Danio rerio

37 known processes

her4.2

hairy-related 4.2

(Aliases: her4.1,si:ch73-21g5.3,HER-4,zgc:55218,MGC113913,her4)

her4.2 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
negative regulation of gliogenesis GO:0014014 1 0.956
Mouse
neuron differentiation GO:0030182 353 0.938
axonogenesis GO:0007409 152 0.852
neuron development GO:0048666 262 0.812
neuron projection development GO:0031175 180 0.726
cell morphogenesis involved in differentiation GO:0000904 195 0.648
neuron projection guidance GO:0097485 86 0.640
inner ear receptor cell differentiation GO:0060113 29 0.636
Mouse
cellular component morphogenesis GO:0032989 336 0.621
regulation of glial cell differentiation GO:0045685 4 0.604
Mouse
regulation of mechanoreceptor differentiation GO:0045631 1 0.603
Mouse
axon development GO:0061564 166 0.601
cell part morphogenesis GO:0032990 246 0.529
neural tube development GO:0021915 62 0.510
Zebrafish Mouse
generation of neurons GO:0048699 385 0.471
neuron projection morphogenesis GO:0048812 161 0.471
cell morphogenesis GO:0000902 289 0.469
cell projection organization GO:0030030 284 0.457
chemotaxis GO:0006935 104 0.437
response to chemical GO:0042221 320 0.435
rostrocaudal neural tube patterning GO:0021903 29 0.434
Zebrafish
neural precursor cell proliferation GO:0061351 20 0.404
Fly
larval development GO:0002164 2 0.396
stem cell proliferation GO:0072089 4 0.389
Fly
regulation of neural precursor cell proliferation GO:2000177 3 0.369
Fly
mechanoreceptor differentiation GO:0042490 37 0.360
Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.358
nucleic acid metabolic process GO:0090304 244 0.329
Zebrafish Mouse Rat Fly
endothelial cell fate commitment GO:0060839 3 0.296
cellular component movement GO:0006928 335 0.295
positive regulation of neural precursor cell proliferation GO:2000179 1 0.291
Fly
auditory receptor cell fate commitment GO:0009912 4 0.281
Mouse
positive regulation of cell cycle GO:0045787 3 0.277
Zebrafish
regulation of synaptic plasticity GO:0048167 1 0.275
gliogenesis GO:0042063 45 0.271
Zebrafish Mouse Rat
cell projection morphogenesis GO:0048858 244 0.266
embryo development ending in birth or egg hatching GO:0009792 271 0.235
Zebrafish Mouse
cell proliferation in forebrain GO:0021846 3 0.234
camera type eye development GO:0043010 222 0.231
Mouse
somite specification GO:0001757 12 0.225
Zebrafish
inner ear receptor cell fate commitment GO:0060120 4 0.223
Mouse
blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:0002043 4 0.220
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.217
Zebrafish
locomotion GO:0040011 313 0.214
Fly
midbrain hindbrain boundary development GO:0030917 23 0.213
Zebrafish
epithelial cell differentiation GO:0030855 116 0.208
Mouse Worm
sensory organ development GO:0007423 393 0.205
Zebrafish Mouse Fly
cellular aromatic compound metabolic process GO:0006725 295 0.201
Zebrafish Mouse Rat Fly
astrocyte differentiation GO:0048708 1 0.195
Mouse
patterning of lymph vessels GO:0060854 1 0.195
cellular macromolecule metabolic process GO:0044260 391 0.190
Zebrafish Mouse Rat Fly
chordate embryonic development GO:0043009 271 0.189
Zebrafish Mouse
lymph vessel development GO:0001945 27 0.180
response to stress GO:0006950 263 0.179
Fly
taxis GO:0042330 109 0.176
cellular biosynthetic process GO:0044249 286 0.175
Zebrafish Mouse Rat Fly
regulation of cell differentiation GO:0045595 142 0.173
Human Zebrafish Mouse Rat Fly
regulation of inner ear receptor cell differentiation GO:2000980 1 0.173
Mouse
inner ear receptor cell development GO:0060119 20 0.171
neuron fate determination GO:0048664 2 0.170
Mouse
glial cell migration GO:0008347 3 0.170
