Danio rerio

0 known processes

nlgn4a

neuroligin 4a

(Aliases: nlgn4b)

nlgn4a biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
neuron neuron synaptic transmission GO:0007270 1 0.705
regulation of postsynaptic membrane potential GO:0060078 1 0.531
regulation of adenylate cyclase activity GO:0045761 6 0.531
negative regulation of adenylate cyclase activity GO:0007194 6 0.450
amino acid transport GO:0006865 2 0.305
carboxylic acid metabolic process GO:0019752 22 0.223
negative regulation of camp biosynthetic process GO:0030818 7 0.223
cell projection organization GO:0030030 284 0.218
organonitrogen compound metabolic process GO:1901564 74 0.217
regulation of cyclase activity GO:0031279 12 0.202
organic substance catabolic process GO:1901575 28 0.198
cognition GO:0050890 1 0.190
cyclic nucleotide biosynthetic process GO:0009190 18 0.189
response to external stimulus GO:0009605 264 0.184
larval development GO:0002164 2 0.184
startle response GO:0001964 4 0.182
behavior GO:0007610 74 0.176
head development GO:0060322 303 0.160
adult behavior GO:0030534 2 0.155
adrenergic receptor signaling pathway GO:0071875 5 0.150
negative regulation of camp metabolic process GO:0030815 7 0.146
maintenance of location GO:0051235 4 0.146
neurological system process GO:0050877 62 0.134
negative regulation of lyase activity GO:0051350 6 0.129
monoamine transport GO:0015844 1 0.129
cellular macromolecule metabolic process GO:0044260 391 0.127
multicellular organism growth GO:0035264 4 0.121
small molecule metabolic process GO:0044281 77 0.120
organic substance biosynthetic process GO:1901576 289 0.119
regulation of response to nutrient levels GO:0032107 1 0.119
multi organism process GO:0051704 134 0.118
purine nucleotide biosynthetic process GO:0006164 20 0.117
regulation of membrane potential GO:0042391 23 0.112
glutamate receptor signaling pathway GO:0007215 1 0.108
regionalization GO:0003002 274 0.106
small molecule catabolic process GO:0044282 3 0.105
g protein coupled receptor signaling pathway GO:0007186 74 0.104
oxoacid metabolic process GO:0043436 31 0.104
sensory perception of smell GO:0007608 2 0.100
membrane hyperpolarization GO:0060081 1 0.099
cellular biosynthetic process GO:0044249 286 0.099
response to drug GO:0042493 3 0.096
system process GO:0003008 185 0.093
sleep GO:0030431 1 0.092
positive regulation of transport GO:0051050 2 0.087
cellular nitrogen compound metabolic process GO:0034641 290 0.085
mechanosensory behavior GO:0007638 2 0.084
regulation of lyase activity GO:0051339 12 0.083
nitrogen compound metabolic process GO:0006807 319 0.078
locomotory behavior GO:0007626 34 0.075
negative regulation of nucleotide metabolic process GO:0045980 7 0.074
negative regulation of cyclic nucleotide metabolic process GO:0030800 7 0.070
neuron differentiation GO:0030182 353 0.068
purine containing compound biosynthetic process GO:0072522 20 0.068
regulation of biological quality GO:0065008 263 0.067
brain development GO:0007420 293 0.067
purine ribonucleotide biosynthetic process GO:0009152 20 0.066
single organism localization GO:1902578 225 0.065
branching morphogenesis of a nerve GO:0048755 4 0.063
regulation of dendrite development GO:0050773 3 0.063
negative regulation of cyclic nucleotide biosynthetic process GO:0030803 7 0.062
regulation of extent of cell growth GO:0061387 29 0.057
regulation of receptor activity GO:0010469 2 0.057
locomotion GO:0040011 313 0.057
negative regulation of biological process GO:0048519 304 0.056
positive regulation of cellular component biogenesis GO:0044089 3 0.056
generation of neurons GO:0048699 385 0.056
regulation of camp biosynthetic process GO:0030817 9 0.055
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.055
multicellular organismal water homeostasis GO:0050891 1 0.055
adenylate cyclase modulating g protein coupled receptor signaling pathway GO:0007188 5 0.052
