Danio rerio

0 known processes

six4b

sine oculis homeobox homolog 4b

(Aliases: six4a,six4.1,six8,wu:fj32d01)

six4b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 0.996
Zebrafish
sensory organ development GO:0007423 393 0.985
Zebrafish Mouse
regionalization GO:0003002 274 0.985
embryonic organ development GO:0048568 381 0.973
Zebrafish Mouse
brain development GO:0007420 293 0.962
Zebrafish
regulation of metabolic process GO:0019222 359 0.960
Zebrafish Mouse
cell fate specification GO:0001708 68 0.957
Worm
otic vesicle morphogenesis GO:0071600 34 0.953
morphogenesis of an epithelium GO:0002009 333 0.951
Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.946
Zebrafish Mouse
tube morphogenesis GO:0035239 349 0.942
Mouse Worm
regulation of rna metabolic process GO:0051252 224 0.942
Zebrafish Mouse
heart development GO:0007507 313 0.941
embryonic organ morphogenesis GO:0048562 274 0.922
Zebrafish Mouse
mesoderm morphogenesis GO:0048332 51 0.922
Worm
digestive tract morphogenesis GO:0048546 231 0.920
Worm
eye development GO:0001654 277 0.915
Zebrafish
cellular component morphogenesis GO:0032989 336 0.910
Mouse Fly
determination of left right symmetry GO:0007368 179 0.908
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.908
Zebrafish Mouse
rna biosynthetic process GO:0032774 181 0.904
Zebrafish Mouse
sensory organ morphogenesis GO:0090596 200 0.904
Zebrafish Mouse
nucleic acid templated transcription GO:0097659 181 0.900
Zebrafish Mouse
renal tubule morphogenesis GO:0061333 1 0.892
Mouse
heterocycle metabolic process GO:0046483 290 0.891
Zebrafish Mouse
skeletal system development GO:0001501 181 0.884
Mouse
retina development in camera type eye GO:0060041 146 0.876
embryonic heart tube development GO:0035050 133 0.864
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.862
Zebrafish Mouse
determination of heart left right asymmetry GO:0061371 117 0.862
camera type eye development GO:0043010 222 0.843
Zebrafish
cellular nitrogen compound biosynthetic process GO:0044271 218 0.836
Zebrafish Mouse
mesodermal cell fate specification GO:0007501 12 0.834
Worm
gastrulation GO:0007369 208 0.833
Worm
embryonic skeletal system morphogenesis GO:0048704 93 0.825
Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.824
Zebrafish Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.818
Zebrafish Mouse
biosynthetic process GO:0009058 294 0.806
Zebrafish Mouse
inner ear morphogenesis GO:0042472 63 0.800
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.799
Zebrafish Mouse
anterior posterior pattern specification GO:0009952 152 0.798
specification of symmetry GO:0009799 204 0.790
nephron epithelium morphogenesis GO:0072088 1 0.786
Mouse
ear morphogenesis GO:0042471 64 0.785
Mouse
sensory system development GO:0048880 76 0.769
heart looping GO:0001947 94 0.769
regulation of nucleic acid templated transcription GO:1903506 213 0.767
Zebrafish Mouse
heart morphogenesis GO:0003007 156 0.766
cellular nitrogen compound metabolic process GO:0034641 290 0.764
Zebrafish Mouse
negative regulation of cellular process GO:0048523 283 0.762
Mouse
cell migration GO:0016477 237 0.753
Mouse
ectodermal placode formation GO:0060788 26 0.742
Mouse
transcription dna templated GO:0006351 181 0.739
Zebrafish Mouse
dorsal ventral pattern formation GO:0009953 125 0.739
nitrogen compound metabolic process GO:0006807 319 0.737
Zebrafish Mouse
regulation of cellular metabolic process GO:0031323 320 0.734
Zebrafish Mouse
pectoral fin development GO:0033339 50 0.731
digestive system development GO:0055123 289 0.711
Zebrafish Worm
cell motility GO:0048870 244 0.710
Mouse
morphogenesis of an epithelial sheet GO:0002011 49 0.704
regulation of multicellular organismal development GO:2000026 223 0.688
Zebrafish Mouse
negative regulation of biological process GO:0048519 304 0.687
Mouse
generation of neurons GO:0048699 385 0.685
Zebrafish Mouse Fly
appendage morphogenesis GO:0035107 56 0.679
retina morphogenesis in camera type eye GO:0060042 79 0.676