hair cell differentiation GO:0035315 32 0.169
Mouse
regulation of cellular metabolic process GO:0031323 320 0.165
Zebrafish Mouse Rat Fly
regulation of neurogenesis GO:0050767 87 0.165
Zebrafish Mouse Rat Fly
connective tissue development GO:0061448 99 0.159
Human Mouse
gastrulation GO:0007369 208 0.159
regulation of multicellular organismal process GO:0051239 277 0.157
Zebrafish Mouse Rat Fly
glial cell differentiation GO:0010001 42 0.153
Mouse Rat
axon guidance GO:0007411 86 0.153
central nervous system neuron differentiation GO:0021953 74 0.151
Rat
neural tube patterning GO:0021532 33 0.149
Zebrafish
lipid storage GO:0019915 1 0.148
hypochord development GO:0055016 3 0.147
forebrain development GO:0030900 96 0.146
Zebrafish Mouse Rat
negative regulation of blood vessel endothelial cell migration GO:0043537 1 0.144
response to external stimulus GO:0009605 264 0.144
Fly
eye development GO:0001654 277 0.143
Zebrafish Mouse Fly
regulation of metabolic process GO:0019222 359 0.141
Zebrafish Mouse Rat Worm Fly
regulation of cell development GO:0060284 100 0.141
Zebrafish Mouse Rat Fly
venous endothelial cell migration involved in lymph vessel development GO:0060855 4 0.141
system process GO:0003008 185 0.139
Mouse Fly
peripheral nervous system neuron differentiation GO:0048934 28 0.137
organic substance biosynthetic process GO:1901576 289 0.137
Zebrafish Mouse Rat Fly
cilium morphogenesis GO:0060271 85 0.131
camera type eye morphogenesis GO:0048593 108 0.126
oligodendrocyte differentiation GO:0048709 23 0.123
Mouse
positive regulation of notch signaling pathway GO:0045747 3 0.122
Mouse
dicarboxylic acid transport GO:0006835 1 0.120
regulation of stem cell proliferation GO:0072091 2 0.117
Fly
regulation of rna biosynthetic process GO:2001141 213 0.116
Zebrafish Mouse Rat Fly
cellular response to chemical stimulus GO:0070887 157 0.115
central nervous system development GO:0007417 387 0.115
Zebrafish Mouse Rat Fly
diencephalon development GO:0021536 58 0.114
Zebrafish
regulation of signaling GO:0023051 235 0.112
Mouse
neuron neuron synaptic transmission GO:0007270 1 0.111
skeletal system development GO:0001501 181 0.110
Human Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.109
Zebrafish Mouse Rat Fly
cellular ketone metabolic process GO:0042180 11 0.105
heterocycle biosynthetic process GO:0018130 215 0.103
Zebrafish Mouse Rat Fly
negative regulation of cellular process GO:0048523 283 0.101
Human Zebrafish Mouse Rat Fly
synaptic transmission GO:0007268 35 0.099
regulation of nucleic acid templated transcription GO:1903506 213 0.097
Zebrafish Mouse Rat Fly
regulation of oligodendrocyte differentiation GO:0048713 1 0.097
Mouse
behavior GO:0007610 74 0.096
Fly
rna biosynthetic process GO:0032774 181 0.096
Zebrafish Mouse Rat Fly
regulation of cell communication GO:0010646 232 0.096
Mouse
positive regulation of stem cell proliferation GO:2000648 1 0.094
Fly
retina development in camera type eye GO:0060041 146 0.092
brain development GO:0007420 293 0.091
Zebrafish Mouse Rat Fly
regionalization GO:0003002 274 0.090
Zebrafish Mouse Worm Fly
negative regulation of neurogenesis GO:0050768 20 0.089
Zebrafish Mouse Rat
epithelial cell development GO:0002064 42 0.089
regulation of nervous system development GO:0051960 90 0.087
Zebrafish Mouse Rat Fly
regulation of neuron projection development GO:0010975 40 0.086
regulation of cellular ketone metabolic process GO:0010565 7 0.084
aromatic compound biosynthetic process GO:0019438 217 0.084
Zebrafish Mouse Rat Fly
cellular nitrogen compound biosynthetic process GO:0044271 218 0.083
Zebrafish Mouse Rat Fly
compound eye development GO:0048749 2 0.083
Fly
muscle tissue development GO:0060537 110 0.082
