Danio rerio

41 known processes

tcf7l2

transcription factor 7-like 2 (T-cell specific, HMG-box)

(Aliases: tcf4)

tcf7l2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
rna biosynthetic process GO:0032774 181 0.982
Human Mouse Worm Fly
posterior lateral line development GO:0048916 38 0.937
Zebrafish
regulation of nitrogen compound metabolic process GO:0051171 251 0.935
Human Mouse Worm Fly
nucleic acid metabolic process GO:0090304 244 0.929
Human Mouse Worm Fly
digestive tract development GO:0048565 265 0.909
neuromast development GO:0048884 46 0.895
Zebrafish
regulation of transcription dna templated GO:0006355 213 0.878
Human Mouse Worm Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.875
Human Mouse Worm Fly
cellular macromolecule biosynthetic process GO:0034645 224 0.870
Human Mouse Worm Fly
sensory system development GO:0048880 76 0.868
Zebrafish
blood circulation GO:0008015 87 0.866
digestive system development GO:0055123 289 0.849
heart looping GO:0001947 94 0.831
regulation of cellular metabolic process GO:0031323 320 0.830
Human Zebrafish Mouse Worm Fly
specification of symmetry GO:0009799 204 0.826
regulation of stem cell proliferation GO:0072091 2 0.821
Fly
embryonic camera type eye development GO:0031076 29 0.819
Zebrafish
cellular biosynthetic process GO:0044249 286 0.817
Human Zebrafish Mouse Worm Fly
organic substance biosynthetic process GO:1901576 289 0.816
Human Zebrafish Mouse Worm Fly
nitrogen compound metabolic process GO:0006807 319 0.804
Human Mouse Worm Fly
macromolecule biosynthetic process GO:0009059 227 0.802
Human Mouse Worm Fly
positive regulation of cellular metabolic process GO:0031325 94 0.788
Human Mouse Worm Fly
regulation of macromolecule biosynthetic process GO:0010556 225 0.785
Human Mouse Worm Fly
determination of heart left right asymmetry GO:0061371 117 0.770
cellular component morphogenesis GO:0032989 336 0.754
regulation of metabolic process GO:0019222 359 0.752
Human Zebrafish Mouse Worm Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.748
Human Mouse Worm Fly
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.741
Mouse
regulation of rna biosynthetic process GO:2001141 213 0.741
Human Mouse Worm Fly
posterior lateral line system development GO:0048915 46 0.714
Zebrafish
somatic stem cell maintenance GO:0035019 1 0.710
Mouse
heart development GO:0007507 313 0.704
Fly
response to drug GO:0042493 3 0.699
lateral line system development GO:0048925 76 0.693
Zebrafish
system process GO:0003008 185 0.692
heterocycle metabolic process GO:0046483 290 0.688
Human Mouse Worm Fly
biosynthetic process GO:0009058 294 0.683
Human Zebrafish Mouse Worm Fly
chemotaxis GO:0006935 104 0.680
cellular macromolecule metabolic process GO:0044260 391 0.679
Human Mouse Worm Fly
positive regulation of cell proliferation GO:0008284 15 0.662
Zebrafish Mouse
heterocycle biosynthetic process GO:0018130 215 0.651
Human Mouse Worm Fly
tissue regeneration GO:0042246 74 0.647
Zebrafish
columnar cuboidal epithelial cell differentiation GO:0002065 38 0.639
regulation of rna metabolic process GO:0051252 224 0.639
Human Mouse Worm Fly
tube morphogenesis GO:0035239 349 0.635
optic placode formation GO:0001743 4 0.631
wound healing GO:0042060 90 0.626
Zebrafish
positive regulation of rna metabolic process GO:0051254 59 0.617
Human Mouse Worm Fly
skeletal system development GO:0001501 181 0.616
positive regulation of gene expression GO:0010628 71 0.613
Human Zebrafish Mouse Worm Fly
cognition GO:0050890 1 0.607
gland development GO:0048732 143 0.597
Mouse Fly
muscle cell differentiation GO:0042692 139 0.592
Human Zebrafish Mouse
brain development GO:0007420 293 0.589
Zebrafish Mouse
regulation of stem cell differentiation GO:2000736 4 0.589
Human
aromatic compound biosynthetic process GO:0019438 217 0.587
