Danio rerio

37 known processes

her4.5

hairy-related 4.5

(Aliases: wu:fb74d11,si:ch73-21g5.6,cb485,sb:cb485)

her4.5 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
mesenchyme development GO:0060485 127 0.174
neuron differentiation GO:0030182 353 0.164
larval development GO:0002164 2 0.137
enzyme linked receptor protein signaling pathway GO:0007167 106 0.106
response to stress GO:0006950 263 0.089
single organism metabolic process GO:0044710 217 0.088
astrocyte differentiation GO:0048708 1 0.082
sensory organ development GO:0007423 393 0.082
regulation of multicellular organismal process GO:0051239 277 0.082
meiotic nuclear division GO:0007126 4 0.070
blood vessel development GO:0001568 246 0.070
cellular macromolecule metabolic process GO:0044260 391 0.069
cell cycle GO:0007049 93 0.068
response to organic substance GO:0010033 153 0.066
retina development in camera type eye GO:0060041 146 0.059
regulation of primary metabolic process GO:0080090 311 0.059
stem cell proliferation GO:0072089 4 0.057
generation of neurons GO:0048699 385 0.054
cellular component morphogenesis GO:0032989 336 0.053
regulation of biological quality GO:0065008 263 0.047
mesenchymal cell development GO:0014031 78 0.046
cellular protein metabolic process GO:0044267 129 0.044
regulation of metabolic process GO:0019222 359 0.043
cellular response to chemical stimulus GO:0070887 157 0.043
cellular response to oxygen levels GO:0071453 1 0.042
positive regulation of transport GO:0051050 2 0.041
regulation of macromolecule metabolic process GO:0060255 317 0.041
multicellular organism growth GO:0035264 4 0.041
aromatic compound biosynthetic process GO:0019438 217 0.040
apoptotic process GO:0006915 116 0.040
negative regulation of biological process GO:0048519 304 0.040
negative regulation of protein kinase activity GO:0006469 4 0.040
adult behavior GO:0030534 2 0.039
regulation of meiotic cell cycle GO:0051445 1 0.038
camera type eye development GO:0043010 222 0.038
cellular aromatic compound metabolic process GO:0006725 295 0.037
regulation of multicellular organism growth GO:0040014 4 0.037
embryonic organ development GO:0048568 381 0.037
response to chemical GO:0042221 320 0.036
response to oxygen containing compound GO:1901700 55 0.036
cell projection morphogenesis GO:0048858 244 0.035
negative regulation of cellular process GO:0048523 283 0.034
eye development GO:0001654 277 0.034
gene expression GO:0010467 252 0.034
embryo development ending in birth or egg hatching GO:0009792 271 0.033
regulation of protein transport GO:0051223 3 0.033
central nervous system development GO:0007417 387 0.032
oxoacid metabolic process GO:0043436 31 0.032
protein metabolic process GO:0019538 183 0.032
heart development GO:0007507 313 0.030
regulation of synaptic plasticity GO:0048167 1 0.030
regulation of multicellular organismal development GO:2000026 223 0.030
protein modification process GO:0036211 100 0.030
maintenance of location GO:0051235 4 0.029
neuroblast proliferation GO:0007405 2 0.029
macromolecule modification GO:0043412 111 0.029
stem cell differentiation GO:0048863 117 0.028
small molecule metabolic process GO:0044281 77 0.028
organelle organization GO:0006996 227 0.028
mesenchymal cell differentiation GO:0048762 87 0.027
muscle cell development GO:0055001 115 0.027
striated muscle cell development GO:0055002 108 0.026
cellular biosynthetic process GO:0044249 286 0.026
phosphorus metabolic process GO:0006793 109 0.026
developmental growth GO:0048589 166 0.026
regulation of neural precursor cell proliferation GO:2000177 3 0.026
positive regulation of biological process GO:0048518 253 0.026
positive regulation of secretion by cell GO:1903532 1 0.025
regulation of establishment of protein localization GO:0070201 4 0.025
organonitrogen compound metabolic process GO:1901564 74 0.025
regulation of transmembrane transporter activity GO:0022898 2 0.025
angiogenesis GO:0001525 158 0.025
negative regulation of kinase activity GO:0033673 4 0.025
skeletal system development GO:0001501 181 0.024
