Danio rerio

14 known processes

mettl3

methyltransferase like 3

(Aliases: fj82g07,wu:fj82g07,zgc:77093,MGC77093)

mettl3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.457
regulation of gene expression GO:0010468 265 0.130
positive regulation of cell cycle GO:0045787 3 0.130
organelle organization GO:0006996 227 0.113
aging GO:0007568 2 0.110
rna metabolic process GO:0016070 219 0.105
Human
heterocycle metabolic process GO:0046483 290 0.095
Human
embryo development ending in birth or egg hatching GO:0009792 271 0.088
nucleobase containing compound biosynthetic process GO:0034654 205 0.083
negative regulation of mitosis GO:0045839 3 0.080
heterocycle biosynthetic process GO:0018130 215 0.078
nucleic acid metabolic process GO:0090304 244 0.078
Human
histone h3 k4 methylation GO:0051568 2 0.077
single organism organelle organization GO:1902589 199 0.075
stem cell maintenance GO:0019827 4 0.074
apoptotic process GO:0006915 116 0.072
regulation of meiotic cell cycle GO:0051445 1 0.067
meiotic chromosome segregation GO:0045132 3 0.066
proteasomal protein catabolic process GO:0010498 2 0.064
cellular aromatic compound metabolic process GO:0006725 295 0.062
Human
female meiotic division GO:0007143 2 0.061
maintenance of location GO:0051235 4 0.059
cellular nitrogen compound metabolic process GO:0034641 290 0.059
Human
macromolecule biosynthetic process GO:0009059 227 0.058
regulation of histone methylation GO:0031060 3 0.057
regulation of biological quality GO:0065008 263 0.055
localization of cell GO:0051674 244 0.055
locomotion GO:0040011 313 0.054
positive regulation of biological process GO:0048518 253 0.054
death GO:0016265 121 0.054
regulation of macromolecule biosynthetic process GO:0010556 225 0.052
regulation of nitrogen compound metabolic process GO:0051171 251 0.051
g1 s transition of mitotic cell cycle GO:0000082 1 0.050
rna biosynthetic process GO:0032774 181 0.049
vasculature development GO:0001944 278 0.048
meiotic cell cycle process GO:1903046 3 0.048
transcription dna templated GO:0006351 181 0.047
protein metabolic process GO:0019538 183 0.047
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.046
meiotic nuclear division GO:0007126 4 0.046
biosynthetic process GO:0009058 294 0.046
positive regulation of muscle tissue development GO:1901863 1 0.046
organic substance biosynthetic process GO:1901576 289 0.045
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.045
cellular component morphogenesis GO:0032989 336 0.045
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.045
cellular macromolecule biosynthetic process GO:0034645 224 0.044
protein acetylation GO:0006473 2 0.043
regulation of cellular amine metabolic process GO:0033238 0 0.043
modification dependent protein catabolic process GO:0019941 3 0.043
internal peptidyl lysine acetylation GO:0018393 2 0.042
regulation of mitotic cell cycle GO:0007346 25 0.042
gene expression GO:0010467 252 0.042
negative regulation of biological process GO:0048519 304 0.042
b cell activation GO:0042113 2 0.042
cellular macromolecule metabolic process GO:0044260 391 0.041
Human
positive regulation of cellular process GO:0048522 201 0.041
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.041
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.041
hemopoiesis GO:0030097 183 0.041
nitrogen compound metabolic process GO:0006807 319 0.040
Human
regulation of rna biosynthetic process GO:2001141 213 0.040
negative regulation of nuclear division GO:0051784 3 0.040
cognition GO:0050890 1 0.040
cell cycle g1 s phase transition GO:0044843 1 0.039
regulation of chromosome segregation GO:0051983 1 0.039
positive regulation of chromatin modification GO:1903310 1 0.039
organic cyclic compound biosynthetic process GO:1901362 223 0.039
positive regulation of cellular component biogenesis GO:0044089 3 0.038
response to chemical GO:0042221 320 0.038
mitochondrion organization GO:0007005 4 0.037
phagocytosis GO:0006909 3 0.037
chordate embryonic development GO:0043009 271 0.037
mitotic cell cycle GO:0000278 64 0.036
digestive system development GO:0055123 289 0.036
regulation of transcription dna templated GO:0006355 213 0.035
stem cell development GO:0048864 82 0.035
