Danio rerio

87 known processes

nkx2.2a

NK2 transcription factor related 2a

(Aliases: nk2.2,nkx2.2,MGC136536,wu:fc83b01,nkx2-2,zgc:136536,MGC100783,id:ibd5090)

nkx2.2a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
oligodendrocyte cell fate specification GO:0021778 4 1.000
ventral spinal cord interneuron fate commitment GO:0060579 3 1.000
Mouse
glial cell fate specification GO:0021780 4 1.000
ventral spinal cord interneuron differentiation GO:0021514 12 0.999
pancreatic a cell development GO:0003322 2 0.999
neuron fate specification GO:0048665 20 0.992
Mouse
endocrine system development GO:0035270 65 0.990
positive regulation of gene expression GO:0010628 71 0.984
Mouse Worm
cell fate specification involved in pattern specification GO:0060573 3 0.984
positive regulation of cellular biosynthetic process GO:0031328 68 0.982
Mouse Worm
spinal cord motor neuron cell fate specification GO:0021520 8 0.978
regulation of gene expression GO:0010468 265 0.977
Mouse Worm
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.977
Mouse Worm
motor neuron axon guidance GO:0008045 23 0.972
cell differentiation in spinal cord GO:0021515 40 0.971
nitrogen compound metabolic process GO:0006807 319 0.962
Mouse Worm
nucleic acid templated transcription GO:0097659 181 0.959
Mouse Worm
positive regulation of biosynthetic process GO:0009891 68 0.959
Mouse Worm
ventral spinal cord interneuron specification GO:0021521 3 0.957
spinal cord oligodendrocyte cell differentiation GO:0021529 5 0.949
generation of neurons GO:0048699 385 0.930
positive regulation of neuron migration GO:2001224 2 0.929
pituitary gland development GO:0021983 16 0.929
regulation of biosynthetic process GO:0009889 250 0.929
Mouse Worm
regulation of rna metabolic process GO:0051252 224 0.922
Mouse Worm
ventral spinal cord development GO:0021517 35 0.922
organic cyclic compound metabolic process GO:1901360 301 0.918
Mouse Worm
positive regulation of biological process GO:0048518 253 0.915
Mouse Worm
cellular macromolecule metabolic process GO:0044260 391 0.913
Mouse Worm
taxis GO:0042330 109 0.894
transcription from rna polymerase ii promoter GO:0006366 80 0.892
Mouse Worm
gabaergic neuron differentiation GO:0097154 2 0.880
positive regulation of macromolecule metabolic process GO:0010604 93 0.879
Mouse Worm
abducens nucleus development GO:0021742 2 0.873
spinal cord motor neuron differentiation GO:0021522 26 0.869
Mouse
transcription dna templated GO:0006351 181 0.868
Mouse Worm
endocrine pancreas development GO:0031018 27 0.867
neuron fate commitment GO:0048663 26 0.865
Mouse
forebrain neuron fate commitment GO:0021877 1 0.865
amide transport GO:0042886 12 0.864
regulation of macromolecule biosynthetic process GO:0010556 225 0.860
Mouse Worm
regulation of macromolecule metabolic process GO:0060255 317 0.850
Mouse Worm
cellular nitrogen compound biosynthetic process GO:0044271 218 0.847
Mouse Worm
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.843
Mouse Worm
chordate embryonic development GO:0043009 271 0.837
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.829
Mouse Worm
rna biosynthetic process GO:0032774 181 0.823
Mouse Worm
response to external biotic stimulus GO:0043207 97 0.821
response to biotic stimulus GO:0009607 97 0.821
central nervous system development GO:0007417 387 0.819
organic cyclic compound biosynthetic process GO:1901362 223 0.812
Mouse Worm
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.805
Mouse Worm
pancreatic d cell differentiation GO:0003311 2 0.795
cell projection organization GO:0030030 284 0.795
cell fate specification GO:0001708 68 0.785
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.784
Mouse Worm
peptide transport GO:0015833 1 0.781
type b pancreatic cell development GO:0003323 4 0.778
Mouse
enteroendocrine cell differentiation GO:0035883 9 0.777
Mouse
single organism transport GO:0044765 206 0.776
negative regulation of biological process GO:0048519 304 0.766
Mouse
