Danio rerio

0 known processes

gch2

GTP cyclohydrolase 2

(Aliases: fb51g02,gch,gch1b,wu:fb51g02)

gch2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
regulation of retina development in camera type eye GO:1902866 2 0.561
regulation of neural retina development GO:0061074 2 0.277
dopamine metabolic process GO:0042417 2 0.259
Worm
dopamine biosynthetic process GO:0042416 2 0.231
Worm
small molecule metabolic process GO:0044281 77 0.207
nitrogen compound metabolic process GO:0006807 319 0.192
Worm
xanthophore differentiation GO:0050936 3 0.166
phenol containing compound biosynthetic process GO:0046189 4 0.158
Worm
regulation of multicellular organismal development GO:2000026 223 0.131
neuron differentiation GO:0030182 353 0.113
organonitrogen compound metabolic process GO:1901564 74 0.104
Worm
skeletal system development GO:0001501 181 0.104
biosynthetic process GO:0009058 294 0.103
Worm
regulation of vascular endothelial growth factor receptor signaling pathway GO:0030947 8 0.097
b cell differentiation GO:0030183 1 0.093
neural crest cell development GO:0014032 62 0.091
locomotion GO:0040011 313 0.090
organic substance biosynthetic process GO:1901576 289 0.084
Worm
aging GO:0007568 2 0.084
mechanosensory behavior GO:0007638 2 0.080
gtp metabolic process GO:0046039 4 0.076
regulation of multicellular organismal process GO:0051239 277 0.072
protein metabolic process GO:0019538 183 0.072
purine ribonucleotide biosynthetic process GO:0009152 20 0.068
cellular component movement GO:0006928 335 0.068
nucleoside phosphate biosynthetic process GO:1901293 21 0.068
generation of neurons GO:0048699 385 0.066
regulation of metabolic process GO:0019222 359 0.065
eye development GO:0001654 277 0.064
vasculature development GO:0001944 278 0.060
cell migration GO:0016477 237 0.058
specification of organ axis polarity GO:0010084 2 0.057
neuroblast proliferation GO:0007405 2 0.057
pharyngeal muscle development GO:0043282 4 0.054
anterior posterior pattern specification GO:0009952 152 0.054
photoreceptor cell fate specification GO:0043704 1 0.053
venous blood vessel development GO:0060841 9 0.053
cellular macromolecule metabolic process GO:0044260 391 0.053
microglia differentiation GO:0014004 1 0.052
catecholamine biosynthetic process GO:0042423 2 0.052
Worm
cell projection organization GO:0030030 284 0.050
localization of cell GO:0051674 244 0.049
cellular aromatic compound metabolic process GO:0006725 295 0.048
Worm
ribonucleoside monophosphate catabolic process GO:0009158 4 0.047
heart development GO:0007507 313 0.047
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.047
sensory organ development GO:0007423 393 0.046
lipid storage GO:0019915 1 0.045
post embryonic organ development GO:0048569 4 0.045
regulation of neural precursor cell proliferation GO:2000177 3 0.044
b cell activation GO:0042113 2 0.043
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.041
signal transduction GO:0007165 455 0.040
regulation of developmental process GO:0050793 247 0.040
embryonic organ morphogenesis GO:0048562 274 0.038
single organism metabolic process GO:0044710 217 0.038
Worm
heterocycle biosynthetic process GO:0018130 215 0.038
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.038
regulation of biological quality GO:0065008 263 0.037
branching morphogenesis of an epithelial tube GO:0048754 15 0.037
leukocyte proliferation GO:0070661 1 0.036
regulation of cell shape GO:0008360 1 0.036
alpha amino acid metabolic process GO:1901605 3 0.035
cellular amino acid metabolic process GO:0006520 7 0.035
neural crest cell migration GO:0001755 42 0.035
intracellular signal transduction GO:0035556 85 0.035
auditory receptor cell fate commitment GO:0009912 4 0.035
larval development GO:0002164 2 0.034
striated muscle tissue development GO:0014706 110 0.034
response to external stimulus GO:0009605 264 0.034
ectodermal placode development GO:0071696 37 0.033
cellular amine metabolic process GO:0044106 2 0.033
developmental pigmentation GO:0048066 48 0.033
regulation of cell death GO:0010941 103 0.032
cell migration involved in heart development GO:0060973 22 0.031
positive regulation of neural precursor cell proliferation GO:2000179 1 0.030
response to abiotic stimulus GO:0009628 122 0.030
melanosome organization GO:0032438 4 0.030