embryonic organ morphogenesis GO:0048562 274 0.081
Zebrafish
stem cell maintenance GO:0019827 4 0.081
Human Mouse Rat
regulation of dendrite morphogenesis GO:0048814 3 0.081
regulation of fatty acid metabolic process GO:0019217 1 0.081
digestive tract morphogenesis GO:0048546 231 0.079
central nervous system neuron development GO:0021954 29 0.079
transcription from rna polymerase ii promoter GO:0006366 80 0.078
Mouse Rat Fly
maintenance of location GO:0051235 4 0.078
neuron fate commitment GO:0048663 26 0.077
Mouse
response to drug GO:0042493 3 0.075
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.073
Mouse Rat Fly
regulation of tyrosine phosphorylation of stat3 protein GO:0042516 1 0.072
Mouse
ear development GO:0043583 127 0.072
Mouse
cell fate specification GO:0001708 68 0.071
Worm
rna metabolic process GO:0016070 219 0.070
Zebrafish Mouse Rat Fly
cellular response to organic substance GO:0071310 105 0.070
aorta morphogenesis GO:0035909 3 0.069
neuroblast proliferation GO:0007405 2 0.069
Fly
lymphatic endothelial cell differentiation GO:0060836 1 0.069
negative regulation of endothelial cell migration GO:0010596 1 0.068
somitogenesis GO:0001756 87 0.065
Zebrafish
positive regulation of jak stat cascade GO:0046427 2 0.064
Mouse
peripheral nervous system neuron axonogenesis GO:0048936 13 0.064
regulation of response to stimulus GO:0048583 269 0.064
Mouse Fly
positive regulation of biological process GO:0048518 253 0.063
Human Zebrafish Mouse Fly
stem cell development GO:0048864 82 0.063
Human Mouse Rat
glucose homeostasis GO:0042593 1 0.063
lateral line development GO:0048882 66 0.063
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.062
Zebrafish Mouse Rat Fly
embryonic organ development GO:0048568 381 0.062
Zebrafish
negative regulation of multicellular organismal process GO:0051241 69 0.061
Zebrafish Mouse Rat
regulation of tyrosine phosphorylation of stat protein GO:0042509 1 0.061
Mouse
negative regulation of cell differentiation GO:0045596 46 0.060
Human Zebrafish Mouse Rat
positive regulation of cell proliferation GO:0008284 15 0.058
Human Fly
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.057
Mouse
response to wounding GO:0009611 116 0.057
ventral spinal cord interneuron fate commitment GO:0060579 3 0.057
sensory organ morphogenesis GO:0090596 200 0.057
Fly
nucleobase containing compound metabolic process GO:0006139 274 0.057
Zebrafish Mouse Rat Fly
negative regulation of neuron differentiation GO:0045665 10 0.056
Mouse Rat
positive regulation of nervous system development GO:0051962 25 0.055
Fly
central nervous system neuron axonogenesis GO:0021955 18 0.054
mammillary body development GO:0021767 4 0.053
neuroblast fate commitment GO:0014017 1 0.053
aorta development GO:0035904 4 0.052
cell fate commitment GO:0045165 99 0.052
Mouse Worm Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.052
Mouse
organic cyclic compound biosynthetic process GO:1901362 223 0.051
Zebrafish Mouse Rat Fly
positive regulation of cell differentiation GO:0045597 30 0.051
Fly
dopaminergic neuron differentiation GO:0071542 14 0.050
organic acid metabolic process GO:0006082 31 0.049
morphogenesis of an epithelium GO:0002009 333 0.049
Mouse
negative regulation of developmental process GO:0051093 65 0.049
Human Zebrafish Mouse Rat
cell motility GO:0048870 244 0.049
auditory receptor cell fate determination GO:0042668 2 0.048
Mouse
regulation of developmental process GO:0050793 247 0.048
Human Zebrafish Mouse Rat Fly
somite development GO:0061053 96 0.048
Zebrafish
tyrosine phosphorylation of stat protein GO:0007260 1 0.047
Mouse
lymph vessel morphogenesis GO:0036303 25 0.047
