Danio rerio

28 known processes

prnp

prion protein

(Aliases: PrP-2,PrP rel-2,PrP-like,PrPL-P1-like,PrP3)

prnp biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
sensory organ development GO:0007423 393 0.092
larval development GO:0002164 2 0.083
response to stress GO:0006950 263 0.083
organic substance biosynthetic process GO:1901576 289 0.058
nitrogen compound metabolic process GO:0006807 319 0.054
aging GO:0007568 2 0.053
cellular nitrogen compound metabolic process GO:0034641 290 0.050
regulation of nitrogen compound metabolic process GO:0051171 251 0.049
embryonic organ development GO:0048568 381 0.047
cellular macromolecule metabolic process GO:0044260 391 0.044
response to chemical GO:0042221 320 0.044
cellular biosynthetic process GO:0044249 286 0.044
heterocycle metabolic process GO:0046483 290 0.042
eye development GO:0001654 277 0.042
regulation of macromolecule metabolic process GO:0060255 317 0.041
biosynthetic process GO:0009058 294 0.040
cellular macromolecule biosynthetic process GO:0034645 224 0.039
cellular aromatic compound metabolic process GO:0006725 295 0.039
phagocytosis GO:0006909 3 0.038
regulation of cellular biosynthetic process GO:0031326 245 0.037
heterocycle biosynthetic process GO:0018130 215 0.037
multicellular organism growth GO:0035264 4 0.036
regulation of stem cell proliferation GO:0072091 2 0.035
cellular nitrogen compound biosynthetic process GO:0044271 218 0.035
regulation of multicellular organism growth GO:0040014 4 0.034
cell migration GO:0016477 237 0.034
single organism localization GO:1902578 225 0.033
macromolecule biosynthetic process GO:0009059 227 0.033
lipid storage GO:0019915 1 0.033
negative regulation of biological process GO:0048519 304 0.033
establishment of protein localization to organelle GO:0072594 4 0.032
positive regulation of transport GO:0051050 2 0.032
regulation of biosynthetic process GO:0009889 250 0.032
single organism metabolic process GO:0044710 217 0.032
maintenance of location GO:0051235 4 0.032
regulation of biological quality GO:0065008 263 0.031
regulation of cellular amino acid metabolic process GO:0006521 0 0.031
organic cyclic compound metabolic process GO:1901360 301 0.031
organic cyclic compound biosynthetic process GO:1901362 223 0.030
nucleobase containing compound biosynthetic process GO:0034654 205 0.030
regulation of metabolic process GO:0019222 359 0.029
aromatic compound biosynthetic process GO:0019438 217 0.029
response to carbohydrate GO:0009743 3 0.029
cellular carbohydrate metabolic process GO:0044262 4 0.029
cellular response to external stimulus GO:0071496 2 0.029
cell substrate adhesion GO:0031589 4 0.028
transcription from rna polymerase ii promoter GO:0006366 80 0.028
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.028
embryonic organ morphogenesis GO:0048562 274 0.028
blood vessel development GO:0001568 246 0.028
regulation of primary metabolic process GO:0080090 311 0.028
regulation of gene expression GO:0010468 265 0.028
signal transduction GO:0007165 455 0.027
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.027
regulation of macromolecule biosynthetic process GO:0010556 225 0.027
protein localization to nucleus GO:0034504 3 0.027
locomotion GO:0040011 313 0.027
heart morphogenesis GO:0003007 156 0.026
vasculature development GO:0001944 278 0.026
neuron neuron synaptic transmission GO:0007270 1 0.026
oxoacid metabolic process GO:0043436 31 0.026
amine metabolic process GO:0009308 2 0.026
carboxylic acid metabolic process GO:0019752 22 0.026
immune system process GO:0002376 241 0.026
protein import GO:0017038 3 0.026
response to drug GO:0042493 3 0.026
cellular response to extracellular stimulus GO:0031668 2 0.026
nuclear transport GO:0051169 4 0.025
heart development GO:0007507 313 0.025
single organism nuclear import GO:1902593 3 0.025
negative regulation of cellular process GO:0048523 283 0.025
cellular ketone metabolic process GO:0042180 11 0.025
