Danio rerio

0 known processes

timp2a

tissue inhibitor of metalloproteinase 2a

(Aliases: MGC136726,timp2,etID32613.12,fa96h09,zgc:136726,wu:fa96h09)

timp2a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
multicellular organismal metabolic process GO:0044236 2 0.243
cellular amide metabolic process GO:0043603 4 0.181
cellular protein catabolic process GO:0044257 4 0.177
plasma membrane repair GO:0001778 2 0.154
protein localization to nucleus GO:0034504 3 0.133
cognition GO:0050890 1 0.130
nucleoside phosphate metabolic process GO:0006753 28 0.125
Mouse
positive regulation of cytokine production GO:0001819 2 0.120
response to hexose GO:0009746 3 0.116
response to glucose GO:0009749 3 0.108
immune system process GO:0002376 241 0.101
regulation of skeletal muscle tissue development GO:0048641 4 0.101
response to abiotic stimulus GO:0009628 122 0.100
small molecule metabolic process GO:0044281 77 0.096
Mouse
response to other organism GO:0051707 97 0.091
collagen metabolic process GO:0032963 2 0.081
regulation of cellular metabolic process GO:0031323 320 0.081
Mouse
response to chemical GO:0042221 320 0.079
Mouse
defense response to other organism GO:0098542 33 0.079
response to external biotic stimulus GO:0043207 97 0.078
response to alkaloid GO:0043279 2 0.071
regulation of chronic inflammatory response GO:0002676 1 0.070
regulation of cellular amine metabolic process GO:0033238 0 0.068
macrophage chemotaxis GO:0048246 3 0.067
regulation of biological quality GO:0065008 263 0.063
larval development GO:0002164 2 0.063
embryonic organ development GO:0048568 381 0.063
convergent extension GO:0060026 118 0.060
multicellular organismal macromolecule metabolic process GO:0044259 2 0.060
response to stress GO:0006950 263 0.059
system process GO:0003008 185 0.058
intestinal absorption GO:0050892 2 0.058
single organism localization GO:1902578 225 0.056
response to monosaccharide GO:0034284 3 0.056
regulation of multicellular organism growth GO:0040014 4 0.056
cytoskeleton dependent cytokinesis GO:0061640 3 0.054
cellular macromolecule biosynthetic process GO:0034645 224 0.054
response to biotic stimulus GO:0009607 97 0.053
response to external stimulus GO:0009605 264 0.053
response to carbohydrate GO:0009743 3 0.052
response to bacterium GO:0009617 58 0.051
defense response GO:0006952 47 0.050
taurine metabolic process GO:0019530 1 0.049
positive regulation of biological process GO:0048518 253 0.049
Mouse
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.048
negative regulation of cell communication GO:0010648 96 0.048
response to corticosteroid GO:0031960 1 0.048
positive regulation of immune effector process GO:0002699 3 0.046
zymogen activation GO:0031638 3 0.045
positive regulation of cellular component biogenesis GO:0044089 3 0.045
regulation of cell activation GO:0050865 1 0.045
amine metabolic process GO:0009308 2 0.045
organonitrogen compound metabolic process GO:1901564 74 0.044
Mouse
biosynthetic process GO:0009058 294 0.042
gastrulation GO:0007369 208 0.042
growth GO:0040007 174 0.041
regulation of epithelial cell proliferation GO:0050678 3 0.040
head development GO:0060322 303 0.040
regulation of cytoplasmic transport GO:1903649 4 0.040
regulation of multicellular organismal development GO:2000026 223 0.039
Mouse
multicellular organism growth GO:0035264 4 0.039
negative regulation of blood circulation GO:1903523 2 0.038
sequestering of metal ion GO:0051238 3 0.037
cellular component morphogenesis GO:0032989 336 0.037
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.037
carboxylic acid metabolic process GO:0019752 22 0.037
locomotion GO:0040011 313 0.036
cell cycle process GO:0022402 53 0.036
purine containing compound metabolic process GO:0072521 29 0.036
Mouse
apoptotic signaling pathway GO:0097190 23 0.036
regulation of response to stimulus GO:0048583 269 0.036
Mouse
mitotic cell cycle process GO:1903047 48 0.036
cell motility GO:0048870 244 0.036
regulation of blood pressure GO:0008217 1 0.035
morphogenesis of an epithelium GO:0002009 333 0.035
aromatic compound biosynthetic process GO:0019438 217 0.035
carbohydrate derivative metabolic process GO:1901135 61 0.035
