Danio rerio

0 known processes

pi4k2a

phosphatidylinositol 4-kinase type 2 alpha

(Aliases: pi4kII alpha,zgc:63646,wu:fc84f05,pi4kii)

pi4k2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.166
signal transduction GO:0007165 455 0.105
maintenance of location GO:0051235 4 0.074
embryonic organ development GO:0048568 381 0.064
lipid storage GO:0019915 1 0.062
developmental programmed cell death GO:0010623 4 0.062
transport GO:0006810 220 0.061
organelle fusion GO:0048284 3 0.060
modification dependent protein catabolic process GO:0019941 3 0.059
proteasomal protein catabolic process GO:0010498 2 0.058
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.058
aging GO:0007568 2 0.057
negative regulation of cellular process GO:0048523 283 0.056
multicellular organism growth GO:0035264 4 0.053
regulation of binding GO:0051098 3 0.051
establishment of localization GO:0051234 244 0.050
ubiquitin dependent protein catabolic process GO:0006511 3 0.050
autophagy GO:0006914 4 0.048
apoptotic process involved in development GO:1902742 2 0.047
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.047
regulation of signal transduction GO:0009966 225 0.047
modification dependent macromolecule catabolic process GO:0043632 3 0.046
single organism membrane fusion GO:0044801 2 0.045
intracellular signal transduction GO:0035556 85 0.044
response to unfolded protein GO:0006986 2 0.044
morphogenesis of an epithelium GO:0002009 333 0.044
positive regulation of catabolic process GO:0009896 4 0.043
sensory organ development GO:0007423 393 0.042
cellular protein catabolic process GO:0044257 4 0.042
extrinsic apoptotic signaling pathway GO:0097191 3 0.041
female sex differentiation GO:0046660 4 0.041
positive regulation of cell cycle GO:0045787 3 0.041
regulation of signaling GO:0023051 235 0.040
cellular response to starvation GO:0009267 1 0.040
cell projection organization GO:0030030 284 0.040
tissue remodeling GO:0048771 4 0.040
positive regulation of cellular catabolic process GO:0031331 3 0.039
heart morphogenesis GO:0003007 156 0.038
regulation of multicellular organism growth GO:0040014 4 0.038
immune system process GO:0002376 241 0.038
regulation of protein catabolic process GO:0042176 1 0.038
developmental growth GO:0048589 166 0.038
meiotic nuclear division GO:0007126 4 0.037
glial cell migration GO:0008347 3 0.037
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.037
response to chemical GO:0042221 320 0.037
regulation of synapse organization GO:0050807 3 0.037
regulation of biological quality GO:0065008 263 0.036
regulation of reproductive process GO:2000241 4 0.036
single organism transport GO:0044765 206 0.036
generation of neurons GO:0048699 385 0.035
locomotion GO:0040011 313 0.035
embryonic limb morphogenesis GO:0030326 2 0.035
positive regulation of transport GO:0051050 2 0.034
synaptic vesicle localization GO:0097479 1 0.034
cell projection morphogenesis GO:0048858 244 0.033
positive regulation of cellular component biogenesis GO:0044089 3 0.033
regulation of cell communication GO:0010646 232 0.033
regulation of protein complex assembly GO:0043254 3 0.033
synaptic growth at neuromuscular junction GO:0051124 2 0.033
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.033
cellular response to topologically incorrect protein GO:0035967 2 0.032
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.032
cellular response to external stimulus GO:0071496 2 0.032
multi organism process GO:0051704 134 0.032
response to topologically incorrect protein GO:0035966 2 0.032
cellular amine metabolic process GO:0044106 2 0.032
negative regulation of protein phosphorylation GO:0001933 4 0.032
camera type eye development GO:0043010 222 0.031
macroautophagy GO:0016236 1 0.030
embryonic organ morphogenesis GO:0048562 274 0.030
positive regulation of biological process GO:0048518 253 0.030
axon development GO:0061564 166 0.029
regulation of intracellular signal transduction GO:1902531 57 0.029
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.029
er nucleus signaling pathway GO:0006984 2 0.029
hemopoiesis GO:0030097 183 0.029
neuron development GO:0048666 262 0.029
development of primary female sexual characteristics GO:0046545 4 0.029
regulation of synapse assembly GO:0051963 3 0.028
mitochondrion organization GO:0007005 4 0.028
cellular component movement GO:0006928 335 0.028
