Danio rerio

0 known processes

mmadhc

methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria

(Aliases: My011,zgc:91819)

mmadhc biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.132
aging GO:0007568 2 0.080
cellular respiration GO:0045333 3 0.044
small molecule metabolic process GO:0044281 77 0.039
oxoacid metabolic process GO:0043436 31 0.039
modification dependent protein catabolic process GO:0019941 3 0.038
lipid storage GO:0019915 1 0.036
response to drug GO:0042493 3 0.034
ubiquitin dependent protein catabolic process GO:0006511 3 0.032
mitochondrion organization GO:0007005 4 0.031
carboxylic acid metabolic process GO:0019752 22 0.029
maintenance of location GO:0051235 4 0.029
cellular protein catabolic process GO:0044257 4 0.029
positive regulation of transport GO:0051050 2 0.027
organic acid metabolic process GO:0006082 31 0.026
embryo development ending in birth or egg hatching GO:0009792 271 0.025
heterocycle metabolic process GO:0046483 290 0.025
multicellular organism growth GO:0035264 4 0.024
purine nucleoside monophosphate catabolic process GO:0009128 4 0.023
single organism metabolic process GO:0044710 217 0.023
cellular amino acid metabolic process GO:0006520 7 0.023
ribonucleoside monophosphate catabolic process GO:0009158 4 0.022
regulation of multicellular organism growth GO:0040014 4 0.021
protein import GO:0017038 3 0.021
regulation of blood pressure GO:0008217 1 0.020
regulation of protein catabolic process GO:0042176 1 0.020
response to corticosteroid GO:0031960 1 0.020
cellular ketone metabolic process GO:0042180 11 0.020
establishment of protein localization to organelle GO:0072594 4 0.020
regulation of biological quality GO:0065008 263 0.020
phagocytosis GO:0006909 3 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
regulation of cell activation GO:0050865 1 0.019
meiotic cell cycle process GO:1903046 3 0.019
nucleoside monophosphate catabolic process GO:0009125 4 0.019
internal protein amino acid acetylation GO:0006475 2 0.019
response to glucocorticoid GO:0051384 1 0.019
cellular carbohydrate metabolic process GO:0044262 4 0.019
amine metabolic process GO:0009308 2 0.019
carboxylic acid catabolic process GO:0046395 3 0.019
biosynthetic process GO:0009058 294 0.019
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.019
regulation of carbohydrate metabolic process GO:0006109 4 0.018
regulation of cytokine production GO:0001817 3 0.018
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.018
cellular amine metabolic process GO:0044106 2 0.018
establishment of localization GO:0051234 244 0.018
organonitrogen compound metabolic process GO:1901564 74 0.018
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.018
alpha amino acid metabolic process GO:1901605 3 0.017
response to stress GO:0006950 263 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
regulation of cytoplasmic transport GO:1903649 4 0.017
regulation of binding GO:0051098 3 0.017
mitochondrial transport GO:0006839 2 0.017
organic acid catabolic process GO:0016054 3 0.017
stem cell maintenance GO:0019827 4 0.016
proteasomal protein catabolic process GO:0010498 2 0.016
atp catabolic process GO:0006200 4 0.016
positive regulation of cell cycle GO:0045787 3 0.016
immune system process GO:0002376 241 0.016
positive regulation of catabolic process GO:0009896 4 0.016
positive regulation of map kinase activity GO:0043406 3 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
cellular component biogenesis GO:0044085 178 0.015
response to nutrient GO:0007584 3 0.015
regulation of macromolecule metabolic process GO:0060255 317 0.015
regulation of protein transport GO:0051223 3 0.015
meiotic nuclear division GO:0007126 4 0.015
exocytosis GO:0006887 1 0.015
nuclear transport GO:0051169 4 0.015
transport GO:0006810 220 0.015
fatty acid oxidation GO:0019395 1 0.015
centrosome organization GO:0051297 1 0.015
regulation of tube size GO:0035150 2 0.015
central nervous system development GO:0007417 387 0.014
regulation of establishment of protein localization GO:0070201 4 0.014
single organism nuclear import GO:1902593 3 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
autophagy GO:0006914 4 0.014
carbohydrate biosynthetic process GO:0016051 1 0.014
lipid catabolic process GO:0016042 4 0.014
spermatid development GO:0007286 2 0.014
negative regulation of kinase activity GO:0033673 4 0.014
tissue remodeling GO:0048771 4 0.014
cellular nitrogen compound metabolic process GO:0034641 290 0.014
lipid oxidation GO:0034440 1 0.014
system process GO:0003008 185 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
positive regulation of cell activation GO:0050867 1 0.014
nuclear export GO:0051168 1 0.014
regulation of reactive oxygen species metabolic process GO:2000377 2 0.014
negative regulation of catabolic process GO:0009895 3 0.014
b cell differentiation GO:0030183 1 0.014
protein targeting to nucleus GO:0044744 3 0.014
regulation of blood vessel size GO:0050880 2 0.014
small molecule catabolic process GO:0044282 3 0.013
organelle fusion GO:0048284 3 0.013
dopamine metabolic process GO:0042417 2 0.013