localization of cell GO:0051674 244 0.676
Mouse
kidney development GO:0001822 92 0.658
Zebrafish Mouse
cell morphogenesis GO:0000902 289 0.654
Fly
regulation of epithelial cell proliferation GO:0050678 3 0.654
Mouse
cell fate commitment GO:0045165 99 0.654
Worm
otic vesicle development GO:0071599 42 0.653
locomotion GO:0040011 313 0.646
Mouse
ear development GO:0043583 127 0.644
Zebrafish Mouse
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.638
Mouse
cellular component movement GO:0006928 335 0.634
Mouse
regulation of multicellular organismal process GO:0051239 277 0.628
Zebrafish Mouse
ameboidal type cell migration GO:0001667 143 0.626
gene expression GO:0010467 252 0.625
Zebrafish Mouse
otic vesicle formation GO:0030916 27 0.624
pectoral fin morphogenesis GO:0035138 29 0.618
regulation of macromolecule biosynthetic process GO:0010556 225 0.615
Zebrafish Mouse
macromolecule biosynthetic process GO:0009059 227 0.612
Zebrafish Mouse
muscle structure development GO:0061061 196 0.612
Zebrafish Mouse Fly
epidermal cell differentiation GO:0009913 36 0.606
forebrain development GO:0030900 96 0.603
Zebrafish
regulation of nitrogen compound metabolic process GO:0051171 251 0.601
Zebrafish Mouse
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.600
Zebrafish Mouse
positive regulation of metabolic process GO:0009893 108 0.595
Mouse
nucleic acid metabolic process GO:0090304 244 0.594
Zebrafish Mouse
organic substance biosynthetic process GO:1901576 289 0.593
Zebrafish Mouse
somatic stem cell maintenance GO:0035019 1 0.592
positive regulation of biological process GO:0048518 253 0.583
Mouse
regulation of developmental process GO:0050793 247 0.581
Zebrafish Mouse
otic placode formation GO:0043049 23 0.577
endoderm development GO:0007492 49 0.575
determination of bilateral symmetry GO:0009855 204 0.569
cranial nerve development GO:0021545 42 0.563
Mouse
embryonic heart tube morphogenesis GO:0003143 108 0.557
nucleobase containing compound metabolic process GO:0006139 274 0.553
Zebrafish Mouse
cellular biosynthetic process GO:0044249 286 0.551
Zebrafish Mouse
organic cyclic compound metabolic process GO:1901360 301 0.539
Zebrafish Mouse
skin development GO:0043588 54 0.533
embryonic skeletal system development GO:0048706 97 0.531
Mouse
regulation of cellular biosynthetic process GO:0031326 245 0.531
Zebrafish Mouse
head development GO:0060322 303 0.529
Zebrafish
cell cycle GO:0007049 93 0.528
regulation of transcription dna templated GO:0006355 213 0.525
Zebrafish Mouse
sympathetic nervous system development GO:0048485 3 0.517
rna metabolic process GO:0016070 219 0.511
Zebrafish Mouse
aging GO:0007568 2 0.503
signal transduction GO:0007165 455 0.503
floor plate development GO:0033504 15 0.487
positive regulation of epithelial cell proliferation GO:0050679 1 0.485
hindbrain development GO:0030902 91 0.483
digestive tract development GO:0048565 265 0.481
Zebrafish Worm
chordate embryonic development GO:0043009 271 0.480
Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.478
Zebrafish Mouse
appendage development GO:0048736 80 0.478
positive regulation of transcription dna templated GO:0045893 57 0.476
Mouse
ectodermal placode morphogenesis GO:0071697 32 0.475
Mouse
regulation of heart morphogenesis GO:2000826 17 0.475
diencephalon development GO:0021536 58 0.470
Zebrafish
cellular macromolecule biosynthetic process GO:0034645 224 0.466
Zebrafish Mouse
endocrine system development GO:0035270 65 0.465
Zebrafish
neuron development GO:0048666 262 0.462
Zebrafish Fly
cell surface receptor signaling pathway GO:0007166 325 0.462
regulation of cell differentiation GO:0045595 142 0.462
Zebrafish Mouse
regulation of primary metabolic process GO:0080090 311 0.459
Zebrafish Mouse
regulation of biosynthetic process GO:0009889 250 0.458
Zebrafish Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.458
Mouse
heart jogging GO:0003146 40 0.449
epidermal cell fate specification GO:0009957 4 0.445
mesodermal cell differentiation GO:0048333 21 0.443
Worm