amine metabolic process GO:0009308 2 0.028
growth GO:0040007 174 0.027
establishment of protein localization to organelle GO:0072594 4 0.027
embryo development ending in birth or egg hatching GO:0009792 271 0.027
single organism localization GO:1902578 225 0.027
synaptic vesicle transport GO:0048489 1 0.027
guanosine containing compound catabolic process GO:1901069 2 0.027
neuron differentiation GO:0030182 353 0.027
i kappab kinase nf kappab signaling GO:0007249 4 0.027
tube morphogenesis GO:0035239 349 0.027
nucleobase containing compound metabolic process GO:0006139 274 0.026
endoplasmic reticulum unfolded protein response GO:0030968 2 0.026
regulation of cell shape GO:0008360 1 0.026
cellular response to extracellular stimulus GO:0031668 2 0.026
immune system development GO:0002520 191 0.026
odontogenesis of dentin containing tooth GO:0042475 1 0.025
oxoacid metabolic process GO:0043436 31 0.025
cellular macromolecule metabolic process GO:0044260 391 0.025
regulation of cytokine production GO:0001817 3 0.025
gtp metabolic process GO:0046039 4 0.025
cell death GO:0008219 121 0.025
embryonic heart tube development GO:0035050 133 0.025
membrane fusion GO:0061025 2 0.025
negative regulation of cell communication GO:0010648 96 0.025
guanosine containing compound metabolic process GO:1901068 4 0.025
regulation of metabolic process GO:0019222 359 0.025
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.024
cellular response to nutrient levels GO:0031669 2 0.024
cellular ketone metabolic process GO:0042180 11 0.024
spermatid differentiation GO:0048515 2 0.024
regulation of nucleoside metabolic process GO:0009118 2 0.024
organelle organization GO:0006996 227 0.024
organic acid metabolic process GO:0006082 31 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
negative regulation of signaling GO:0023057 96 0.023
phagocytosis GO:0006909 3 0.023
cell part morphogenesis GO:0032990 246 0.023
response to organic substance GO:0010033 153 0.023
vacuolar transport GO:0007034 2 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
establishment of synaptic vesicle localization GO:0097480 1 0.023
negative regulation of signal transduction GO:0009968 94 0.023
central nervous system development GO:0007417 387 0.023
female gonad development GO:0008585 4 0.023
regulation of metal ion transport GO:0010959 4 0.022
negative regulation of protein kinase activity GO:0006469 4 0.022
cell morphogenesis involved in differentiation GO:0000904 195 0.022
cell morphogenesis GO:0000902 289 0.022
regulation of cellular amino acid metabolic process GO:0006521 0 0.022
cellular component disassembly GO:0022411 1 0.022
endosomal transport GO:0016197 2 0.022
epithelial tube morphogenesis GO:0060562 148 0.022
g1 s transition of mitotic cell cycle GO:0000082 1 0.022
regulation of nucleotide catabolic process GO:0030811 2 0.021
protein polyubiquitination GO:0000209 4 0.021
gtp catabolic process GO:0006184 2 0.021
centrosome organization GO:0051297 1 0.021
golgi vesicle transport GO:0048193 3 0.021
fertilization GO:0009566 3 0.021
response to stress GO:0006950 263 0.021
positive regulation of stress activated mapk cascade GO:0032874 3 0.021
hematopoietic or lymphoid organ development GO:0048534 191 0.021
regulation of cell projection assembly GO:0060491 4 0.021
membrane invagination GO:0010324 1 0.021
adult behavior GO:0030534 2 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
positive regulation of apoptotic signaling pathway GO:2001235 1 0.021
cellular component morphogenesis GO:0032989 336 0.021
stem cell maintenance GO:0019827 4 0.020
brain development GO:0007420 293 0.020
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.020
regulation of autophagy GO:0010506 3 0.020
leukocyte proliferation GO:0070661 1 0.020
digestive system development GO:0055123 289 0.020
compound eye development GO:0048749 2 0.020
regulation of response to stimulus GO:0048583 269 0.019
regulation of response to extracellular stimulus GO:0032104 1 0.019
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.019
cellular response to unfolded protein GO:0034620 2 0.019
negative regulation of response to stimulus GO:0048585 104 0.019
positive regulation of nucleotide catabolic process GO:0030813 1 0.019
post embryonic morphogenesis GO:0009886 4 0.019
positive regulation of map kinase activity GO:0043406 3 0.019
