Danio rerio

79 known processes

casp8

caspase 8, apoptosis-related cysteine peptidase

(Aliases: caspase-8,MGC92075,zgc:92075)

casp8 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
signal transduction GO:0007165 455 0.216
Human Mouse
regulation of cell communication GO:0010646 232 0.203
Human Mouse
positive regulation of cellular process GO:0048522 201 0.171
regulation of signal transduction GO:0009966 225 0.169
Human Mouse
cellular nitrogen compound metabolic process GO:0034641 290 0.166
programmed cell death GO:0012501 119 0.160
cell migration GO:0016477 237 0.136
regulation of metabolic process GO:0019222 359 0.131
transcription dna templated GO:0006351 181 0.128
cellular macromolecule metabolic process GO:0044260 391 0.124
regulation of apoptotic process GO:0042981 98 0.123
cell death GO:0008219 121 0.120
rna biosynthetic process GO:0032774 181 0.118
regulation of cellular metabolic process GO:0031323 320 0.118
heterocycle metabolic process GO:0046483 290 0.116
apoptotic process GO:0006915 116 0.116
death GO:0016265 121 0.112
chordate embryonic development GO:0043009 271 0.108
single organism metabolic process GO:0044710 217 0.106
immune system process GO:0002376 241 0.103
protein metabolic process GO:0019538 183 0.103
response to other organism GO:0051707 97 0.102
regulation of nucleic acid templated transcription GO:1903506 213 0.101
response to organic substance GO:0010033 153 0.100
regulation of macromolecule metabolic process GO:0060255 317 0.100
heterocycle biosynthetic process GO:0018130 215 0.096
regulation of programmed cell death GO:0043067 101 0.095
regulation of signaling GO:0023051 235 0.094
Human Mouse
regulation of cell death GO:0010941 103 0.093
positive regulation of cell death GO:0010942 29 0.093
regulation of cellular biosynthetic process GO:0031326 245 0.089
response to chemical GO:0042221 320 0.089
cellular macromolecule biosynthetic process GO:0034645 224 0.088
nitrogen compound metabolic process GO:0006807 319 0.088
hematopoietic or lymphoid organ development GO:0048534 191 0.087
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.086
negative regulation of cellular process GO:0048523 283 0.085
Human Mouse
stem cell proliferation GO:0072089 4 0.084
positive regulation of biological process GO:0048518 253 0.084
regulation of transcription dna templated GO:0006355 213 0.083
regulation of biosynthetic process GO:0009889 250 0.083
response to external stimulus GO:0009605 264 0.081
cellular aromatic compound metabolic process GO:0006725 295 0.080
mitochondrion organization GO:0007005 4 0.080
cellular protein catabolic process GO:0044257 4 0.079
regulation of response to stimulus GO:0048583 269 0.079
Human Mouse
modification dependent macromolecule catabolic process GO:0043632 3 0.079
proteasomal protein catabolic process GO:0010498 2 0.079
hemopoiesis GO:0030097 183 0.079
gene expression GO:0010467 252 0.075
positive regulation of transport GO:0051050 2 0.075
regulation of nitrogen compound metabolic process GO:0051171 251 0.074
organic cyclic compound metabolic process GO:1901360 301 0.074
morphogenesis of an epithelium GO:0002009 333 0.074
nucleobase containing compound metabolic process GO:0006139 274 0.074
nuclear transport GO:0051169 4 0.074
cellular response to chemical stimulus GO:0070887 157 0.072
response to virus GO:0009615 21 0.072
extrinsic apoptotic signaling pathway GO:0097191 3 0.071
Human Mouse
ubiquitin dependent protein catabolic process GO:0006511 3 0.071
regulation of macromolecule biosynthetic process GO:0010556 225 0.071
cellular protein metabolic process GO:0044267 129 0.070
regulation of stem cell differentiation GO:2000736 4 0.066
heart morphogenesis GO:0003007 156 0.065
regulation of multicellular organismal process GO:0051239 277 0.065