negative regulation of developmental process GO:0051093 65 0.435
Mouse
eye morphogenesis GO:0048592 144 0.425
Zebrafish
epithelial cell differentiation GO:0030855 116 0.425
mesoderm development GO:0007498 88 0.424
Worm Fly
nephron epithelium development GO:0072009 16 0.422
Mouse
transcription from rna polymerase ii promoter GO:0006366 80 0.412
Zebrafish Mouse
pharyngeal muscle development GO:0043282 4 0.407
Zebrafish
embryo development ending in birth or egg hatching GO:0009792 271 0.407
Mouse
developmental growth GO:0048589 166 0.405
Zebrafish Mouse
epithelial tube morphogenesis GO:0060562 148 0.393
Mouse
gland development GO:0048732 143 0.392
Zebrafish Mouse
anterior posterior axis specification GO:0009948 20 0.390
negative regulation of cell differentiation GO:0045596 46 0.389
Mouse
central nervous system neuron differentiation GO:0021953 74 0.388
positive regulation of rna metabolic process GO:0051254 59 0.378
Mouse
mesoderm formation GO:0001707 43 0.378
Worm
aromatic compound biosynthetic process GO:0019438 217 0.371
Zebrafish Mouse
skeletal system morphogenesis GO:0048705 102 0.371
Mouse
cell projection organization GO:0030030 284 0.369
Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.368
Mouse
ectodermal placode development GO:0071696 37 0.368
Mouse
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.366
Mouse
axis specification GO:0009798 43 0.357
cell migration involved in heart development GO:0060973 22 0.350
peripheral nervous system neuron differentiation GO:0048934 28 0.347
Zebrafish
nephron tubule morphogenesis GO:0072078 1 0.346
Mouse
vasculature development GO:0001944 278 0.343
nephron morphogenesis GO:0072028 2 0.337
Mouse
muscle cell differentiation GO:0042692 139 0.329
Zebrafish Mouse Fly
larval development GO:0002164 2 0.327
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.325
segmentation GO:0035282 97 0.325
neuron projection guidance GO:0097485 86 0.321
cranial ganglion development GO:0061550 3 0.319
Mouse
camera type eye morphogenesis GO:0048593 108 0.315
Zebrafish
heterocycle biosynthetic process GO:0018130 215 0.314
Zebrafish Mouse
stem cell differentiation GO:0048863 117 0.312
Mouse
cell migration involved in gastrulation GO:0042074 79 0.309
positive regulation of cellular metabolic process GO:0031325 94 0.308
Mouse
mechanosensory lateral line system development GO:0048881 49 0.305
neuroepithelial cell differentiation GO:0060563 26 0.305
compound eye development GO:0048749 2 0.304
regulation of embryonic development GO:0045995 47 0.303
Mouse
fin development GO:0033333 77 0.302
gliogenesis GO:0042063 45 0.299
adenohypophysis development GO:0021984 15 0.299
Zebrafish
cell proliferation involved in heart morphogenesis GO:0061323 2 0.299
reproduction GO:0000003 40 0.298
positive regulation of biosynthetic process GO:0009891 68 0.293
Mouse
hemopoiesis GO:0030097 183 0.293
renal system development GO:0072001 94 0.291
Zebrafish Mouse
formation of primary germ layer GO:0001704 62 0.289
Worm
central nervous system myelin formation GO:0032289 1 0.284
regulation of gene expression GO:0010468 265 0.284
Zebrafish Mouse
regulation of organ morphogenesis GO:2000027 35 0.282
Mouse
myotube cell development GO:0014904 35 0.281
Zebrafish
blood vessel development GO:0001568 246 0.279
lateral line system development GO:0048925 76 0.276
mesodermal cell fate commitment GO:0001710 14 0.269
Worm
nerve development GO:0021675 45 0.269
Mouse
regulation of rna biosynthetic process GO:2001141 213 0.267
Zebrafish Mouse
lateral line development GO:0048882 66 0.267
cardiocyte differentiation GO:0035051 44 0.266
positive regulation of stem cell proliferation GO:2000648 1 0.265
cartilage development GO:0051216 96 0.263
chemotaxis GO:0006935 104 0.263
cardiac muscle tissue development GO:0048738 48 0.262
branching morphogenesis of an epithelial tube GO:0048754 15 0.262
Mouse
morphogenesis of a branching structure GO:0001763 21 0.261
Mouse
regulation of inner ear receptor cell differentiation GO:2000980 1 0.259
Zebrafish
neuron fate commitment GO:0048663 26 0.259