regulation of multicellular organismal development GO:2000026 223 0.764
Zebrafish Mouse
positive regulation of oligodendrocyte differentiation GO:0048714 1 0.752
Mouse
rostrocaudal neural tube patterning GO:0021903 29 0.752
adenohypophysis development GO:0021984 15 0.751
forebrain anterior posterior pattern specification GO:0021797 3 0.744
spinal cord dorsal ventral patterning GO:0021513 5 0.734
Mouse
post embryonic morphogenesis GO:0009886 4 0.732
larval development GO:0002164 2 0.730
pancreas development GO:0031016 84 0.729
neural tube patterning GO:0021532 33 0.728
digestive system development GO:0055123 289 0.719
Mouse Worm
regulation of hormone secretion GO:0046883 2 0.717
neuroblast differentiation GO:0014016 1 0.711
single organism localization GO:1902578 225 0.706
positive regulation of neural precursor cell proliferation GO:2000179 1 0.702
anterior commissure morphogenesis GO:0021960 3 0.697
biosynthetic process GO:0009058 294 0.696
Mouse Worm
neuron projection guidance GO:0097485 86 0.691
regulation of metabolic process GO:0019222 359 0.691
Mouse Worm
regulation of transcription involved in cell fate commitment GO:0060850 1 0.690
regulation of neural retina development GO:0061074 2 0.683
positive regulation of rna metabolic process GO:0051254 59 0.676
Mouse Worm
regulation of nucleic acid templated transcription GO:1903506 213 0.675
Mouse Worm
stem cell fate determination GO:0048867 1 0.664
central nervous system neuron differentiation GO:0021953 74 0.646
hormone transport GO:0009914 2 0.643
negative regulation of cellular process GO:0048523 283 0.620
Mouse
cardiocyte differentiation GO:0035051 44 0.610
Zebrafish
response to glucose GO:0009749 3 0.609
regulation of cellular biosynthetic process GO:0031326 245 0.604
Mouse Worm
thyroid gland development GO:0030878 12 0.575
Zebrafish
digestive tract development GO:0048565 265 0.574
Mouse Worm
nucleic acid metabolic process GO:0090304 244 0.574
Mouse Worm
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.565
forebrain dorsal ventral pattern formation GO:0021798 1 0.563
multi organism process GO:0051704 134 0.563
negative regulation of developmental process GO:0051093 65 0.562
Mouse
regionalization GO:0003002 274 0.562
Mouse
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.546
Mouse Worm
regulation of neural precursor cell proliferation GO:2000177 3 0.545
regeneration GO:0031099 91 0.544
glandular epithelial cell differentiation GO:0002067 9 0.535
Mouse
spinal cord association neuron differentiation GO:0021527 1 0.528
regulation of glial cell differentiation GO:0045685 4 0.528
Mouse
regulation of cell development GO:0060284 100 0.525
Mouse
embryonic organ development GO:0048568 381 0.524
Zebrafish
axon development GO:0061564 166 0.518
head development GO:0060322 303 0.513
response to wounding GO:0009611 116 0.509
cell proliferation in forebrain GO:0021846 3 0.507
neuroblast fate commitment GO:0014017 1 0.501
response to carbohydrate GO:0009743 3 0.498
brain development GO:0007420 293 0.493
nucleobase containing compound metabolic process GO:0006139 274 0.490
Mouse Worm
positive regulation of rna biosynthetic process GO:1902680 57 0.489
Mouse Worm
neuroblast fate determination GO:0007400 1 0.486
response to other organism GO:0051707 97 0.479
wound healing GO:0042060 90 0.469
photoreceptor cell fate specification GO:0043704 1 0.467
nucleocytoplasmic transport GO:0006913 4 0.452
endocardium formation GO:0060214 1 0.445
transport GO:0006810 220 0.443
Worm
endocardium morphogenesis GO:0003160 4 0.440
auditory receptor cell fate commitment GO:0009912 4 0.432
gene expression GO:0010467 252 0.426
Mouse Worm
cell projection morphogenesis GO:0048858 244 0.424
multicellular organism growth GO:0035264 4 0.415
regulation of neuron migration GO:2001222 2 0.413
oligodendrocyte differentiation GO:0048709 23 0.412
macromolecule biosynthetic process GO:0009059 227 0.412
Mouse Worm
positive regulation of transport GO:0051050 2 0.411
regulation of hormone levels GO:0010817 21 0.410
