Danio rerio

0 known processes

map3k12

mitogen-activated protein kinase kinase kinase 12

(Aliases: MGC77370,zgc:77370)

map3k12 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.074
Worm
cellular component movement GO:0006928 335 0.047
response to chemical GO:0042221 320 0.045
aging GO:0007568 2 0.044
signal transduction GO:0007165 455 0.043
Worm
positive regulation of transport GO:0051050 2 0.042
neurotransmitter secretion GO:0007269 2 0.041
cell surface receptor signaling pathway GO:0007166 325 0.041
regulation of signaling GO:0023051 235 0.041
Worm
cell morphogenesis GO:0000902 289 0.040
cell part morphogenesis GO:0032990 246 0.039
cytokinesis GO:0000910 3 0.039
embryonic organ development GO:0048568 381 0.038
cell projection organization GO:0030030 284 0.038
maintenance of location GO:0051235 4 0.037
phagocytosis GO:0006909 3 0.037
positive regulation of cellular component biogenesis GO:0044089 3 0.037
cognition GO:0050890 1 0.036
regulation of synapse organization GO:0050807 3 0.035
Worm
establishment of localization GO:0051234 244 0.034
digestive system development GO:0055123 289 0.034
synaptic vesicle localization GO:0097479 1 0.034
regulation of signal transduction GO:0009966 225 0.034
Worm
regulation of cell communication GO:0010646 232 0.033
Worm
mitochondrion organization GO:0007005 4 0.033
cell projection morphogenesis GO:0048858 244 0.033
neurotransmitter transport GO:0006836 2 0.032
regionalization GO:0003002 274 0.032
regulation of reproductive process GO:2000241 4 0.032
synaptic vesicle transport GO:0048489 1 0.032
regulation of multicellular organism growth GO:0040014 4 0.032
establishment of synaptic vesicle localization GO:0097480 1 0.030
establishment of protein localization to plasma membrane GO:0090002 1 0.030
digestive tract development GO:0048565 265 0.030
multicellular organism growth GO:0035264 4 0.029
digestive tract morphogenesis GO:0048546 231 0.029
positive regulation of cell cycle GO:0045787 3 0.029
tube morphogenesis GO:0035239 349 0.029
regulation of purine nucleotide catabolic process GO:0033121 2 0.029
regulation of synapse assembly GO:0051963 3 0.029
meiotic nuclear division GO:0007126 4 0.028
amine metabolic process GO:0009308 2 0.028
regulation of nucleoside metabolic process GO:0009118 2 0.028
cell migration GO:0016477 237 0.028
locomotion GO:0040011 313 0.028
gtp catabolic process GO:0006184 2 0.027
gtp metabolic process GO:0046039 4 0.027
cellular macromolecule metabolic process GO:0044260 391 0.027
Mouse Worm
chemosensory behavior GO:0007635 1 0.027
system process GO:0003008 185 0.027
cellular amine metabolic process GO:0044106 2 0.027
regulation of nucleotide catabolic process GO:0030811 2 0.026
lipid storage GO:0019915 1 0.026
stem cell proliferation GO:0072089 4 0.026
gastrulation GO:0007369 208 0.026
axon development GO:0061564 166 0.026
specification of symmetry GO:0009799 204 0.026
microtubule based movement GO:0007018 33 0.025
neuron projection morphogenesis GO:0048812 161 0.025
regulation of biological quality GO:0065008 263 0.025
Worm
guanosine containing compound metabolic process GO:1901068 4 0.025
regulation of gtp catabolic process GO:0033124 2 0.025
cellular component morphogenesis GO:0032989 336 0.025
positive regulation of catabolic process GO:0009896 4 0.025
embryonic organ morphogenesis GO:0048562 274 0.025
protein localization to plasma membrane GO:0072659 1 0.025
regulation of cell shape GO:0008360 1 0.024
neuron differentiation GO:0030182 353 0.024
regulation of synaptic plasticity GO:0048167 1 0.024
rna metabolic process GO:0016070 219 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.024
guanosine containing compound catabolic process GO:1901069 2 0.024
regulation of cellular amine metabolic process GO:0033238 0 0.024
response to stress GO:0006950 263 0.023
regulation of metabolic process GO:0019222 359 0.023
Worm
positive regulation of secretion by cell GO:1903532 1 0.023
membrane fusion GO:0061025 2 0.023
regulation of protein transport GO:0051223 3 0.022
regulation of response to stimulus GO:0048583 269 0.022
Worm
regulation of establishment of protein localization GO:0070201 4 0.022