regulation of gene expression GO:0010468 265 0.051
positive regulation of catabolic process GO:0009896 4 0.050
regulation of synapse organization GO:0050807 3 0.050
nucleic acid metabolic process GO:0090304 244 0.050
sensory perception GO:0007600 39 0.050
regulation of metabolic process GO:0019222 359 0.049
neuron projection development GO:0031175 180 0.049
regulation of protein complex assembly GO:0043254 3 0.049
ribonucleotide biosynthetic process GO:0009260 20 0.048
synaptic transmission glycinergic GO:0060012 1 0.048
heterocycle biosynthetic process GO:0018130 215 0.047
cellular amino acid metabolic process GO:0006520 7 0.046
nucleobase containing compound metabolic process GO:0006139 274 0.046
regulation of response to extracellular stimulus GO:0032104 1 0.046
negative regulation of nucleotide biosynthetic process GO:0030809 7 0.045
negative regulation of purine nucleotide metabolic process GO:1900543 7 0.045
regulation of multicellular organismal process GO:0051239 277 0.043
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.043
regulation of reproductive process GO:2000241 4 0.042
cellular aromatic compound metabolic process GO:0006725 295 0.041
neuromuscular process GO:0050905 7 0.041
response to stress GO:0006950 263 0.040
camp biosynthetic process GO:0006171 11 0.040
aging GO:0007568 2 0.039
g protein coupled receptor signaling pathway coupled to cyclic nucleotide second messenger GO:0007187 5 0.038
carboxylic acid catabolic process GO:0046395 3 0.037
organic acid metabolic process GO:0006082 31 0.036
receptor internalization GO:0031623 2 0.036
establishment of localization GO:0051234 244 0.036
tube morphogenesis GO:0035239 349 0.036
organic cyclic compound metabolic process GO:1901360 301 0.036
macromolecule biosynthetic process GO:0009059 227 0.035
regulation of multicellular organism growth GO:0040014 4 0.035
neuron projection morphogenesis GO:0048812 161 0.035
nucleotide biosynthetic process GO:0009165 21 0.035
chemosensory behavior GO:0007635 1 0.035
multi organism reproductive process GO:0044703 36 0.033
circadian sleep wake cycle process GO:0022410 2 0.033
heterocycle metabolic process GO:0046483 290 0.033
negative regulation of cyclase activity GO:0031280 6 0.033
amine metabolic process GO:0009308 2 0.033
cellular amine metabolic process GO:0044106 2 0.032
cellular catabolic process GO:0044248 27 0.032
reflex GO:0060004 2 0.032
regulation of cellular metabolic process GO:0031323 320 0.032
response to amine GO:0014075 1 0.032
single organism behavior GO:0044708 24 0.032
nephron morphogenesis GO:0072028 2 0.031
single organism biosynthetic process GO:0044711 71 0.031
regulation of nervous system development GO:0051960 90 0.031
cellular protein metabolic process GO:0044267 129 0.030
regulation of biosynthetic process GO:0009889 250 0.030
cellular response to chemical stimulus GO:0070887 157 0.030
regulation of multicellular organismal development GO:2000026 223 0.029
dendrite development GO:0016358 9 0.029
cellular component morphogenesis GO:0032989 336 0.029
regulation of cellular component organization GO:0051128 86 0.028
nucleoside phosphate biosynthetic process GO:1901293 21 0.028
gene expression GO:0010467 252 0.028
atp catabolic process GO:0006200 4 0.028
actin polymerization or depolymerization GO:0008154 2 0.028
regulation of receptor recycling GO:0001919 3 0.028
phosphorus metabolic process GO:0006793 109 0.027
meiotic nuclear division GO:0007126 4 0.027
female gonad development GO:0008585 4 0.027
regulation of cell development GO:0060284 100 0.026
regulation of neuron differentiation GO:0045664 56 0.026
dicarboxylic acid metabolic process GO:0043648 1 0.026
muscle system process GO:0003012 20 0.026
growth GO:0040007 174 0.026
positive regulation of metabolic process GO:0009893 108 0.026