lymphatic endothelial cell fate commitment GO:0060838 1 0.046
transcription dna templated GO:0006351 181 0.046
Zebrafish Mouse Rat Fly
epidermal cell fate specification GO:0009957 4 0.046
Worm
determination of bilateral symmetry GO:0009855 204 0.046
regulation of biosynthetic process GO:0009889 250 0.045
Zebrafish Mouse Rat Fly
neuromast development GO:0048884 46 0.045
regulation of dendrite development GO:0050773 3 0.045
lymphangiogenesis GO:0001946 25 0.044
phosphate containing compound metabolic process GO:0006796 108 0.044
Zebrafish Mouse
multicellular organismal response to stress GO:0033555 2 0.043
response to endogenous stimulus GO:0009719 83 0.043
neuronal stem cell maintenance GO:0097150 2 0.043
Human Mouse Rat
neuroblast fate determination GO:0007400 1 0.043
paraxial mesoderm development GO:0048339 8 0.043
cartilage development GO:0051216 96 0.043
Human Mouse
specification of symmetry GO:0009799 204 0.042
skin development GO:0043588 54 0.041
Mouse Worm
positive regulation of developmental process GO:0051094 50 0.041
Fly
startle response GO:0001964 4 0.041
Fly
negative regulation of cell development GO:0010721 26 0.041
Zebrafish Mouse Rat
mesenchymal cell differentiation GO:0048762 87 0.041
regulation of cellular response to growth factor stimulus GO:0090287 35 0.040
ameboidal type cell migration GO:0001667 143 0.040
ventral spinal cord development GO:0021517 35 0.039
heterocycle metabolic process GO:0046483 290 0.039
Zebrafish Mouse Rat Fly
abducens nucleus development GO:0021742 2 0.039
organic cyclic compound metabolic process GO:1901360 301 0.039
Zebrafish Mouse Rat Fly
small molecule metabolic process GO:0044281 77 0.039
negative regulation of epithelial cell migration GO:0010633 1 0.039
regulation of stem cell differentiation GO:2000736 4 0.038
Human
locomotory behavior GO:0007626 34 0.038
Fly
determination of pancreatic left right asymmetry GO:0035469 11 0.038
blood vessel development GO:0001568 246 0.038
regulation of gliogenesis GO:0014013 6 0.038
Mouse
cell proliferation GO:0008283 80 0.038
Human Fly
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.037
Zebrafish Mouse Rat Fly
lateral inhibition GO:0046331 1 0.037
cellular amine metabolic process GO:0044106 2 0.037
regulation of gene expression GO:0010468 265 0.037
Zebrafish Mouse Rat Worm Fly
negative regulation of cytokine production GO:0001818 1 0.037
neuron migration GO:0001764 22 0.036
cellular response to extracellular stimulus GO:0031668 2 0.036
brain morphogenesis GO:0048854 18 0.036
Fly
cell migration GO:0016477 237 0.036
digestive system development GO:0055123 289 0.036
positive regulation of cellular biosynthetic process GO:0031328 68 0.036
Mouse
eye morphogenesis GO:0048592 144 0.036
Fly
aging GO:0007568 2 0.035
mitotic dna damage checkpoint GO:0044773 4 0.035
carbohydrate homeostasis GO:0033500 1 0.035
negative regulation of biological process GO:0048519 304 0.035
Human Zebrafish Mouse Rat Worm Fly
response to abiotic stimulus GO:0009628 122 0.034
epithelial cell fate commitment GO:0072148 11 0.034
Mouse
positive regulation of gene expression GO:0010628 71 0.034
Mouse
negative regulation of nervous system development GO:0051961 22 0.033
Zebrafish Mouse Rat
transcription from rna polymerase iii promoter GO:0006383 1 0.033
tyrosine phosphorylation of stat3 protein GO:0042503 1 0.033
Mouse
establishment of localization GO:0051234 244 0.032
nitrogen compound metabolic process GO:0006807 319 0.032
Zebrafish Mouse Rat Fly
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.032
epithelial cell migration GO:0010631 25 0.032
cell proliferation in midbrain GO:0033278 4 0.031
amine metabolic process GO:0009308 2 0.031
regulation of binding GO:0051098 3 0.031