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.024
cellular nitrogen compound metabolic process GO:0034641 290 0.024
pectoral fin development GO:0033339 50 0.024
signal transduction GO:0007165 455 0.024
nucleobase containing compound metabolic process GO:0006139 274 0.024
vasculature development GO:0001944 278 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
organic acid metabolic process GO:0006082 31 0.024
cellular response to hypoxia GO:0071456 1 0.024
regulation of cell communication GO:0010646 232 0.024
death GO:0016265 121 0.024
brain development GO:0007420 293 0.023
single organism transport GO:0044765 206 0.023
blood vessel morphogenesis GO:0048514 216 0.023
epithelial tube morphogenesis GO:0060562 148 0.023
cardiac cell development GO:0055006 21 0.023
positive regulation of secretion GO:0051047 1 0.023
regulation of gene expression GO:0010468 265 0.023
growth GO:0040007 174 0.023
regulation of cell development GO:0060284 100 0.023
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.022
positive regulation of catabolic process GO:0009896 4 0.022
cellular response to organic substance GO:0071310 105 0.022
pectoral fin morphogenesis GO:0035138 29 0.022
regulation of nucleic acid templated transcription GO:1903506 213 0.022
regeneration GO:0031099 91 0.022
protein secretion GO:0009306 1 0.021
stem cell development GO:0048864 82 0.021
neuron development GO:0048666 262 0.021
regulation of oligodendrocyte differentiation GO:0048713 1 0.021
negative regulation of macromolecule metabolic process GO:0010605 76 0.021
regulation of anatomical structure morphogenesis GO:0022603 130 0.021
aging GO:0007568 2 0.021
cell morphogenesis GO:0000902 289 0.021
stem cell maintenance GO:0019827 4 0.021
muscle cell differentiation GO:0042692 139 0.021
negative regulation of mitosis GO:0045839 3 0.020
digestive system development GO:0055123 289 0.020
organic cyclic compound metabolic process GO:1901360 301 0.020
morphogenesis of an epithelium GO:0002009 333 0.019
regulation of circadian rhythm GO:0042752 4 0.019
positive regulation of cellular catabolic process GO:0031331 3 0.019
negative regulation of nuclear division GO:0051784 3 0.019
response to external stimulus GO:0009605 264 0.019
cellular protein modification process GO:0006464 100 0.019
mitochondrion organization GO:0007005 4 0.019
proteasomal protein catabolic process GO:0010498 2 0.019
cellular component biogenesis GO:0044085 178 0.018
neural crest cell differentiation GO:0014033 72 0.018
neuron projection morphogenesis GO:0048812 161 0.018
heart morphogenesis GO:0003007 156 0.018
biosynthetic process GO:0009058 294 0.018
regulation of cellular amine metabolic process GO:0033238 0 0.018
modification dependent protein catabolic process GO:0019941 3 0.018
regulation of nitrogen compound metabolic process GO:0051171 251 0.018
response to wounding GO:0009611 116 0.018
cellular amine metabolic process GO:0044106 2 0.018
regulation of cell death GO:0010941 103 0.017
phosphate containing compound metabolic process GO:0006796 108 0.017
vasculogenesis GO:0001570 41 0.017
response to endogenous stimulus GO:0009719 83 0.017
camera type eye morphogenesis GO:0048593 108 0.017
ectodermal placode morphogenesis GO:0071697 32 0.017
organic substance biosynthetic process GO:1901576 289 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
mesoderm development GO:0007498 88 0.017
regulation of phosphate metabolic process GO:0019220 43 0.017
regulation of wnt signaling pathway GO:0030111 53 0.017
gtp metabolic process GO:0046039 4 0.017
cell surface receptor signaling pathway GO:0007166 325 0.017
positive regulation of signal transduction GO:0009967 56 0.017
heterocycle metabolic process GO:0046483 290 0.016
regulation of axon extension GO:0030516 24 0.016
response to bacterium GO:0009617 58 0.016
regulation of cell cycle GO:0051726 52 0.016
cytokinesis GO:0000910 3 0.016
liver development GO:0001889 96 0.016
establishment of localization GO:0051234 244 0.016
dorsal ventral pattern formation GO:0009953 125 0.016