embryonic pattern specification GO:0009880 44 0.257
mechanoreceptor differentiation GO:0042490 37 0.250
Zebrafish
stem cell maintenance GO:0019827 4 0.249
positive regulation of epithelial cell differentiation GO:0030858 2 0.246
positive regulation of cellular process GO:0048522 201 0.244
Mouse
neuron differentiation GO:0030182 353 0.244
Zebrafish Fly
inner ear development GO:0048839 126 0.244
Zebrafish Mouse
outflow tract morphogenesis GO:0003151 1 0.241
cellular component assembly involved in morphogenesis GO:0010927 107 0.236
Mouse
blood vessel morphogenesis GO:0048514 216 0.235
axon guidance GO:0007411 86 0.235
glial cell differentiation GO:0010001 42 0.233
response to external stimulus GO:0009605 264 0.232
axon development GO:0061564 166 0.230
enzyme linked receptor protein signaling pathway GO:0007167 106 0.226
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.226
Mouse
regulation of endodermal cell fate specification GO:0042663 15 0.217
regulation of blood circulation GO:1903522 32 0.212
regulation of cell fate specification GO:0042659 20 0.212
mesenchymal cell proliferation GO:0010463 1 0.211
glial cell migration GO:0008347 3 0.209
taxis GO:0042330 109 0.209
blood circulation GO:0008015 87 0.208
negative regulation of cellular biosynthetic process GO:0031327 55 0.207
Mouse
embryonic viscerocranium morphogenesis GO:0048703 52 0.207
sexual reproduction GO:0019953 36 0.207
multi organism process GO:0051704 134 0.206
reproductive process GO:0022414 40 0.206
Mouse Fly
peripheral nervous system development GO:0007422 55 0.205
Zebrafish
bmp signaling pathway GO:0030509 52 0.203
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.202
positive regulation of cellular biosynthetic process GO:0031328 68 0.197
Mouse
regulation of signal transduction GO:0009966 225 0.196
regulation of response to stimulus GO:0048583 269 0.196
stem cell proliferation GO:0072089 4 0.194
endodermal cell fate specification GO:0001714 17 0.193
single organism reproductive process GO:0044702 40 0.189
Mouse Fly
connective tissue development GO:0061448 99 0.189
Fly
gamete generation GO:0007276 33 0.189
embryonic retina morphogenesis in camera type eye GO:0060059 22 0.188
endocrine pancreas development GO:0031018 27 0.188
somite development GO:0061053 96 0.184
Mouse
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.182
auditory receptor cell fate commitment GO:0009912 4 0.177
pigmentation GO:0043473 85 0.175
rhombomere development GO:0021546 19 0.174
axonogenesis GO:0007409 152 0.173
cell projection morphogenesis GO:0048858 244 0.172
Fly
developmental pigmentation GO:0048066 48 0.172
immune system development GO:0002520 191 0.171
Mouse
striated muscle tissue development GO:0014706 110 0.170
Zebrafish Mouse
melanocyte differentiation GO:0030318 26 0.169
gastrulation with mouth forming second GO:0001702 44 0.167
positive regulation of gene expression GO:0010628 71 0.165
Mouse
foregut morphogenesis GO:0007440 4 0.163
regulation of biological quality GO:0065008 263 0.163
Mouse
central nervous system myelination GO:0022010 2 0.162
neural crest cell migration GO:0001755 42 0.161
epithelial cell development GO:0002064 42 0.160
odontogenesis of dentin containing tooth GO:0042475 1 0.160
epidermis development GO:0008544 48 0.156
muscle tissue development GO:0060537 110 0.154
Zebrafish Mouse
heart valve formation GO:0003188 4 0.153
positive regulation of macromolecule metabolic process GO:0010604 93 0.152
Mouse
angiogenesis GO:0001525 158 0.151
endothelial cell differentiation GO:0045446 20 0.149
immune system process GO:0002376 241 0.149
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.149
pigment cell differentiation GO:0050931 38 0.147
rhombomere boundary formation GO:0021654 10 0.147
regulation of cell communication GO:0010646 232 0.146
hematopoietic progenitor cell differentiation GO:0002244 23 0.144
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.142
Mouse
developmental cell growth GO:0048588 52 0.141
hematopoietic or lymphoid organ development GO:0048534 191 0.140
