Danio rerio

0 known processes

mep1a.1

meprin A, alpha.1

(Aliases: MEP1A,si:dkey-30j22.7)

mep1a.1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular protein catabolic process GO:0044257 4 0.168
regulation of biological quality GO:0065008 263 0.142
Worm
response to glucocorticoid GO:0051384 1 0.134
regulation of multicellular organismal process GO:0051239 277 0.102
Zebrafish
response to external stimulus GO:0009605 264 0.093
vasculature development GO:0001944 278 0.090
Zebrafish
cellular response to xenobiotic stimulus GO:0071466 35 0.090
leukocyte proliferation GO:0070661 1 0.066
b cell activation GO:0042113 2 0.060
aging GO:0007568 2 0.058
Worm
toxin metabolic process GO:0009404 1 0.057
regionalization GO:0003002 274 0.057
Zebrafish
mononuclear cell proliferation GO:0032943 1 0.054
embryo development ending in birth or egg hatching GO:0009792 271 0.052
Worm
oxidative demethylation GO:0070989 1 0.051
mycotoxin metabolic process GO:0043385 1 0.051
protein metabolic process GO:0019538 183 0.050
Zebrafish Worm
medial fin development GO:0033338 16 0.050
Zebrafish
immune system process GO:0002376 241 0.049
Zebrafish
ether metabolic process GO:0018904 1 0.048
gastrulation GO:0007369 208 0.047
Zebrafish
single organism metabolic process GO:0044710 217 0.046
response to stress GO:0006950 263 0.045
fertilization GO:0009566 3 0.044
larval development GO:0002164 2 0.043
response to other organism GO:0051707 97 0.043
regulation of metal ion transport GO:0010959 4 0.043
positive regulation of biological process GO:0048518 253 0.042
Zebrafish
cell death GO:0008219 121 0.040
organic substance biosynthetic process GO:1901576 289 0.040
regulation of cell activation GO:0050865 1 0.038
nucleobase containing compound metabolic process GO:0006139 274 0.038
gene expression GO:0010467 252 0.037
proteasomal protein catabolic process GO:0010498 2 0.036
modification dependent macromolecule catabolic process GO:0043632 3 0.036
response to xenobiotic stimulus GO:0009410 45 0.036
cellular biosynthetic process GO:0044249 286 0.036
lipid storage GO:0019915 1 0.035
Worm
protein activation cascade GO:0072376 6 0.035
system process GO:0003008 185 0.035
signal transduction GO:0007165 455 0.033
Zebrafish
striated muscle cell development GO:0055002 108 0.033
aflatoxin metabolic process GO:0046222 1 0.033
secondary metabolic process GO:0019748 3 0.032
regulation of metabolic process GO:0019222 359 0.032
Zebrafish
blood vessel development GO:0001568 246 0.032
Zebrafish
death GO:0016265 121 0.032
negative regulation of gene expression GO:0010629 65 0.032
nitrogen compound metabolic process GO:0006807 319 0.032
response to corticosteroid GO:0031960 1 0.032
modification dependent protein catabolic process GO:0019941 3 0.030
cellular macromolecule metabolic process GO:0044260 391 0.030
heterocycle metabolic process GO:0046483 290 0.029
gtp metabolic process GO:0046039 4 0.028
neurological system process GO:0050877 62 0.028
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.027
eye development GO:0001654 277 0.027
positive regulation of cellular component biogenesis GO:0044089 3 0.026
antimicrobial humoral response GO:0019730 2 0.026
vitamin biosynthetic process GO:0009110 2 0.026
organic cyclic compound biosynthetic process GO:1901362 223 0.026
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.025
cell cell recognition GO:0009988 1 0.025
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.025
myofibril assembly GO:0030239 48 0.025
regulation of signal transduction GO:0009966 225 0.025
Zebrafish
mitochondrion organization GO:0007005 4 0.025
organic cyclic compound metabolic process GO:1901360 301 0.024
camera type eye development GO:0043010 222 0.024
positive regulation of cytokine production GO:0001819 2 0.024
establishment of localization GO:0051234 244 0.024
immune response GO:0006955 28 0.024
regulation of protein complex assembly GO:0043254 3 0.023
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
caudal fin development GO:0033336 9 0.023
Zebrafish
monovalent inorganic cation transport GO:0015672 42 0.022
cellular response to chemical stimulus GO:0070887 157 0.022
lipid catabolic process GO:0016042 4 0.022
positive regulation of cell killing GO:0031343 2 0.022
defense response GO:0006952 47 0.022
leukocyte mediated cytotoxicity GO:0001909 1 0.022
fat soluble vitamin biosynthetic process GO:0042362 2 0.021
response to carbohydrate GO:0009743 3 0.021
single fertilization GO:0007338 3 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
response to hexose GO:0009746 3 0.021
regulation of cell killing GO:0031341 2 0.021
maintenance of location GO:0051235 4 0.020
Worm
response to organic substance GO:0010033 153 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