neuron differentiation GO:0030182 353 0.064
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.063
tube morphogenesis GO:0035239 349 0.061
positive regulation of cytokine production GO:0001819 2 0.060
segmentation GO:0035282 97 0.060
positive regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043280 10 0.059
positive regulation of neuron death GO:1901216 1 0.059
single organism membrane fusion GO:0044801 2 0.059
cell surface receptor signaling pathway GO:0007166 325 0.059
Human Mouse
response to biotic stimulus GO:0009607 97 0.058
leukocyte proliferation GO:0070661 1 0.058
regulation of mitochondrion organization GO:0010821 1 0.057
brain development GO:0007420 293 0.057
regulation of cytokine production GO:0001817 3 0.057
regulation of cell shape GO:0008360 1 0.057
lipid storage GO:0019915 1 0.056
response to antibiotic GO:0046677 1 0.056
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.055
embryonic organ development GO:0048568 381 0.055
cell projection morphogenesis GO:0048858 244 0.055
heart development GO:0007507 313 0.055
positive regulation of neuron apoptotic process GO:0043525 1 0.054
cellular biosynthetic process GO:0044249 286 0.054
response to external biotic stimulus GO:0043207 97 0.054
regulation of rna metabolic process GO:0051252 224 0.053
signal transduction in absence of ligand GO:0038034 1 0.052
cellular nitrogen compound biosynthetic process GO:0044271 218 0.052
aging GO:0007568 2 0.052
regulation of rna biosynthetic process GO:2001141 213 0.052
negative regulation of cell death GO:0060548 60 0.052
Human Mouse
regulation of cell killing GO:0031341 2 0.052
intracellular signal transduction GO:0035556 85 0.052
positive regulation of programmed cell death GO:0043068 29 0.051
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.051
Human Mouse
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.051
secondary metabolic process GO:0019748 3 0.050
organic cyclic compound biosynthetic process GO:1901362 223 0.050
determination of left right symmetry GO:0007368 179 0.049
establishment of protein localization to organelle GO:0072594 4 0.049
regulation of gene expression GO:0010468 265 0.049
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.049
embryo development ending in birth or egg hatching GO:0009792 271 0.049
mitotic dna damage checkpoint GO:0044773 4 0.049
fertilization GO:0009566 3 0.049
modification dependent protein catabolic process GO:0019941 3 0.049
regulation of localization GO:0032879 104 0.048
Human
cell part morphogenesis GO:0032990 246 0.048
organic substance biosynthetic process GO:1901576 289 0.048
cell substrate adhesion GO:0031589 4 0.047
regulation of cysteine type endopeptidase activity GO:2000116 21 0.046
negative regulation of programmed cell death GO:0043069 58 0.046
Human Mouse
negative regulation of protein phosphorylation GO:0001933 4 0.046
generation of neurons GO:0048699 385 0.046
multi organism cellular process GO:0044764 2 0.046
localization of cell GO:0051674 244 0.045
phosphorus metabolic process GO:0006793 109 0.045
nuclear import GO:0051170 3 0.045
organelle fusion GO:0048284 3 0.045
single organism transport GO:0044765 206 0.044
Human
response to abiotic stimulus GO:0009628 122 0.044
cellular protein modification process GO:0006464 100 0.044
nucleocytoplasmic transport GO:0006913 4 0.044
gland development GO:0048732 143 0.044
membrane fusion GO:0061025 2 0.044
immune system development GO:0002520 191 0.044
somitogenesis GO:0001756 87 0.043
guanosine containing compound metabolic process GO:1901068 4 0.043
protein localization to nucleus GO:0034504 3 0.043
regulation of multicellular organismal development GO:2000026 223 0.043
nucleobase containing compound biosynthetic process GO:0034654 205 0.043
protein import into nucleus GO:0006606 3 0.043