regulation of developmental process GO:0050793 247 0.022
organic cyclic compound metabolic process GO:1901360 301 0.022
transport GO:0006810 220 0.022
stem cell maintenance GO:0019827 4 0.022
exocytosis GO:0006887 1 0.022
negative regulation of biological process GO:0048519 304 0.022
neuron neuron synaptic transmission GO:0007270 1 0.022
single organism organelle organization GO:1902589 199 0.022
Mouse
regulation of multicellular organismal development GO:2000026 223 0.022
regulation of primary metabolic process GO:0080090 311 0.021
Worm
single organism transport GO:0044765 206 0.021
single organism localization GO:1902578 225 0.021
synaptic growth at neuromuscular junction GO:0051124 2 0.021
nucleocytoplasmic transport GO:0006913 4 0.021
determination of bilateral symmetry GO:0009855 204 0.021
regulation of protein complex assembly GO:0043254 3 0.021
adult behavior GO:0030534 2 0.021
synaptic transmission cholinergic GO:0007271 4 0.020
phagocytosis engulfment GO:0006911 1 0.020
regulation of multicellular organismal process GO:0051239 277 0.020
single organism membrane fusion GO:0044801 2 0.020
regulation of nitrogen compound metabolic process GO:0051171 251 0.020
heterocycle metabolic process GO:0046483 290 0.020
regulation of neurotransmitter transport GO:0051588 1 0.020
angiogenesis GO:0001525 158 0.020
embryo development ending in birth or egg hatching GO:0009792 271 0.020
positive regulation of nucleoside metabolic process GO:0045979 1 0.020
eye development GO:0001654 277 0.020
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.019
cilium morphogenesis GO:0060271 85 0.019
negative regulation of protein phosphorylation GO:0001933 4 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
nuclear import GO:0051170 3 0.019
regulation of exocytosis GO:0017157 1 0.019
positive regulation of cellular process GO:0048522 201 0.019
Worm
generation of neurons GO:0048699 385 0.019
organelle organization GO:0006996 227 0.019
Mouse
nuclear transport GO:0051169 4 0.019
localization of cell GO:0051674 244 0.019
aromatic compound biosynthetic process GO:0019438 217 0.019
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
cellular nitrogen compound metabolic process GO:0034641 290 0.019
cellular nitrogen compound biosynthetic process GO:0044271 218 0.019
neuron development GO:0048666 262 0.019
sensory perception of chemical stimulus GO:0007606 3 0.019
rna localization GO:0006403 4 0.019
endosomal transport GO:0016197 2 0.019
regulation of muscle contraction GO:0006937 3 0.018
organelle fusion GO:0048284 3 0.018
regulation of neural precursor cell proliferation GO:2000177 3 0.018
negative regulation of cellular process GO:0048523 283 0.018
membrane invagination GO:0010324 1 0.018
macromolecular complex disassembly GO:0032984 1 0.018
regulation of neurotransmitter secretion GO:0046928 1 0.018
heart development GO:0007507 313 0.018
heart contraction GO:0060047 71 0.018
cilium assembly GO:0042384 58 0.018
protein polymerization GO:0051258 4 0.018
response to carbohydrate GO:0009743 3 0.018
anterior posterior pattern specification GO:0009952 152 0.018
compound eye development GO:0048749 2 0.018
regulation of gtpase activity GO:0043087 2 0.018
response to external stimulus GO:0009605 264 0.018
morphogenesis of an epithelium GO:0002009 333 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.017
carboxylic acid metabolic process GO:0019752 22 0.017
blood vessel development GO:0001568 246 0.017
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.017
cellular component assembly involved in morphogenesis GO:0010927 107 0.017
positive regulation of biological process GO:0048518 253 0.017
Worm
cellular aromatic compound metabolic process GO:0006725 295 0.017
actin polymerization or depolymerization GO:0008154 2 0.017
vasculature development GO:0001944 278 0.017
protein import GO:0017038 3 0.017
dorsal ventral pattern formation GO:0009953 125 0.017
regulation of cellular amino acid metabolic process GO:0006521 0 0.017
actin filament polymerization GO:0030041 2 0.017
hemopoiesis GO:0030097 183 0.017
protein localization to nucleus GO:0034504 3 0.017