spinal cord patterning GO:0021511 6 0.406
Mouse
positive regulation of metabolic process GO:0009893 108 0.405
Mouse Worm
cell motility GO:0048870 244 0.399
embryo development ending in birth or egg hatching GO:0009792 271 0.395
regulation of endodermal cell fate specification GO:0042663 15 0.392
stem cell fate commitment GO:0048865 1 0.379
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.379
Mouse Worm
midbrain hindbrain boundary development GO:0030917 23 0.378
response to hexose GO:0009746 3 0.369
forebrain generation of neurons GO:0021872 14 0.367
neuron projection morphogenesis GO:0048812 161 0.366
cell fate commitment GO:0045165 99 0.366
hormone secretion GO:0046879 2 0.364
midbrain development GO:0030901 28 0.362
type b pancreatic cell differentiation GO:0003309 8 0.351
Mouse
ventral midline development GO:0007418 13 0.344
establishment of localization GO:0051234 244 0.344
Worm
heterocycle biosynthetic process GO:0018130 215 0.340
Mouse Worm
cellular response to prostaglandin stimulus GO:0071379 3 0.333
regulation of transcription dna templated GO:0006355 213 0.325
Mouse Worm
spinal cord development GO:0021510 46 0.323
cellular nitrogen compound metabolic process GO:0034641 290 0.321
Mouse Worm
multicellular organismal reproductive process GO:0048609 35 0.321
protein localization to nucleus GO:0034504 3 0.320
cellular localization GO:0051641 97 0.320
protein import into nucleus GO:0006606 3 0.315
growth GO:0040007 174 0.314
Zebrafish
aromatic compound biosynthetic process GO:0019438 217 0.311
Mouse Worm
cellular response to organic substance GO:0071310 105 0.307
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.305
Mouse
diencephalon development GO:0021536 58 0.300
cerebellar cortex development GO:0021695 5 0.296
regulation of inner ear receptor cell differentiation GO:2000980 1 0.295
oligodendrocyte development GO:0014003 7 0.295
Mouse
tissue regeneration GO:0042246 74 0.288
cardiac muscle tissue development GO:0048738 48 0.286
Zebrafish
cellular aromatic compound metabolic process GO:0006725 295 0.285
Mouse Worm
facial nucleus development GO:0021754 7 0.281
regulation of establishment of protein localization GO:0070201 4 0.280
hindbrain morphogenesis GO:0021575 22 0.274
striated muscle cell differentiation GO:0051146 129 0.270
Zebrafish
mechanoreceptor differentiation GO:0042490 37 0.268
regulation of multicellular organism growth GO:0040014 4 0.268
positive regulation of glial cell differentiation GO:0045687 1 0.268
Mouse
paraxial mesoderm morphogenesis GO:0048340 2 0.266
glial cell migration GO:0008347 3 0.264
locomotion GO:0040011 313 0.263
forebrain development GO:0030900 96 0.259
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.258
glial cell fate commitment GO:0021781 6 0.257
rna metabolic process GO:0016070 219 0.257
Mouse Worm
cardiac chamber formation GO:0003207 4 0.257
Zebrafish
cellular response to chemical stimulus GO:0070887 157 0.255
foregut morphogenesis GO:0007440 4 0.252
response to external stimulus GO:0009605 264 0.251
forebrain regionalization GO:0021871 4 0.249
negative regulation of cell differentiation GO:0045596 46 0.245
Mouse
midbrain hindbrain boundary morphogenesis GO:0021555 5 0.244
apoptotic process GO:0006915 116 0.241
adult behavior GO:0030534 2 0.238
cellular biosynthetic process GO:0044249 286 0.233
Mouse Worm
cellular component movement GO:0006928 335 0.233
regulation of cell fate specification GO:0042659 20 0.232
positive regulation of cell cycle GO:0045787 3 0.232
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.231
response to stress GO:0006950 263 0.231
positive regulation of cellular metabolic process GO:0031325 94 0.230
Mouse Worm
protein targeting to nucleus GO:0044744 3 0.230
regulation of oligodendrocyte differentiation GO:0048713 1 0.228
Mouse
negative regulation of multicellular organismal process GO:0051241 69 0.227
Mouse
cognition GO:0050890 1 0.225
regulation of cell fate commitment GO:0010453 22 0.224