synaptic growth at neuromuscular junction GO:0051124 2 0.029
heart contraction GO:0060047 71 0.029
mononuclear cell migration GO:0071674 1 0.028
melanin biosynthetic process GO:0042438 1 0.028
Worm
cell morphogenesis involved in differentiation GO:0000904 195 0.028
cellular nitrogen compound metabolic process GO:0034641 290 0.028
immune system development GO:0002520 191 0.028
embryonic skeletal system morphogenesis GO:0048704 93 0.028
death GO:0016265 121 0.028
positive regulation of macrophage chemotaxis GO:0010759 1 0.028
positive regulation of chromatin modification GO:1903310 1 0.027
neurological system process GO:0050877 62 0.027
chordate embryonic development GO:0043009 271 0.026
axon development GO:0061564 166 0.026
angiogenesis GO:0001525 158 0.025
immune system process GO:0002376 241 0.025
hematopoietic or lymphoid organ development GO:0048534 191 0.025
nucleoside monophosphate catabolic process GO:0009125 4 0.025
macromolecule modification GO:0043412 111 0.025
specification of axis polarity GO:0065001 4 0.024
central nervous system neuron differentiation GO:0021953 74 0.024
embryonic organ development GO:0048568 381 0.024
pigmentation GO:0043473 85 0.024
epithelial cell differentiation GO:0030855 116 0.024
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.024
neural retina development GO:0003407 49 0.023
osteoclast differentiation GO:0030316 1 0.023
negative regulation of programmed cell death GO:0043069 58 0.023
melanocyte migration GO:0097324 4 0.022
osteoclast development GO:0036035 1 0.022
response to radiation GO:0009314 51 0.022
pigment cell differentiation GO:0050931 38 0.022
cell morphogenesis GO:0000902 289 0.022
notch signaling pathway GO:0007219 35 0.022
regulation of cell proliferation GO:0042127 37 0.022
muscle organ development GO:0007517 101 0.022
muscle structure development GO:0061061 196 0.022
regulation of programmed cell death GO:0043067 101 0.022
response to organic substance GO:0010033 153 0.022
carboxylic acid metabolic process GO:0019752 22 0.021
circulatory system process GO:0003013 87 0.021
heterocycle metabolic process GO:0046483 290 0.021
cellular nitrogen compound biosynthetic process GO:0044271 218 0.021
epithelial tube morphogenesis GO:0060562 148 0.021
positive regulation of cell killing GO:0031343 2 0.020
organophosphate metabolic process GO:0019637 37 0.020
preganglionic parasympathetic nervous system development GO:0021783 6 0.020
negative regulation of apoptotic process GO:0043066 55 0.020
organic acid metabolic process GO:0006082 31 0.020
nucleoside biosynthetic process GO:0009163 2 0.020
regulation of response to stimulus GO:0048583 269 0.020
regulation of synapse assembly GO:0051963 3 0.020
positive regulation of epithelial cell proliferation GO:0050679 1 0.020
negative regulation of multicellular organismal process GO:0051241 69 0.020
chondrocyte development GO:0002063 4 0.019
regulation of mononuclear cell migration GO:0071675 1 0.019
cell part morphogenesis GO:0032990 246 0.019
regulation of protein catabolic process GO:0042176 1 0.019
stem cell maintenance GO:0019827 4 0.019
single organism localization GO:1902578 225 0.019
regulation of cell proliferation involved in heart morphogenesis GO:2000136 2 0.019
cellular biosynthetic process GO:0044249 286 0.019
Worm
regulation of cell communication GO:0010646 232 0.019
smooth muscle contraction GO:0006939 2 0.019
growth GO:0040007 174 0.018
growth plate cartilage development GO:0003417 2 0.018
ectodermal placode morphogenesis GO:0071697 32 0.018
regionalization GO:0003002 274 0.018
tube morphogenesis GO:0035239 349 0.018
maintenance of location GO:0051235 4 0.018
cellular component morphogenesis GO:0032989 336 0.018
muscle tissue development GO:0060537 110 0.018
guanosine containing compound catabolic process GO:1901069 2 0.018
cartilage development GO:0051216 96 0.017
blood vessel development GO:0001568 246 0.017
cell motility GO:0048870 244 0.017
catechol containing compound metabolic process GO:0009712 2 0.017
Worm
atp catabolic process GO:0006200 4 0.017
secondary metabolic process GO:0019748 3 0.017
Worm
ribonucleoside biosynthetic process GO:0042455 2 0.017
nucleic acid templated transcription GO:0097659 181 0.017
phosphorus metabolic process GO:0006793 109 0.017
sensory perception GO:0007600 39 0.017
auditory receptor cell fate determination GO:0042668 2 0.017