regulation of primary metabolic process GO:0080090 311 0.020
Zebrafish
regulation of tube size GO:0035150 2 0.020
response to bacterium GO:0009617 58 0.020
negative regulation of rna biosynthetic process GO:1902679 45 0.019
regulation of cell communication GO:0010646 232 0.019
Zebrafish
response to external biotic stimulus GO:0043207 97 0.019
aflatoxin b1 metabolic process GO:0043390 1 0.019
cellular response to external stimulus GO:0071496 2 0.019
post embryonic organ development GO:0048569 4 0.019
multicellular organism growth GO:0035264 4 0.019
cell morphogenesis GO:0000902 289 0.019
regulation of gene expression GO:0010468 265 0.019
Zebrafish
negative regulation of transcription dna templated GO:0045892 45 0.019
sensory organ development GO:0007423 393 0.019
digestive tract mesoderm development GO:0007502 1 0.019
retina morphogenesis in camera type eye GO:0060042 79 0.019
centrosome organization GO:0051297 1 0.019
cognition GO:0050890 1 0.019
positive regulation of muscle organ development GO:0048636 1 0.018
cellular component biogenesis GO:0044085 178 0.018
regulation of systemic arterial blood pressure GO:0003073 1 0.018
cellular macromolecule biosynthetic process GO:0034645 224 0.018
lymphocyte mediated immunity GO:0002449 5 0.018
response to steroid hormone GO:0048545 35 0.018
cellular ketone metabolic process GO:0042180 11 0.018
phagocytosis GO:0006909 3 0.018
growth GO:0040007 174 0.018
cell killing GO:0001906 2 0.018
heart development GO:0007507 313 0.017
regulation of protein catabolic process GO:0042176 1 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
endothelial cell differentiation GO:0045446 20 0.017
Zebrafish
cellular nitrogen compound metabolic process GO:0034641 290 0.017
regulation of immune system process GO:0002682 34 0.017
response to abiotic stimulus GO:0009628 122 0.017
embryonic hemopoiesis GO:0035162 53 0.017
Zebrafish
regulation of multicellular organism growth GO:0040014 4 0.017
response to monosaccharide GO:0034284 3 0.017
negative regulation of cellular process GO:0048523 283 0.017
water homeostasis GO:0030104 4 0.017
cellular response to light stimulus GO:0071482 4 0.017
organism emergence from protective structure GO:0071684 4 0.017
Zebrafish
carbohydrate homeostasis GO:0033500 1 0.017
embryonic skeletal joint morphogenesis GO:0060272 3 0.016
small molecule metabolic process GO:0044281 77 0.016
vitamin metabolic process GO:0006766 11 0.016
negative regulation of innate immune response GO:0045824 2 0.016
cellular response to radiation GO:0071478 4 0.016
positive regulation of gtpase activity GO:0043547 1 0.016
response to transition metal nanoparticle GO:1990267 28 0.016
post anal tail morphogenesis GO:0036342 19 0.016
Zebrafish
organic heteropentacyclic compound metabolic process GO:1901376 1 0.016
modification of morphology or physiology of other organism GO:0035821 4 0.016
sensory perception of chemical stimulus GO:0007606 3 0.016
regulation of circadian sleep wake cycle GO:0042749 1 0.016
response to chemical GO:0042221 320 0.016
tissue remodeling GO:0048771 4 0.016
purine nucleotide metabolic process GO:0006163 27 0.016
oxidation reduction process GO:0055114 41 0.016
regulation of developmental process GO:0050793 247 0.016
Zebrafish
cellular component assembly involved in morphogenesis GO:0010927 107 0.016
cellular nitrogen compound biosynthetic process GO:0044271 218 0.016
cellular response to extracellular stimulus GO:0031668 2 0.015
cellular response to lipid GO:0071396 39 0.015
triglyceride homeostasis GO:0070328 2 0.015
cellular response to starvation GO:0009267 1 0.015
stem cell maintenance GO:0019827 4 0.015
rna biosynthetic process GO:0032774 181 0.015
cellular response to steroid hormone stimulus GO:0071383 31 0.015
specification of organ identity GO:0010092 2 0.015
regulation of nucleoside metabolic process GO:0009118 2 0.015
regulation of hormone secretion GO:0046883 2 0.015
lipid homeostasis GO:0055088 3 0.015
tube morphogenesis GO:0035239 349 0.015
Zebrafish
regulation of multicellular organismal development GO:2000026 223 0.015
Zebrafish
response to lipid GO:0033993 60 0.014
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.014
Zebrafish
leukocyte homeostasis GO:0001776 2 0.014
negative regulation of mitosis GO:0045839 3 0.014
regulation of cellular amine metabolic process GO:0033238 0 0.014
circulatory system process GO:0003013 87 0.014
fat soluble vitamin metabolic process GO:0006775 4 0.014
endothelial cell development GO:0001885 12 0.014
Zebrafish
cellular component morphogenesis GO:0032989 336 0.014
embryonic skeletal joint development GO:0072498 3 0.014
opioid receptor signaling pathway GO:0038003 3 0.014