positive regulation of transcription dna templated GO:0045893 57 0.223
Mouse Worm
iris morphogenesis GO:0061072 1 0.220
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.220
tube morphogenesis GO:0035239 349 0.220
Zebrafish
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.218
cell fate commitment involved in pattern specification GO:0060581 6 0.216
Mouse
hindbrain development GO:0030902 91 0.214
somitogenesis GO:0001756 87 0.214
floor plate development GO:0033504 15 0.213
developmental programmed cell death GO:0010623 4 0.211
regulation of rna biosynthetic process GO:2001141 213 0.210
Mouse Worm
establishment of protein localization to organelle GO:0072594 4 0.210
auditory receptor cell fate determination GO:0042668 2 0.209
positive regulation of nucleic acid templated transcription GO:1903508 57 0.208
Mouse Worm
epithelial tube morphogenesis GO:0060562 148 0.208
Zebrafish
response to chemical GO:0042221 320 0.206
negative regulation of transcription dna templated GO:0045892 45 0.206
nuclear transport GO:0051169 4 0.205
positive regulation of gliogenesis GO:0014015 2 0.202
Mouse
forebrain midbrain boundary formation GO:0021905 1 0.202
axial mesodermal cell fate specification GO:0048327 3 0.198
cell proliferation in hindbrain GO:0021534 4 0.194
forebrain neuron development GO:0021884 7 0.194
heart growth GO:0060419 7 0.193
Zebrafish
regulation of cell migration GO:0030334 40 0.192
dorsal spinal cord development GO:0021516 1 0.184
cellular macromolecule biosynthetic process GO:0034645 224 0.184
Mouse Worm
gastrulation GO:0007369 208 0.183
regulation of multicellular organismal process GO:0051239 277 0.183
Zebrafish Mouse
cellular protein metabolic process GO:0044267 129 0.178
neuron fate determination GO:0048664 2 0.174
Mouse
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.173
oligodendrocyte cell fate commitment GO:0021779 5 0.171
developmental process involved in reproduction GO:0003006 27 0.171
regulation of primary metabolic process GO:0080090 311 0.169
Mouse Worm
cellular macromolecule localization GO:0070727 21 0.168
negative regulation of signaling GO:0023057 96 0.166
digestive tract morphogenesis GO:0048546 231 0.165
positive regulation of nervous system development GO:0051962 25 0.163
Mouse
photoreceptor cell fate commitment GO:0046552 1 0.161
embryonic digestive tract morphogenesis GO:0048557 3 0.161
cell death GO:0008219 121 0.159
pronephros development GO:0048793 69 0.157
embryonic camera type eye morphogenesis GO:0048596 19 0.156
glucose homeostasis GO:0042593 1 0.155
inner ear receptor cell fate commitment GO:0060120 4 0.154
positive regulation of epithelial cell differentiation GO:0030858 2 0.154
regulation of cell differentiation GO:0045595 142 0.151
Mouse
central nervous system myelin formation GO:0032289 1 0.150
response to bacterium GO:0009617 58 0.149
formation of primary germ layer GO:0001704 62 0.149
regulation of biological quality GO:0065008 263 0.148
embryonic camera type eye development GO:0031076 29 0.146
dorsal ventral neural tube patterning GO:0021904 1 0.145
pancreatic a cell differentiation GO:0003310 6 0.144
Mouse
neural tube development GO:0021915 62 0.141
regulation of production of molecular mediator of immune response GO:0002700 1 0.140
protein import GO:0017038 3 0.140
stem cell differentiation GO:0048863 117 0.138
aorta morphogenesis GO:0035909 3 0.137
regulation of mesodermal cell fate specification GO:0042661 9 0.136
positive regulation of secretion by cell GO:1903532 1 0.135
response to monosaccharide GO:0034284 3 0.134
regulation of nitrogen compound metabolic process GO:0051171 251 0.134
Mouse Worm
diencephalon morphogenesis GO:0048852 5 0.133
regulation of gastrulation GO:0010470 24 0.133
neuron migration GO:0001764 22 0.129
nuclear import GO:0051170 3 0.129
reproduction GO:0000003 40 0.129
positive regulation of gastrulation GO:2000543 2 0.128
mesodermal cell fate specification GO:0007501 12 0.128
regulation of cell proliferation GO:0042127 37 0.126