cell cycle arrest GO:0007050 1 0.031
regulation of jak stat cascade GO:0046425 3 0.030
Mouse
regulation of chemotaxis GO:0050920 18 0.030
midbrain development GO:0030901 28 0.030
regulation of cell motility GO:2000145 46 0.030
spinal cord development GO:0021510 46 0.030
liver development GO:0001889 96 0.030
limbic system development GO:0021761 16 0.030
regulation of embryonic development GO:0045995 47 0.029
telencephalon development GO:0021537 14 0.029
Mouse
regulation of macromolecule metabolic process GO:0060255 317 0.029
Zebrafish Mouse Rat Worm Fly
blood vessel morphogenesis GO:0048514 216 0.029
response to organic substance GO:0010033 153 0.029
regulation of nitrogen compound metabolic process GO:0051171 251 0.029
Zebrafish Mouse Rat Fly
regulation of cell migration GO:0030334 40 0.029
regulation of primary metabolic process GO:0080090 311 0.029
Zebrafish Mouse Rat Fly
nucleic acid templated transcription GO:0097659 181 0.029
Zebrafish Mouse Rat Fly
anterior commissure morphogenesis GO:0021960 3 0.029
localization of cell GO:0051674 244 0.029
nuclear import GO:0051170 3 0.028
cellular nitrogen compound metabolic process GO:0034641 290 0.028
Zebrafish Mouse Rat Fly
muscle structure development GO:0061061 196 0.028
cellular component biogenesis GO:0044085 178 0.028
Mouse
carboxylic acid metabolic process GO:0019752 22 0.028
antimicrobial humoral response GO:0019730 2 0.028
negative regulation of stem cell differentiation GO:2000737 2 0.027
Human
positive regulation of cell communication GO:0010647 56 0.027
Mouse
dorsal ventral pattern formation GO:0009953 125 0.027
Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.027
Zebrafish Mouse Rat Fly
cellular amino acid metabolic process GO:0006520 7 0.027
stem cell differentiation GO:0048863 117 0.027
Human Mouse Rat
epidermal cell differentiation GO:0009913 36 0.027
Mouse Worm
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.027
Zebrafish Mouse Rat Fly
positive regulation of cellular metabolic process GO:0031325 94 0.027
Zebrafish Mouse
positive regulation of neurogenesis GO:0050769 24 0.027
Fly
multi organism process GO:0051704 134 0.027
sensory perception GO:0007600 39 0.027
cell surface receptor signaling pathway GO:0007166 325 0.027
Human Zebrafish Mouse
phenol containing compound biosynthetic process GO:0046189 4 0.026
stem cell fate determination GO:0048867 1 0.026
skeletal muscle organ development GO:0060538 78 0.026
dorsal aorta development GO:0035907 4 0.026
embryonic skeletal system development GO:0048706 97 0.026
positive regulation of multicellular organismal process GO:0051240 52 0.026
Fly
regulation of cellular component movement GO:0051270 55 0.026
anterior posterior pattern specification GO:0009952 152 0.026
Zebrafish Worm
membrane fusion GO:0061025 2 0.025
negative regulation of rna biosynthetic process GO:1902679 45 0.025
Zebrafish Mouse Rat Fly
kupffer s vesicle development GO:0070121 50 0.025
regulation of cellular amine metabolic process GO:0033238 0 0.025
negative regulation of transcription dna templated GO:0045892 45 0.025
Zebrafish Mouse Rat Fly
cellular response to external stimulus GO:0071496 2 0.025
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.025
glial cell development GO:0021782 20 0.025
Mouse
tissue regeneration GO:0042246 74 0.025
gene expression GO:0010467 252 0.024
Zebrafish Mouse Rat Worm Fly
head development GO:0060322 303 0.024
Zebrafish Mouse Rat Fly
regulation of anatomical structure morphogenesis GO:0022603 130 0.024
multicellular organism growth GO:0035264 4 0.024
regulation of neuron differentiation GO:0045664 56 0.024
Zebrafish Mouse Rat
regulation of blood vessel endothelial cell migration GO:0043535 5 0.024