Human Mouse Worm Fly
fin development GO:0033333 77 0.583
Zebrafish
multi organism process GO:0051704 134 0.581
hematopoietic or lymphoid organ development GO:0048534 191 0.578
cell proliferation in dorsal spinal cord GO:0010456 2 0.575
Zebrafish
regulation of cell differentiation GO:0045595 142 0.570
Human Zebrafish Mouse Worm Fly
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.568
Human Mouse Worm Fly
nucleobase containing compound biosynthetic process GO:0034654 205 0.567
Human Mouse Worm Fly
posterior lateral line neuromast development GO:0048919 20 0.565
Zebrafish
regulation of cell cycle GO:0051726 52 0.556
Human
dorsal ventral pattern formation GO:0009953 125 0.550
Zebrafish
transcription from rna polymerase ii promoter GO:0006366 80 0.547
Human Mouse Worm Fly
negative regulation of macromolecule metabolic process GO:0010605 76 0.545
Human Mouse Worm Fly
ectodermal placode formation GO:0060788 26 0.537
diencephalon development GO:0021536 58 0.533
Zebrafish Mouse
cellular nitrogen compound biosynthetic process GO:0044271 218 0.533
Human Mouse Worm Fly
regulation of multicellular organismal process GO:0051239 277 0.526
Human Zebrafish Mouse Worm Fly
generation of neurons GO:0048699 385 0.525
Zebrafish Mouse Worm
circulatory system process GO:0003013 87 0.523
stem cell maintenance GO:0019827 4 0.519
Mouse
response to chemical GO:0042221 320 0.516
Mouse
regulation of primary metabolic process GO:0080090 311 0.515
Human Zebrafish Mouse Worm Fly
embryonic eye morphogenesis GO:0048048 30 0.512
Zebrafish
stem cell proliferation GO:0072089 4 0.503
Fly
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.496
Mouse
negative regulation of metabolic process GO:0009892 86 0.495
Human Mouse Worm Fly
sensory organ development GO:0007423 393 0.483
Zebrafish
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.483
Human Mouse Worm Fly
embryonic heart tube development GO:0035050 133 0.483
positive regulation of nucleic acid templated transcription GO:1903508 57 0.481
Human Mouse Worm Fly
programmed cell death GO:0012501 119 0.476
Human Mouse Worm
canonical wnt signaling pathway GO:0060070 48 0.474
cell morphogenesis GO:0000902 289 0.473
oxoacid metabolic process GO:0043436 31 0.471
Human Zebrafish
cellular response to lipid GO:0071396 39 0.468
regulation of biological quality GO:0065008 263 0.466
response to bacterium GO:0009617 58 0.465
negative regulation of gene expression GO:0010629 65 0.463
Human Mouse Worm Fly
taxis GO:0042330 109 0.452
regulation of organ morphogenesis GO:2000027 35 0.451
axon guidance GO:0007411 86 0.450
ossification GO:0001503 23 0.450
Mouse
heart morphogenesis GO:0003007 156 0.447
immune system development GO:0002520 191 0.444
embryonic heart tube morphogenesis GO:0003143 108 0.438
positive regulation of rna biosynthetic process GO:1902680 57 0.436
Human Mouse Worm Fly
regulation of immune system process GO:0002682 34 0.433
Fly
regulation of macromolecule metabolic process GO:0060255 317 0.432
Human Zebrafish Mouse Worm Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.428
Human Mouse Worm Fly
defense response GO:0006952 47 0.427
regulation of glial cell differentiation GO:0045685 4 0.425
Mouse
liver development GO:0001889 96 0.425
maintenance of location GO:0051235 4 0.423
digestive tract morphogenesis GO:0048546 231 0.420
positive regulation of cellular biosynthetic process GO:0031328 68 0.419
Human Mouse Worm Fly
response to wounding GO:0009611 116 0.408
Zebrafish
embryonic camera type eye morphogenesis GO:0048596 19 0.407
Zebrafish
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.406
Human Mouse Worm Fly
positive regulation of epithelial cell proliferation GO:0050679 1 0.405
Mouse
neuron differentiation GO:0030182 353 0.404
Zebrafish Worm
