Danio rerio

26 known processes

psenen

presenilin enhancer 2 homolog

(Aliases: zgc:109727,pen-2,pen2)

psenen biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell projection organization GO:0030030 284 0.193
cell projection morphogenesis GO:0048858 244 0.148
cellular component morphogenesis GO:0032989 336 0.095
cell morphogenesis GO:0000902 289 0.091
cell part morphogenesis GO:0032990 246 0.090
modification dependent protein catabolic process GO:0019941 3 0.088
aging GO:0007568 2 0.081
neuron development GO:0048666 262 0.079
cell morphogenesis involved in differentiation GO:0000904 195 0.079
neuron projection development GO:0031175 180 0.075
ubiquitin dependent protein catabolic process GO:0006511 3 0.069
larval development GO:0002164 2 0.062
positive regulation of protein complex assembly GO:0031334 2 0.062
single organism transport GO:0044765 206 0.061
somitogenesis GO:0001756 87 0.061
cellular protein catabolic process GO:0044257 4 0.060
neuron differentiation GO:0030182 353 0.060
regulation of binding GO:0051098 3 0.059
cellular response to external stimulus GO:0071496 2 0.059
central nervous system development GO:0007417 387 0.059
nucleobase containing compound biosynthetic process GO:0034654 205 0.058
generation of neurons GO:0048699 385 0.058
localization of cell GO:0051674 244 0.056
meiotic nuclear division GO:0007126 4 0.055
response to chemical GO:0042221 320 0.054
response to external stimulus GO:0009605 264 0.053
regulation of cellular metabolic process GO:0031323 320 0.053
cell surface receptor signaling pathway GO:0007166 325 0.052
Worm
axonogenesis GO:0007409 152 0.051
heterocycle biosynthetic process GO:0018130 215 0.051
modification dependent macromolecule catabolic process GO:0043632 3 0.051
macromolecule biosynthetic process GO:0009059 227 0.049
cellular response to nutrient levels GO:0031669 2 0.047
axon development GO:0061564 166 0.047
response to stress GO:0006950 263 0.046
transcription dna templated GO:0006351 181 0.046
extrinsic apoptotic signaling pathway GO:0097191 3 0.045
positive regulation of cellular process GO:0048522 201 0.045
head development GO:0060322 303 0.044
meiotic cell cycle process GO:1903046 3 0.044
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.044
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.043
regulation of protein complex assembly GO:0043254 3 0.042
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.042
neuron projection morphogenesis GO:0048812 161 0.041
negative regulation of cellular process GO:0048523 283 0.041
organelle organization GO:0006996 227 0.041
proteasomal protein catabolic process GO:0010498 2 0.041
cellular localization GO:0051641 97 0.040
purine nucleoside monophosphate catabolic process GO:0009128 4 0.039
heterocycle metabolic process GO:0046483 290 0.039
regulation of cell shape GO:0008360 1 0.039
regulation of reproductive process GO:2000241 4 0.038
cellular macromolecule biosynthetic process GO:0034645 224 0.038
cellular aromatic compound metabolic process GO:0006725 295 0.038
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.037
cellular component assembly GO:0022607 170 0.037
regulation of signaling GO:0023051 235 0.037
cellular nitrogen compound biosynthetic process GO:0044271 218 0.037
atp catabolic process GO:0006200 4 0.036
positive regulation of map kinase activity GO:0043406 3 0.035
positive regulation of cellular component biogenesis GO:0044089 3 0.035
signal transduction GO:0007165 455 0.035
Worm
establishment of protein localization to organelle GO:0072594 4 0.035
vasculature development GO:0001944 278 0.034
organic substance biosynthetic process GO:1901576 289 0.034
response to organic substance GO:0010033 153 0.034
cellular response to extracellular stimulus GO:0031668 2 0.034
cellular component biogenesis GO:0044085 178 0.034
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.034
positive regulation of biological process GO:0048518 253 0.033
rna biosynthetic process GO:0032774 181 0.033
positive regulation of transport GO:0051050 2 0.033
regulation of signal transduction GO:0009966 225 0.033
chordate embryonic development GO:0043009 271 0.032
enzyme linked receptor protein signaling pathway GO:0007167 106 0.032
regulation of metal ion transport GO:0010959 4 0.032
locomotion GO:0040011 313 0.032
single organism localization GO:1902578 225 0.032
organelle fusion GO:0048284 3 0.031
nuclear transport GO:0051169 4 0.031