regulation of cellular amino acid metabolic process GO:0006521 0 0.016
peptidyl serine phosphorylation GO:0018105 1 0.016
amine metabolic process GO:0009308 2 0.016
cognition GO:0050890 1 0.016
cellular response to growth factor stimulus GO:0071363 39 0.016
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.016
modification dependent macromolecule catabolic process GO:0043632 3 0.016
cellular ketone metabolic process GO:0042180 11 0.015
negative regulation of gliogenesis GO:0014014 1 0.015
guanosine containing compound catabolic process GO:1901069 2 0.015
cellular component movement GO:0006928 335 0.015
protein polymerization GO:0051258 4 0.015
cellular macromolecule biosynthetic process GO:0034645 224 0.015
regulation of cellular ketone metabolic process GO:0010565 7 0.015
transmembrane transport GO:0055085 120 0.015
nitrogen compound metabolic process GO:0006807 319 0.015
regulation of response to stimulus GO:0048583 269 0.015
regulation of purine nucleotide catabolic process GO:0033121 2 0.015
positive regulation of cell division GO:0051781 2 0.015
tube morphogenesis GO:0035239 349 0.015
system process GO:0003008 185 0.015
regulation of ion transmembrane transporter activity GO:0032412 2 0.015
retina morphogenesis in camera type eye GO:0060042 79 0.015
regulation of vasculature development GO:1901342 33 0.015
positive regulation of cytokine production GO:0001819 2 0.015
response to carbohydrate GO:0009743 3 0.015
regulation of embryonic development GO:0045995 47 0.015
immune system development GO:0002520 191 0.015
regulation of protein catabolic process GO:0042176 1 0.015
determination of bilateral symmetry GO:0009855 204 0.015
sensory organ morphogenesis GO:0090596 200 0.015
eye morphogenesis GO:0048592 144 0.014
single organism organelle organization GO:1902589 199 0.014
cellular response to decreased oxygen levels GO:0036294 1 0.014
regulation of transporter activity GO:0032409 2 0.014
intracellular signal transduction GO:0035556 85 0.014
cell proliferation GO:0008283 80 0.014
gtp catabolic process GO:0006184 2 0.014
positive regulation of cell cycle GO:0045787 3 0.014
circulatory system process GO:0003013 87 0.014
regulation of dendrite morphogenesis GO:0048814 3 0.014
positive regulation of neural precursor cell proliferation GO:2000179 1 0.014
sensory perception of pain GO:0019233 1 0.014
negative regulation of collateral sprouting GO:0048671 2 0.014
glial cell proliferation GO:0014009 4 0.014
positive regulation of cellular process GO:0048522 201 0.014
protein dephosphorylation GO:0006470 3 0.014
rna metabolic process GO:0016070 219 0.014
single organism nuclear import GO:1902593 3 0.014
ubiquitin dependent protein catabolic process GO:0006511 3 0.014
chemosensory behavior GO:0007635 1 0.014
response to oxygen levels GO:0070482 25 0.014
cellular component assembly GO:0022607 170 0.014
positive regulation of programmed cell death GO:0043068 29 0.013
sleep GO:0030431 1 0.013
regulation of metal ion transport GO:0010959 4 0.013
hepaticobiliary system development GO:0061008 98 0.013
cellular response to stress GO:0033554 62 0.013
regulation of cellular protein metabolic process GO:0032268 52 0.013
regulation of cytoplasmic transport GO:1903649 4 0.013
regulation of cellular response to growth factor stimulus GO:0090287 35 0.013
negative regulation of gene expression GO:0010629 65 0.013
striated muscle cell differentiation GO:0051146 129 0.013
anterior posterior pattern specification GO:0009952 152 0.013
embryonic heart tube development GO:0035050 133 0.013
transport GO:0006810 220 0.013
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
response to hypoxia GO:0001666 25 0.013
blood circulation GO:0008015 87 0.013
lipid catabolic process GO:0016042 4 0.013
somite development GO:0061053 96 0.012
regulation of cell differentiation GO:0045595 142 0.012
neural crest cell development GO:0014032 62 0.012
positive regulation of gtpase activity GO:0043547 1 0.012
positive regulation of apoptotic signaling pathway GO:2001235 1 0.012
regulation of reproductive process GO:2000241 4 0.012