positive regulation of immune effector process GO:0002699 3 0.016
cellular response to molecule of bacterial origin GO:0071219 3 0.016
skin development GO:0043588 54 0.016
synaptic target recognition GO:0008039 1 0.016
cellular response to retinoic acid GO:0071300 1 0.016
camera type eye development GO:0043010 222 0.016
cellular response to biotic stimulus GO:0071216 3 0.016
antimicrobial humoral response GO:0019730 2 0.016
positive regulation of secretion GO:0051047 1 0.016
regulation of skeletal muscle cell differentiation GO:2001014 1 0.016
myeloid cell differentiation GO:0030099 86 0.016
positive regulation of cellular catabolic process GO:0031331 3 0.016
epithelial cell morphogenesis GO:0003382 2 0.015
response to stress GO:0006950 263 0.015
regulation of nitrogen compound metabolic process GO:0051171 251 0.015
positive regulation of retina development in camera type eye GO:1902868 1 0.015
mesoderm development GO:0007498 88 0.015
mesenchyme development GO:0060485 127 0.015
behavior GO:0007610 74 0.015
proteasomal protein catabolic process GO:0010498 2 0.015
regulation of response to cytokine stimulus GO:0060759 3 0.015
positive regulation of biological process GO:0048518 253 0.015
organophosphate biosynthetic process GO:0090407 23 0.015
cellular protein metabolic process GO:0044267 129 0.015
adult behavior GO:0030534 2 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
Worm
vascular endothelial growth factor receptor signaling pathway GO:0048010 13 0.014
regulation of cell activation GO:0050865 1 0.014
blood circulation GO:0008015 87 0.014
specification of organ identity GO:0010092 2 0.014
regulation of cellular metabolic process GO:0031323 320 0.014
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.014
cellular component assembly GO:0022607 170 0.014
lymphocyte proliferation GO:0046651 1 0.014
apical junction assembly GO:0043297 1 0.014
oocyte maturation GO:0001556 4 0.014
positive regulation of protein complex assembly GO:0031334 2 0.014
embryonic viscerocranium morphogenesis GO:0048703 52 0.014
positive regulation of secretion by cell GO:1903532 1 0.014
cytoskeleton organization GO:0007010 96 0.014
developmental growth GO:0048589 166 0.014
gtp catabolic process GO:0006184 2 0.014
stem cell proliferation GO:0072089 4 0.014
regulation of embryonic development GO:0045995 47 0.014
negative regulation of biological process GO:0048519 304 0.014
macrophage chemotaxis GO:0048246 3 0.014
ameboidal type cell migration GO:0001667 143 0.014
neural crest cell differentiation GO:0014033 72 0.014
regulation of developmental pigmentation GO:0048070 6 0.014
cell projection morphogenesis GO:0048858 244 0.014
morphogenesis of an epithelium GO:0002009 333 0.014
somatic muscle development GO:0007525 4 0.013
gland morphogenesis GO:0022612 13 0.013
sensory organ morphogenesis GO:0090596 200 0.013
endochondral bone growth GO:0003416 2 0.013
embryonic heart tube development GO:0035050 133 0.013
purine nucleoside monophosphate catabolic process GO:0009128 4 0.013
regulation of gene expression GO:0010468 265 0.013
optic nerve development GO:0021554 15 0.013
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.013
response to other organism GO:0051707 97 0.013
purine containing compound biosynthetic process GO:0072522 20 0.013
chemosensory behavior GO:0007635 1 0.013
neuron development GO:0048666 262 0.013
head development GO:0060322 303 0.013
regulation of cell projection assembly GO:0060491 4 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
nucleobase containing compound metabolic process GO:0006139 274 0.013
cardiac atrium morphogenesis GO:0003209 2 0.013
endocardial cushion formation GO:0003272 2 0.013
actin mediated cell contraction GO:0070252 1 0.013
olfactory lobe development GO:0021988 4 0.013
cell differentiation in spinal cord GO:0021515 40 0.013
embryonic limb morphogenesis GO:0030326 2 0.013
retina development in camera type eye GO:0060041 146 0.013
olfactory placode development GO:0071698 12 0.013
neuron fate commitment GO:0048663 26 0.013
regulation of erk1 and erk2 cascade GO:0070372 4 0.013
gland development GO:0048732 143 0.013
enzyme linked receptor protein signaling pathway GO:0007167 106 0.012
carbohydrate derivative biosynthetic process GO:1901137 43 0.012
amine metabolic process GO:0009308 2 0.012
