Danio rerio

14 known processes

p2rx8

purinergic receptor P2X, ligand-gated ion channel, 8

(Aliases: p2xr514,P2X.514)

p2rx8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
protein heterooligomerization GO:0051291 1 0.224
Zebrafish
neuromuscular synaptic transmission GO:0007274 2 0.159
sensory perception of chemical stimulus GO:0007606 3 0.152
cation transmembrane transport GO:0098655 65 0.151
transmembrane transport GO:0055085 120 0.116
ion transport GO:0006811 114 0.112
regulation of synaptic plasticity GO:0048167 1 0.102
cell part morphogenesis GO:0032990 246 0.084
phasic smooth muscle contraction GO:0014821 1 0.083
multicellular organismal response to stress GO:0033555 2 0.078
neuron development GO:0048666 262 0.078
single organism transport GO:0044765 206 0.075
cell morphogenesis GO:0000902 289 0.068
cell morphogenesis involved in differentiation GO:0000904 195 0.068
response to carbohydrate GO:0009743 3 0.067
response to chemical GO:0042221 320 0.066
response to cold GO:0009409 4 0.066
axon development GO:0061564 166 0.066
axonogenesis GO:0007409 152 0.066
cell projection organization GO:0030030 284 0.061
regulation of blood pressure GO:0008217 1 0.056
transmission of nerve impulse GO:0019226 19 0.056
neuron differentiation GO:0030182 353 0.055
ion transmembrane transport GO:0034220 91 0.055
establishment of localization GO:0051234 244 0.053
organic cyclic compound biosynthetic process GO:1901362 223 0.053
neurological system process GO:0050877 62 0.053
neuron projection morphogenesis GO:0048812 161 0.051
macromolecule biosynthetic process GO:0009059 227 0.050
regulation of cellular biosynthetic process GO:0031326 245 0.050
muscle structure development GO:0061061 196 0.049
multicellular organismal signaling GO:0035637 22 0.049
cell projection morphogenesis GO:0048858 244 0.048
cellular macromolecule metabolic process GO:0044260 391 0.048
mechanosensory behavior GO:0007638 2 0.048
larval development GO:0002164 2 0.047
cellular macromolecule biosynthetic process GO:0034645 224 0.046
response to external stimulus GO:0009605 264 0.046
regulation of biological quality GO:0065008 263 0.044
response to stress GO:0006950 263 0.044
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.043
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.042
embryonic organ morphogenesis GO:0048562 274 0.042
positive regulation of cellular process GO:0048522 201 0.041
axon guidance GO:0007411 86 0.041
monovalent inorganic cation transport GO:0015672 42 0.040
phagocytosis GO:0006909 3 0.040
neurotransmitter secretion GO:0007269 2 0.038
cellular component biogenesis GO:0044085 178 0.037
Zebrafish
signal transduction GO:0007165 455 0.036
regulation of neural precursor cell proliferation GO:2000177 3 0.036
response to methanol GO:0033986 4 0.036
pancreatic d cell differentiation GO:0003311 2 0.036
single organism localization GO:1902578 225 0.035
response to decreased oxygen levels GO:0036293 25 0.035
system process GO:0003008 185 0.035
chemosensory behavior GO:0007635 1 0.034
nucleobase containing compound biosynthetic process GO:0034654 205 0.034
stem cell proliferation GO:0072089 4 0.034
morphogenesis of an epithelium GO:0002009 333 0.033
smooth muscle contraction GO:0006939 2 0.033
cellular response to chemical stimulus GO:0070887 157 0.033
cation transport GO:0006812 81 0.033
transport GO:0006810 220 0.032
response to oxygen levels GO:0070482 25 0.032
generation of neurons GO:0048699 385 0.032
nitrogen compound metabolic process GO:0006807 319 0.032
response to endogenous stimulus GO:0009719 83 0.032
female sex differentiation GO:0046660 4 0.032
regulation of endocrine process GO:0044060 2 0.032
muscle tissue development GO:0060537 110 0.031
regulation of multicellular organismal process GO:0051239 277 0.031
female gonad development GO:0008585 4 0.031
endocrine hormone secretion GO:0060986 2 0.030
regulation of meiotic cell cycle GO:0051445 1 0.030
regulation of dna replication GO:0006275 3 0.030
negative regulation of dna replication GO:0008156 2 0.030
regulation of circadian rhythm GO:0042752 4 0.030
maintenance of location GO:0051235 4 0.030
blood circulation GO:0008015 87 0.030
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.029
response to organic cyclic compound GO:0014070 51 0.029
circulatory system process GO:0003013 87 0.029
action potential GO:0001508 19 0.029
endocrine process GO:0050886 2 0.029