Mouse
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.035
protein dephosphorylation GO:0006470 3 0.034
central nervous system development GO:0007417 387 0.034
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.034
organic cyclic compound metabolic process GO:1901360 301 0.033
Mouse
reactive oxygen species metabolic process GO:0072593 6 0.033
cell proliferation GO:0008283 80 0.033
Mouse
determination of heart left right asymmetry GO:0061371 117 0.032
negative regulation of chemotaxis GO:0050922 4 0.032
cellular amine metabolic process GO:0044106 2 0.032
positive regulation of cellular process GO:0048522 201 0.032
cytokinesis GO:0000910 3 0.032
regulation of nervous system development GO:0051960 90 0.031
Mouse
regulation of tube size GO:0035150 2 0.031
regulation of rna biosynthetic process GO:2001141 213 0.030
negative chemotaxis GO:0050919 1 0.030
cell cycle g2 m phase transition GO:0044839 4 0.030
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.029
generation of neurons GO:0048699 385 0.029
Mouse
muscle structure development GO:0061061 196 0.029
golgi vesicle transport GO:0048193 3 0.029
nitrogen compound metabolic process GO:0006807 319 0.028
Mouse
branched chain amino acid metabolic process GO:0009081 1 0.028
neuronal action potential GO:0019228 18 0.028
reactive oxygen species biosynthetic process GO:1903409 1 0.028
vasculature development GO:0001944 278 0.028
cellular carbohydrate metabolic process GO:0044262 4 0.028
cell migration GO:0016477 237 0.028
regulation of carbohydrate metabolic process GO:0006109 4 0.028
cellular nitrogen compound metabolic process GO:0034641 290 0.027
Mouse
regulation of chondrocyte differentiation GO:0032330 1 0.027
chronic inflammatory response GO:0002544 1 0.027
meiotic nuclear division GO:0007126 4 0.027
phagocytosis GO:0006909 3 0.027
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.027
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.027
regulation of cellular amino acid metabolic process GO:0006521 0 0.027
phosphorus metabolic process GO:0006793 109 0.026
Mouse
positive regulation of cellular amine metabolic process GO:0033240 0 0.026
mononuclear cell proliferation GO:0032943 1 0.026
macromolecule biosynthetic process GO:0009059 227 0.026
neurological system process GO:0050877 62 0.026
transcription dna templated GO:0006351 181 0.026
protein metabolic process GO:0019538 183 0.026
Mouse
leukocyte proliferation GO:0070661 1 0.026
positive regulation of catabolic process GO:0009896 4 0.026
rna metabolic process GO:0016070 219 0.025
ameboidal type cell migration GO:0001667 143 0.025
trabecula morphogenesis GO:0061383 2 0.025
organic acid metabolic process GO:0006082 31 0.025
hematopoietic or lymphoid organ development GO:0048534 191 0.025
regulation of hormone secretion GO:0046883 2 0.025
single organism metabolic process GO:0044710 217 0.025
Mouse
cell morphogenesis GO:0000902 289 0.025
synaptic growth at neuromuscular junction GO:0051124 2 0.025
protein import GO:0017038 3 0.024
circulatory system process GO:0003013 87 0.024
regulation of bone mineralization GO:0030500 2 0.024
nucleotide metabolic process GO:0009117 28 0.024
Mouse
regulation of developmental process GO:0050793 247 0.024
Mouse
oxoacid metabolic process GO:0043436 31 0.024
regulation of multicellular organismal process GO:0051239 277 0.023
Mouse
response to salt stress GO:0009651 10 0.023
ubiquitin dependent protein catabolic process GO:0006511 3 0.023
purine ribonucleotide metabolic process GO:0009150 27 0.023
Mouse
liver development GO:0001889 96 0.023
g2 m transition of mitotic cell cycle GO:0000086 4 0.023
cellular component movement GO:0006928 335 0.023
cell death GO:0008219 121 0.023
regulation of ion transmembrane transport GO:0034765 18 0.023
positive regulation of leukocyte mediated immunity GO:0002705 1 0.023
peptide transport GO:0015833 1 0.022
retina development in camera type eye GO:0060041 146 0.022
tissue regeneration GO:0042246 74 0.022
cellular aromatic compound metabolic process GO:0006725 295 0.022
Mouse
regulation of skeletal muscle fiber development GO:0048742 2 0.022
regulation of protein catabolic process GO:0042176 1 0.021