meiotic cell cycle process GO:1903046 3 0.019
eye development GO:0001654 277 0.019
chordate embryonic development GO:0043009 271 0.019
synaptic vesicle recycling GO:0036465 1 0.018
cellular protein metabolic process GO:0044267 129 0.018
post embryonic organ development GO:0048569 4 0.018
regulation of programmed cell death GO:0043067 101 0.018
small gtpase mediated signal transduction GO:0007264 8 0.018
apoptotic process involved in morphogenesis GO:0060561 2 0.018
signal transduction in absence of ligand GO:0038034 1 0.018
stem cell proliferation GO:0072089 4 0.018
digestive tract development GO:0048565 265 0.018
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.018
heart development GO:0007507 313 0.017
embryonic heart tube morphogenesis GO:0003143 108 0.017
regulation of cellular component organization GO:0051128 86 0.017
cellular response to radiation GO:0071478 4 0.017
protein metabolic process GO:0019538 183 0.017
nitrogen compound metabolic process GO:0006807 319 0.017
negative regulation of sequestering of calcium ion GO:0051283 4 0.017
neuron projection morphogenesis GO:0048812 161 0.017
b cell activation GO:0042113 2 0.017
skeletal system development GO:0001501 181 0.017
positive regulation of protein complex assembly GO:0031334 2 0.017
positive regulation of nucleoside metabolic process GO:0045979 1 0.017
regulation of meiotic cell cycle GO:0051445 1 0.017
small molecule metabolic process GO:0044281 77 0.017
regulation of filopodium assembly GO:0051489 2 0.017
cellular response to stress GO:0033554 62 0.017
regulation of circadian rhythm GO:0042752 4 0.017
apoptotic process GO:0006915 116 0.017
mononuclear cell proliferation GO:0032943 1 0.017
regulation of cytoplasmic transport GO:1903649 4 0.017
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.017
positive regulation of cytokine production GO:0001819 2 0.016
regulation of tube size GO:0035150 2 0.016
regulation of gtp catabolic process GO:0033124 2 0.016
sequestering of metal ion GO:0051238 3 0.016
regulation of protein binding GO:0043393 3 0.016
cellular response to chemical stimulus GO:0070887 157 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.016
positive regulation of gtp catabolic process GO:0033126 1 0.016
regulation of apoptotic process GO:0042981 98 0.016
response to uv GO:0009411 3 0.016
ovulation cycle GO:0042698 2 0.016
head development GO:0060322 303 0.016
carboxylic acid metabolic process GO:0019752 22 0.016
cell growth GO:0016049 57 0.016
death GO:0016265 121 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
macromolecule modification GO:0043412 111 0.016
regulation of protein ubiquitination GO:0031396 3 0.016
microtubule organizing center organization GO:0031023 1 0.016
sequestering of calcium ion GO:0051208 3 0.016
regulation of organ growth GO:0046620 3 0.016
regulation of blood vessel size GO:0050880 2 0.016
negative regulation of kinase activity GO:0033673 4 0.016
positive regulation of secretion by cell GO:1903532 1 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.015
cellular component assembly GO:0022607 170 0.015
synaptic vesicle endocytosis GO:0048488 1 0.015
organic substance biosynthetic process GO:1901576 289 0.015
axonogenesis GO:0007409 152 0.015
neuron projection development GO:0031175 180 0.015
regulation of gtpase activity GO:0043087 2 0.015
cell motility GO:0048870 244 0.015
response to nutrient GO:0007584 3 0.015
regulation of primary metabolic process GO:0080090 311 0.015
regulation of nitrogen compound metabolic process GO:0051171 251 0.015
centrosome cycle GO:0007098 1 0.015
regulation of response to cytokine stimulus GO:0060759 3 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
cytokinesis GO:0000910 3 0.015
regulation of synaptic plasticity GO:0048167 1 0.015
homeostasis of number of cells GO:0048872 62 0.015
actin polymerization or depolymerization GO:0008154 2 0.015
single organism metabolic process GO:0044710 217 0.015
single organism intracellular transport GO:1902582 25 0.015
establishment of localization in cell GO:0051649 77 0.015
localization of cell GO:0051674 244 0.015
positive regulation of gtpase activity GO:0043547 1 0.015
mitochondrial transport GO:0006839 2 0.015
cellular response to light stimulus GO:0071482 4 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.014