cell projection organization GO:0030030 284 0.042
gtp catabolic process GO:0006184 2 0.042
protein polyubiquitination GO:0000209 4 0.042
response to lipid GO:0033993 60 0.042
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.042
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.042
cellular component morphogenesis GO:0032989 336 0.042
organonitrogen compound metabolic process GO:1901564 74 0.042
axon development GO:0061564 166 0.041
nucleic acid metabolic process GO:0090304 244 0.041
positive regulation of response to stimulus GO:0048584 80 0.040
Mouse
neuron projection morphogenesis GO:0048812 161 0.040
immune response GO:0006955 28 0.040
regionalization GO:0003002 274 0.040
determination of bilateral symmetry GO:0009855 204 0.040
phosphate containing compound metabolic process GO:0006796 108 0.040
cytokinesis GO:0000910 3 0.039
homeostatic process GO:0042592 142 0.039
positive regulation of stress activated mapk cascade GO:0032874 3 0.039
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.039
Human Mouse
viral process GO:0016032 1 0.039
rna metabolic process GO:0016070 219 0.038
negative regulation of biological process GO:0048519 304 0.038
Human Mouse
positive regulation of metabolic process GO:0009893 108 0.038
phosphorylation GO:0016310 69 0.038
response to stress GO:0006950 263 0.038
specification of symmetry GO:0009799 204 0.038
cellular amine metabolic process GO:0044106 2 0.038
nucleic acid templated transcription GO:0097659 181 0.037
regulation of primary metabolic process GO:0080090 311 0.036
positive regulation of macromolecule metabolic process GO:0010604 93 0.036
reactive oxygen species metabolic process GO:0072593 6 0.036
gtp metabolic process GO:0046039 4 0.036
axonogenesis GO:0007409 152 0.036
neuron development GO:0048666 262 0.036
positive regulation of cell cycle GO:0045787 3 0.035
regulation of biological quality GO:0065008 263 0.035
protein targeting to nucleus GO:0044744 3 0.035
response to amino acid GO:0043200 2 0.035
guanosine containing compound catabolic process GO:1901069 2 0.035
regulation of reactive oxygen species metabolic process GO:2000377 2 0.035
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.035
cellular response to stress GO:0033554 62 0.035
larval development GO:0002164 2 0.034
positive regulation of cell killing GO:0031343 2 0.034
leukocyte differentiation GO:0002521 25 0.034
phagocytosis GO:0006909 3 0.034
cell motility GO:0048870 244 0.034
regulation of peptidase activity GO:0052547 23 0.034
interspecies interaction between organisms GO:0044419 4 0.034
cellular amino acid metabolic process GO:0006520 7 0.034
actin filament based movement GO:0030048 1 0.033
protein modification process GO:0036211 100 0.033
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.033
vasculature development GO:0001944 278 0.033
developmental pigmentation GO:0048066 48 0.033
positive regulation of cellular metabolic process GO:0031325 94 0.033
macromolecule biosynthetic process GO:0009059 227 0.033
regulation of jak stat cascade GO:0046425 3 0.033
nik nf kappab signaling GO:0038061 1 0.033
regulation of intracellular signal transduction GO:1902531 57 0.033
somite development GO:0061053 96 0.033
neuron projection development GO:0031175 180 0.032
response to alkaloid GO:0043279 2 0.032
interaction with host GO:0051701 4 0.032
regulation of establishment of protein localization GO:0070201 4 0.032
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.032
single organism organelle organization GO:1902589 199 0.032
biosynthetic process GO:0009058 294 0.032
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.031
Human Mouse
regulation of gtp catabolic process GO:0033124 2 0.031
cellular component movement GO:0006928 335 0.031