positive regulation of protein kinase b signaling GO:0051897 1 0.021
neuron death GO:0070997 21 0.021
negative regulation of heart contraction GO:0045822 2 0.021
response to radiation GO:0009314 51 0.021
cellular response to external stimulus GO:0071496 2 0.021
autophagy GO:0006914 4 0.021
negative regulation of feeding behavior GO:2000252 2 0.021
regulation of protein complex assembly GO:0043254 3 0.020
regulation of canonical wnt signaling pathway GO:0060828 34 0.020
embryo development ending in birth or egg hatching GO:0009792 271 0.020
organelle organization GO:0006996 227 0.020
primitive erythrocyte differentiation GO:0060319 5 0.020
septum transversum development GO:0003343 4 0.020
positive regulation of transport GO:0051050 2 0.020
glial cell proliferation GO:0014009 4 0.020
peptide metabolic process GO:0006518 1 0.020
nucleoside phosphate biosynthetic process GO:1901293 21 0.020
multicellular organismal signaling GO:0035637 22 0.020
blood circulation GO:0008015 87 0.020
positive regulation of cell cycle GO:0045787 3 0.019
tube morphogenesis GO:0035239 349 0.019
aging GO:0007568 2 0.019
wound healing GO:0042060 90 0.019
cytoskeleton organization GO:0007010 96 0.019
regulation of cell death GO:0010941 103 0.019
regulation of biosynthetic process GO:0009889 250 0.019
cell surface receptor signaling pathway GO:0007166 325 0.019
neuron differentiation GO:0030182 353 0.019
Mouse
b cell activation GO:0042113 2 0.019
organic substance biosynthetic process GO:1901576 289 0.018
activation of mapk activity GO:0000187 3 0.018
olfactory bulb development GO:0021772 4 0.018
mucopolysaccharide metabolic process GO:1903510 2 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.018
nucleic acid templated transcription GO:0097659 181 0.018
brain development GO:0007420 293 0.018
phosphorylation GO:0016310 69 0.018
Mouse
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.018
regulation of rna metabolic process GO:0051252 224 0.018
bleb assembly GO:0032060 1 0.018
b cell differentiation GO:0030183 1 0.018
positive regulation of protein complex assembly GO:0031334 2 0.018
regulation of autophagy GO:0010506 3 0.018
lymphocyte proliferation GO:0046651 1 0.018
regulation of nucleic acid templated transcription GO:1903506 213 0.018
mitotic cell cycle GO:0000278 64 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
cellular ketone metabolic process GO:0042180 11 0.018
positive regulation of map kinase activity GO:0043406 3 0.018
gland development GO:0048732 143 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.017
Mouse
inositol lipid mediated signaling GO:0048017 2 0.017
nucleic acid metabolic process GO:0090304 244 0.017
cell cycle arrest GO:0007050 1 0.017
regulation of response to biotic stimulus GO:0002831 2 0.017
cytosolic calcium ion transport GO:0060401 3 0.017
regulation of endothelial cell proliferation GO:0001936 1 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.017
rrna catabolic process GO:0016075 1 0.017
signal transduction GO:0007165 455 0.017
Mouse
cellular response to chemical stimulus GO:0070887 157 0.017
Mouse
positive regulation of cell activation GO:0050867 1 0.017
positive regulation of oocyte development GO:0060282 1 0.017
response to amino acid GO:0043200 2 0.017
regulation of transporter activity GO:0032409 2 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
positive regulation of muscle cell differentiation GO:0051149 1 0.017
specification of symmetry GO:0009799 204 0.017
organophosphate metabolic process GO:0019637 37 0.017
Mouse
extracellular matrix assembly GO:0085029 1 0.017
oocyte maturation GO:0001556 4 0.017
sequestering of calcium ion GO:0051208 3 0.017
insulin like growth factor receptor signaling pathway GO:0048009 4 0.016
regulation of primary metabolic process GO:0080090 311 0.016
Mouse
intramembranous ossification GO:0001957 3 0.016
skeletal muscle organ development GO:0060538 78 0.016
production of molecular mediator of immune response GO:0002440 2 0.016
connective tissue development GO:0061448 99 0.016
astrocyte differentiation GO:0048708 1 0.016
chordate embryonic development GO:0043009 271 0.016
establishment of protein localization to organelle GO:0072594 4 0.016