negative regulation of protein phosphorylation GO:0001933 4 0.023
regulation of protein phosphorylation GO:0001932 18 0.023
Zebrafish Mouse
response to fibroblast growth factor GO:0071774 22 0.023
negative regulation of cellular biosynthetic process GO:0031327 55 0.023
Zebrafish Mouse Rat Fly
mesenchymal cell development GO:0014031 78 0.023
positive regulation of transport GO:0051050 2 0.023
adult behavior GO:0030534 2 0.023
forebrain cell migration GO:0021885 1 0.023
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.023
cellular response to growth factor stimulus GO:0071363 39 0.023
epidermis development GO:0008544 48 0.022
Mouse Worm
sensory system development GO:0048880 76 0.022
ventricular system development GO:0021591 12 0.022
heart morphogenesis GO:0003007 156 0.022
neuron fate specification GO:0048665 20 0.022
ear morphogenesis GO:0042471 64 0.022
forebrain neuron fate commitment GO:0021877 1 0.022
endocrine pancreas development GO:0031018 27 0.022
cell proliferation in hindbrain GO:0021534 4 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
forebrain anterior posterior pattern specification GO:0021797 3 0.022
neuron projection regeneration GO:0031102 16 0.022
segmentation GO:0035282 97 0.022
Zebrafish Mouse
cell cell signaling GO:0007267 52 0.022
cellular response to stress GO:0033554 62 0.021
Fly
neuroblast differentiation GO:0014016 1 0.021
response to other organism GO:0051707 97 0.021
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.021
negative regulation of rna metabolic process GO:0051253 48 0.021
Zebrafish Mouse Rat Fly
protein import into nucleus GO:0006606 3 0.021
auditory receptor cell differentiation GO:0042491 15 0.021
Mouse
regulation of protein localization to nucleus GO:1900180 2 0.021
negative regulation of cell communication GO:0010648 96 0.021
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.020
phosphorus metabolic process GO:0006793 109 0.020
Zebrafish Mouse
protein dephosphorylation GO:0006470 3 0.020
immune system process GO:0002376 241 0.020
Rat
hepaticobiliary system development GO:0061008 98 0.020
positive regulation of translation GO:0045727 1 0.020
forebrain midbrain boundary formation GO:0021905 1 0.020
tube morphogenesis GO:0035239 349 0.020
Mouse
cell differentiation in spinal cord GO:0021515 40 0.020
photoreceptor cell differentiation GO:0046530 55 0.019
Fly
photoreceptor cell fate commitment GO:0046552 1 0.019
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.019
regeneration GO:0031099 91 0.019
inner ear morphogenesis GO:0042472 63 0.019
peripheral nervous system neuron development GO:0048935 22 0.019
spinal cord motor neuron differentiation GO:0021522 26 0.019
vasculature development GO:0001944 278 0.019
arterial endothelial cell differentiation GO:0060842 2 0.018
positive regulation of gliogenesis GO:0014015 2 0.018
cellular protein modification process GO:0006464 100 0.018
Zebrafish Mouse
organonitrogen compound metabolic process GO:1901564 74 0.018
cellular response to endogenous stimulus GO:0071495 68 0.018
cellular macromolecule biosynthetic process GO:0034645 224 0.018
Zebrafish Mouse Rat Fly
muscle organ development GO:0007517 101 0.018
establishment of protein localization to organelle GO:0072594 4 0.018
motor neuron axon guidance GO:0008045 23 0.018
pancreas development GO:0031016 84 0.017
endothelial cell migration GO:0043542 19 0.017
sympathetic ganglion development GO:0061549 2 0.017
female meiotic division GO:0007143 2 0.017
ventral spinal cord interneuron differentiation GO:0021514 12 0.017
primary neural tube formation GO:0014020 1 0.017
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.017
Rat