aromatic compound biosynthetic process GO:0019438 217 0.031
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.031
killing of cells in other organism involved in symbiotic interaction GO:0051883 1 0.031
system process GO:0003008 185 0.031
single organism nuclear import GO:1902593 3 0.030
maintenance of location GO:0051235 4 0.030
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.030
erk1 and erk2 cascade GO:0070371 4 0.030
taxis GO:0042330 109 0.030
transcription from rna polymerase ii promoter GO:0006366 80 0.030
response to xenobiotic stimulus GO:0009410 45 0.030
amine metabolic process GO:0009308 2 0.030
cellular ketone metabolic process GO:0042180 11 0.030
regulation of protein catabolic process GO:0042176 1 0.030
regulation of production of molecular mediator of immune response GO:0002700 1 0.030
regulation of cell development GO:0060284 100 0.030
peptidyl serine phosphorylation GO:0018105 1 0.030
cellular response to organic substance GO:0071310 105 0.029
centrosome organization GO:0051297 1 0.029
centrosome cycle GO:0007098 1 0.029
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.029
multicellular organism growth GO:0035264 4 0.029
positive regulation of catabolic process GO:0009896 4 0.029
regulation of protein transport GO:0051223 3 0.029
cellular component biogenesis GO:0044085 178 0.029
adult behavior GO:0030534 2 0.028
regulation of phosphorus metabolic process GO:0051174 43 0.028
hormone transport GO:0009914 2 0.028
negative regulation of apoptotic process GO:0043066 55 0.028
Human Mouse
cell morphogenesis GO:0000902 289 0.028
membrane invagination GO:0010324 1 0.028
positive regulation of secretion GO:0051047 1 0.028
enzyme linked receptor protein signaling pathway GO:0007167 106 0.028
carboxylic acid metabolic process GO:0019752 22 0.028
regulation of multicellular organism growth GO:0040014 4 0.028
positive regulation of jnk cascade GO:0046330 3 0.028
response to oxygen containing compound GO:1901700 55 0.028
regulation of cytoplasmic transport GO:1903649 4 0.027
negative chemotaxis GO:0050919 1 0.027
regulation of blood vessel size GO:0050880 2 0.027
innate immune response GO:0045087 13 0.027
single organism localization GO:1902578 225 0.027
Human
myeloid cell differentiation GO:0030099 86 0.027
head development GO:0060322 303 0.027
embryonic heart tube morphogenesis GO:0003143 108 0.027
cellular response to endogenous stimulus GO:0071495 68 0.027
meiotic nuclear division GO:0007126 4 0.027
regulation of protein import into nucleus GO:0042306 2 0.027
positive regulation of map kinase activity GO:0043406 3 0.026
zymogen activation GO:0031638 3 0.026
regulation of protein metabolic process GO:0051246 56 0.026
cell migration involved in gastrulation GO:0042074 79 0.026
regulation of cellular amino acid metabolic process GO:0006521 0 0.026
cellular response to decreased oxygen levels GO:0036294 1 0.026
p38mapk cascade GO:0038066 1 0.026
phagocytosis engulfment GO:0006911 1 0.026
b cell activation GO:0042113 2 0.026
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.026
regulation of cellular protein catabolic process GO:1903362 1 0.026
anterior posterior pattern specification GO:0009952 152 0.025
locomotion GO:0040011 313 0.025
positive regulation of signal transduction GO:0009967 56 0.025
Mouse
regulation of cellular amine metabolic process GO:0033238 0 0.025
cellular response to growth factor stimulus GO:0071363 39 0.025
positive regulation of secretion by cell GO:1903532 1 0.025
mitotic dna integrity checkpoint GO:0044774 4 0.024
regulation of cell differentiation GO:0045595 142 0.024
regulation of tube size GO:0035150 2 0.024
reactive nitrogen species metabolic process GO:2001057 0 0.024
antimicrobial humoral response GO:0019730 2 0.024
hormone secretion GO:0046879 2 0.024