negative regulation of myeloid cell differentiation GO:0045638 1 0.035
spindle assembly GO:0051225 2 0.035
lipid storage GO:0019915 1 0.035
cell motility GO:0048870 244 0.034
cellular response to starvation GO:0009267 1 0.034
growth GO:0040007 174 0.034
sensory organ development GO:0007423 393 0.034
developmental growth involved in morphogenesis GO:0060560 86 0.033
positive regulation of chromosome organization GO:2001252 1 0.033
chemosensory behavior GO:0007635 1 0.033
cell cycle arrest GO:0007050 1 0.033
immune system development GO:0002520 191 0.032
peptidyl lysine acetylation GO:0018394 2 0.032
nucleic acid templated transcription GO:0097659 181 0.032
regulation of rna metabolic process GO:0051252 224 0.032
immune system process GO:0002376 241 0.032
response to abiotic stimulus GO:0009628 122 0.032
organic cyclic compound metabolic process GO:1901360 301 0.031
Human
cellular amine metabolic process GO:0044106 2 0.031
protein modification process GO:0036211 100 0.031
single organism metabolic process GO:0044710 217 0.031
angiogenesis GO:0001525 158 0.031
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.031
rna polyadenylation GO:0043631 2 0.031
regulation of metabolic process GO:0019222 359 0.030
homeostasis of number of cells GO:0048872 62 0.030
cellular nitrogen compound biosynthetic process GO:0044271 218 0.030
establishment of protein localization to organelle GO:0072594 4 0.030
regulation of primary metabolic process GO:0080090 311 0.029
cell death GO:0008219 121 0.029
covalent chromatin modification GO:0016569 20 0.029
cellular response to external stimulus GO:0071496 2 0.029
programmed cell death GO:0012501 119 0.029
multicellular organism growth GO:0035264 4 0.029
organelle fission GO:0048285 23 0.028
regulation of macromolecule metabolic process GO:0060255 317 0.028
response to nutrient GO:0007584 3 0.028
cellular response to chemical stimulus GO:0070887 157 0.028
gland development GO:0048732 143 0.028
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.028
synaptic growth at neuromuscular junction GO:0051124 2 0.027
regulation of cell cycle GO:0051726 52 0.027
negative regulation of secretion GO:0051048 2 0.027
modification dependent macromolecule catabolic process GO:0043632 3 0.027
negative regulation of dna metabolic process GO:0051053 4 0.027
methylation GO:0032259 22 0.027
Human
regulation of cellular ketone metabolic process GO:0010565 7 0.027
aromatic compound biosynthetic process GO:0019438 217 0.027
tube morphogenesis GO:0035239 349 0.026
b cell differentiation GO:0030183 1 0.026
cellular response to nutrient levels GO:0031669 2 0.026
cellular response to extracellular stimulus GO:0031668 2 0.026
centrosome cycle GO:0007098 1 0.026
cellular ketone metabolic process GO:0042180 11 0.026
anterior posterior pattern specification GO:0009952 152 0.026
determination of left right symmetry GO:0007368 179 0.026
positive regulation of muscle organ development GO:0048636 1 0.026
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.026
protein localization to nucleus GO:0034504 3 0.026
regulation of multicellular organismal process GO:0051239 277 0.025
blood vessel development GO:0001568 246 0.025
protein acylation GO:0043543 3 0.025
cell morphogenesis involved in differentiation GO:0000904 195 0.025
regulation of multicellular organism growth GO:0040014 4 0.025
regulation of cellular component organization GO:0051128 86 0.025
ubiquitin dependent protein catabolic process GO:0006511 3 0.025
regulation of cellular biosynthetic process GO:0031326 245 0.025
stem cell differentiation GO:0048863 117 0.025
liver development GO:0001889 96 0.025
embryonic organ morphogenesis GO:0048562 274 0.025
eye development GO:0001654 277 0.024
rna 3 end processing GO:0031123 2 0.024
response to corticosteroid GO:0031960 1 0.024
multi organism process GO:0051704 134 0.024
regulation of cellular metabolic process GO:0031323 320 0.024
negative chemotaxis GO:0050919 1 0.024
homeostatic process GO:0042592 142 0.024
positive regulation of transport GO:0051050 2 0.024
regulation of apoptotic process GO:0042981 98 0.024
stem cell proliferation GO:0072089 4 0.024
embryonic organ development GO:0048568 381 0.024
cellular protein modification process GO:0006464 100 0.023