organic acid metabolic process GO:0006082 31 0.403
Human Zebrafish
positive regulation of myeloid cell differentiation GO:0045639 2 0.402
cell motility GO:0048870 244 0.399
Zebrafish
embryonic appendage morphogenesis GO:0035113 30 0.393
determination of bilateral symmetry GO:0009855 204 0.391
larval development GO:0002164 2 0.380
Worm
negative regulation of developmental process GO:0051093 65 0.378
Mouse Worm
locomotion GO:0040011 313 0.377
Zebrafish
regulation of gene expression GO:0010468 265 0.371
Human Zebrafish Mouse Worm Fly
cell morphogenesis involved in differentiation GO:0000904 195 0.371
negative regulation of biological process GO:0048519 304 0.365
Human Zebrafish Mouse Worm Fly
cell differentiation in spinal cord GO:0021515 40 0.362
immune response GO:0006955 28 0.355
regeneration GO:0031099 91 0.355
Zebrafish
cellular aromatic compound metabolic process GO:0006725 295 0.354
Human Mouse Worm Fly
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.353
Human Mouse Worm Fly
regulation of neurogenesis GO:0050767 87 0.351
Zebrafish Mouse
retinal pigment epithelium development GO:0003406 8 0.350
response to other organism GO:0051707 97 0.350
organic cyclic compound metabolic process GO:1901360 301 0.350
Human Mouse Worm Fly
regulation of cell fate specification GO:0042659 20 0.342
Worm
rhythmic process GO:0048511 21 0.340
Worm
formation of primary germ layer GO:0001704 62 0.340
Worm
negative regulation of transcription dna templated GO:0045892 45 0.338
Human Mouse Worm Fly
pancreas development GO:0031016 84 0.332
heart contraction GO:0060047 71 0.332
cellular ketone metabolic process GO:0042180 11 0.329
Zebrafish Mouse
neuroblast proliferation GO:0007405 2 0.317
pharyngeal muscle development GO:0043282 4 0.315
Worm
neuron recognition GO:0008038 18 0.313
positive regulation of metabolic process GO:0009893 108 0.311
Human Zebrafish Mouse Worm Fly
cell fate commitment involved in formation of primary germ layer GO:0060795 26 0.306
Worm
embryonic organ development GO:0048568 381 0.305
Zebrafish Mouse
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.305
determination of left right symmetry GO:0007368 179 0.304
response to stress GO:0006950 263 0.304
Zebrafish Mouse
regulation of cell cycle process GO:0010564 20 0.299
epithelial cell differentiation GO:0030855 116 0.299
protein metabolic process GO:0019538 183 0.298
Human Mouse
regulation of biosynthetic process GO:0009889 250 0.298
Human Zebrafish Mouse Worm Fly
defense response to bacterium GO:0042742 22 0.298
hemopoiesis GO:0030097 183 0.298
neuron projection development GO:0031175 180 0.296
somatic cell dna recombination GO:0016444 1 0.295
regulation of multicellular organismal development GO:2000026 223 0.294
Human Zebrafish Mouse Worm
eye morphogenesis GO:0048592 144 0.293
Zebrafish
positive regulation of immune response GO:0050778 11 0.290
retina development in camera type eye GO:0060041 146 0.289
regulation of cell death GO:0010941 103 0.287
Human Mouse
neuron projection morphogenesis GO:0048812 161 0.286
central nervous system development GO:0007417 387 0.286
Zebrafish Mouse
heart process GO:0003015 71 0.274
cellular protein metabolic process GO:0044267 129 0.271
mesenchymal cell proliferation GO:0010463 1 0.268
bone development GO:0060348 14 0.264
appendage development GO:0048736 80 0.264
Zebrafish Fly
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.262
Human Mouse Worm Fly
regulation of cell fate commitment GO:0010453 22 0.259
Worm
lateral line development GO:0048882 66 0.256
Zebrafish
response to external stimulus GO:0009605 264 0.255
Mouse
negative regulation of gastrulation GO:2000542 11 0.254
inner ear development GO:0048839 126 0.251
foregut morphogenesis GO:0007440 4 0.249
immune effector process GO:0002252 23 0.249