programmed cell death GO:0012501 119 0.125
muscle cell differentiation GO:0042692 139 0.125
Zebrafish
heterocycle metabolic process GO:0046483 290 0.125
Mouse Worm
pancreatic d cell development GO:0003324 1 0.125
atrioventricular valve formation GO:0003190 3 0.123
protein n linked glycosylation GO:0006487 1 0.120
positive regulation of translation GO:0045727 1 0.120
dopaminergic neuron differentiation GO:0071542 14 0.119
phagocytosis GO:0006909 3 0.118
cell differentiation in hindbrain GO:0021533 5 0.118
nucleobase containing compound biosynthetic process GO:0034654 205 0.117
Mouse Worm
cellular amide metabolic process GO:0043603 4 0.117
specification of symmetry GO:0009799 204 0.114
Zebrafish
positive regulation of cell fate specification GO:0042660 1 0.112
positive regulation of multicellular organismal process GO:0051240 52 0.112
Mouse
floor plate morphogenesis GO:0033505 12 0.111
hair cell differentiation GO:0035315 32 0.111
multicellular organism reproduction GO:0032504 35 0.110
regulation of signaling GO:0023051 235 0.109
pons development GO:0021548 11 0.109
epidermal cell fate specification GO:0009957 4 0.108
regulation of programmed cell death GO:0043067 101 0.108
regulation of cell death GO:0010941 103 0.107
protein metabolic process GO:0019538 183 0.106
embryonic skeletal system development GO:0048706 97 0.106
negative regulation of gene expression GO:0010629 65 0.106
muscle structure development GO:0061061 196 0.105
Zebrafish Worm
macromolecule localization GO:0033036 54 0.104
fin regeneration GO:0031101 51 0.104
system process GO:0003008 185 0.103
cell proliferation GO:0008283 80 0.103
Zebrafish
organic acid metabolic process GO:0006082 31 0.103
inner ear receptor cell development GO:0060119 20 0.103
regulation of mechanoreceptor differentiation GO:0045631 1 0.102
reproductive process GO:0022414 40 0.101
embryonic viscerocranium morphogenesis GO:0048703 52 0.100
positive regulation of neurogenesis GO:0050769 24 0.099
Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.099
cell cell signaling GO:0007267 52 0.097
positive regulation of secretion GO:0051047 1 0.097
pharyngeal muscle development GO:0043282 4 0.097
Worm
regulation of cellular metabolic process GO:0031323 320 0.097
Mouse Worm
determination of intestine left right asymmetry GO:0071908 2 0.097
oxoacid metabolic process GO:0043436 31 0.096
positive regulation of cellular component biogenesis GO:0044089 3 0.096
negative regulation of cell death GO:0060548 60 0.096
cellular ketone metabolic process GO:0042180 11 0.095
keratinocyte differentiation GO:0030216 0 0.094
carbohydrate homeostasis GO:0033500 1 0.094
axon guidance GO:0007411 86 0.094
metencephalon development GO:0022037 27 0.091
negative regulation of macromolecule metabolic process GO:0010605 76 0.090
proximal distal pattern formation GO:0009954 1 0.090
positive regulation of developmental process GO:0051094 50 0.090
Mouse
specification of axis polarity GO:0065001 4 0.089
stem cell development GO:0048864 82 0.088
apoptotic process involved in morphogenesis GO:0060561 2 0.088
negative regulation of nucleic acid templated transcription GO:1903507 45 0.088
morphogenesis of a branching epithelium GO:0061138 16 0.087
positive regulation of leukocyte differentiation GO:1902107 1 0.086
locomotory behavior GO:0007626 34 0.086
single organism organelle organization GO:1902589 199 0.086
chemotaxis GO:0006935 104 0.085
olfactory lobe development GO:0021988 4 0.084
negative regulation of mesodermal cell fate specification GO:0042662 3 0.084
death GO:0016265 121 0.083
developmental growth GO:0048589 166 0.083
regulation of localization GO:0032879 104 0.083
neural nucleus development GO:0048857 15 0.083
canonical wnt signaling pathway involved in neural plate anterior posterior pattern formation GO:0060823 4 0.081
single organism metabolic process GO:0044710 217 0.081
establishment of localization in cell GO:0051649 77 0.081
protein localization GO:0008104 40 0.080