positive regulation of histone modification GO:0031058 1 0.023
regulation of establishment of protein localization GO:0070201 4 0.023
negative regulation of synapse assembly GO:0051964 2 0.023
response to monosaccharide GO:0034284 3 0.023
cell projection morphogenesis GO:0048858 244 0.023
adult behavior GO:0030534 2 0.023
cell morphogenesis GO:0000902 289 0.023
regulation of heart growth GO:0060420 2 0.023
regulation of protein catabolic process GO:0042176 1 0.023
cellular component movement GO:0006928 335 0.022
cell cycle GO:0007049 93 0.022
developmental cell growth GO:0048588 52 0.022
negative regulation of cellular process GO:0048523 283 0.022
regulation of signal transduction GO:0009966 225 0.022
axonogenesis GO:0007409 152 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
developmental growth GO:0048589 166 0.022
regulation of biosynthetic process GO:0009889 250 0.022
chromosome organization GO:0051276 31 0.022
stem cell division GO:0017145 1 0.022
neuron projection extension GO:1990138 45 0.022
cytokinesis GO:0000910 3 0.022
reciprocal dna recombination GO:0035825 1 0.022
digestive tract morphogenesis GO:0048546 231 0.021
regulation of protein complex assembly GO:0043254 3 0.021
somatic muscle development GO:0007525 4 0.021
blood vessel morphogenesis GO:0048514 216 0.021
regulation of organelle organization GO:0033043 29 0.021
macromolecule modification GO:0043412 111 0.021
Human
heart development GO:0007507 313 0.021
chromatin organization GO:0006325 22 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.020
positive regulation of striated muscle tissue development GO:0045844 1 0.020
small molecule metabolic process GO:0044281 77 0.020
centrosome localization GO:0051642 1 0.020
organism emergence from protective structure GO:0071684 4 0.020
mesenchymal cell differentiation GO:0048762 87 0.020
nuclear division GO:0000280 23 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.020
response to ketone GO:1901654 1 0.020
regulation of growth GO:0040008 42 0.020
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.020
organelle localization GO:0051640 49 0.020
g2 m transition of mitotic cell cycle GO:0000086 4 0.020
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.020
amine metabolic process GO:0009308 2 0.020
regulation of multicellular organismal development GO:2000026 223 0.020
membrane invagination GO:0010324 1 0.019
cell projection organization GO:0030030 284 0.019
histone methylation GO:0016571 13 0.019
digestive tract development GO:0048565 265 0.019
regulation of developmental process GO:0050793 247 0.019
macromolecular complex subunit organization GO:0043933 74 0.019
macromolecule methylation GO:0043414 19 0.019
Human
regulation of nucleic acid templated transcription GO:1903506 213 0.019
rna splicing GO:0008380 16 0.019
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
regulation of cellular protein catabolic process GO:1903362 1 0.019
chromatin modification GO:0016568 21 0.019
cellular protein metabolic process GO:0044267 129 0.018
rna processing GO:0006396 25 0.018
cell part morphogenesis GO:0032990 246 0.018
histone modification GO:0016570 20 0.018
somitogenesis GO:0001756 87 0.018
camera type eye development GO:0043010 222 0.018
nucleobase containing compound metabolic process GO:0006139 274 0.018
Human
cellular biosynthetic process GO:0044249 286 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
oocyte anterior posterior axis specification GO:0007314 4 0.018
oxoacid metabolic process GO:0043436 31 0.018
gamete generation GO:0007276 33 0.018
release of sequestered calcium ion into cytosol GO:0051209 3 0.018
positive regulation of muscle cell differentiation GO:0051149 1 0.018
recombinational repair GO:0000725 1 0.018
microtubule based process GO:0007017 60 0.018
organonitrogen compound metabolic process GO:1901564 74 0.017
regulation of dna replication GO:0006275 3 0.017
response to carbohydrate GO:0009743 3 0.017
chromosome segregation GO:0007059 12 0.017
somatic stem cell maintenance GO:0035019 1 0.017
rrna catabolic process GO:0016075 1 0.017
cellular component biogenesis GO:0044085 178 0.017
regulation of cell growth GO:0001558 29 0.017
hatching GO:0035188 4 0.017