spinal cord development GO:0021510 46 0.247
Zebrafish
stem cell development GO:0048864 82 0.247
Zebrafish Mouse
exocrine system development GO:0035272 28 0.246
Fly
localization of cell GO:0051674 244 0.241
Zebrafish
regulation of molecular function GO:0065009 70 0.240
Human
rhombomere boundary formation GO:0021654 10 0.240
gene expression GO:0010467 252 0.239
Human Zebrafish Mouse Worm Fly
ectodermal placode development GO:0071696 37 0.238
regulation of protein complex assembly GO:0043254 3 0.237
growth GO:0040007 174 0.235
Zebrafish Mouse
secondary metabolic process GO:0019748 3 0.233
camera type eye photoreceptor cell differentiation GO:0060219 19 0.233
determination of ventral identity GO:0048264 21 0.233
bmp signaling pathway GO:0030509 52 0.229
Mouse
renal tubule morphogenesis GO:0061333 1 0.227
defense response to gram negative bacterium GO:0050829 8 0.227
muscle cell development GO:0055001 115 0.227
Zebrafish
negative regulation of cellular process GO:0048523 283 0.225
Human Zebrafish Mouse Worm Fly
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.223
positive regulation of stem cell proliferation GO:2000648 1 0.223
cell part morphogenesis GO:0032990 246 0.222
positive regulation of map kinase activity GO:0043406 3 0.221
eye field cell fate commitment involved in camera type eye formation GO:0060898 3 0.221
cell surface receptor signaling pathway GO:0007166 325 0.219
specification of organ identity GO:0010092 2 0.217
forebrain development GO:0030900 96 0.217
Zebrafish Mouse
post embryonic morphogenesis GO:0009886 4 0.217
Fly
positive regulation of immune system process GO:0002684 17 0.214
steroid hormone mediated signaling pathway GO:0043401 9 0.213
optic placode formation involved in camera type eye formation GO:0046619 3 0.211
lipid storage GO:0019915 1 0.206
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.204
Human Mouse Worm Fly
negative regulation of multicellular organismal process GO:0051241 69 0.204
Mouse Worm
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.204
Human Mouse
apoptotic process GO:0006915 116 0.200
Human Mouse Worm
reproduction GO:0000003 40 0.199
Worm
regulation of catalytic activity GO:0050790 55 0.199
urogenital system development GO:0001655 97 0.198
regulation of mesenchymal cell proliferation GO:0010464 1 0.196
cardioblast migration to the midline involved in heart field formation GO:0060975 7 0.195
cell projection organization GO:0030030 284 0.193
single organism reproductive process GO:0044702 40 0.192
Mouse Worm
enzyme linked receptor protein signaling pathway GO:0007167 106 0.191
Mouse
regulation of signaling GO:0023051 235 0.190
Human Zebrafish Mouse Fly
muscle fiber development GO:0048747 52 0.189
Zebrafish
single organism localization GO:1902578 225 0.189
Human Mouse Worm
positive regulation of multicellular organismal process GO:0051240 52 0.188
Human Zebrafish Worm
cellular response to biotic stimulus GO:0071216 3 0.188
segmentation GO:0035282 97 0.187
Zebrafish
heart formation GO:0060914 13 0.185
hormone transport GO:0009914 2 0.185
Human Mouse
regulation of endodermal cell differentiation GO:1903224 15 0.185
cellular response to organic cyclic compound GO:0071407 38 0.184
single organism organelle organization GO:1902589 199 0.184
Human Worm
myeloid cell differentiation GO:0030099 86 0.184
regulation of vitamin metabolic process GO:0030656 6 0.183
Zebrafish
positive regulation of neurogenesis GO:0050769 24 0.183
Zebrafish
regulation of oligodendrocyte differentiation GO:0048713 1 0.180
Mouse
negative regulation of signal transduction GO:0009968 94 0.178
Human Zebrafish Mouse
positive regulation of jun kinase activity GO:0043507 2 0.176
regulation of retinoic acid biosynthetic process GO:1900052 6 0.176
Zebrafish
midbrain development GO:0030901 28 0.175