positive regulation of chromatin modification GO:1903310 1 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
cellular localization GO:0051641 97 0.014
peptidyl serine modification GO:0018209 2 0.014
periodic partitioning GO:0007365 1 0.014
lymphocyte proliferation GO:0046651 1 0.014
positive regulation of cellular process GO:0048522 201 0.014
embryonic skeletal system morphogenesis GO:0048704 93 0.014
protein localization to nucleus GO:0034504 3 0.014
positive regulation of jnk cascade GO:0046330 3 0.014
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.014
protein stabilization GO:0050821 2 0.014
mitotic dna damage checkpoint GO:0044773 4 0.014
lamellipodium organization GO:0097581 1 0.014
protein modification process GO:0036211 100 0.014
post golgi vesicle mediated transport GO:0006892 1 0.014
response to corticosteroid GO:0031960 1 0.014
regulation of cell death GO:0010941 103 0.014
organic cyclic compound metabolic process GO:1901360 301 0.014
inorganic cation transmembrane transport GO:0098662 50 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
leukocyte homeostasis GO:0001776 2 0.014
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.014
post embryonic organ morphogenesis GO:0048563 1 0.013
cytoskeleton dependent cytokinesis GO:0061640 3 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
digestive tract morphogenesis GO:0048546 231 0.013
sensory organ morphogenesis GO:0090596 200 0.013
rna metabolic process GO:0016070 219 0.013
gene expression GO:0010467 252 0.013
response to vitamin GO:0033273 3 0.013
nucleic acid metabolic process GO:0090304 244 0.013
release of sequestered calcium ion into cytosol GO:0051209 3 0.013
regulation of calcium ion transport GO:0051924 2 0.013
response to hydrogen peroxide GO:0042542 3 0.013
long chain fatty acid metabolic process GO:0001676 1 0.013
exocytosis GO:0006887 1 0.013
ovulation cycle process GO:0022602 2 0.013
regulation of multicellular organismal process GO:0051239 277 0.013
regulation of blood pressure GO:0008217 1 0.013
regulation of cell activation GO:0050865 1 0.013
lateral inhibition GO:0046331 1 0.013
cell migration GO:0016477 237 0.013
myeloid cell homeostasis GO:0002262 56 0.013
regulation of catalytic activity GO:0050790 55 0.013
inositol lipid mediated signaling GO:0048017 2 0.013
negative regulation of synapse assembly GO:0051964 2 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
programmed cell death GO:0012501 119 0.013
negative regulation of biological process GO:0048519 304 0.013
cellular response to organic substance GO:0071310 105 0.013
ear development GO:0043583 127 0.013
positive regulation of secretion GO:0051047 1 0.013
cortical actin cytoskeleton organization GO:0030866 1 0.013
endocrine process GO:0050886 2 0.013
protein k48 linked ubiquitination GO:0070936 1 0.012
stem cell fate commitment GO:0048865 1 0.012
positive regulation of metabolic process GO:0009893 108 0.012
regulation of mitochondrion organization GO:0010821 1 0.012
regulation of neurotransmitter secretion GO:0046928 1 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
cell aging GO:0007569 2 0.012
retina development in camera type eye GO:0060041 146 0.012
phosphorylation GO:0016310 69 0.012
gastrulation GO:0007369 208 0.012
hormone biosynthetic process GO:0042446 3 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
wnt signaling pathway GO:0016055 80 0.012
regulation of jak stat cascade GO:0046425 3 0.012
calcium ion transport into cytosol GO:0060402 3 0.012
b cell differentiation GO:0030183 1 0.012
positive regulation of protein polymerization GO:0032273 2 0.012
cellular biosynthetic process GO:0044249 286 0.012
phosphorus metabolic process GO:0006793 109 0.012
negative regulation of defense response GO:0031348 2 0.012
appendage development GO:0048736 80 0.012
cartilage development GO:0051216 96 0.012
negative regulation of response to cytokine stimulus GO:0060761 2 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
regulation of developmental process GO:0050793 247 0.012
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.012
small molecule catabolic process GO:0044282 3 0.012
lipid metabolic process GO:0006629 52 0.012
response to external stimulus GO:0009605 264 0.012
secondary metabolic process GO:0019748 3 0.012
ion transport GO:0006811 114 0.012
phosphate containing compound metabolic process GO:0006796 108 0.012
actin filament polymerization GO:0030041 2 0.012