heart development GO:0007507 313 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
macromolecule biosynthetic process GO:0009059 227 0.013
cellular lipid catabolic process GO:0044242 3 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
peptidyl lysine acetylation GO:0018394 2 0.013
protein acetylation GO:0006473 2 0.013
nitrogen compound metabolic process GO:0006807 319 0.013
antimicrobial humoral response GO:0019730 2 0.013
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
regulation of systemic arterial blood pressure GO:0003073 1 0.013
negative regulation of cellular process GO:0048523 283 0.013
regulation of response to stimulus GO:0048583 269 0.013
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.013
positive regulation of stem cell proliferation GO:2000648 1 0.013
cytoskeleton dependent cytokinesis GO:0061640 3 0.013
single organism localization GO:1902578 225 0.013
negative regulation of immune response GO:0050777 2 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.012
positive regulation of cytokine production GO:0001819 2 0.012
b cell activation GO:0042113 2 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
localization of cell GO:0051674 244 0.012
cytokinesis GO:0000910 3 0.012
cellular amide metabolic process GO:0043603 4 0.012
response to topologically incorrect protein GO:0035966 2 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
endosomal transport GO:0016197 2 0.012
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.012
regulation of protein localization to nucleus GO:1900180 2 0.012
nuclear import GO:0051170 3 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
multicellular organismal response to stress GO:0033555 2 0.012
germ line stem cell maintenance GO:0030718 2 0.012
regulation of primary metabolic process GO:0080090 311 0.012
regulation of protein import into nucleus GO:0042306 2 0.012
negative regulation of cytokine production GO:0001818 1 0.012
cellular component assembly GO:0022607 170 0.012
signal transduction GO:0007165 455 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
protein homooligomerization GO:0051260 3 0.011
peptide transport GO:0015833 1 0.011
regulation of metabolic process GO:0019222 359 0.011
single organism biosynthetic process GO:0044711 71 0.011
organic substance biosynthetic process GO:1901576 289 0.011
regulation of leukocyte mediated immunity GO:0002703 1 0.011
cellular macromolecule metabolic process GO:0044260 391 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
regulation of protein complex assembly GO:0043254 3 0.011
mononuclear cell proliferation GO:0032943 1 0.011
response to other organism GO:0051707 97 0.011
regulation of cell communication GO:0010646 232 0.011
microtubule organizing center organization GO:0031023 1 0.011
positive regulation of secretion GO:0051047 1 0.011
negative regulation of biological process GO:0048519 304 0.011
response to cold GO:0009409 4 0.011
positive regulation of immune effector process GO:0002699 3 0.011
protein stabilization GO:0050821 2 0.011
protein acylation GO:0043543 3 0.011
cellular transition metal ion homeostasis GO:0046916 3 0.011
secondary metabolic process GO:0019748 3 0.011
energy reserve metabolic process GO:0006112 2 0.011
mesenchymal cell proliferation GO:0010463 1 0.011
meiosis i GO:0007127 1 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
positive regulation of cellular catabolic process GO:0031331 3 0.011
death GO:0016265 121 0.011
transmembrane transport GO:0055085 120 0.011
protein localization to plasma membrane GO:0072659 1 0.011
cell part morphogenesis GO:0032990 246 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
i kappab kinase nf kappab signaling GO:0007249 4 0.011
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
protein polymerization GO:0051258 4 0.011
protein secretion GO:0009306 1 0.011
female sex differentiation GO:0046660 4 0.011
regulation of gene expression GO:0010468 265 0.011
positive regulation of apoptotic signaling pathway GO:2001235 1 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
single organism organelle organization GO:1902589 199 0.011
membrane fusion GO:0061025 2 0.010
female gonad development GO:0008585 4 0.010
oxidation reduction process GO:0055114 41 0.010
fatty acid beta oxidation GO:0006635 1 0.010
regulation of mrna processing GO:0050684 3 0.010
gtp metabolic process GO:0046039 4 0.010
regulation of cellular protein catabolic process GO:1903362 1 0.010
cellular protein modification process GO:0006464 100 0.010
peptide metabolic process GO:0006518 1 0.010
negative regulation of defense response GO:0031348 2 0.010
response to chemical GO:0042221 320 0.010
regulation of lipid transport GO:0032368 4 0.010
production of molecular mediator of immune response GO:0002440 2 0.010

mmadhc disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.024
disease of cellular proliferation DOID:14566 0 0.024
disease of metabolism DOID:0014667 0 0.022
Human
inherited metabolic disorder DOID:655 0 0.020
Human
organ system cancer DOID:0050686 0 0.014
disease of anatomical entity DOID:7 0 0.011