regulation of protein transport GO:0051223 3 0.017
myeloid cell differentiation GO:0030099 86 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
generation of neurons GO:0048699 385 0.016
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.016
regulation of cell cycle process GO:0010564 20 0.016
regulation of signaling GO:0023051 235 0.016
hepaticobiliary system development GO:0061008 98 0.016
regulation of synapse organization GO:0050807 3 0.016
mitotic cell cycle process GO:1903047 48 0.016
response to stress GO:0006950 263 0.016
regulation of epithelial cell proliferation GO:0050678 3 0.016
protein import into nucleus GO:0006606 3 0.016
cellular protein catabolic process GO:0044257 4 0.016
response to glucose GO:0009749 3 0.016
response to amino acid GO:0043200 2 0.016
regulation of cell proliferation GO:0042127 37 0.016
regulation of stem cell proliferation GO:0072091 2 0.016
cytoskeleton dependent cytokinesis GO:0061640 3 0.016
astrocyte differentiation GO:0048708 1 0.016
calcium ion transport into cytosol GO:0060402 3 0.016
cellular component assembly GO:0022607 170 0.015
microtubule organizing center organization GO:0031023 1 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
response to drug GO:0042493 3 0.015
neuron neuron synaptic transmission GO:0007270 1 0.015
response to hexose GO:0009746 3 0.015
establishment of localization GO:0051234 244 0.015
positive regulation of stem cell proliferation GO:2000648 1 0.015
mitotic dna integrity checkpoint GO:0044774 4 0.015
sequestering of calcium ion GO:0051208 3 0.015
regulation of cell activation GO:0050865 1 0.015
rna localization GO:0006403 4 0.015
response to organic substance GO:0010033 153 0.015
response to glucocorticoid GO:0051384 1 0.015
female sex differentiation GO:0046660 4 0.015
single organism localization GO:1902578 225 0.015
meiotic spindle organization GO:0000212 1 0.014
cellular amino acid metabolic process GO:0006520 7 0.014
mononuclear cell proliferation GO:0032943 1 0.014
positive regulation of multi organism process GO:0043902 3 0.014
response to uv GO:0009411 3 0.014
regulation of synapse assembly GO:0051963 3 0.014
nucleoside monophosphate catabolic process GO:0009125 4 0.014
positive regulation of catabolic process GO:0009896 4 0.014
chromosome organization involved in meiosis GO:0070192 1 0.014
protein secretion GO:0009306 1 0.014
regulation of dna recombination GO:0000018 2 0.014
germ cell development GO:0007281 22 0.014
negative regulation of epithelial cell proliferation GO:0050680 1 0.014
autophagy GO:0006914 4 0.014
double strand break repair via homologous recombination GO:0000724 1 0.014
neuroblast fate determination GO:0007400 1 0.014
positive regulation of biosynthetic process GO:0009891 68 0.014
cell cycle g2 m phase transition GO:0044839 4 0.014
viral process GO:0016032 1 0.014
signal transduction GO:0007165 455 0.014
wnt signaling pathway GO:0016055 80 0.014
cellular response to stress GO:0033554 62 0.014
intracellular signal transduction GO:0035556 85 0.014
negative regulation of chromosome organization GO:2001251 1 0.014
spliceosomal snrnp assembly GO:0000387 2 0.014
sequestering of metal ion GO:0051238 3 0.013
maternal determination of anterior posterior axis embryo GO:0008358 4 0.013
meiosis i GO:0007127 1 0.013
nuclear import GO:0051170 3 0.013
cell cycle process GO:0022402 53 0.013
negative regulation of secretion by cell GO:1903531 2 0.013
negative regulation of gene expression GO:0010629 65 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
transcription elongation from rna polymerase ii promoter GO:0006368 3 0.013
behavior GO:0007610 74 0.013
transport GO:0006810 220 0.013
specification of axis polarity GO:0065001 4 0.013
forebrain regionalization GO:0021871 4 0.013
regulation of cell differentiation GO:0045595 142 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
regulation of cell shape GO:0008360 1 0.013
histone lysine methylation GO:0034968 12 0.013
reciprocal meiotic recombination GO:0007131 1 0.013
gtp catabolic process GO:0006184 2 0.013
determination of bilateral symmetry GO:0009855 204 0.013
regulation of response to extracellular stimulus GO:0032104 1 0.013