amine metabolic process GO:0009308 2 0.030
nitrogen compound metabolic process GO:0006807 319 0.030
death GO:0016265 121 0.030
nucleic acid templated transcription GO:0097659 181 0.030
single organism metabolic process GO:0044710 217 0.030
segmentation GO:0035282 97 0.030
regulation of synaptic plasticity GO:0048167 1 0.030
positive regulation of cytoskeleton organization GO:0051495 3 0.029
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.029
protein localization to nucleus GO:0034504 3 0.029
regulation of metabolic process GO:0019222 359 0.029
negative regulation of protein phosphorylation GO:0001933 4 0.029
secondary metabolic process GO:0019748 3 0.029
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.029
neuroblast proliferation GO:0007405 2 0.029
regulation of oocyte development GO:0060281 3 0.028
regulation of nucleic acid templated transcription GO:1903506 213 0.028
lipid storage GO:0019915 1 0.028
regulation of cellular amino acid metabolic process GO:0006521 0 0.028
aromatic compound biosynthetic process GO:0019438 217 0.028
phosphate containing compound metabolic process GO:0006796 108 0.028
sensory organ development GO:0007423 393 0.028
cellular response to chemical stimulus GO:0070887 157 0.028
brain development GO:0007420 293 0.028
regulation of cellular biosynthetic process GO:0031326 245 0.028
blood vessel development GO:0001568 246 0.028
protein targeting to nucleus GO:0044744 3 0.028
stem cell maintenance GO:0019827 4 0.028
stem cell proliferation GO:0072089 4 0.027
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.027
morphogenesis of an epithelium GO:0002009 333 0.027
taxis GO:0042330 109 0.027
cellular nitrogen compound metabolic process GO:0034641 290 0.027
regulation of cell development GO:0060284 100 0.027
single organism nuclear import GO:1902593 3 0.027
cellular component movement GO:0006928 335 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.026
gene expression GO:0010467 252 0.026
cellular amine metabolic process GO:0044106 2 0.026
maintenance of location GO:0051235 4 0.025
cellular biosynthetic process GO:0044249 286 0.025
regulation of macromolecule biosynthetic process GO:0010556 225 0.025
transport GO:0006810 220 0.025
heart development GO:0007507 313 0.024
cellular ketone metabolic process GO:0042180 11 0.024
immune system process GO:0002376 241 0.024
regulation of biosynthetic process GO:0009889 250 0.024
regulation of protein ubiquitination GO:0031396 3 0.024
response to other organism GO:0051707 97 0.024
organic cyclic compound metabolic process GO:1901360 301 0.024
cellular response to organic substance GO:0071310 105 0.024
gastrulation GO:0007369 208 0.023
meiotic chromosome segregation GO:0045132 3 0.023
digestive tract morphogenesis GO:0048546 231 0.023
exocytosis GO:0006887 1 0.023
organonitrogen compound metabolic process GO:1901564 74 0.023
transcription from rna polymerase ii promoter GO:0006366 80 0.023
cell proliferation GO:0008283 80 0.023
multi organism process GO:0051704 134 0.022
Worm
cell motility GO:0048870 244 0.022
regulation of cell differentiation GO:0045595 142 0.022
nucleocytoplasmic transport GO:0006913 4 0.022
cell migration GO:0016477 237 0.022
fertilization GO:0009566 3 0.022
regulation of gene expression GO:0010468 265 0.022
peptidyl serine phosphorylation GO:0018105 1 0.022
tube morphogenesis GO:0035239 349 0.022
regulation of cell communication GO:0010646 232 0.022
positive regulation of cell cycle GO:0045787 3 0.022
regulation of cellular ketone metabolic process GO:0010565 7 0.022
membrane fusion GO:0061025 2 0.021
regulation of anatomical structure morphogenesis GO:0022603 130 0.021
retina development in camera type eye GO:0060041 146 0.021
response to wounding GO:0009611 116 0.021
positive regulation of cellular catabolic process GO:0031331 3 0.021
lateral inhibition GO:0046331 1 0.021
regulation of calcium ion transport GO:0051924 2 0.021
regulation of developmental process GO:0050793 247 0.021
rna metabolic process GO:0016070 219 0.021
digestive system development GO:0055123 289 0.021
Worm
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
cytoskeleton dependent cytokinesis GO:0061640 3 0.020
nucleobase containing compound metabolic process GO:0006139 274 0.020
endocrine process GO:0050886 2 0.020
regulation of neuron projection development GO:0010975 40 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
negative regulation of biological process GO:0048519 304 0.020