response to external stimulus GO:0009605 264 0.025
gene expression GO:0010467 252 0.025
cellular component movement GO:0006928 335 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.024
rna metabolic process GO:0016070 219 0.024
synaptic vesicle localization GO:0097479 1 0.024
transcription dna templated GO:0006351 181 0.024
angiogenesis GO:0001525 158 0.024
small molecule metabolic process GO:0044281 77 0.024
cellular amine metabolic process GO:0044106 2 0.024
pyruvate metabolic process GO:0006090 1 0.024
regulation of cellular metabolic process GO:0031323 320 0.023
regulation of developmental process GO:0050793 247 0.023
stem cell proliferation GO:0072089 4 0.023
rna biosynthetic process GO:0032774 181 0.023
regulation of protein transport GO:0051223 3 0.023
positive regulation of catabolic process GO:0009896 4 0.023
regulation of nucleic acid templated transcription GO:1903506 213 0.023
positive regulation of biological process GO:0048518 253 0.023
camera type eye development GO:0043010 222 0.023
regulation of multicellular organismal process GO:0051239 277 0.023
cellular component morphogenesis GO:0032989 336 0.023
protein targeting to nucleus GO:0044744 3 0.023
central nervous system development GO:0007417 387 0.023
morphogenesis of an epithelium GO:0002009 333 0.023
positive regulation of cellular component biogenesis GO:0044089 3 0.023
regulation of synapse organization GO:0050807 3 0.023
female sex differentiation GO:0046660 4 0.023
organic acid metabolic process GO:0006082 31 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.022
female gonad development GO:0008585 4 0.022
localization of cell GO:0051674 244 0.022
regulation of nucleocytoplasmic transport GO:0046822 2 0.022
blood vessel morphogenesis GO:0048514 216 0.022
nucleocytoplasmic transport GO:0006913 4 0.022
tube morphogenesis GO:0035239 349 0.022
regulation of establishment of protein localization GO:0070201 4 0.022
cell motility GO:0048870 244 0.021
regulation of synaptic plasticity GO:0048167 1 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
nucleic acid metabolic process GO:0090304 244 0.021
cellular response to nutrient levels GO:0031669 2 0.021
neuron differentiation GO:0030182 353 0.021
nuclear import GO:0051170 3 0.020
response to hexose GO:0009746 3 0.020
development of primary female sexual characteristics GO:0046545 4 0.020
single organism biosynthetic process GO:0044711 71 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
stem cell maintenance GO:0019827 4 0.020
regulation of binding GO:0051098 3 0.020
positive regulation of cellular catabolic process GO:0031331 3 0.020
transport GO:0006810 220 0.020
regulation of reproductive process GO:2000241 4 0.020
generation of neurons GO:0048699 385 0.020
response to monosaccharide GO:0034284 3 0.019
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.019
protein import into nucleus GO:0006606 3 0.019
regulation of ion transmembrane transporter activity GO:0032412 2 0.019
neuron development GO:0048666 262 0.019
negative regulation of cytoplasmic transport GO:1903650 2 0.019
fertilization GO:0009566 3 0.019
digestive system development GO:0055123 289 0.019
adult behavior GO:0030534 2 0.019
regulation of synapse assembly GO:0051963 3 0.019
regulation of signaling GO:0023051 235 0.019
nucleic acid templated transcription GO:0097659 181 0.018
protein localization to plasma membrane GO:0072659 1 0.018
positive regulation of cellular process GO:0048522 201 0.018
glucose homeostasis GO:0042593 1 0.018
establishment of localization GO:0051234 244 0.018
system process GO:0003008 185 0.018
cytokinesis GO:0000910 3 0.018
head development GO:0060322 303 0.018
regulation of cellular ketone metabolic process GO:0010565 7 0.018
cell morphogenesis GO:0000902 289 0.018
carbohydrate homeostasis GO:0033500 1 0.018
regulation of metal ion transport GO:0010959 4 0.018
specification of symmetry GO:0009799 204 0.017
cell projection morphogenesis GO:0048858 244 0.017