wnt signaling pathway involved in digestive tract morphogenesis GO:0044333 4 0.016
defense response to fungus GO:0050832 2 0.016
regulation of cell communication GO:0010646 232 0.016
Mouse
endosomal transport GO:0016197 2 0.016
heterocycle metabolic process GO:0046483 290 0.016
Mouse
regulation of cell motility GO:2000145 46 0.016
regulation of organelle assembly GO:1902115 4 0.015
mrna polyadenylation GO:0006378 2 0.015
membrane invagination GO:0010324 1 0.015
outflow tract morphogenesis GO:0003151 1 0.015
cell cycle g1 s phase transition GO:0044843 1 0.015
regulation of synapse organization GO:0050807 3 0.015
cellular response to oxygen containing compound GO:1901701 20 0.015
ncrna catabolic process GO:0034661 1 0.015
cell morphogenesis involved in differentiation GO:0000904 195 0.015
positive regulation of chronic inflammatory response GO:0002678 1 0.015
positive regulation of multicellular organismal process GO:0051240 52 0.015
cellular response to oxygen levels GO:0071453 1 0.015
positive regulation of neuron death GO:1901216 1 0.015
notochord development GO:0030903 54 0.015
skeletal system morphogenesis GO:0048705 102 0.015
myeloid leukocyte migration GO:0097529 12 0.015
muscle organ development GO:0007517 101 0.015
response to organic substance GO:0010033 153 0.015
Mouse
positive regulation of cellular carbohydrate metabolic process GO:0010676 1 0.015
negative regulation of sequestering of calcium ion GO:0051283 4 0.015
protein polymerization GO:0051258 4 0.014
meiotic cell cycle process GO:1903046 3 0.014
embryonic organ morphogenesis GO:0048562 274 0.014
positive regulation of developmental process GO:0051094 50 0.014
heart looping GO:0001947 94 0.014
cellular response to growth factor stimulus GO:0071363 39 0.014
negative regulation of cellular process GO:0048523 283 0.014
Mouse
cellular biosynthetic process GO:0044249 286 0.014
sprouting angiogenesis GO:0002040 53 0.014
regulation of defense response to virus GO:0050688 2 0.014
nucleobase containing small molecule metabolic process GO:0055086 32 0.014
Mouse
immunoglobulin production GO:0002377 1 0.014
response to wounding GO:0009611 116 0.014
gene expression GO:0010467 252 0.014
Mouse
regeneration GO:0031099 91 0.014
cell part morphogenesis GO:0032990 246 0.014
determination of left right symmetry GO:0007368 179 0.014
positive regulation of lipid metabolic process GO:0045834 1 0.014
homeostasis of number of cells GO:0048872 62 0.014
positive regulation of cell division GO:0051781 2 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
glial cell development GO:0021782 20 0.013
cellular macromolecule metabolic process GO:0044260 391 0.013
Mouse
regulation of signaling GO:0023051 235 0.013
Mouse
cellular protein metabolic process GO:0044267 129 0.013
Mouse
regulation of systemic arterial blood pressure GO:0003073 1 0.013
negative regulation of defense response GO:0031348 2 0.013
direct ossification GO:0036072 3 0.013
protein modification process GO:0036211 100 0.013
phosphatidylinositol mediated signaling GO:0048015 2 0.013
carbohydrate biosynthetic process GO:0016051 1 0.013
regulation of synapse assembly GO:0051963 3 0.013
skeletal system development GO:0001501 181 0.013
extracellular matrix constituent secretion GO:0070278 3 0.013
response to light stimulus GO:0009416 46 0.013
single organism cellular localization GO:1902580 46 0.013
regulation of signal transduction GO:0009966 225 0.012
Mouse
developmental growth GO:0048589 166 0.012
nucleotide biosynthetic process GO:0009165 21 0.012
nucleobase containing compound biosynthetic process GO:0034654 205 0.012
muscle fiber development GO:0048747 52 0.012
response to glucocorticoid GO:0051384 1 0.012
regulation of carbohydrate biosynthetic process GO:0043255 1 0.012
localization of cell GO:0051674 244 0.012
regulation of blood vessel size GO:0050880 2 0.012
single organism membrane organization GO:0044802 20 0.012
cellular response to organic substance GO:0071310 105 0.012
Mouse
eye development GO:0001654 277 0.012
response to hypoxia GO:0001666 25 0.012
positive regulation of biosynthetic process GO:0009891 68 0.012