response to abiotic stimulus GO:0009628 122 0.028
nucleic acid metabolic process GO:0090304 244 0.028
meiotic cell cycle process GO:1903046 3 0.028
regulation of stem cell proliferation GO:0072091 2 0.028
inorganic ion transmembrane transport GO:0098660 57 0.028
neuron projection development GO:0031175 180 0.028
inorganic cation transmembrane transport GO:0098662 50 0.027
aging GO:0007568 2 0.027
regulation of signaling GO:0023051 235 0.027
response to mechanical stimulus GO:0009612 24 0.027
developmental growth involved in morphogenesis GO:0060560 86 0.026
cell surface receptor signaling pathway GO:0007166 325 0.026
neuron projection guidance GO:0097485 86 0.026
peristalsis GO:0030432 1 0.026
positive regulation of transport GO:0051050 2 0.026
regulation of metabolic process GO:0019222 359 0.025
adult behavior GO:0030534 2 0.025
regulation of primary metabolic process GO:0080090 311 0.025
gene expression GO:0010467 252 0.025
nucleic acid templated transcription GO:0097659 181 0.024
taxis GO:0042330 109 0.024
development of primary female sexual characteristics GO:0046545 4 0.024
synaptic vesicle transport GO:0048489 1 0.024
meiotic nuclear division GO:0007126 4 0.024
cellular component movement GO:0006928 335 0.024
synaptic vesicle localization GO:0097479 1 0.023
multicellular organism growth GO:0035264 4 0.023
cellular protein catabolic process GO:0044257 4 0.023
embryonic organ development GO:0048568 381 0.023
sympathetic nervous system development GO:0048485 3 0.023
regulation of cell communication GO:0010646 232 0.022
neuronal action potential GO:0019228 18 0.022
regulation of multicellular organism growth GO:0040014 4 0.022
negative regulation of dna metabolic process GO:0051053 4 0.022
transcription dna templated GO:0006351 181 0.022
negative regulation of mapk cascade GO:0043409 4 0.022
regulation of neuronal synaptic plasticity GO:0048168 1 0.022
regulation of dendrite development GO:0050773 3 0.021
protein homooligomerization GO:0051260 3 0.021
sensory organ development GO:0007423 393 0.021
eye development GO:0001654 277 0.021
muscle contraction GO:0006936 18 0.020
steroid hormone secretion GO:0035929 1 0.020
transcription from rna polymerase ii promoter GO:0006366 80 0.020
erk1 and erk2 cascade GO:0070371 4 0.020
gabaergic neuron differentiation GO:0097154 2 0.020
rna biosynthetic process GO:0032774 181 0.020
b cell differentiation GO:0030183 1 0.020
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.020
locomotor rhythm GO:0045475 3 0.019
response to glucocorticoid GO:0051384 1 0.019
regulation of macromolecule biosynthetic process GO:0010556 225 0.019
larval behavior GO:0030537 5 0.019
cellular response to methanol GO:0071405 4 0.019
regulation of metal ion transport GO:0010959 4 0.019
positive regulation of cell cycle GO:0045787 3 0.019
diencephalon development GO:0021536 58 0.019
cellular aromatic compound metabolic process GO:0006725 295 0.019
rna metabolic process GO:0016070 219 0.019
heterocycle metabolic process GO:0046483 290 0.018
muscle cell development GO:0055001 115 0.018
response to organic substance GO:0010033 153 0.018
cell cell signaling GO:0007267 52 0.018
organic cyclic compound metabolic process GO:1901360 301 0.018
establishment of synaptic vesicle localization GO:0097480 1 0.018
response to hypoxia GO:0001666 25 0.018
regulation of gene expression GO:0010468 265 0.018
larval locomotory behavior GO:0008345 5 0.018
negative regulation of biological process GO:0048519 304 0.018
striated muscle cell development GO:0055002 108 0.018
detection of chemical stimulus GO:0009593 4 0.017
cognition GO:0050890 1 0.017
protein oligomerization GO:0051259 7 0.017
Zebrafish
spermatid differentiation GO:0048515 2 0.017
organic substance biosynthetic process GO:1901576 289 0.017
motor neuron axon guidance GO:0008045 23 0.017
metal ion transport GO:0030001 58 0.017
regulation of biosynthetic process GO:0009889 250 0.017
carbohydrate biosynthetic process GO:0016051 1 0.017
regulation of reproductive process GO:2000241 4 0.017
regulation of transmembrane transport GO:0034762 18 0.017
medulla oblongata development GO:0021550 4 0.017
muscle fiber development GO:0048747 52 0.017
biosynthetic process GO:0009058 294 0.017
gland development GO:0048732 143 0.017
cellular component disassembly GO:0022411 1 0.017
autophagy GO:0006914 4 0.016
spermatid development GO:0007286 2 0.016
regulation of systemic arterial blood pressure GO:0003073 1 0.016