regulation of transcription dna templated GO:0006355 213 0.017
regulation of protein localization to nucleus GO:1900180 2 0.017
nucleobase containing compound metabolic process GO:0006139 274 0.017
regulation of blood vessel size GO:0050880 2 0.017
cognition GO:0050890 1 0.017
single organism transport GO:0044765 206 0.017
neurotransmitter secretion GO:0007269 2 0.017
regionalization GO:0003002 274 0.017
neurotransmitter transport GO:0006836 2 0.017
cellular protein catabolic process GO:0044257 4 0.017
organonitrogen compound metabolic process GO:1901564 74 0.016
muscle structure development GO:0061061 196 0.016
regulation of meiotic cell cycle GO:0051445 1 0.016
positive regulation of protein complex assembly GO:0031334 2 0.016
compound eye development GO:0048749 2 0.016
response to topologically incorrect protein GO:0035966 2 0.016
autophagy GO:0006914 4 0.016
synaptic growth at neuromuscular junction GO:0051124 2 0.016
mitochondrion organization GO:0007005 4 0.016
regulation of signal transduction GO:0009966 225 0.016
olfactory lobe development GO:0021988 4 0.016
somatic muscle development GO:0007525 4 0.016
regulation of transporter activity GO:0032409 2 0.016
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.016
sensory organ morphogenesis GO:0090596 200 0.016
digestive tract development GO:0048565 265 0.016
regulation of cell shape GO:0008360 1 0.016
positive regulation of cellular amine metabolic process GO:0033240 0 0.016
negative regulation of metabolic process GO:0009892 86 0.016
amino acid transport GO:0006865 2 0.016
synaptic vesicle transport GO:0048489 1 0.015
post embryonic organ development GO:0048569 4 0.015
negative regulation of reproductive process GO:2000242 3 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
regulation of rna biosynthetic process GO:2001141 213 0.015
regulation of protein binding GO:0043393 3 0.015
cell part morphogenesis GO:0032990 246 0.015
cellular response to starvation GO:0009267 1 0.015
sensory system development GO:0048880 76 0.015
cell surface receptor signaling pathway GO:0007166 325 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
embryonic skeletal system morphogenesis GO:0048704 93 0.015
exocytosis GO:0006887 1 0.015
guanosine containing compound catabolic process GO:1901069 2 0.015
epithelial tube morphogenesis GO:0060562 148 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
embryonic skeletal system development GO:0048706 97 0.015
sensory perception of chemical stimulus GO:0007606 3 0.015
positive regulation of cytoskeleton organization GO:0051495 3 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
multi organism cellular process GO:0044764 2 0.015
response to organic substance GO:0010033 153 0.015
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.014
gtp catabolic process GO:0006184 2 0.014
negative regulation of intracellular protein transport GO:0090317 3 0.014
epithelial cell differentiation GO:0030855 116 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.014
regulation of rna metabolic process GO:0051252 224 0.014
establishment of synaptic vesicle localization GO:0097480 1 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
gland development GO:0048732 143 0.014
regulation of tube size GO:0035150 2 0.014
regulation of response to stimulus GO:0048583 269 0.014
peptidyl lysine acetylation GO:0018394 2 0.014
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.014
regulation of circadian rhythm GO:0042752 4 0.014
negative regulation of synapse assembly GO:0051964 2 0.014
positive regulation of secretion GO:0051047 1 0.014
single organism organelle organization GO:1902589 199 0.014
embryonic heart tube morphogenesis GO:0003143 108 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
modification dependent protein catabolic process GO:0019941 3 0.014
hormone secretion GO:0046879 2 0.014
organelle organization GO:0006996 227 0.014
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.014
actin polymerization or depolymerization GO:0008154 2 0.014