regulation of stem cell differentiation GO:2000736 4 0.012
double strand break repair GO:0006302 3 0.012
convergent extension GO:0060026 118 0.012
germ line stem cell maintenance GO:0030718 2 0.011
single organism nuclear import GO:1902593 3 0.011
protein secretion GO:0009306 1 0.011
entrainment of circadian clock GO:0009649 2 0.011
response to xenobiotic stimulus GO:0009410 45 0.011
spermatid development GO:0007286 2 0.011
activation of mapk activity GO:0000187 3 0.011
skeletal system morphogenesis GO:0048705 102 0.011
mitotic dna integrity checkpoint GO:0044774 4 0.011
protein phosphorylation GO:0006468 47 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
spindle assembly GO:0051225 2 0.011
heterocycle biosynthetic process GO:0018130 215 0.011
positive regulation of cytoskeleton organization GO:0051495 3 0.011
response to drug GO:0042493 3 0.011
negative regulation of reproductive process GO:2000242 3 0.011
cellular protein modification process GO:0006464 100 0.011
positive regulation of response to stimulus GO:0048584 80 0.011
negative regulation of multi organism process GO:0043901 3 0.011
vesicle localization GO:0051648 27 0.011
positive regulation of protein kinase b signaling GO:0051897 1 0.011
nuclear import GO:0051170 3 0.011
intracellular transport GO:0046907 32 0.011
negative regulation of nuclear division GO:0051784 3 0.011
single organism organelle organization GO:1902589 199 0.011
negative regulation of map kinase activity GO:0043407 2 0.011
cellular nitrogen compound metabolic process GO:0034641 290 0.011
cellular lipid metabolic process GO:0044255 36 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
regulation of organelle assembly GO:1902115 4 0.011
protein homooligomerization GO:0051260 3 0.011
embryonic viscerocranium morphogenesis GO:0048703 52 0.011
protein ubiquitination involved in ubiquitin dependent protein catabolic process GO:0042787 1 0.011
protein localization to plasma membrane GO:0072659 1 0.011
homeostasis of number of cells within a tissue GO:0048873 4 0.011
ras protein signal transduction GO:0007265 7 0.011
cellular lipid catabolic process GO:0044242 3 0.011
osteoclast differentiation GO:0030316 1 0.011
nuclear transport GO:0051169 4 0.011
translational initiation GO:0006413 3 0.011
cell surface receptor signaling pathway GO:0007166 325 0.011
fatty acid transport GO:0015908 1 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
nucleic acid templated transcription GO:0097659 181 0.010
regulation of nervous system development GO:0051960 90 0.010
endosome organization GO:0007032 2 0.010
ovarian follicle development GO:0001541 2 0.010
regulation of neurogenesis GO:0050767 87 0.010
organic acid catabolic process GO:0016054 3 0.010
blood vessel development GO:0001568 246 0.010
blood vessel morphogenesis GO:0048514 216 0.010
cell substrate adhesion GO:0031589 4 0.010
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.010
neurotransmitter secretion GO:0007269 2 0.010
regulation of transporter activity GO:0032409 2 0.010
ion transmembrane transport GO:0034220 91 0.010
regulation of protein transport GO:0051223 3 0.010
regulation of multicellular organismal development GO:2000026 223 0.010
neurotransmitter transport GO:0006836 2 0.010
meiosis i GO:0007127 1 0.010
actin filament based movement GO:0030048 1 0.010
regulation of response to nutrient levels GO:0032107 1 0.010
positive regulation of immune effector process GO:0002699 3 0.010
positive regulation of myeloid cell differentiation GO:0045639 2 0.010
nuclear export GO:0051168 1 0.010
negative regulation of stem cell differentiation GO:2000737 2 0.010
dicarboxylic acid transport GO:0006835 1 0.010
cortical cytoskeleton organization GO:0030865 1 0.010
protein polymerization GO:0051258 4 0.010
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.010
connective tissue development GO:0061448 99 0.010
protein import GO:0017038 3 0.010
regulation of cellular biosynthetic process GO:0031326 245 0.010

pi4k2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.035
nervous system disease DOID:863 0 0.019
disease of cellular proliferation DOID:14566 0 0.019
cancer DOID:162 0 0.019
organ system cancer DOID:0050686 0 0.019
disease of metabolism DOID:0014667 0 0.015
musculoskeletal system disease DOID:17 0 0.014
cardiovascular system disease DOID:1287 0 0.012