response to drug GO:0042493 3 0.078
negative regulation of biosynthetic process GO:0009890 55 0.077
cellular amine metabolic process GO:0044106 2 0.076
neuron development GO:0048666 262 0.076
negative regulation of neural precursor cell proliferation GO:2000178 1 0.074
lipid metabolic process GO:0006629 52 0.073
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.073
Mouse
embryonic heart tube formation GO:0003144 1 0.072
glomerulus development GO:0032835 27 0.072
regulation of organ morphogenesis GO:2000027 35 0.071
Zebrafish
ectoderm development GO:0007398 9 0.071
sensory organ development GO:0007423 393 0.070
photoreceptor cell development GO:0042461 40 0.070
neural precursor cell proliferation GO:0061351 20 0.070
post embryonic foregut morphogenesis GO:0048618 3 0.070
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.068
regulation of retina development in camera type eye GO:1902866 2 0.068
cellular amino acid metabolic process GO:0006520 7 0.068
eye morphogenesis GO:0048592 144 0.068
determination of left right symmetry GO:0007368 179 0.068
Zebrafish
compound eye development GO:0048749 2 0.067
central nervous system myelination GO:0022010 2 0.066
forebrain neuron differentiation GO:0021879 14 0.066
negative regulation of response to stimulus GO:0048585 104 0.066
macromolecule modification GO:0043412 111 0.065
mesodermal cell fate commitment GO:0001710 14 0.064
eye photoreceptor cell development GO:0042462 30 0.064
embryonic cranial skeleton morphogenesis GO:0048701 90 0.064
neuron neuron synaptic transmission GO:0007270 1 0.063
organic substance biosynthetic process GO:1901576 289 0.063
Mouse Worm
organic substance transport GO:0071702 58 0.063
positive regulation of signaling GO:0023056 56 0.061
dendrite guidance GO:0070983 0 0.061
aging GO:0007568 2 0.061
sensory organ morphogenesis GO:0090596 200 0.061
optic placode formation GO:0001743 4 0.061
embryonic skeletal system morphogenesis GO:0048704 93 0.060
skeletal system development GO:0001501 181 0.060
female sex differentiation GO:0046660 4 0.059
regulation of embryonic development GO:0045995 47 0.059
astrocyte differentiation GO:0048708 1 0.058
Mouse
regulation of cellular component movement GO:0051270 55 0.057
dna alkylation GO:0006305 8 0.057
regulation of endothelial cell differentiation GO:0045601 3 0.057
endodermal digestive tract morphogenesis GO:0061031 2 0.057
photoreceptor cell differentiation GO:0046530 55 0.056
determination of bilateral symmetry GO:0009855 204 0.056
Zebrafish
development of primary female sexual characteristics GO:0046545 4 0.055
gland development GO:0048732 143 0.055
Zebrafish
regulation of cell communication GO:0010646 232 0.055
periodic partitioning GO:0007365 1 0.055
regulation of immune system process GO:0002682 34 0.054
auditory receptor cell development GO:0060117 8 0.054
determination of heart left right asymmetry GO:0061371 117 0.054
Zebrafish
dorsal ventral pattern formation GO:0009953 125 0.054
Mouse
ectoderm formation GO:0001705 2 0.053
cerebellum formation GO:0021588 2 0.053
positive regulation of neuron differentiation GO:0045666 12 0.053
Mouse
cellular component morphogenesis GO:0032989 336 0.052
renal system development GO:0072001 94 0.052
cellular protein localization GO:0034613 20 0.052
positive regulation of cell proliferation GO:0008284 15 0.052
positive regulation of cell fate commitment GO:0010455 1 0.051
brain segmentation GO:0035284 6 0.051
signal transduction GO:0007165 455 0.051
Mouse
cardiogenic plate morphogenesis GO:0003142 1 0.051
central nervous system neuron axonogenesis GO:0021955 18 0.051
neuroblast proliferation GO:0007405 2 0.051
morphogenesis of embryonic epithelium GO:0016331 30 0.050
regulation of neurogenesis GO:0050767 87 0.050
Mouse
protein secretion GO:0009306 1 0.050
epiboly GO:0090504 41 0.050
regulation of developmental process GO:0050793 247 0.050
Zebrafish Mouse
positive regulation of muscle tissue development GO:1901863 1 0.050