regulation of protein import into nucleus GO:0042306 2 0.014
regulation of cell activation GO:0050865 1 0.014
response to amino acid GO:0043200 2 0.014
neuromuscular process controlling balance GO:0050885 3 0.014
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.014
negative regulation of protein phosphorylation GO:0001933 4 0.014
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.014
gtp metabolic process GO:0046039 4 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
positive regulation of epithelial cell proliferation GO:0050679 1 0.013
protein metabolic process GO:0019538 183 0.013
digestive tract morphogenesis GO:0048546 231 0.013
fin development GO:0033333 77 0.013
cell matrix adhesion GO:0007160 4 0.013
carbohydrate biosynthetic process GO:0016051 1 0.013
muscle cell development GO:0055001 115 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
striated muscle cell development GO:0055002 108 0.013
regulation of mrna processing GO:0050684 3 0.013
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.013
growth GO:0040007 174 0.013
organonitrogen compound biosynthetic process GO:1901566 47 0.013
inner ear development GO:0048839 126 0.013
negative regulation of protein transport GO:0051224 3 0.013
embryonic cranial skeleton morphogenesis GO:0048701 90 0.013
regulation of protein complex assembly GO:0043254 3 0.013
startle response GO:0001964 4 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
muscle cell differentiation GO:0042692 139 0.013
adherens junction organization GO:0034332 4 0.013
regulation of neural precursor cell proliferation GO:2000177 3 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
determination of bilateral symmetry GO:0009855 204 0.013
interspecies interaction between organisms GO:0044419 4 0.013
dicarboxylic acid transport GO:0006835 1 0.013
negative regulation of protein import into nucleus GO:0042308 2 0.013
atp catabolic process GO:0006200 4 0.013
regulation of localization GO:0032879 104 0.013
positive regulation of secretion by cell GO:1903532 1 0.013
protein dephosphorylation GO:0006470 3 0.013
modification dependent macromolecule catabolic process GO:0043632 3 0.013
positive regulation of cellular metabolic process GO:0031325 94 0.013
embryo development ending in birth or egg hatching GO:0009792 271 0.013
production of molecular mediator of immune response GO:0002440 2 0.012
organelle assembly GO:0070925 110 0.012
lipid catabolic process GO:0016042 4 0.012
striated muscle cell differentiation GO:0051146 129 0.012
mechanosensory behavior GO:0007638 2 0.012
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.012
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.012
regulation of inflammatory response GO:0050727 2 0.012
fat soluble vitamin metabolic process GO:0006775 4 0.012
immune system development GO:0002520 191 0.012
alcohol biosynthetic process GO:0046165 2 0.012
homeostatic process GO:0042592 142 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
nucleoside monophosphate catabolic process GO:0009125 4 0.012
ion transport GO:0006811 114 0.012
spermatid differentiation GO:0048515 2 0.012
protein acylation GO:0043543 3 0.012
cellular component biogenesis GO:0044085 178 0.012
death GO:0016265 121 0.012
peptidyl serine modification GO:0018209 2 0.012
gastrulation GO:0007369 208 0.012
hormone transport GO:0009914 2 0.012
regulation of purine nucleotide catabolic process GO:0033121 2 0.012
response to uv GO:0009411 3 0.012
protein stabilization GO:0050821 2 0.012
inositol lipid mediated signaling GO:0048017 2 0.012
appendage development GO:0048736 80 0.012
regulation of cytokine production GO:0001817 3 0.012
polarized epithelial cell differentiation GO:0030859 4 0.012
negative regulation of protein localization to nucleus GO:1900181 2 0.012
response to glucose GO:0009749 3 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
negative regulation of catabolic process GO:0009895 3 0.012
