016322 1 0.011
regulation of myotube differentiation GO:0010830 2 0.011
membrane invagination GO:0010324 1 0.011
protein complex subunit organization GO:0071822 46 0.011
organelle localization GO:0051640 49 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
inositol lipid mediated signaling GO:0048017 2 0.011
determination of bilateral symmetry GO:0009855 204 0.011
macromolecule biosynthetic process GO:0009059 227 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
homeostatic process GO:0042592 142 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
cell substrate junction assembly GO:0007044 2 0.011
startle response GO:0001964 4 0.011
establishment of endothelial barrier GO:0061028 3 0.011
synaptic transmission GO:0007268 35 0.011
cellular ketone metabolic process GO:0042180 11 0.011
head development GO:0060322 303 0.011
sensory perception of chemical stimulus GO:0007606 3 0.011
regulation of mrna processing GO:0050684 3 0.011
glucose homeostasis GO:0042593 1 0.011
intracellular signal transduction GO:0035556 85 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
cellular nitrogen compound biosynthetic process GO:0044271 218 0.011
heterocycle metabolic process GO:0046483 290 0.011
response to glucose GO:0009749 3 0.011
brain development GO:0007420 293 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
specification of symmetry GO:0009799 204 0.011
regulation of gtpase activity GO:0043087 2 0.011
lateral line system development GO:0048925 76 0.010
regulation of programmed cell death GO:0043067 101 0.010
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.010
catechol containing compound metabolic process GO:0009712 2 0.010
response to monosaccharide GO:0034284 3 0.010
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.010
regulation of bone remodeling GO:0046850 2 0.010
synaptic vesicle endocytosis GO:0048488 1 0.010
response to nicotine GO:0035094 2 0.010
embryonic skeletal system morphogenesis GO:0048704 93 0.010
positive regulation of exocytosis GO:0045921 1 0.010
catecholamine metabolic process GO:0006584 2 0.010
negative regulation of kinase activity GO:0033673 4 0.010
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.010
response to inorganic substance GO:0010035 38 0.010
actin filament based movement GO:0030048 1 0.010
muscle cell differentiation GO:0042692 139 0.010
Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.010
nucleic acid transport GO:0050657 2 0.010
regulation of tissue remodeling GO:0034103 2 0.010
convergent extension GO:0060026 118 0.010
skeletal system development GO:0001501 181 0.010
post golgi vesicle mediated transport GO:0006892 1 0.010
regulation of nucleoside metabolic process GO:0009118 2 0.010
regulation of macromolecule metabolic process GO:0060255 317 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010

sort1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.053
disease of cellular proliferation DOID:14566 0 0.023
cancer DOID:162 0 0.020
organ system cancer DOID:0050686 0 0.013
disease of metabolism DOID:0014667 0 0.012
musculoskeletal system disease DOID:17 0 0.011
bone disease DOID:0080001 0 0.011
connective tissue disease DOID:65 0 0.011