regulation of cellular metabolic process GO:0031323 320 0.016
regulation of response to stimulus GO:0048583 269 0.016
regulation of ion transmembrane transport GO:0034765 18 0.016
positive regulation of cytokine production GO:0001819 2 0.016
stem cell maintenance GO:0019827 4 0.016
behavior GO:0007610 74 0.016
synaptic transmission GO:0007268 35 0.016
specification of symmetry GO:0009799 204 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
regulation of developmental process GO:0050793 247 0.016
regulation of macromolecule metabolic process GO:0060255 317 0.016
sensory perception GO:0007600 39 0.016
regulation of nitrogen compound metabolic process GO:0051171 251 0.015
cellular nitrogen compound biosynthetic process GO:0044271 218 0.015
cellular component morphogenesis GO:0032989 336 0.015
positive regulation of secretion GO:0051047 1 0.015
muscle system process GO:0003012 20 0.015
regulation of ion transmembrane transporter activity GO:0032412 2 0.015
thermosensory behavior GO:0040040 1 0.015
regulation of transcription dna templated GO:0006355 213 0.015
regulation of cytokine production GO:0001817 3 0.015
regulation of multicellular organismal development GO:2000026 223 0.014
neuroblast proliferation GO:0007405 2 0.014
synaptic vesicle endocytosis GO:0048488 1 0.014
swimming behavior GO:0036269 8 0.014
organism emergence from protective structure GO:0071684 4 0.014
hormone secretion GO:0046879 2 0.014
regulation of steroid hormone secretion GO:2000831 1 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
regulation of tube size GO:0035150 2 0.014
eye morphogenesis GO:0048592 144 0.014
cellular biosynthetic process GO:0044249 286 0.014
positive regulation of cellular catabolic process GO:0031331 3 0.014
embryonic camera type eye development GO:0031076 29 0.014
cellular response to molecule of bacterial origin GO:0071219 3 0.014
cellular nitrogen compound metabolic process GO:0034641 290 0.014
sensory organ morphogenesis GO:0090596 200 0.014
regulation of ph GO:0006885 3 0.014
cellular response to lipopolysaccharide GO:0071222 3 0.014
negative regulation of cellular process GO:0048523 283 0.014
positive regulation of cellular component biogenesis GO:0044089 3 0.014
positive regulation of notch signaling pathway GO:0045747 3 0.014
pancreatic a cell development GO:0003322 2 0.013
central nervous system development GO:0007417 387 0.013
lamellipodium organization GO:0097581 1 0.013
positive regulation of reproductive process GO:2000243 2 0.013
sequestering of calcium ion GO:0051208 3 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
toxin metabolic process GO:0009404 1 0.013
digestive system development GO:0055123 289 0.013
regulation of rna metabolic process GO:0051252 224 0.013
immune system process GO:0002376 241 0.013
phagocytosis engulfment GO:0006911 1 0.013
cell cycle arrest GO:0007050 1 0.013
chemotaxis GO:0006935 104 0.013
regulation of membrane potential GO:0042391 23 0.013
positive regulation of catabolic process GO:0009896 4 0.013
regulation of mrna processing GO:0050684 3 0.013
b cell activation GO:0042113 2 0.013
locus ceruleus development GO:0021703 3 0.013
synaptic vesicle recycling GO:0036465 1 0.013
regulation of protein catabolic process GO:0042176 1 0.013
regulation of neurogenesis GO:0050767 87 0.013
muscle organ development GO:0007517 101 0.013
enteroendocrine cell differentiation GO:0035883 9 0.013
guanosine containing compound metabolic process GO:1901068 4 0.013
neurotransmitter transport GO:0006836 2 0.013
response to hydrogen peroxide GO:0042542 3 0.013
cell differentiation in spinal cord GO:0021515 40 0.013
localization of cell GO:0051674 244 0.013
germ line stem cell maintenance GO:0030718 2 0.013
endocrine system development GO:0035270 65 0.013
regulation of cell activation GO:0050865 1 0.013
embryonic heart tube development GO:0035050 133 0.013
negative regulation of biosynthetic process GO:0009890 55 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
positive regulation of cell killing GO:0031343 2 0.012
cranial nerve development GO:0021545 42 0.012
protein metabolic process GO:0019538 183 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
heart looping GO:0001947 94 0.012
energy reserve metabolic process GO:0006112 2 0.012
muscle cell differentiation GO:0042692 139 0.012
organic acid metabolic process GO:0006082 31 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