cellular response to dna damage stimulus GO:0006974 24 0.024
regulation of protein localization to nucleus GO:1900180 2 0.024
motor neuron axon guidance GO:0008045 23 0.024
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.024
negative regulation of mitosis GO:0045839 3 0.024
production of molecular mediator of immune response GO:0002440 2 0.024
stem cell maintenance GO:0019827 4 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.024
actin cytoskeleton organization GO:0030036 63 0.024
stem cell division GO:0017145 1 0.023
cortical actin cytoskeleton organization GO:0030866 1 0.023
regulation of nucleotide catabolic process GO:0030811 2 0.023
regulation of cell projection assembly GO:0060491 4 0.023
protein localization to plasma membrane GO:0072659 1 0.023
small molecule metabolic process GO:0044281 77 0.023
embryonic organ morphogenesis GO:0048562 274 0.023
positive regulation of apoptotic signaling pathway GO:2001235 1 0.023
Mouse
regulation of phosphorylation GO:0042325 26 0.023
regulation of developmental process GO:0050793 247 0.023
regulation of stem cell proliferation GO:0072091 2 0.022
cellular carbohydrate metabolic process GO:0044262 4 0.022
glucose homeostasis GO:0042593 1 0.022
regulation of protein targeting GO:1903533 2 0.022
regulation of heart growth GO:0060420 2 0.022
cell matrix adhesion GO:0007160 4 0.022
response to glucocorticoid GO:0051384 1 0.022
ear development GO:0043583 127 0.022
pigment cell differentiation GO:0050931 38 0.022
oxoacid metabolic process GO:0043436 31 0.022
pigmentation GO:0043473 85 0.021
cell proliferation GO:0008283 80 0.021
central nervous system development GO:0007417 387 0.021
response to bacterium GO:0009617 58 0.021
positive regulation of protein complex assembly GO:0031334 2 0.021
cellular lipid metabolic process GO:0044255 36 0.021
proteolysis GO:0006508 38 0.021
regulation of system process GO:0044057 40 0.021
response to hormone GO:0009725 48 0.021
protein import GO:0017038 3 0.021
positive regulation of cell adhesion GO:0045785 1 0.021
cellular response to radiation GO:0071478 4 0.021
defense response to other organism GO:0098542 33 0.021
actomyosin structure organization GO:0031032 53 0.021
regulation of anatomical structure morphogenesis GO:0022603 130 0.020
microtubule organizing center organization GO:0031023 1 0.020
regulation of cellular protein metabolic process GO:0032268 52 0.020
negative regulation of protein kinase activity GO:0006469 4 0.020
embryonic skeletal system morphogenesis GO:0048704 93 0.020
regulation of hormone secretion GO:0046883 2 0.020
cellular response to hormone stimulus GO:0032870 39 0.020
regulation of blood pressure GO:0008217 1 0.020
ovulation cycle GO:0042698 2 0.020
blood circulation GO:0008015 87 0.020
neurological system process GO:0050877 62 0.020
convergent extension GO:0060026 118 0.020
macromolecule modification GO:0043412 111 0.020
carbohydrate homeostasis GO:0033500 1 0.020
regulation of molecular function GO:0065009 70 0.020
positive regulation of signaling GO:0023056 56 0.020
Mouse
peptidyl serine modification GO:0018209 2 0.020
cognition GO:0050890 1 0.020
macromolecule localization GO:0033036 54 0.020
regulation of response to stress GO:0080134 36 0.020
regulation of cellular ketone metabolic process GO:0010565 7 0.020
embryonic skeletal system development GO:0048706 97 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.019
positive regulation of apoptotic process GO:0043065 29 0.019
response to drug GO:0042493 3 0.019
single fertilization GO:0007338 3 0.019
regulation of protein complex assembly GO:0043254 3 0.019
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.019
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.019
regulation of response to cytokine stimulus GO:0060759 3 0.019