nucleoside monophosphate catabolic process GO:0009125 4 0.020
single organism membrane fusion GO:0044801 2 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
camera type eye development GO:0043010 222 0.020
regulation of meiotic cell cycle GO:0051445 1 0.020
cellular response to starvation GO:0009267 1 0.020
regulation of rna metabolic process GO:0051252 224 0.019
dorsal ventral pattern formation GO:0009953 125 0.019
regulation of cellular protein catabolic process GO:1903362 1 0.019
regulation of biological quality GO:0065008 263 0.019
response to corticosteroid GO:0031960 1 0.019
embryo development ending in birth or egg hatching GO:0009792 271 0.019
Worm
negative regulation of catabolic process GO:0009895 3 0.019
glial cell migration GO:0008347 3 0.019
muscle hypertrophy GO:0014896 2 0.019
positive regulation of gene expression GO:0010628 71 0.019
biosynthetic process GO:0009058 294 0.019
response to nutrient GO:0007584 3 0.019
regulation of macromolecule metabolic process GO:0060255 317 0.019
organic acid metabolic process GO:0006082 31 0.018
cellular macromolecule metabolic process GO:0044260 391 0.018
Mouse
protein import into nucleus GO:0006606 3 0.018
somatic muscle development GO:0007525 4 0.018
regulation of transporter activity GO:0032409 2 0.018
regulation of cytokine production GO:0001817 3 0.018
canonical wnt signaling pathway GO:0060070 48 0.018
regulation of establishment of protein localization GO:0070201 4 0.018
positive regulation of epithelial cell migration GO:0010634 2 0.018
peptidyl serine modification GO:0018209 2 0.018
negative regulation of cell communication GO:0010648 96 0.018
hormone transport GO:0009914 2 0.018
autophagy GO:0006914 4 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.018
regulation of response to stimulus GO:0048583 269 0.018
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
chemotaxis GO:0006935 104 0.018
protein import GO:0017038 3 0.018
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.018
regulation of filopodium assembly GO:0051489 2 0.017
golgi vesicle transport GO:0048193 3 0.017
establishment of localization GO:0051234 244 0.017
mitochondrion organization GO:0007005 4 0.017
regulation of epithelial cell proliferation GO:0050678 3 0.017
angiogenesis GO:0001525 158 0.017
regulation of synapse assembly GO:0051963 3 0.017
response to glucocorticoid GO:0051384 1 0.017
cell death in response to oxidative stress GO:0036473 2 0.017
regulation of nitrogen compound metabolic process GO:0051171 251 0.017
behavior GO:0007610 74 0.017
Worm
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.017
regulation of multicellular organismal development GO:2000026 223 0.017
oxoacid metabolic process GO:0043436 31 0.017
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.017
spindle assembly involved in mitosis GO:0090307 1 0.017
synaptic vesicle transport GO:0048489 1 0.017
negative regulation of nuclear division GO:0051784 3 0.017
regulation of axonogenesis GO:0050770 32 0.017
phagocytosis GO:0006909 3 0.017
cellular response to stress GO:0033554 62 0.017
neurotransmitter transport GO:0006836 2 0.017
negative regulation of kinase activity GO:0033673 4 0.017
regulation of embryonic development GO:0045995 47 0.017
adult behavior GO:0030534 2 0.016
synaptic vesicle localization GO:0097479 1 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.016
negative regulation of protein kinase activity GO:0006469 4 0.016
protein metabolic process GO:0019538 183 0.016
Mouse
mononuclear cell proliferation GO:0032943 1 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.016
pronuclear migration GO:0035046 1 0.016
somite development GO:0061053 96 0.016
cell fate specification GO:0001708 68 0.016
centrosome organization GO:0051297 1 0.016
positive regulation of epithelial cell differentiation GO:0030858 2 0.016
peptide transport GO:0015833 1 0.016
apoptotic process involved in development GO:1902742 2 0.016
striated muscle cell differentiation GO:0051146 129 0.016
positive regulation of signaling GO:0023056 56 0.016
regulation of protein transport GO:0051223 3 0.016
cellular transition metal ion homeostasis GO:0046916 3 0.016
positive regulation of catabolic process GO:0009896 4 0.016
regulation of synapse organization GO:0050807 3 0.016
antimicrobial humoral response GO:0019730 2 0.016
intracellular signal transduction GO:0035556 85 0.016
phosphorylation GO:0016310 69 0.015