carbohydrate derivative biosynthetic process GO:1901137 43 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
heart looping GO:0001947 94 0.011
positive regulation of immune effector process GO:0002699 3 0.011
energy reserve metabolic process GO:0006112 2 0.011
determination of left right symmetry GO:0007368 179 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
positive regulation of cell cycle GO:0045787 3 0.011
positive regulation of cellular biosynthetic process GO:0031328 68 0.011
multicellular organismal response to stress GO:0033555 2 0.011
lipid homeostasis GO:0055088 3 0.011
peptide transport GO:0015833 1 0.011
membrane fusion GO:0061025 2 0.011
retina development in camera type eye GO:0060041 146 0.011
regulation of protein catabolic process GO:0042176 1 0.011
regulation of apoptotic process GO:0042981 98 0.011
response to unfolded protein GO:0006986 2 0.011
proteasomal protein catabolic process GO:0010498 2 0.011
cellular localization GO:0051641 97 0.011
somatic stem cell maintenance GO:0035019 1 0.011
response to endogenous stimulus GO:0009719 83 0.011
organic substance transport GO:0071702 58 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
positive regulation of epithelial cell differentiation GO:0030858 2 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
transmembrane transport GO:0055085 120 0.011
cell projection organization GO:0030030 284 0.011
regulation of neuronal synaptic plasticity GO:0048168 1 0.011
establishment of protein localization to plasma membrane GO:0090002 1 0.011
regulation of nucleotide catabolic process GO:0030811 2 0.011
regulation of cell projection assembly GO:0060491 4 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.011
ear development GO:0043583 127 0.011
phagocytosis engulfment GO:0006911 1 0.011
small molecule catabolic process GO:0044282 3 0.011
olfactory bulb development GO:0021772 4 0.011
antimicrobial humoral response GO:0019730 2 0.011
glucose import GO:0046323 2 0.011
positive regulation of nucleoside metabolic process GO:0045979 1 0.011
regulation of cell substrate adhesion GO:0010810 1 0.011
negative regulation of neural precursor cell proliferation GO:2000178 1 0.011
neuroblast proliferation GO:0007405 2 0.011
protein acetylation GO:0006473 2 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
regulation of autophagy GO:0010506 3 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
chemotaxis GO:0006935 104 0.010
negative regulation of dna metabolic process GO:0051053 4 0.010
negative regulation of kinase activity GO:0033673 4 0.010
negative regulation of defense response GO:0031348 2 0.010
cellular component disassembly GO:0022411 1 0.010
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.010
kidney development GO:0001822 92 0.010
lateral line system development GO:0048925 76 0.010
apoptotic process GO:0006915 116 0.010
actin filament polymerization GO:0030041 2 0.010
regulation of glucose import GO:0046324 1 0.010
hypothalamus cell differentiation GO:0021979 4 0.010
chordate embryonic development GO:0043009 271 0.010
smooth muscle contraction GO:0006939 2 0.010
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.010
meiotic nuclear division GO:0007126 4 0.010
negative regulation of epithelial cell proliferation GO:0050680 1 0.010
dorsal ventral pattern formation GO:0009953 125 0.010
sympathetic nervous system development GO:0048485 3 0.010
peptidyl serine phosphorylation GO:0018105 1 0.010

prnp disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.056
nervous system disease DOID:863 0 0.027
musculoskeletal system disease DOID:17 0 0.020
cardiovascular system disease DOID:1287 0 0.016
immune system disease DOID:2914 0 0.014
disease of cellular proliferation DOID:14566 0 0.012
disease of metabolism DOID:0014667 0 0.012
cancer DOID:162 0 0.011
muscular disease DOID:0080000 0 0.011
organ system cancer DOID:0050686 0 0.011
sensory system disease DOID:0050155 0 0.010
myopathy DOID:423 0 0.010
muscle tissue disease DOID:66 0 0.010