establishment of protein localization to plasma membrane GO:0090002 1 0.019
establishment of localization GO:0051234 244 0.019
Human
protein secretion GO:0009306 1 0.019
embryonic limb morphogenesis GO:0030326 2 0.019
cell death in response to oxidative stress GO:0036473 2 0.019
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.019
Mouse
cellular component disassembly GO:0022411 1 0.019
regulation of intracellular protein transport GO:0033157 3 0.019
i kappab kinase nf kappab signaling GO:0007249 4 0.019
response to organic cyclic compound GO:0014070 51 0.019
inner ear development GO:0048839 126 0.019
melanin metabolic process GO:0006582 2 0.019
g1 s transition of mitotic cell cycle GO:0000082 1 0.018
negative regulation of hormone secretion GO:0046888 2 0.018
cellular response to external stimulus GO:0071496 2 0.018
neurotransmitter transport GO:0006836 2 0.018
regulation of cellular component organization GO:0051128 86 0.018
regulation of organ growth GO:0046620 3 0.018
regulation of filopodium assembly GO:0051489 2 0.018
response to endogenous stimulus GO:0009719 83 0.018
negative regulation of epithelial cell proliferation GO:0050680 1 0.018
post embryonic organ development GO:0048569 4 0.018
regulation of nucleoside metabolic process GO:0009118 2 0.018
regulation of gtpase activity GO:0043087 2 0.018
regulation of locomotion GO:0040012 55 0.018
regulation of axonogenesis GO:0050770 32 0.017
positive regulation of immune effector process GO:0002699 3 0.017
cell substrate junction assembly GO:0007044 2 0.017
convergent extension involved in gastrulation GO:0060027 71 0.017
regulation of reproductive process GO:2000241 4 0.017
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.017
positive regulation of epithelial cell migration GO:0010634 2 0.017
positive regulation of cell activation GO:0050867 1 0.017
positive regulation of cell communication GO:0010647 56 0.017
Mouse
defense response GO:0006952 47 0.017
development of primary female sexual characteristics GO:0046545 4 0.017
digestive system development GO:0055123 289 0.017
striated muscle cell differentiation GO:0051146 129 0.017
protein complex subunit organization GO:0071822 46 0.017
organic acid metabolic process GO:0006082 31 0.017
hepaticobiliary system development GO:0061008 98 0.017
circulatory system process GO:0003013 87 0.017
female sex differentiation GO:0046660 4 0.017
positive regulation of molecular function GO:0044093 33 0.017
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.017
negative regulation of kinase activity GO:0033673 4 0.016
lipid metabolic process GO:0006629 52 0.016
neuroblast proliferation GO:0007405 2 0.016
cellular response to hypoxia GO:0071456 1 0.016
homeostasis of number of cells GO:0048872 62 0.016
cellular component assembly GO:0022607 170 0.016
positive regulation of cellular protein metabolic process GO:0032270 22 0.016
regulation of epithelial cell proliferation GO:0050678 3 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
regulation of immune system process GO:0002682 34 0.016
negative regulation of cell communication GO:0010648 96 0.016
Human Mouse
mononuclear cell proliferation GO:0032943 1 0.016
embryonic cranial skeleton morphogenesis GO:0048701 90 0.016
response to mechanical stimulus GO:0009612 24 0.016
positive regulation of hydrolase activity GO:0051345 13 0.015
regulation of receptor activity GO:0010469 2 0.015
mitochondrial transport GO:0006839 2 0.015
regulation of cellular component movement GO:0051270 55 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
positive regulation of gtpase activity GO:0043547 1 0.015
multi organism process GO:0051704 134 0.015
digestive tract morphogenesis GO:0048546 231 0.015
cellular response to biotic stimulus GO:0071216 3 0.015