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.015
response to external biotic stimulus GO:0043207 97 0.015
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.015
mesenchyme development GO:0060485 127 0.015
apoptotic process GO:0006915 116 0.015
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.015
anterior posterior pattern specification GO:0009952 152 0.015
cell fate commitment GO:0045165 99 0.015
Worm
eye morphogenesis GO:0048592 144 0.015
nucleic acid metabolic process GO:0090304 244 0.015
pigmentation GO:0043473 85 0.015
retina morphogenesis in camera type eye GO:0060042 79 0.015
erk1 and erk2 cascade GO:0070371 4 0.015
regulation of multicellular organismal process GO:0051239 277 0.015
phosphorus metabolic process GO:0006793 109 0.015
signal transduction in absence of ligand GO:0038034 1 0.015
protein complex localization GO:0031503 1 0.015
wnt signaling pathway GO:0016055 80 0.014
embryonic limb morphogenesis GO:0030326 2 0.014
muscle structure development GO:0061061 196 0.014
pole plasm assembly GO:0007315 4 0.014
stem cell division GO:0017145 1 0.014
regulation of carbohydrate metabolic process GO:0006109 4 0.014
negative regulation of mitosis GO:0045839 3 0.014
germ line stem cell maintenance GO:0030718 2 0.014
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.014
regulation of receptor activity GO:0010469 2 0.014
ion transport GO:0006811 114 0.014
cytokinetic process GO:0032506 2 0.014
regulation of oxidative stress induced cell death GO:1903201 2 0.014
positive regulation of apoptotic signaling pathway GO:2001235 1 0.014
eye development GO:0001654 277 0.014
cell cell signaling GO:0007267 52 0.014
regulation of wound healing GO:0061041 2 0.014
cognition GO:0050890 1 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
blood vessel morphogenesis GO:0048514 216 0.014
regulation of mitochondrion organization GO:0010821 1 0.013
epithelial cell differentiation GO:0030855 116 0.013
regulation of intracellular protein transport GO:0033157 3 0.013
ion transmembrane transport GO:0034220 91 0.013
microtubule organizing center organization GO:0031023 1 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
organelle localization GO:0051640 49 0.013
cellular protein metabolic process GO:0044267 129 0.013
Mouse
odontogenesis of dentin containing tooth GO:0042475 1 0.013
organic cyclic compound biosynthetic process GO:1901362 223 0.013
single organism organelle organization GO:1902589 199 0.013
post embryonic organ development GO:0048569 4 0.013
regulation of cellular component organization GO:0051128 86 0.013
muscle cell development GO:0055001 115 0.013
regulation of response to cytokine stimulus GO:0060759 3 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
negative regulation of response to stimulus GO:0048585 104 0.013
vacuolar transport GO:0007034 2 0.013
regulation of muscle hypertrophy GO:0014743 2 0.013
cell cycle process GO:0022402 53 0.013
compound eye development GO:0048749 2 0.013
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.013
b cell differentiation GO:0030183 1 0.013
small molecule metabolic process GO:0044281 77 0.013
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.012
embryonic cranial skeleton morphogenesis GO:0048701 90 0.012
regulation of erk1 and erk2 cascade GO:0070372 4 0.012
guanosine containing compound metabolic process GO:1901068 4 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
regulation of inflammatory response GO:0050727 2 0.012
positive regulation of cell division GO:0051781 2 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
negative regulation of apoptotic process GO:0043066 55 0.012
regulation of transcription dna templated GO:0006355 213 0.012
i kappab kinase nf kappab signaling GO:0007249 4 0.012
muscle tissue development GO:0060537 110 0.012
mesenchymal cell development GO:0014031 78 0.012
regulation of primary metabolic process GO:0080090 311 0.012
single fertilization GO:0007338 3 0.012
mesenchymal cell differentiation GO:0048762 87 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
adherens junction organization GO:0034332 4 0.012
lymphocyte proliferation GO:0046651 1 0.012
regulation of response to oxidative stress GO:1902882 2 0.012
negative regulation of cytoplasmic transport GO:1903650 2 0.012
positive regulation of transcription dna templated GO:0045893 57 0.012
hormone secretion GO:0046879 2 0.012