regulation of cellular component movement GO:0051270 55 0.012
positive regulation of response to stimulus GO:0048584 80 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
sensory organ development GO:0007423 393 0.012
positive regulation of protein deacetylation GO:0090312 1 0.012
hepaticobiliary system development GO:0061008 98 0.011
negative regulation of protein phosphorylation GO:0001933 4 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
glycoprotein metabolic process GO:0009100 23 0.011
negative regulation of innate immune response GO:0045824 2 0.011
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.011
regulation of molecular function GO:0065009 70 0.011
Mouse
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
positive regulation of leukocyte chemotaxis GO:0002690 1 0.011
olfactory lobe development GO:0021988 4 0.011
regulation of dendrite development GO:0050773 3 0.011
glutamate receptor signaling pathway GO:0007215 1 0.011
collagen biosynthetic process GO:0032964 2 0.011
cellular response to biotic stimulus GO:0071216 3 0.011
positive regulation of molecular function GO:0044093 33 0.011
Mouse
epithelial tube morphogenesis GO:0060562 148 0.011
atp catabolic process GO:0006200 4 0.011
erythrocyte differentiation GO:0030218 54 0.011
cellular component assembly GO:0022607 170 0.011
fin morphogenesis GO:0033334 53 0.011
positive regulation of signal transduction GO:0009967 56 0.011
purine nucleotide metabolic process GO:0006163 27 0.011
Mouse
regulation of system process GO:0044057 40 0.011
primitive hemopoiesis GO:0060215 27 0.011
regulation of cell differentiation GO:0045595 142 0.011
Mouse
phosphate containing compound metabolic process GO:0006796 108 0.011
Mouse
protein import into nucleus GO:0006606 3 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.011
lipid digestion GO:0044241 3 0.011
positive regulation of carbohydrate metabolic process GO:0045913 1 0.011
digestive tract morphogenesis GO:0048546 231 0.011
lipid metabolic process GO:0006629 52 0.011
intracellular signal transduction GO:0035556 85 0.011
Mouse
regulation of cellular component organization GO:0051128 86 0.011
cell growth GO:0016049 57 0.010
adipose tissue development GO:0060612 1 0.010
modification dependent protein catabolic process GO:0019941 3 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.010
positive regulation of epithelial cell differentiation GO:0030858 2 0.010
positive regulation of nervous system development GO:0051962 25 0.010
ribose phosphate metabolic process GO:0019693 27 0.010
Mouse
regulation of immunoglobulin production GO:0002637 1 0.010
carbohydrate homeostasis GO:0033500 1 0.010
regulation of peptidase activity GO:0052547 23 0.010
Mouse
negative regulation of immune response GO:0050777 2 0.010
cellular response to nutrient levels GO:0031669 2 0.010
cellular response to hypoxia GO:0071456 1 0.010
cellular response to vascular endothelial growth factor stimulus GO:0035924 3 0.010
regulation of locomotion GO:0040012 55 0.010
nuclear transport GO:0051169 4 0.010
lipid storage GO:0019915 1 0.010
ribonucleoside monophosphate catabolic process GO:0009158 4 0.010
maintenance of location GO:0051235 4 0.010
regulation of cytokine production GO:0001817 3 0.010
cell substrate adhesion GO:0031589 4 0.010
regulation of phosphate metabolic process GO:0019220 43 0.010
Mouse
response to drug GO:0042493 3 0.010
single organism organelle organization GO:1902589 199 0.010
negative regulation of response to stimulus GO:0048585 104 0.010
taxis GO:0042330 109 0.010

timp2a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
charcot marie tooth disease type 4 DOID:0050541 0 0.025
neuromuscular disease DOID:440 0 0.025
disease of anatomical entity DOID:7 0 0.025
charcot marie tooth disease DOID:10595 0 0.025
nervous system disease DOID:863 0 0.025
neuropathy DOID:870 0 0.025
immune system disease DOID:2914 0 0.022
disease of metabolism DOID:0014667 0 0.020
lipid metabolism disorder DOID:3146 0 0.018
inherited metabolic disorder DOID:655 0 0.018
bone marrow disease DOID:4961 0 0.014
hematopoietic system disease DOID:74 0 0.014
amyloidosis DOID:9120 0 0.011
acquired metabolic disease DOID:0060158 0 0.011