Mouse
fin morphogenesis GO:0033334 53 0.138
myelin assembly GO:0032288 1 0.138
regulation of stem cell proliferation GO:0072091 2 0.138
cell differentiation in spinal cord GO:0021515 40 0.137
regulation of synapse organization GO:0050807 3 0.136
Mouse
convergent extension GO:0060026 118 0.136
embryonic camera type eye formation GO:0060900 10 0.135
regulation of developmental growth GO:0048638 38 0.134
Mouse
negative regulation of macromolecule metabolic process GO:0010605 76 0.133
Mouse
striated muscle cell differentiation GO:0051146 129 0.132
Zebrafish Mouse Fly
regulation of nervous system development GO:0051960 90 0.132
Zebrafish Mouse
pancreas development GO:0031016 84 0.130
regulation of reproductive process GO:2000241 4 0.129
cellular component biogenesis GO:0044085 178 0.129
Mouse
spinal cord radial glial cell differentiation GO:0021531 2 0.127
glial cell fate commitment GO:0021781 6 0.126
regulation of cell fate commitment GO:0010453 22 0.124
cardiac chamber morphogenesis GO:0003206 12 0.124
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.124
Mouse
inner ear receptor cell fate commitment GO:0060120 4 0.124
regulation of mesenchymal cell proliferation GO:0010464 1 0.123
heart formation GO:0060914 13 0.122
growth GO:0040007 174 0.121
Zebrafish Mouse
neuron projection extension GO:1990138 45 0.121
forebrain neuron fate commitment GO:0021877 1 0.120
positive regulation of notch signaling pathway GO:0045747 3 0.119
regulation of neurogenesis GO:0050767 87 0.118
Zebrafish
neural tube development GO:0021915 62 0.117
hatching gland development GO:0048785 3 0.117
posterior lateral line neuromast hair cell differentiation GO:0048923 8 0.117
mitotic cell cycle GO:0000278 64 0.114
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.112
Mouse
wnt signaling pathway GO:0016055 80 0.111
epiboly GO:0090504 41 0.111
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.109
apoptotic process involved in development GO:1902742 2 0.109
neuron fate specification GO:0048665 20 0.107
lateral line ganglion development GO:0048890 2 0.106
cardiac chamber formation GO:0003207 4 0.106
negative regulation of cell fate commitment GO:0010454 13 0.105
developmental process involved in reproduction GO:0003006 27 0.104
Mouse Fly
inner ear receptor cell differentiation GO:0060113 29 0.103
Zebrafish
cardiac chamber development GO:0003205 19 0.103
maintenance of blood brain barrier GO:0035633 1 0.103
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.103
Worm
kidney epithelium development GO:0072073 23 0.102
Mouse
forebrain generation of neurons GO:0021872 14 0.102
mesenchymal cell development GO:0014031 78 0.101
embryonic appendage morphogenesis GO:0035113 30 0.101
oligodendrocyte differentiation GO:0048709 23 0.100
mesenchyme development GO:0060485 127 0.099
Mouse
mesenchymal cell differentiation GO:0048762 87 0.098
endodermal cell fate commitment GO:0001711 18 0.097
regulation of gastrulation GO:0010470 24 0.097
exocrine pancreas development GO:0031017 28 0.096
hair cell differentiation GO:0035315 32 0.096
epiboly involved in gastrulation with mouth forming second GO:0055113 35 0.095
embryonic eye morphogenesis GO:0048048 30 0.094
Zebrafish
regulation of vascular permeability GO:0043114 5 0.093
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.093
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.092
endoderm formation GO:0001706 29 0.091
embryonic pectoral fin morphogenesis GO:0035118 24 0.091
cell migration in hindbrain GO:0021535 7 0.091
olfactory lobe development GO:0021988 4 0.091
organ formation GO:0048645 17 0.090
multicellular organism reproduction GO:0032504 35 0.090
response to other organism GO:0051707 97 0.089
cell projection assembly GO:0030031 64 0.089
regulation of mechanoreceptor differentiation GO:0045631 1 0.088
Zebrafish
optic cup morphogenesis involved in camera type eye development GO:0002072 7 0.088
embryonic camera type eye development GO:0031076 29 0.087
Zebrafish