determination of heart left right asymmetry GO:0061371 117 0.017
smoothened signaling pathway GO:0007224 30 0.017
Mouse
positive regulation of rna biosynthetic process GO:1902680 57 0.017
Mouse
response to growth factor GO:0070848 39 0.017
sex determination GO:0007530 1 0.017
regulation of multicellular organism growth GO:0040014 4 0.017
oligodendrocyte cell fate specification GO:0021778 4 0.017
single organism behavior GO:0044708 24 0.016
regulation of cellular biosynthetic process GO:0031326 245 0.016
Zebrafish Mouse Rat Fly
oxoacid metabolic process GO:0043436 31 0.016
single organism localization GO:1902578 225 0.016
positive regulation of cell development GO:0010720 25 0.016
Fly
determination of left right symmetry GO:0007368 179 0.016
somatic stem cell maintenance GO:0035019 1 0.016
regulation of cell fate commitment GO:0010453 22 0.016
response to oxygen containing compound GO:1901700 55 0.016
regulation of response to stress GO:0080134 36 0.016
Fly
cognition GO:0050890 1 0.016
embryonic cranial skeleton morphogenesis GO:0048701 90 0.016
transport GO:0006810 220 0.016
regulation of protein targeting GO:1903533 2 0.016
positive regulation of cellular process GO:0048522 201 0.015
Human Zebrafish Mouse Fly
regulation of rna metabolic process GO:0051252 224 0.015
Zebrafish Mouse Rat Fly
positive regulation of glial cell differentiation GO:0045687 1 0.015
muscle cell differentiation GO:0042692 139 0.015
response to carbohydrate GO:0009743 3 0.015
dna templated transcription initiation GO:0006352 1 0.015
cell fate determination GO:0001709 7 0.015
Mouse Fly
macromolecule biosynthetic process GO:0009059 227 0.015
Zebrafish Mouse Rat Fly
response to hormone GO:0009725 48 0.015
regulation of notch signaling pathway GO:0008593 16 0.015
Mouse
enzyme linked receptor protein signaling pathway GO:0007167 106 0.015
Mouse
cellular lipid metabolic process GO:0044255 36 0.014
renal system development GO:0072001 94 0.014
Mouse
endothelium development GO:0003158 25 0.014
regulation of epithelial cell proliferation GO:0050678 3 0.014
germ line stem cell maintenance GO:0030718 2 0.014
signal transduction GO:0007165 455 0.014
Human Zebrafish Mouse
purine nucleoside monophosphate catabolic process GO:0009128 4 0.014
negative regulation of protein kinase activity GO:0006469 4 0.014
positive regulation of tyrosine phosphorylation of stat3 protein GO:0042517 1 0.014
Mouse
positive regulation of response to stimulus GO:0048584 80 0.014
Mouse
multicellular organismal reproductive process GO:0048609 35 0.014
metencephalon development GO:0022037 27 0.014
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.014
Zebrafish Mouse Rat Fly
forebrain regionalization GO:0021871 4 0.013
striated muscle tissue development GO:0014706 110 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
gabaergic neuron differentiation GO:0097154 2 0.013
regulation of phosphate metabolic process GO:0019220 43 0.013
Zebrafish Mouse
regulation of localization GO:0032879 104 0.013
mesoderm development GO:0007498 88 0.013
Fly
apoptotic process GO:0006915 116 0.013
positive regulation of macromolecule metabolic process GO:0010604 93 0.013
Zebrafish Mouse
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.013
Mouse Rat Fly
semicircular canal development GO:0060872 24 0.013
catecholamine biosynthetic process GO:0042423 2 0.013
central nervous system projection neuron axonogenesis GO:0021952 15 0.013
negative regulation of gene expression GO:0010629 65 0.013
Zebrafish Mouse Rat Worm Fly
cilium organization GO:0044782 71 0.013
phosphorylation GO:0016310 69 0.013
Zebrafish Mouse
modification of morphology or physiology of other organism GO:0035821 4 0.013