positive regulation of biological process GO:0048518 253 0.012
striated muscle tissue development GO:0014706 110 0.012
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.012
angiogenesis GO:0001525 158 0.012
protein dephosphorylation GO:0006470 3 0.012
sequestering of metal ion GO:0051238 3 0.012
positive regulation of stem cell proliferation GO:2000648 1 0.012
lateral inhibition GO:0046331 1 0.012
leukocyte mediated cytotoxicity GO:0001909 1 0.012
protein localization to nucleus GO:0034504 3 0.012
regulation of lipid transport GO:0032368 4 0.012
positive regulation of immune effector process GO:0002699 3 0.012
cellular ketone metabolic process GO:0042180 11 0.012
sodium ion transmembrane transport GO:0035725 21 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
gtp metabolic process GO:0046039 4 0.012
regulation of localization GO:0032879 104 0.012
adherens junction organization GO:0034332 4 0.012
pancreas development GO:0031016 84 0.012
regulation of epithelial cell proliferation GO:0050678 3 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
release of sequestered calcium ion into cytosol GO:0051209 3 0.011
polarized epithelial cell differentiation GO:0030859 4 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
vasculature development GO:0001944 278 0.011
response to drug GO:0042493 3 0.011
digestive tract development GO:0048565 265 0.011
sprouting angiogenesis GO:0002040 53 0.011
carbohydrate homeostasis GO:0033500 1 0.011
multi organism process GO:0051704 134 0.011
regulation of blood vessel size GO:0050880 2 0.011
membrane invagination GO:0010324 1 0.011
lipid storage GO:0019915 1 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.011
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.011
regulation of neurotransmitter transport GO:0051588 1 0.011
developmental programmed cell death GO:0010623 4 0.011
regulation of cellular component movement GO:0051270 55 0.011
hormone transport GO:0009914 2 0.011
catechol containing compound metabolic process GO:0009712 2 0.011
brain development GO:0007420 293 0.011
mitotic cell cycle embryonic GO:0045448 2 0.011
sex determination GO:0007530 1 0.011
type b pancreatic cell differentiation GO:0003309 8 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
nucleobase containing compound metabolic process GO:0006139 274 0.011
macromolecular complex subunit organization GO:0043933 74 0.011
Zebrafish
positive regulation of secretion by cell GO:1903532 1 0.011
regulation of calcium ion transport GO:0051924 2 0.011
spinal cord development GO:0021510 46 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
peptidyl lysine acetylation GO:0018394 2 0.011
nerve development GO:0021675 45 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
compound eye development GO:0048749 2 0.011
epithelial cell differentiation GO:0030855 116 0.011
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.011
modification dependent protein catabolic process GO:0019941 3 0.011
response to alkaloid GO:0043279 2 0.010
phototransduction GO:0007602 2 0.010
response to monosaccharide GO:0034284 3 0.010
oxoacid metabolic process GO:0043436 31 0.010
regulation of cell differentiation GO:0045595 142 0.010
regulation of cell development GO:0060284 100 0.010
organelle assembly GO:0070925 110 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.010
positive regulation of leukocyte differentiation GO:1902107 1 0.010
entrainment of circadian clock GO:0009649 2 0.010
cellular component assembly GO:0022607 170 0.010
Zebrafish
protein localization to plasma membrane GO:0072659 1 0.010
positive regulation of cell activation GO:0050867 1 0.010
regulation of cellular ketone metabolic process GO:0010565 7 0.010
protein secretion GO:0009306 1 0.010
single organism metabolic process GO:0044710 217 0.010
regulation of rna biosynthetic process GO:2001141 213 0.010
regulation of transporter activity GO:0032409 2 0.010
chordate embryonic development GO:0043009 271 0.010
calcium ion transport into cytosol GO:0060402 3 0.010
protein acylation GO:0043543 3 0.010
meiotic chromosome segregation GO:0045132 3 0.010

p2rx8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.025
musculoskeletal system disease DOID:17 0 0.014
disease of metabolism DOID:0014667 0 0.014
nervous system disease DOID:863 0 0.011
connective tissue disease DOID:65 0 0.010
disease of cellular proliferation DOID:14566 0 0.010