organic cyclic compound biosynthetic process GO:1901362 223 0.017
cellular response to nutrient levels GO:0031669 2 0.017
single organism nuclear import GO:1902593 3 0.017
synaptic vesicle endocytosis GO:0048488 1 0.017
growth GO:0040007 174 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
neurological system process GO:0050877 62 0.017
biosynthetic process GO:0009058 294 0.017
regulation of cell activation GO:0050865 1 0.017
regulation of mrna processing GO:0050684 3 0.016
stem cell division GO:0017145 1 0.016
positive regulation of gtpase activity GO:0043547 1 0.016
organic substance biosynthetic process GO:1901576 289 0.016
gene expression GO:0010467 252 0.016
heterocycle biosynthetic process GO:0018130 215 0.016
nitrogen compound metabolic process GO:0006807 319 0.016
single organism metabolic process GO:0044710 217 0.016
Mouse Worm
cortical cytoskeleton organization GO:0030865 1 0.016
sensory organ development GO:0007423 393 0.016
regulation of embryonic development GO:0045995 47 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
positive regulation of secretion GO:0051047 1 0.016
cytoskeleton dependent cytokinesis GO:0061640 3 0.016
positive regulation of nucleotide catabolic process GO:0030813 1 0.016
regulation of cell differentiation GO:0045595 142 0.016
regulation of protein polymerization GO:0032271 2 0.016
cellular amino acid metabolic process GO:0006520 7 0.016
positive regulation of protein complex assembly GO:0031334 2 0.016
female meiotic division GO:0007143 2 0.015
alcohol biosynthetic process GO:0046165 2 0.015
regulation of transmembrane transporter activity GO:0022898 2 0.015
establishment of protein localization to organelle GO:0072594 4 0.015
negative regulation of kinase activity GO:0033673 4 0.015
negative regulation of signal transduction GO:0009968 94 0.015
enzyme linked receptor protein signaling pathway GO:0007167 106 0.015
hatching GO:0035188 4 0.015
cellular biosynthetic process GO:0044249 286 0.015
cellular response to external stimulus GO:0071496 2 0.015
brain development GO:0007420 293 0.015
regulation of circadian rhythm GO:0042752 4 0.015
axonogenesis GO:0007409 152 0.015
cellular localization GO:0051641 97 0.015
multicellular organismal response to stress GO:0033555 2 0.015
regulation of binding GO:0051098 3 0.015
regulation of macromolecule metabolic process GO:0060255 317 0.015
Worm
tissue remodeling GO:0048771 4 0.015
protein secretion GO:0009306 1 0.015
neuromuscular synaptic transmission GO:0007274 2 0.015
lateral inhibition GO:0046331 1 0.015
g protein coupled receptor signaling pathway GO:0007186 74 0.014
cellular ketone metabolic process GO:0042180 11 0.014
cellular component disassembly GO:0022411 1 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
i kappab kinase nf kappab signaling GO:0007249 4 0.014
regulation of meiotic cell cycle GO:0051445 1 0.014
regulation of anatomical structure morphogenesis GO:0022603 130 0.014
muscle structure development GO:0061061 196 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
central nervous system development GO:0007417 387 0.014
embryonic heart tube development GO:0035050 133 0.014
positive regulation of cytoskeleton organization GO:0051495 3 0.014
neuroblast proliferation GO:0007405 2 0.014
actin filament based movement GO:0030048 1 0.014
meiotic cell cycle process GO:1903046 3 0.014
camera type eye development GO:0043010 222 0.014
circulatory system process GO:0003013 87 0.014
atp catabolic process GO:0006200 4 0.014
regulation of nucleocytoplasmic transport GO:0046822 2 0.014
spermatid development GO:0007286 2 0.014
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.014
neuron projection development GO:0031175 180 0.014
sequestering of metal ion GO:0051238 3 0.014
hormone secretion GO:0046879 2 0.014
chordate embryonic development GO:0043009 271 0.014
synaptic vesicle recycling GO:0036465 1 0.014
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.014
cilium organization GO:0044782 71 0.014
axon ensheathment in central nervous system GO:0032291 2 0.014
regulation of filopodium assembly GO:0051489 2 0.014
cell motility GO:0048870 244 0.014