Zebrafish
positive regulation of response to stimulus GO:0048584 80 0.174
Human
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.173
Human Mouse Worm Fly
neuron projection guidance GO:0097485 86 0.173
determination of dorsal ventral asymmetry GO:0048262 34 0.171
retina morphogenesis in camera type eye GO:0060042 79 0.168
maintenance of gastrointestinal epithelium GO:0030277 7 0.166
nucleobase containing compound metabolic process GO:0006139 274 0.165
Human Mouse Worm Fly
negative regulation of rna biosynthetic process GO:1902679 45 0.165
Human Mouse Worm Fly
forebrain regionalization GO:0021871 4 0.164
ectodermal placode morphogenesis GO:0071697 32 0.164
immune system process GO:0002376 241 0.161
Fly
axonogenesis GO:0007409 152 0.159
positive regulation of transport GO:0051050 2 0.158
Human Mouse
positive regulation of striated muscle tissue development GO:0045844 1 0.157
embryonic organ morphogenesis GO:0048562 274 0.157
Zebrafish Mouse
regulation of hormone secretion GO:0046883 2 0.157
Human Mouse
positive regulation of macromolecule metabolic process GO:0010604 93 0.156
Human Zebrafish Mouse Worm Fly
gastrulation GO:0007369 208 0.155
Worm
regulation of endodermal cell fate specification GO:0042663 15 0.154
establishment of protein localization to organelle GO:0072594 4 0.152
Mouse
camera type eye morphogenesis GO:0048593 108 0.152
Zebrafish
negative regulation of signaling GO:0023057 96 0.151
Human Zebrafish Mouse
gland morphogenesis GO:0022612 13 0.149
Fly
ventral spinal cord development GO:0021517 35 0.148
cardiac cell fate commitment GO:0060911 1 0.148
polarized epithelial cell differentiation GO:0030859 4 0.148
cardioblast migration GO:0003260 7 0.148
ameboidal type cell migration GO:0001667 143 0.148
Zebrafish
cellular component movement GO:0006928 335 0.145
Zebrafish
skeletal system morphogenesis GO:0048705 102 0.145
muscle tissue development GO:0060537 110 0.144
Mouse
regulation of cell proliferation GO:0042127 37 0.143
Human Zebrafish Mouse Fly
neurological system process GO:0050877 62 0.143
female gonad development GO:0008585 4 0.143
negative regulation of cell growth GO:0030308 7 0.143
retinoic acid metabolic process GO:0042573 9 0.141
Zebrafish
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.141
rna metabolic process GO:0016070 219 0.138
Human Mouse Worm Fly
nucleic acid templated transcription GO:0097659 181 0.137
Human Mouse Worm Fly
single organism transport GO:0044765 206 0.137
Human Mouse Worm
regulation of cell migration GO:0030334 40 0.137
Zebrafish
eye development GO:0001654 277 0.136
Zebrafish
hair cell differentiation GO:0035315 32 0.136
cell proliferation GO:0008283 80 0.134
Human Zebrafish Mouse Fly
glial cell migration GO:0008347 3 0.134
positive regulation of cell communication GO:0010647 56 0.134
Human Mouse
regulation of nervous system development GO:0051960 90 0.133
Zebrafish Mouse
positive regulation of cell differentiation GO:0045597 30 0.132
Human Zebrafish
regulation of transcription involved in cell fate commitment GO:0060850 1 0.132
regulation of cellular biosynthetic process GO:0031326 245 0.132
Human Zebrafish Mouse Worm Fly
heart jogging GO:0003146 40 0.131
oligodendrocyte differentiation GO:0048709 23 0.131
Mouse
camera type eye development GO:0043010 222 0.128
Zebrafish
regulation of heart growth GO:0060420 2 0.128
negative regulation of protein kinase activity GO:0006469 4 0.127
regulation of epithelial cell proliferation GO:0050678 3 0.127
Mouse
reactive oxygen species metabolic process GO:0072593 6 0.127
macromolecule modification GO:0043412 111 0.126
protein import GO:0017038 3 0.126
Mouse
neuron projection extension GO:1990138 45 0.126
somitogenesis GO:0001756 87 0.124
Zebrafish
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.123
Human Mouse Worm Fly