regionalization GO:0003002 274 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
sympathetic nervous system development GO:0048485 3 0.012
response to uv GO:0009411 3 0.012
cellular localization GO:0051641 97 0.012
negative regulation of secretion by cell GO:1903531 2 0.012
protein targeting to nucleus GO:0044744 3 0.012
regulation of intracellular protein transport GO:0033157 3 0.012
ameboidal type cell migration GO:0001667 143 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
neuronal action potential GO:0019228 18 0.012
regulation of dendrite development GO:0050773 3 0.012
digestive tract morphogenesis GO:0048546 231 0.012
regulation of cytokine production GO:0001817 3 0.012
head development GO:0060322 303 0.012
positive regulation of map kinase activity GO:0043406 3 0.012
response to vitamin GO:0033273 3 0.012
regulation of glial cell differentiation GO:0045685 4 0.012
digestive tract development GO:0048565 265 0.012
positive regulation of apoptotic process GO:0043065 29 0.012
cellular response to endogenous stimulus GO:0071495 68 0.012
adherens junction organization GO:0034332 4 0.012
cellular response to light stimulus GO:0071482 4 0.011
response to external biotic stimulus GO:0043207 97 0.011
response to growth factor GO:0070848 39 0.011
single organism localization GO:1902578 225 0.011
regulation of cell growth GO:0001558 29 0.011
otic vesicle formation GO:0030916 27 0.011
wnt signaling pathway GO:0016055 80 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
response to other organism GO:0051707 97 0.011
protein complex localization GO:0031503 1 0.011
meiotic chromosome segregation GO:0045132 3 0.011
regulation of gtp catabolic process GO:0033124 2 0.011
regulation of phosphorus metabolic process GO:0051174 43 0.011
response to fibroblast growth factor GO:0071774 22 0.011
regulation of gtpase activity GO:0043087 2 0.011
neuron neuron synaptic transmission GO:0007270 1 0.011
embryonic cranial skeleton morphogenesis GO:0048701 90 0.011
regulation of inflammatory response GO:0050727 2 0.011
cell projection organization GO:0030030 284 0.011
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.011
meiotic cell cycle process GO:1903046 3 0.011
developmental cell growth GO:0048588 52 0.011
cell migration GO:0016477 237 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
positive regulation of macromolecule metabolic process GO:0010604 93 0.011
renal system development GO:0072001 94 0.011
immune system process GO:0002376 241 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
regulation of cell morphogenesis GO:0022604 42 0.011
neural precursor cell proliferation GO:0061351 20 0.010
epidermal cell fate specification GO:0009957 4 0.010
embryonic viscerocranium morphogenesis GO:0048703 52 0.010
regulation of angiogenesis GO:0045765 26 0.010
regulation of cellular component organization GO:0051128 86 0.010
cell cycle arrest GO:0007050 1 0.010
response to monosaccharide GO:0034284 3 0.010
cell cell recognition GO:0009988 1 0.010
regulation of microtubule depolymerization GO:0031114 1 0.010
cell fate specification GO:0001708 68 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
cellular response to fibroblast growth factor stimulus GO:0044344 22 0.010
nucleic acid metabolic process GO:0090304 244 0.010
negative regulation of protein transport GO:0051224 3 0.010
multicellular organismal signaling GO:0035637 22 0.010
regulation of ras gtpase activity GO:0032318 2 0.010
phosphorylation GO:0016310 69 0.010
positive regulation of metabolic process GO:0009893 108 0.010
cytoskeleton organization GO:0007010 96 0.010
estrogen metabolic process GO:0008210 2 0.010
response to drug GO:0042493 3 0.010
embryonic organ morphogenesis GO:0048562 274 0.010
nucleocytoplasmic transport GO:0006913 4 0.010

her4.5 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.035
cancer DOID:162 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
organ system cancer DOID:0050686 0 0.019
eye and adnexa disease DOID:1492 0 0.011
sensory system disease DOID:0050155 0 0.011