response to organic cyclic compound GO:0014070 51 0.014
positive regulation of cell activation GO:0050867 1 0.014
organelle organization GO:0006996 227 0.014
proteolysis GO:0006508 38 0.014
Zebrafish Worm
biosynthetic process GO:0009058 294 0.014
negative regulation of macromolecule metabolic process GO:0010605 76 0.014
single organism localization GO:1902578 225 0.013
specification of symmetry GO:0009799 204 0.013
Zebrafish
response to nutrient GO:0007584 3 0.013
cellular amine metabolic process GO:0044106 2 0.013
homeostatic process GO:0042592 142 0.013
regulation of rna metabolic process GO:0051252 224 0.013
Zebrafish
phototransduction GO:0007602 2 0.013
negative regulation of apoptotic process GO:0043066 55 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
regulation of growth rate GO:0040009 1 0.013
small molecule catabolic process GO:0044282 3 0.013
stem cell development GO:0048864 82 0.013
interspecies interaction between organisms GO:0044419 4 0.013
cellular aromatic compound metabolic process GO:0006725 295 0.013
response to biotic stimulus GO:0009607 97 0.013
endocardial cushion morphogenesis GO:0003203 3 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
response to amine GO:0014075 1 0.013
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.012
endoplasmic reticulum unfolded protein response GO:0030968 2 0.012
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.012
cellular response to organic cyclic compound GO:0071407 38 0.012
regulation of programmed cell death GO:0043067 101 0.012
amine metabolic process GO:0009308 2 0.012
positive regulation of catabolic process GO:0009896 4 0.012
pigmentation GO:0043473 85 0.012
retina development in camera type eye GO:0060041 146 0.012
nucleic acid templated transcription GO:0097659 181 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
regulation of circadian rhythm GO:0042752 4 0.012
response to hormone GO:0009725 48 0.012
cellular response to organic substance GO:0071310 105 0.012
mesenchymal cell differentiation GO:0048762 87 0.012
nuclear transport GO:0051169 4 0.012
transport GO:0006810 220 0.012
mesoderm development GO:0007498 88 0.012
Zebrafish
regulation of cellular metabolic process GO:0031323 320 0.012
Zebrafish
negative regulation of cell death GO:0060548 60 0.012
cellular response to nutrient levels GO:0031669 2 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
response to ketone GO:1901654 1 0.012
lymphocyte proliferation GO:0046651 1 0.011
blood vessel morphogenesis GO:0048514 216 0.011
Zebrafish
neural crest cell development GO:0014032 62 0.011
negative regulation of multi organism process GO:0043901 3 0.011
sensory perception of smell GO:0007608 2 0.011
aromatic compound biosynthetic process GO:0019438 217 0.011
lymphocyte homeostasis GO:0002260 1 0.011
negative regulation of cellular biosynthetic process GO:0031327 55 0.011
negative regulation of reproductive process GO:2000242 3 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
g protein coupled receptor signaling pathway GO:0007186 74 0.011
negative regulation of metabolic process GO:0009892 86 0.011
negative regulation of blood circulation GO:1903523 2 0.011
cellular response to retinoic acid GO:0071300 1 0.011
regulation of macromolecule metabolic process GO:0060255 317 0.011
Zebrafish
digestive tract development GO:0048565 265 0.011
Zebrafish
humoral immune response GO:0006959 5 0.011
regulation of blood pressure GO:0008217 1 0.011
regulation of cell development GO:0060284 100 0.011
developmental growth GO:0048589 166 0.011
locomotion GO:0040011 313 0.011
Worm
peptide transport GO:0015833 1 0.011
glucose homeostasis GO:0042593 1 0.011
stem cell proliferation GO:0072089 4 0.011
regulation of bmp signaling pathway GO:0030510 39 0.010
Zebrafish
multi organism process GO:0051704 134 0.010
retinal metabolic process GO:0042574 3 0.010
cellular protein metabolic process GO:0044267 129 0.010
internal protein amino acid acetylation GO:0006475 2 0.010
female sex differentiation GO:0046660 4 0.010
cell aging GO:0007569 2 0.010
b cell proliferation GO:0042100 1 0.010
positive regulation of gtp catabolic process GO:0033126 1 0.010
meiosis i GO:0007127 1 0.010
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.010
cellular hormone metabolic process GO:0034754 19 0.010
muscle cell development GO:0055001 115 0.010

mep1a.1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.024
musculoskeletal system disease DOID:17 0 0.013
muscle tissue disease DOID:66 0 0.013
myopathy DOID:423 0 0.013
cardiovascular system disease DOID:1287 0 0.013
cardiomyopathy DOID:0050700 0 0.013
intrinsic cardiomyopathy DOID:0060036 0 0.013
muscular disease DOID:0080000 0 0.013
heart disease DOID:114 0 0.013