blood vessel morphogenesis GO:0048514 216 0.122
forebrain generation of neurons GO:0021872 14 0.122
Zebrafish
positive regulation of cell cycle GO:0045787 3 0.122
forebrain neuron fate commitment GO:0021877 1 0.121
convergent extension involved in organogenesis GO:0060029 10 0.121
hepaticobiliary system development GO:0061008 98 0.120
pectoral fin development GO:0033339 50 0.120
Zebrafish
positive regulation of transcription dna templated GO:0045893 57 0.119
Human Mouse Worm Fly
negative regulation of apoptotic process GO:0043066 55 0.119
Human
regulation of isoprenoid metabolic process GO:0019747 6 0.119
Zebrafish
regulation of developmental process GO:0050793 247 0.119
Human Zebrafish Mouse Worm Fly
sexual reproduction GO:0019953 36 0.119
peptide transport GO:0015833 1 0.118
Human Mouse
cellular amino acid metabolic process GO:0006520 7 0.117
cardiocyte differentiation GO:0035051 44 0.117
bone morphogenesis GO:0060349 11 0.116
cell fate specification GO:0001708 68 0.116
Worm
photoreceptor cell fate commitment GO:0046552 1 0.116
sequestering of calcium ion GO:0051208 3 0.116
single organism metabolic process GO:0044710 217 0.115
Human Zebrafish Mouse
mesoderm development GO:0007498 88 0.114
Worm
regulation of cell development GO:0060284 100 0.114
Human Zebrafish Mouse
response to steroid hormone GO:0048545 35 0.114
wnt signaling pathway involved in digestive tract morphogenesis GO:0044333 4 0.114
embryonic digestive tract development GO:0048566 4 0.113
Mouse
caudal fin development GO:0033336 9 0.113
Zebrafish
olfactory lobe development GO:0021988 4 0.113
long chain fatty acid transport GO:0015909 1 0.112
cell cycle process GO:0022402 53 0.112
Human Worm
negative regulation of rna metabolic process GO:0051253 48 0.111
Human Mouse Worm Fly
appendage morphogenesis GO:0035107 56 0.110
Zebrafish Fly
response to lipid GO:0033993 60 0.109
neuron fate commitment GO:0048663 26 0.109
tongue morphogenesis GO:0043587 3 0.109
cellular response to lipopolysaccharide GO:0071222 3 0.108
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.108
Human Mouse Worm Fly
regulation of response to stimulus GO:0048583 269 0.108
Human Zebrafish Mouse Fly
lipid metabolic process GO:0006629 52 0.107
Zebrafish Mouse
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.107
Human
response to growth factor GO:0070848 39 0.106
Mouse
proximal distal pattern formation GO:0009954 1 0.106
Worm
small molecule metabolic process GO:0044281 77 0.105
Human Zebrafish Mouse
response to organic cyclic compound GO:0014070 51 0.103
spinal cord radial glial cell differentiation GO:0021531 2 0.103
posterior lateral line neuromast deposition GO:0048922 5 0.103
Zebrafish
negative regulation of protein phosphorylation GO:0001933 4 0.102
carboxylic acid metabolic process GO:0019752 22 0.101
Zebrafish
oogenesis GO:0048477 14 0.101
negative regulation of cellular protein metabolic process GO:0032269 16 0.101
regulation of protein binding GO:0043393 3 0.101
Human
cellular component assembly GO:0022607 170 0.100
axonal fasciculation GO:0007413 11 0.099
negative regulation of cellular biosynthetic process GO:0031327 55 0.099
Human Mouse Worm Fly
axon development GO:0061564 166 0.099
gliogenesis GO:0042063 45 0.099
Mouse
transcription dna templated GO:0006351 181 0.098
Human Mouse Worm Fly
cell fate commitment GO:0045165 99 0.098
Human Mouse Worm
positive regulation of biological process GO:0048518 253 0.098
Human Zebrafish Mouse Worm Fly
female gamete generation GO:0007292 14 0.097
fin morphogenesis GO:0033334 53 0.097
Zebrafish
cell projection morphogenesis GO:0048858 244 0.096
hormone secretion GO:0046879 2 0.096
Human Mouse
hindbrain morphogenesis GO:0021575 22 0.096
regulation of kinase activity GO:0043549 15 0.096
embryonic limb morphogenesis GO:0030326 2 0.094