negative regulation of programmed cell death GO:0043069 58 0.012
response to drug GO:0042493 3 0.012
developmental growth involved in morphogenesis GO:0060560 86 0.012
positive regulation of stress activated mapk cascade GO:0032874 3 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
regulation of rna biosynthetic process GO:2001141 213 0.012
camera type eye morphogenesis GO:0048593 108 0.012
gtp catabolic process GO:0006184 2 0.011
negative regulation of macromolecule metabolic process GO:0010605 76 0.011
homeostatic process GO:0042592 142 0.011
neurotransmitter secretion GO:0007269 2 0.011
reflex GO:0060004 2 0.011
actin cytoskeleton organization GO:0030036 63 0.011
cytoskeleton organization GO:0007010 96 0.011
endosomal transport GO:0016197 2 0.011
guanosine containing compound catabolic process GO:1901069 2 0.011
positive regulation of cell communication GO:0010647 56 0.011
response to carbohydrate GO:0009743 3 0.011
neuron neuron synaptic transmission GO:0007270 1 0.011
response to endogenous stimulus GO:0009719 83 0.011
receptor recycling GO:0001881 4 0.011
beta amyloid metabolic process GO:0050435 1 0.011
embryonic skeletal system development GO:0048706 97 0.011
glucose homeostasis GO:0042593 1 0.011
lipid catabolic process GO:0016042 4 0.011
actin filament based movement GO:0030048 1 0.011
regulation of protein binding GO:0043393 3 0.011
positive regulation of dna metabolic process GO:0051054 1 0.011
negative regulation of signaling GO:0023057 96 0.011
regulation of receptor recycling GO:0001919 3 0.011
dna templated transcription initiation GO:0006352 1 0.011
tissue remodeling GO:0048771 4 0.011
hematopoietic or lymphoid organ development GO:0048534 191 0.011
nuclear import GO:0051170 3 0.011
actin mediated cell contraction GO:0070252 1 0.011
b cell activation GO:0042113 2 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
mitochondrial transport GO:0006839 2 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
dorsal ventral neural tube patterning GO:0021904 1 0.011
cellular component disassembly GO:0022411 1 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
regulation of autophagy GO:0010506 3 0.011
lens development in camera type eye GO:0002088 22 0.011
carbohydrate homeostasis GO:0033500 1 0.011
cortical actin cytoskeleton organization GO:0030866 1 0.011
interspecies interaction between organisms GO:0044419 4 0.011
response to biotic stimulus GO:0009607 97 0.011
negative regulation of protein transport GO:0051224 3 0.011
stem cell differentiation GO:0048863 117 0.011
carbohydrate derivative metabolic process GO:1901135 61 0.011
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.011
response to monosaccharide GO:0034284 3 0.011
regulation of wnt signaling pathway GO:0030111 53 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
cation transport GO:0006812 81 0.010
protein stabilization GO:0050821 2 0.010
regulation of apoptotic process GO:0042981 98 0.010
positive regulation of rna metabolic process GO:0051254 59 0.010
gtp metabolic process GO:0046039 4 0.010
negative regulation of reproductive process GO:2000242 3 0.010
peptide metabolic process GO:0006518 1 0.010
positive regulation of chromosome organization GO:2001252 1 0.010
spindle assembly GO:0051225 2 0.010
forebrain cell migration GO:0021885 1 0.010
mitotic cell cycle embryonic GO:0045448 2 0.010
skeletal muscle tissue development GO:0007519 67 0.010
muscle organ development GO:0007517 101 0.010
digestive tract development GO:0048565 265 0.010
Worm
negative regulation of epithelial cell proliferation GO:0050680 1 0.010
regulation of transmembrane transporter activity GO:0022898 2 0.010
oocyte anterior posterior axis specification GO:0007314 4 0.010
cell death GO:0008219 121 0.010
protein polyubiquitination GO:0000209 4 0.010
regionalization GO:0003002 274 0.010
energy reserve metabolic process GO:0006112 2 0.010
striated muscle cell development GO:0055002 108 0.010
regulation of neurogenesis GO:0050767 87 0.010
pancreas development GO:0031016 84 0.010
vacuole organization GO:0007033 9 0.010

psenen disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.036
inherited metabolic disorder DOID:655 0 0.027
disease of anatomical entity DOID:7 0 0.025
nervous system disease DOID:863 0 0.021
cardiovascular system disease DOID:1287 0 0.020
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
musculoskeletal system disease DOID:17 0 0.016
organ system cancer DOID:0050686 0 0.011