endodermal cell differentiation GO:0035987 19 0.086
negative regulation of transcription dna templated GO:0045892 45 0.086
Mouse
positive regulation of nervous system development GO:0051962 25 0.086
hepaticobiliary system development GO:0061008 98 0.086
rhombomere formation GO:0021594 12 0.086
negative regulation of cell fate specification GO:0009996 11 0.086
embryonic camera type eye morphogenesis GO:0048596 19 0.083
Zebrafish
liver development GO:0001889 96 0.083
pancreatic d cell differentiation GO:0003311 2 0.083
cartilage development involved in endochondral bone morphogenesis GO:0060351 8 0.082
canonical wnt signaling pathway GO:0060070 48 0.082
kidney morphogenesis GO:0060993 15 0.082
Mouse
regulation of axon extension GO:0030516 24 0.082
negative regulation of cellular metabolic process GO:0031324 77 0.082
Mouse
radial glial cell differentiation GO:0060019 2 0.082
embryonic hemopoiesis GO:0035162 53 0.081
negative regulation of gene expression GO:0010629 65 0.081
Mouse
cellular component assembly GO:0022607 170 0.079
Mouse
phosphorylation GO:0016310 69 0.079
regulation of bmp signaling pathway GO:0030510 39 0.079
response to chemical GO:0042221 320 0.078
neuromast development GO:0048884 46 0.077
protein modification process GO:0036211 100 0.076
autonomic nervous system development GO:0048483 19 0.076
regulation of synapse assembly GO:0051963 3 0.076
Mouse
intracellular signal transduction GO:0035556 85 0.076
posterior lateral line development GO:0048916 38 0.072
cardiac atrium morphogenesis GO:0003209 2 0.072
definitive hemopoiesis GO:0060216 18 0.072
neuron projection morphogenesis GO:0048812 161 0.071
Fly
positive regulation of cell fate commitment GO:0010455 1 0.070
negative regulation of rna biosynthetic process GO:1902679 45 0.069
Mouse
embryonic limb morphogenesis GO:0030326 2 0.069
regulation of heart contraction GO:0008016 32 0.069
convergent extension involved in organogenesis GO:0060029 10 0.068
single organism organelle organization GO:1902589 199 0.068
Mouse
endodermal cell fate determination GO:0007493 2 0.068
muscle organ development GO:0007517 101 0.067
Zebrafish Mouse
ganglion development GO:0061548 5 0.067
Mouse
keratinocyte differentiation GO:0030216 0 0.067
negative regulation of multicellular organismal process GO:0051241 69 0.067
Mouse
type b pancreatic cell development GO:0003323 4 0.067
regulation of multicellular organism growth GO:0040014 4 0.066
cell growth GO:0016049 57 0.066
cell morphogenesis involved in differentiation GO:0000904 195 0.066
tube formation GO:0035148 25 0.066
Mouse
regulation of intracellular signal transduction GO:1902531 57 0.065
nephron development GO:0072006 31 0.065
Mouse
positive regulation of cell cycle GO:0045787 3 0.065
polarized epithelial cell differentiation GO:0030859 4 0.065
respiratory system development GO:0060541 5 0.064
Mouse
retina layer formation GO:0010842 24 0.064
regulation of cell shape GO:0008360 1 0.064
heart contraction GO:0060047 71 0.064
regulation of axonogenesis GO:0050770 32 0.063
water homeostasis GO:0030104 4 0.063
axon extension GO:0048675 45 0.063
gabaergic neuron differentiation GO:0097154 2 0.063
response to external biotic stimulus GO:0043207 97 0.063
epithelial cell morphogenesis GO:0003382 2 0.063
positive regulation of developmental process GO:0051094 50 0.062
Mouse
neuroblast differentiation GO:0014016 1 0.061
neuron projection development GO:0031175 180 0.061
Fly
organelle organization GO:0006996 227 0.061
Mouse
aorta development GO:0035904 4 0.060
forebrain regionalization GO:0021871 4 0.060
multicellular organism growth GO:0035264 4 0.059
skeletal muscle fiber development GO:0048741 35 0.059
Zebrafish
axial mesoderm development GO:0048318 10 0.059
system process GO:0003008 185 0.059
regulation of neuron differentiation GO:0045664 56 0.059
Zebrafish
posterior lateral line neuromast primordium migration GO:0048920 12 0.058
striated muscle cell proliferation GO:0014855 7 0.058
Zebrafish
neural plate anterior posterior regionalization GO:0021999 8 0.058