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.094
Human Mouse Worm Fly
negative regulation of cellular component organization GO:0051129 16 0.093
endoderm formation GO:0001706 29 0.093
regulation of cytokine production GO:0001817 3 0.092
regulation of cell motility GO:2000145 46 0.092
Zebrafish
cell recognition GO:0008037 19 0.092
response to hormone GO:0009725 48 0.090
regulation of sequence specific dna binding transcription factor activity GO:0051090 9 0.090
Human
striated muscle cell differentiation GO:0051146 129 0.090
Zebrafish
negative regulation of cell differentiation GO:0045596 46 0.090
Mouse
dorsal ventral axis specification GO:0009950 14 0.089
positive regulation of molecular function GO:0044093 33 0.089
Human
striated muscle cell development GO:0055002 108 0.088
Zebrafish
regulation of organ growth GO:0046620 3 0.088
Mouse
regulation of chondrocyte differentiation GO:0032330 1 0.088
lipid catabolic process GO:0016042 4 0.087
negative regulation of cell migration GO:0030336 17 0.087
Zebrafish
neural retina development GO:0003407 49 0.087
regulation of hormone levels GO:0010817 21 0.087
Human Zebrafish Mouse
cellular response to molecule of bacterial origin GO:0071219 3 0.087
transport GO:0006810 220 0.086
Human Mouse Worm
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.086
neuron development GO:0048666 262 0.086
Worm
regulation of ossification GO:0030278 5 0.086
regulation of cellular ketone metabolic process GO:0010565 7 0.086
Zebrafish Mouse
mesenchymal cell development GO:0014031 78 0.086
Zebrafish
medial fin development GO:0033338 16 0.086
Zebrafish
homeostatic process GO:0042592 142 0.085
regulation of programmed cell death GO:0043067 101 0.084
Human Mouse
mrna catabolic process GO:0006402 6 0.084
myotube differentiation GO:0014902 45 0.084
oocyte maturation GO:0001556 4 0.084
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.084
neuromast hair cell differentiation GO:0048886 12 0.083
release of sequestered calcium ion into cytosol GO:0051209 3 0.083
cardiac muscle cell differentiation GO:0055007 30 0.083
negative regulation of catalytic activity GO:0043086 21 0.083
macromolecule deacylation GO:0098732 3 0.082
establishment of localization GO:0051234 244 0.082
Human Mouse Worm
nephron morphogenesis GO:0072028 2 0.082
positive regulation of muscle organ development GO:0048636 1 0.081
regionalization GO:0003002 274 0.081
Zebrafish Worm
negative regulation of nucleic acid templated transcription GO:1903507 45 0.081
Human Mouse Worm Fly
protein localization to nucleus GO:0034504 3 0.081
Mouse
regulation of binding GO:0051098 3 0.079
Human
central nervous system neuron differentiation GO:0021953 74 0.079
Zebrafish
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.078
photoreceptor cell differentiation GO:0046530 55 0.078
endoderm development GO:0007492 49 0.078
development of primary female sexual characteristics GO:0046545 4 0.078
positive regulation of muscle cell differentiation GO:0051149 1 0.076
blood vessel endothelial cell migration GO:0043534 18 0.076
regulation of myeloid cell differentiation GO:0045637 8 0.076
negative regulation of neurogenesis GO:0050768 20 0.075
neuroblast differentiation GO:0014016 1 0.075
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.075
Human Mouse Worm Fly
stem cell fate commitment GO:0048865 1 0.075
melanin metabolic process GO:0006582 2 0.074
mesodermal cell fate commitment GO:0001710 14 0.073
Worm
metencephalon development GO:0022037 27 0.073
positive regulation of biosynthetic process GO:0009891 68 0.073
Human Mouse Worm Fly
morphogenesis of an epithelium GO:0002009 333 0.072
positive regulation of stress activated mapk cascade GO:0032874 3 0.072
regulation of signal transduction GO:0009966 225 0.072