cytokine mediated signaling pathway GO:0019221 7 0.015
dorsal ventral pattern formation GO:0009953 125 0.015
negative regulation of neuron projection regeneration GO:0070571 4 0.015
notochord development GO:0030903 54 0.015
compound eye development GO:0048749 2 0.015
apoptotic process involved in development GO:1902742 2 0.015
leukocyte homeostasis GO:0001776 2 0.015
negative regulation of response to dna damage stimulus GO:2001021 3 0.015
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.015
synaptic vesicle localization GO:0097479 1 0.015
negative regulation of signal transduction by p53 class mediator GO:1901797 8 0.015
macromolecular complex subunit organization GO:0043933 74 0.015
lymphocyte proliferation GO:0046651 1 0.015
kidney development GO:0001822 92 0.015
transport GO:0006810 220 0.015
Human
chemotaxis GO:0006935 104 0.014
epithelial cell morphogenesis GO:0003382 2 0.014
cell cycle g1 s phase transition GO:0044843 1 0.014
response to corticosteroid GO:0031960 1 0.014
regulation of establishment of protein localization to plasma membrane GO:0090003 1 0.014
embryonic heart tube development GO:0035050 133 0.014
protein localization GO:0008104 40 0.014
lamellipodium assembly GO:0030032 1 0.014
protein homooligomerization GO:0051260 3 0.014
cellular response to extracellular stimulus GO:0031668 2 0.014
keratinocyte differentiation GO:0030216 0 0.014
axon guidance GO:0007411 86 0.014
endocrine process GO:0050886 2 0.014
regulation of cell morphogenesis GO:0022604 42 0.014
b cell differentiation GO:0030183 1 0.014
response to fluid shear stress GO:0034405 2 0.014
regulation of cell activation GO:0050865 1 0.014
skeletal system development GO:0001501 181 0.014
positive regulation of leukocyte differentiation GO:1902107 1 0.014
regulation of cell substrate adhesion GO:0010810 1 0.013
regulation of proteolysis GO:0030162 24 0.013
er nucleus signaling pathway GO:0006984 2 0.013
regulation of glucose import GO:0046324 1 0.013
Human
regulation of metal ion transport GO:0010959 4 0.013
epithelial tube morphogenesis GO:0060562 148 0.013
osteoclast development GO:0036035 1 0.013
regulation of protein binding GO:0043393 3 0.013
osteoclast differentiation GO:0030316 1 0.013
cellular response to oxygen levels GO:0071453 1 0.013
exocytosis GO:0006887 1 0.013
response to decreased oxygen levels GO:0036293 25 0.013
endocrine system development GO:0035270 65 0.013
lipid homeostasis GO:0055088 3 0.013
cellular localization GO:0051641 97 0.013
regulation of cytokine mediated signaling pathway GO:0001959 3 0.013
positive regulation of wound healing GO:0090303 1 0.013
positive regulation of endothelial cell migration GO:0010595 2 0.013
steroid hormone secretion GO:0035929 1 0.013
appendage development GO:0048736 80 0.013
negative regulation of signaling GO:0023057 96 0.013
Human Mouse
regulation of protein localization to plasma membrane GO:1903076 1 0.013
lymphocyte homeostasis GO:0002260 1 0.013
leukocyte chemotaxis GO:0030595 12 0.013
cellular response to lipid GO:0071396 39 0.013
extracellular structure organization GO:0043062 27 0.013
response to nutrient GO:0007584 3 0.013
positive regulation of lipid metabolic process GO:0045834 1 0.013
response to uv GO:0009411 3 0.013
regulation of defense response to virus by host GO:0050691 1 0.013
cell morphogenesis involved in differentiation GO:0000904 195 0.013
positive regulation of inflammatory response GO:0050729 1 0.013

casp8 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.048
immune system disease DOID:2914 0 0.022
nervous system disease DOID:863 0 0.020
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.019
hematopoietic system disease DOID:74 0 0.018
disease of metabolism DOID:0014667 0 0.014
inherited metabolic disorder DOID:655 0 0.014