cell cycle g1 s phase transition GO:0044843 1 0.013
determination of liver left right asymmetry GO:0071910 11 0.013
positive regulation of cyclin dependent protein serine threonine kinase activity GO:0045737 1 0.013
Zebrafish
regulation of wnt signaling pathway GO:0030111 53 0.013
regulation of cell death GO:0010941 103 0.013
auditory receptor cell development GO:0060117 8 0.012
cardiac cell fate commitment GO:0060911 1 0.012
regulation of neuron migration GO:2001222 2 0.012
regulation of mitotic cell cycle GO:0007346 25 0.012
blood vessel endothelial cell migration GO:0043534 18 0.012
cardiocyte differentiation GO:0035051 44 0.012
intracellular receptor signaling pathway GO:0030522 30 0.012
fertilization GO:0009566 3 0.012
regulation of establishment of protein localization GO:0070201 4 0.012
regulation of signal transduction GO:0009966 225 0.012
Mouse
regulation of transcription dna templated GO:0006355 213 0.012
Zebrafish Mouse Rat Fly
regulation of blood pressure GO:0008217 1 0.012
regulation of transcription from rna polymerase iii promoter GO:0006359 1 0.012
regulation of protein transport GO:0051223 3 0.012
cellular localization GO:0051641 97 0.012
regulation of cell cycle GO:0051726 52 0.012
Zebrafish
regulation of protein modification process GO:0031399 29 0.012
Zebrafish Mouse
regulation of circadian rhythm GO:0042752 4 0.012
spinal cord association neuron differentiation GO:0021527 1 0.012
retinal cell programmed cell death GO:0046666 2 0.012
segment specification GO:0007379 12 0.012
Zebrafish Mouse
spinal cord oligodendrocyte cell fate specification GO:0021530 2 0.012
forebrain neuron development GO:0021884 7 0.012
positive regulation of secretion GO:0051047 1 0.011
notch signaling pathway GO:0007219 35 0.011
Human Zebrafish Mouse
biosynthetic process GO:0009058 294 0.011
Zebrafish Mouse Rat Fly
negative regulation of neural precursor cell proliferation GO:2000178 1 0.011
regulation of intracellular protein transport GO:0033157 3 0.011
inner ear development GO:0048839 126 0.011
Mouse
forebrain neuron differentiation GO:0021879 14 0.011
Rat
negative regulation of signal transduction GO:0009968 94 0.011
neural nucleus development GO:0048857 15 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
regulation of ph GO:0006885 3 0.011
regulation of hormone secretion GO:0046883 2 0.011
formation of primary germ layer GO:0001704 62 0.011
phagocytosis engulfment GO:0006911 1 0.011
protein targeting to nucleus GO:0044744 3 0.011
glial cell fate specification GO:0021780 4 0.011
multi organism reproductive process GO:0044703 36 0.011
regulation of exocytosis GO:0017157 1 0.011
response to external biotic stimulus GO:0043207 97 0.011
proximal distal pattern formation GO:0009954 1 0.011
Mouse
cell migration to the midline involved in heart development GO:0003318 12 0.011
establishment of synaptic vesicle localization GO:0097480 1 0.011
renal absorption GO:0070293 1 0.011
gtp catabolic process GO:0006184 2 0.011
lens fiber cell development GO:0070307 3 0.011
response to metal ion GO:0010038 34 0.011
positive regulation of gtpase activity GO:0043547 1 0.011
regulation of endodermal cell fate specification GO:0042663 15 0.011
negative regulation of kinase activity GO:0033673 4 0.010
negative regulation of mapk cascade GO:0043409 4 0.010

her4.2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.044
bone development disease DOID:0080006 0 0.029
bone disease DOID:0080001 0 0.029
dysostosis DOID:1934 0 0.029
musculoskeletal system disease DOID:17 0 0.029
connective tissue disease DOID:65 0 0.029
physical disorder DOID:0080015 0 0.012
congenital nervous system abnormality DOID:2490 0 0.012
nervous system disease DOID:863 0 0.012