response to wounding GO:0009611 116 0.014
intracellular signal transduction GO:0035556 85 0.014
Worm
oxoacid metabolic process GO:0043436 31 0.014
regulation of cytokine production GO:0001817 3 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
negative regulation of synapse assembly GO:0051964 2 0.013
proteasomal protein catabolic process GO:0010498 2 0.013
cell substrate adhesion GO:0031589 4 0.013
sequestering of calcium ion GO:0051208 3 0.013
regulation of cellular metabolic process GO:0031323 320 0.013
Worm
regulation of neuronal synaptic plasticity GO:0048168 1 0.013
b cell activation GO:0042113 2 0.013
protein complex disassembly GO:0043241 1 0.013
cellular response to chemical stimulus GO:0070887 157 0.013
modification dependent macromolecule catabolic process GO:0043632 3 0.013
response to monosaccharide GO:0034284 3 0.013
cell morphogenesis involved in differentiation GO:0000904 195 0.013
developmental growth GO:0048589 166 0.013
organic acid metabolic process GO:0006082 31 0.013
cellular component biogenesis GO:0044085 178 0.013
amino acid transport GO:0006865 2 0.013
response to organic substance GO:0010033 153 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
Mouse Worm
regulation of mrna splicing via spliceosome GO:0048024 3 0.013
ion transport GO:0006811 114 0.013
regulation of tube size GO:0035150 2 0.013
regulation of cellular component organization GO:0051128 86 0.013
Worm
protein targeting to nucleus GO:0044744 3 0.013
peptide transport GO:0015833 1 0.013
pancreas development GO:0031016 84 0.013
calcium mediated signaling GO:0019722 2 0.013
hormone transport GO:0009914 2 0.013
developmental growth involved in morphogenesis GO:0060560 86 0.013
regulation of cell projection assembly GO:0060491 4 0.013
death GO:0016265 121 0.013
cell projection assembly GO:0030031 64 0.013
nuclear migration GO:0007097 3 0.012
ubiquitin dependent protein catabolic process GO:0006511 3 0.012
regulation of metal ion transport GO:0010959 4 0.012
regulation of sequestering of calcium ion GO:0051282 4 0.012
negative regulation of sequestering of calcium ion GO:0051283 4 0.012
determination of heart left right asymmetry GO:0061371 117 0.012
positive regulation of reproductive process GO:2000243 2 0.012
lateral line system development GO:0048925 76 0.012
regulation of gene expression GO:0010468 265 0.012
immune system process GO:0002376 241 0.012
heart process GO:0003015 71 0.012
nucleic acid templated transcription GO:0097659 181 0.012
positive regulation of protein polymerization GO:0032273 2 0.012
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.012
negative regulation of signaling GO:0023057 96 0.012
modification dependent protein catabolic process GO:0019941 3 0.012
immune system development GO:0002520 191 0.012
nucleobase containing compound biosynthetic process GO:0034654 205 0.012
organelle assembly GO:0070925 110 0.012
nucleic acid metabolic process GO:0090304 244 0.012
cellular protein catabolic process GO:0044257 4 0.012
ameboidal type cell migration GO:0001667 143 0.012
phosphorus metabolic process GO:0006793 109 0.012
Mouse Worm
positive regulation of jnk cascade GO:0046330 3 0.012
autophagy GO:0006914 4 0.012
regulation of rna biosynthetic process GO:2001141 213 0.012
vesicle localization GO:0051648 27 0.012
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.012
regulation of rna metabolic process GO:0051252 224 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
cellular response to starvation GO:0009267 1 0.012
response to hexose GO:0009746 3 0.012
protein homooligomerization GO:0051260 3 0.012
regulation of rho protein signal transduction GO:0035023 2 0.012
macromolecule modification GO:0043412 111 0.012
Mouse Worm
blood vessel morphogenesis GO:0048514 216 0.012
wound healing GO:0042060 90 0.012
cytoplasm organization GO:0007028 4 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
regulation of cell substrate adhesion GO:0010810 1 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
organelle localization GO:0051640 49 0.012
protein stabilization GO:0050821 2 0.012
mechanosensory behavior GO:0007638 2 0.011