response to external stimulus GO:0009605 264 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
negative regulation of signal transduction GO:0009968 94 0.013
positive regulation of metabolic process GO:0009893 108 0.013
cell proliferation GO:0008283 80 0.013
negative regulation of signaling GO:0023057 96 0.013
mrna 3 end processing GO:0031124 2 0.012
guanosine containing compound metabolic process GO:1901068 4 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
phagocytosis engulfment GO:0006911 1 0.012
specification of symmetry GO:0009799 204 0.012
negative regulation of multicellular organismal process GO:0051241 69 0.012
regulation of binding GO:0051098 3 0.012
mitotic dna damage checkpoint GO:0044773 4 0.012
mrna polyadenylation GO:0006378 2 0.012
pancreas development GO:0031016 84 0.012
negative regulation of sequestering of calcium ion GO:0051283 4 0.012
regulation of cellular protein metabolic process GO:0032268 52 0.012
carbohydrate homeostasis GO:0033500 1 0.012
negative regulation of dna replication GO:0008156 2 0.012
negative regulation of developmental process GO:0051093 65 0.012
positive regulation of nucleotide catabolic process GO:0030813 1 0.012
macroautophagy GO:0016236 1 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.012
regulation of chromosome organization GO:0033044 5 0.012
cell surface receptor signaling pathway GO:0007166 325 0.012
regulation of nucleoside metabolic process GO:0009118 2 0.012
male meiosis GO:0007140 2 0.012
tissue remodeling GO:0048771 4 0.012
development of primary female sexual characteristics GO:0046545 4 0.012
protein alkylation GO:0008213 13 0.012
negative regulation of signal transduction by p53 class mediator GO:1901797 8 0.012
cellular component disassembly GO:0022411 1 0.012
meiosis ii GO:0007135 1 0.012
negative regulation of myeloid leukocyte differentiation GO:0002762 1 0.012
regulation of synaptic plasticity GO:0048167 1 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
fertilization GO:0009566 3 0.011
negative regulation of intracellular transport GO:0032387 3 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
embryonic skeletal system development GO:0048706 97 0.011
reproduction GO:0000003 40 0.011
cell migration involved in gastrulation GO:0042074 79 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.011
cell migration GO:0016477 237 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
sister chromatid cohesion GO:0007062 2 0.011
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
regulation of programmed cell death GO:0043067 101 0.011
regulation of response to stimulus GO:0048583 269 0.011
cilium morphogenesis GO:0060271 85 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
interspecies interaction between organisms GO:0044419 4 0.011
glucose homeostasis GO:0042593 1 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
protein sumoylation GO:0016925 2 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
cilium organization GO:0044782 71 0.011
cellular response to organic substance GO:0071310 105 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
internal protein amino acid acetylation GO:0006475 2 0.011
negative regulation of rna biosynthetic process GO:1902679 45 0.011
response to temperature stimulus GO:0009266 15 0.011
dna templated transcription elongation GO:0006354 3 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.010
positive regulation of camp metabolic process GO:0030816 2 0.010
negative regulation of kinase activity GO:0033673 4 0.010
cytosolic calcium ion transport GO:0060401 3 0.010
positive regulation of epithelial cell proliferation GO:0050679 1 0.010
protein import GO:0017038 3 0.010
muscle cell differentiation GO:0042692 139 0.010
ribosome assembly GO:0042255 1 0.010
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.010

mettl3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.032
nervous system disease DOID:863 0 0.030
cancer DOID:162 0 0.022
disease of cellular proliferation DOID:14566 0 0.022
organ system cancer DOID:0050686 0 0.022
musculoskeletal system disease DOID:17 0 0.013
connective tissue disease DOID:65 0 0.013
retinal disease DOID:5679 0 0.011
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011
eye disease DOID:5614 0 0.011