central nervous system development GO:0007417 387 0.012
sympathetic ganglion development GO:0061549 2 0.012
purine ribonucleotide metabolic process GO:0009150 27 0.012
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.012
skeletal muscle cell differentiation GO:0035914 5 0.012
activation of jun kinase activity GO:0007257 2 0.012
catecholamine metabolic process GO:0006584 2 0.012
Worm
embryonic skeletal joint morphogenesis GO:0060272 3 0.012
photoreceptor cell fate commitment GO:0046552 1 0.012
regulation of cellular amine metabolic process GO:0033238 0 0.012
single organism transport GO:0044765 206 0.012
cell proliferation in forebrain GO:0021846 3 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
regulation of epithelial cell proliferation GO:0050678 3 0.012
cellular protein modification process GO:0006464 100 0.012
stem cell differentiation GO:0048863 117 0.012
regulation of anatomical structure morphogenesis GO:0022603 130 0.012
developmental programmed cell death GO:0010623 4 0.012
cell substrate junction assembly GO:0007044 2 0.012
somite development GO:0061053 96 0.012
regulation of signal transduction GO:0009966 225 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
neuron projection development GO:0031175 180 0.011
phosphorylation GO:0016310 69 0.011
response to chemical GO:0042221 320 0.011
regulation of macromolecule metabolic process GO:0060255 317 0.011
organic cyclic compound biosynthetic process GO:1901362 223 0.011
Worm
spinal cord development GO:0021510 46 0.011
regulation of reproductive process GO:2000241 4 0.011
response to antibiotic GO:0046677 1 0.011
establishment of epithelial cell apical basal polarity GO:0045198 2 0.011
endothelial cell differentiation GO:0045446 20 0.011
neuron projection morphogenesis GO:0048812 161 0.011
ribonucleotide metabolic process GO:0009259 27 0.011
oxidation reduction process GO:0055114 41 0.011
embryonic skeletal system development GO:0048706 97 0.011
embryonic skeletal joint development GO:0072498 3 0.011
regulation of binding GO:0051098 3 0.011
internal peptidyl lysine acetylation GO:0018393 2 0.011
establishment or maintenance of monopolar cell polarity GO:0061339 2 0.011
nucleobase containing compound biosynthetic process GO:0034654 205 0.011
endochondral bone morphogenesis GO:0060350 8 0.011
nucleoside triphosphate biosynthetic process GO:0009142 2 0.011
digestive tract morphogenesis GO:0048546 231 0.011
cranial nerve morphogenesis GO:0021602 15 0.011
positive regulation of cellular component biogenesis GO:0044089 3 0.011
rna metabolic process GO:0016070 219 0.011
morphogenesis of a branching structure GO:0001763 21 0.011
secondary metabolite biosynthetic process GO:0044550 1 0.011
Worm
transport GO:0006810 220 0.011
heart process GO:0003015 71 0.011
hemopoiesis GO:0030097 183 0.011
cell proliferation GO:0008283 80 0.010
mesenchymal cell development GO:0014031 78 0.010
negative regulation of nucleic acid templated transcription GO:1903507 45 0.010
mononuclear cell proliferation GO:0032943 1 0.010
positive regulation of cytoskeleton organization GO:0051495 3 0.010
primitive hemopoiesis GO:0060215 27 0.010
actin filament based process GO:0030029 64 0.010
purine ribonucleoside biosynthetic process GO:0046129 2 0.010
regulation of cytokine mediated signaling pathway GO:0001959 3 0.010
regulation of neurogenesis GO:0050767 87 0.010
gastrulation GO:0007369 208 0.010
cellular response to stress GO:0033554 62 0.010
positive regulation of cellular process GO:0048522 201 0.010
connective tissue development GO:0061448 99 0.010
regulation of nervous system development GO:0051960 90 0.010
organism emergence from protective structure GO:0071684 4 0.010
response to alkaloid GO:0043279 2 0.010
regulation of cell killing GO:0031341 2 0.010
compound eye development GO:0048749 2 0.010
cellular component biogenesis GO:0044085 178 0.010
hematopoietic progenitor cell differentiation GO:0002244 23 0.010
regulation of cytokine production GO:0001817 3 0.010

gch2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
immune system disease DOID:2914 0 0.019
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
organ system cancer DOID:0050686 0 0.015
nervous system disease DOID:863 0 0.015
auditory system disease DOID:2742 0 0.014
nonsyndromic deafness DOID:0050563 0 0.014
sensory system disease DOID:0050155 0 0.014