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.058
Mouse
pancreatic a cell development GO:0003322 2 0.058
semicircular canal morphogenesis GO:0048752 18 0.057
pronephros development GO:0048793 69 0.057
Zebrafish
regulation of transcription from rna polymerase ii promoter involved in determination of left right symmetry GO:1900094 17 0.057
regulation of cell development GO:0060284 100 0.057
Zebrafish
cell substrate adhesion GO:0031589 4 0.057
cytoskeleton organization GO:0007010 96 0.056
Mouse
actin filament based process GO:0030029 64 0.056
Mouse
muscle fiber development GO:0048747 52 0.056
Zebrafish
pharyngeal system development GO:0060037 18 0.056
Mouse
determination of ventral identity GO:0048264 21 0.056
regulation of organ growth GO:0046620 3 0.056
negative regulation of apoptotic process GO:0043066 55 0.056
Mouse
negative regulation of biosynthetic process GO:0009890 55 0.055
Mouse
negative regulation of rna metabolic process GO:0051253 48 0.055
Mouse
semicircular canal development GO:0060872 24 0.055
somitogenesis GO:0001756 87 0.055
stem cell development GO:0048864 82 0.055
neural crest cell development GO:0014032 62 0.054
cell proliferation GO:0008283 80 0.054
Zebrafish Mouse
female sex differentiation GO:0046660 4 0.054
positive regulation of nucleic acid templated transcription GO:1903508 57 0.054
Mouse
ventral spinal cord development GO:0021517 35 0.054
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.054
cellular localization GO:0051641 97 0.053
Mouse
notch signaling pathway GO:0007219 35 0.053
anatomical structure homeostasis GO:0060249 36 0.053
developmental growth involved in morphogenesis GO:0060560 86 0.053
Mouse
developmental programmed cell death GO:0010623 4 0.052
posterior lateral line system development GO:0048915 46 0.052
sensory neuron axon guidance GO:0097374 3 0.052
neuromast hair cell differentiation GO:0048886 12 0.052
positive regulation of rna biosynthetic process GO:1902680 57 0.051
Mouse
apoptotic process involved in morphogenesis GO:0060561 2 0.051
negative regulation of neurogenesis GO:0050768 20 0.051
motor neuron axon guidance GO:0008045 23 0.050
atrioventricular valve formation GO:0003190 3 0.050
endothelium development GO:0003158 25 0.050
single organism metabolic process GO:0044710 217 0.050
urogenital system development GO:0001655 97 0.050
Zebrafish Mouse
positive regulation of mesoderm development GO:2000382 1 0.049
glial cell development GO:0021782 20 0.049
cardiac atrium development GO:0003230 4 0.049
oogenesis GO:0048477 14 0.048
nuclear transport GO:0051169 4 0.048
homeostatic process GO:0042592 142 0.047
specification of organ identity GO:0010092 2 0.047
olfactory placode development GO:0071698 12 0.047
Mouse
regulation of epidermis development GO:0045682 2 0.046
exocrine system development GO:0035272 28 0.046
glucose homeostasis GO:0042593 1 0.046
somatic muscle development GO:0007525 4 0.046
regulation of signaling GO:0023051 235 0.046
glial cell fate determination GO:0007403 1 0.046
epithelial cell proliferation GO:0050673 17 0.045
Mouse
posterior lateral line neuromast development GO:0048919 20 0.045
neural crest cell differentiation GO:0014033 72 0.044
development of primary female sexual characteristics GO:0046545 4 0.044
auditory receptor cell fate specification GO:0042667 2 0.044
ectoderm formation GO:0001705 2 0.044
tissue regeneration GO:0042246 74 0.044
Zebrafish
cilium organization GO:0044782 71 0.043
nucleocytoplasmic transport GO:0006913 4 0.043
organic substance transport GO:0071702 58 0.043
epithelial cell migration GO:0010631 25 0.043
response to glucose GO:0009749 3 0.042
regulation of endodermal cell differentiation GO:1903224 15 0.042

six4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
auditory system disease DOID:2742 0 0.086
autosomal dominant nonsyndromic deafness DOID:0050564 0 0.086
nonsyndromic deafness DOID:0050563 0 0.086
sensory system disease DOID:0050155 0 0.086
disease of anatomical entity DOID:7 0 0.086
nervous system disease DOID:863 0 0.086