cell matrix adhesion GO:0007160 4 0.011
negative regulation of cell communication GO:0010648 96 0.011
ear development GO:0043583 127 0.011
regulation of transporter activity GO:0032409 2 0.011
protein dephosphorylation GO:0006470 3 0.011
regulation of biosynthetic process GO:0009889 250 0.011
nucleobase containing compound metabolic process GO:0006139 274 0.011
establishment of organelle localization GO:0051656 45 0.011
muscle cell differentiation GO:0042692 139 0.011
fertilization GO:0009566 3 0.011
protein import into nucleus GO:0006606 3 0.011
organonitrogen compound metabolic process GO:1901564 74 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
establishment of vesicle localization GO:0051650 24 0.011
ventricular cardiac muscle tissue development GO:0003229 3 0.011
programmed cell death GO:0012501 119 0.011
developmental programmed cell death GO:0010623 4 0.011
retina development in camera type eye GO:0060041 146 0.011
cortical actin cytoskeleton organization GO:0030866 1 0.011
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.011
striated muscle cell differentiation GO:0051146 129 0.011
blood circulation GO:0008015 87 0.011
catecholamine metabolic process GO:0006584 2 0.011
alternative mrna splicing via spliceosome GO:0000380 1 0.011
tube closure GO:0060606 1 0.011
determination of left right symmetry GO:0007368 179 0.011
protein metabolic process GO:0019538 183 0.011
Mouse Worm
cellular response to light stimulus GO:0071482 4 0.011
negative regulation of defense response GO:0031348 2 0.011
cell cell signaling GO:0007267 52 0.011
Worm
spermatid differentiation GO:0048515 2 0.011
skeletal system development GO:0001501 181 0.011
response to uv GO:0009411 3 0.011
heart morphogenesis GO:0003007 156 0.011
response to nutrient GO:0007584 3 0.011
secondary metabolic process GO:0019748 3 0.011
nucleoside monophosphate catabolic process GO:0009125 4 0.011
cell death GO:0008219 121 0.011
neuron projection extension GO:1990138 45 0.011
ribonucleoside monophosphate catabolic process GO:0009158 4 0.011
golgi vesicle transport GO:0048193 3 0.011
response to drug GO:0042493 3 0.011
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.011
head development GO:0060322 303 0.011
macromolecule biosynthetic process GO:0009059 227 0.011
small molecule metabolic process GO:0044281 77 0.011
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.011
gland development GO:0048732 143 0.011
hindbrain development GO:0030902 91 0.011
pole plasm assembly GO:0007315 4 0.011
single fertilization GO:0007338 3 0.011
protein acetylation GO:0006473 2 0.011
regulation of inflammatory response GO:0050727 2 0.011
leukocyte proliferation GO:0070661 1 0.010
transcription dna templated GO:0006351 181 0.010
heart looping GO:0001947 94 0.010
embryonic heart tube morphogenesis GO:0003143 108 0.010
carbohydrate homeostasis GO:0033500 1 0.010
regulation of protein catabolic process GO:0042176 1 0.010
organism emergence from protective structure GO:0071684 4 0.010
positive regulation of cell adhesion GO:0045785 1 0.010
establishment of localization in cell GO:0051649 77 0.010
catechol containing compound metabolic process GO:0009712 2 0.010
developmental cell growth GO:0048588 52 0.010
homeostatic process GO:0042592 142 0.010
cellular component assembly GO:0022607 170 0.010
muscle cell development GO:0055001 115 0.010
hard palate development GO:0060022 4 0.010
negative regulation of protein complex assembly GO:0031333 1 0.010
axon extension GO:0048675 45 0.010
cell growth GO:0016049 57 0.010
regulation of dendrite development GO:0050773 3 0.010
negative regulation of catabolic process GO:0009895 3 0.010
glial cell migration GO:0008347 3 0.010
convergent extension GO:0060026 118 0.010

map3k12 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.046
nervous system disease DOID:863 0 0.023
disease of cellular proliferation DOID:14566 0 0.013
cancer DOID:162 0 0.012
organ system cancer DOID:0050686 0 0.012
cardiovascular system disease DOID:1287 0 0.012
musculoskeletal system disease DOID:17 0 0.011
sensory system disease DOID:0050155 0 0.010
eye and adnexa disease DOID:1492 0 0.010