cell differentiation involved in kidney development GO:0061005 13 0.049
single organism cellular localization GO:1902580 46 0.049
mitotic cell cycle process GO:1903047 48 0.049
negative regulation of canonical wnt signaling pathway GO:0090090 21 0.048
regulation of locomotion GO:0040012 55 0.048
canonical wnt signaling pathway GO:0060070 48 0.047
response to nutrient levels GO:0031667 10 0.047
sexual reproduction GO:0019953 36 0.047
carboxylic acid metabolic process GO:0019752 22 0.046
retinal cell programmed cell death GO:0046666 2 0.046
response to abiotic stimulus GO:0009628 122 0.046
cell part morphogenesis GO:0032990 246 0.046
pronephric glomerulus morphogenesis GO:0035775 6 0.046
pronephric glomerulus development GO:0039021 13 0.046
cell morphogenesis involved in differentiation GO:0000904 195 0.046
cardiac muscle cell differentiation GO:0055007 30 0.046
Zebrafish
protein complex subunit organization GO:0071822 46 0.045
mesodermal cell differentiation GO:0048333 21 0.045
aorta development GO:0035904 4 0.045
posttranscriptional regulation of gene expression GO:0010608 14 0.044
lateral line development GO:0048882 66 0.044
primitive hemopoiesis GO:0060215 27 0.044
stem cell maintenance GO:0019827 4 0.044
cell morphogenesis GO:0000902 289 0.043
reflex GO:0060004 2 0.042
inner ear development GO:0048839 126 0.042
peripheral nervous system neuron differentiation GO:0048934 28 0.042
regulation of growth GO:0040008 42 0.042
embryonic digestive tract development GO:0048566 4 0.042
behavior GO:0007610 74 0.041
retina morphogenesis in camera type eye GO:0060042 79 0.041
embryonic organ morphogenesis GO:0048562 274 0.041
Zebrafish
epidermal cell differentiation GO:0009913 36 0.041
female gamete generation GO:0007292 14 0.041
negative regulation of phosphorus metabolic process GO:0010563 13 0.041
cellular response to molecule of bacterial origin GO:0071219 3 0.041
heart development GO:0007507 313 0.041
Zebrafish
protein modification process GO:0036211 100 0.041
thalamus development GO:0021794 6 0.040
positive regulation of cell division GO:0051781 2 0.040
single organism nuclear import GO:1902593 3 0.040
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.040
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.039
endodermal cell fate determination GO:0007493 2 0.039
regulation of cellular ketone metabolic process GO:0010565 7 0.039
intracellular estrogen receptor signaling pathway GO:0030520 3 0.039
defense response to fungus GO:0050832 2 0.038
cellular component assembly GO:0022607 170 0.038
cellular response to biotic stimulus GO:0071216 3 0.038
mammillary body development GO:0021767 4 0.038
negative regulation of programmed cell death GO:0043069 58 0.037
cellular response to fatty acid GO:0071398 3 0.037
cell surface receptor signaling pathway GO:0007166 325 0.037
Mouse
nephric duct development GO:0072176 13 0.037
posterior lateral line system development GO:0048915 46 0.037
positive regulation of striated muscle cell differentiation GO:0051155 1 0.037
adrenal gland development GO:0030325 10 0.037
endodermal cell fate specification GO:0001714 17 0.037
polarized epithelial cell differentiation GO:0030859 4 0.036
apoptotic process involved in development GO:1902742 2 0.036
hypochord development GO:0055016 3 0.036
regulation of response to biotic stimulus GO:0002831 2 0.036
anterior posterior pattern specification GO:0009952 152 0.035
negative regulation of gliogenesis GO:0014014 1 0.035
homeostatic process GO:0042592 142 0.035
negative regulation of apoptotic process GO:0043066 55 0.035
intramembranous ossification GO:0001957 3 0.035
leukocyte proliferation GO:0070661 1 0.035
regulation of reproductive process GO:2000241 4 0.034
paraxial mesoderm development GO:0048339 8 0.034
rhombomere development GO:0021546 19 0.034

nkx2.2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.157
sensory system disease DOID:0050155 0 0.038
eye and adnexa disease DOID:1492 0 0.038
nervous system disease DOID:863 0 0.038