Human Zebrafish Mouse Fly
regulation of heart contraction GO:0008016 32 0.072
nephron tubule morphogenesis GO:0072078 1 0.072
regulation of apoptotic process GO:0042981 98 0.071
Human Mouse
epithelial cell development GO:0002064 42 0.070
regulation of anatomical structure morphogenesis GO:0022603 130 0.070
Human
positive regulation of developmental process GO:0051094 50 0.070
Human Zebrafish Worm
cartilage development GO:0051216 96 0.069
response to carbohydrate GO:0009743 3 0.069
Mouse
eye photoreceptor cell differentiation GO:0001754 45 0.069
nephron development GO:0072006 31 0.069
negative regulation of cell death GO:0060548 60 0.069
Human
positive regulation of neuron apoptotic process GO:0043525 1 0.069
exocrine pancreas development GO:0031017 28 0.068
epithelial cell migration GO:0010631 25 0.068
regulation of cellular amino acid metabolic process GO:0006521 0 0.068
olfactory bulb development GO:0021772 4 0.067
antimicrobial humoral response GO:0019730 2 0.067
autophagy GO:0006914 4 0.067
embryonic digestive tract morphogenesis GO:0048557 3 0.067
Mouse
innate immune response GO:0045087 13 0.067
embryonic hemopoiesis GO:0035162 53 0.067
astrocyte differentiation GO:0048708 1 0.067
connective tissue development GO:0061448 99 0.067
cellular protein modification process GO:0006464 100 0.067
phosphorylation GO:0016310 69 0.066
heart field specification GO:0003128 1 0.066
response to external biotic stimulus GO:0043207 97 0.066
positive regulation of signal transduction GO:0009967 56 0.066
Human
multicellular organism growth GO:0035264 4 0.066
Mouse
regulation of embryonic development GO:0045995 47 0.065
rhombomere formation GO:0021594 12 0.065
positive regulation of neural precursor cell proliferation GO:2000179 1 0.065
cell migration involved in heart formation GO:0060974 10 0.065
neural plate pattern specification GO:0060896 12 0.064
axon extension GO:0048675 45 0.064
muscle structure development GO:0061061 196 0.064
Human Zebrafish Mouse Worm
stem cell differentiation GO:0048863 117 0.064
Zebrafish Mouse
positive regulation of cellular process GO:0048522 201 0.064
Human Zebrafish Mouse Worm Fly
histone deacetylation GO:0016575 2 0.064
cellular response to organic substance GO:0071310 105 0.064
Mouse
epidermis development GO:0008544 48 0.062
cellular component assembly involved in morphogenesis GO:0010927 107 0.062
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.062
cardiac muscle tissue development GO:0048738 48 0.061
regulation of cell communication GO:0010646 232 0.061
Human Zebrafish Mouse Fly
embryonic pattern specification GO:0009880 44 0.061
Zebrafish Worm Fly
pigment cell differentiation GO:0050931 38 0.060
glial cell differentiation GO:0010001 42 0.060
Mouse
homeostasis of number of cells GO:0048872 62 0.060
Zebrafish
spinal cord motor neuron differentiation GO:0021522 26 0.060
cytosolic calcium ion transport GO:0060401 3 0.059
circadian rhythm GO:0007623 19 0.059
radial glial cell differentiation GO:0060019 2 0.058
somite development GO:0061053 96 0.058
Zebrafish
germ line stem cell maintenance GO:0030718 2 0.058
regulation of reproductive process GO:2000241 4 0.057
positive regulation of protein complex assembly GO:0031334 2 0.057
sarcomere organization GO:0045214 26 0.057
negative regulation of anterior neural cell fate commitment of the neural plate GO:0022001 1 0.056
endodermal cell fate determination GO:0007493 2 0.056
sequestering of metal ion GO:0051238 3 0.056
endocrine pancreas development GO:0031018 27 0.056
nephron epithelium morphogenesis GO:0072088 1 0.056
pigment metabolic process GO:0042440 12 0.056
forebrain neuron differentiation GO:0021879 14 0.056
Zebrafish
regulation of cell division GO:0051302 12 0.055
Worm

tcf7l2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.358