cellular nitrogen compound biosynthetic process GO:0044271 218 0.026
regulation of growth rate GO:0040009 1 0.026
regulation of inhibitory postsynaptic membrane potential GO:0060080 1 0.025
cell projection morphogenesis GO:0048858 244 0.025
response to nutrient GO:0007584 3 0.025
cell cycle GO:0007049 93 0.025
biosynthetic process GO:0009058 294 0.025
sensory perception of mechanical stimulus GO:0050954 16 0.025
regulation of sodium ion transport GO:0002028 2 0.025
neuromuscular process controlling balance GO:0050885 3 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.024
regulation of histone methylation GO:0031060 3 0.024
regulation of heart growth GO:0060420 2 0.024
cellular response to extracellular stimulus GO:0031668 2 0.024
endocrine process GO:0050886 2 0.023
protein complex assembly GO:0006461 30 0.023
response to amphetamine GO:0001975 1 0.023
rna metabolic process GO:0016070 219 0.023
cellular response to hormone stimulus GO:0032870 39 0.023
organic acid catabolic process GO:0016054 3 0.023
macromolecular complex subunit organization GO:0043933 74 0.023
dicarboxylic acid transport GO:0006835 1 0.023
regulation of cell differentiation GO:0045595 142 0.023
cellular component assembly GO:0022607 170 0.022
water homeostasis GO:0030104 4 0.022
lipid storage GO:0019915 1 0.022
regulation of macromolecule metabolic process GO:0060255 317 0.022
cellular response to decreased oxygen levels GO:0036294 1 0.022
regulation of tube size GO:0035150 2 0.022
l amino acid transport GO:0015807 1 0.022
response to chemical GO:0042221 320 0.022
purine ribonucleotide metabolic process GO:0009150 27 0.022
negative regulation of behavior GO:0048521 6 0.022
cytokinesis GO:0000910 3 0.021
sensory perception of touch GO:0050975 2 0.021
regulation of axonogenesis GO:0050770 32 0.021
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.021
regulation of metal ion transport GO:0010959 4 0.021
ion transmembrane transport GO:0034220 91 0.021
regulation of dendrite morphogenesis GO:0048814 3 0.020
response to food GO:0032094 1 0.020
ovulation cycle GO:0042698 2 0.020
regulation of ph GO:0006885 3 0.020
regulation of sodium ion transmembrane transport GO:1902305 1 0.019
nephron epithelium morphogenesis GO:0072088 1 0.019
alpha amino acid metabolic process GO:1901605 3 0.019
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.019
regulation of synaptic vesicle transport GO:1902803 1 0.019
response to alkaloid GO:0043279 2 0.019
ribose phosphate metabolic process GO:0019693 27 0.018
monocarboxylic acid catabolic process GO:0072329 3 0.018
ribonucleotide metabolic process GO:0009259 27 0.018
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.018
forebrain development GO:0030900 96 0.018
cellular response to starvation GO:0009267 1 0.018
nucleoside phosphate metabolic process GO:0006753 28 0.018
rna biosynthetic process GO:0032774 181 0.018
regulation of developmental process GO:0050793 247 0.017
regulation of purine nucleotide metabolic process GO:1900542 17 0.017
organonitrogen compound biosynthetic process GO:1901566 47 0.017
positive regulation of lipid metabolic process GO:0045834 1 0.017
negative regulation of cellular process GO:0048523 283 0.017
negative regulation of protein kinase b signaling GO:0051898 2 0.017
postsynaptic membrane organization GO:0001941 3 0.017
phasic smooth muscle contraction GO:0014821 1 0.017
regulation of neurotransmitter transport GO:0051588 1 0.017
purine nucleotide metabolic process GO:0006163 27 0.016
negative regulation of phosphate metabolic process GO:0045936 13 0.016
regulation of dna templated transcription in response to stress GO:0043620 0 0.016
regulation of photoreceptor cell differentiation GO:0046532 2 0.016
neuron development GO:0048666 262 0.016
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.016
regulation of cell projection organization GO:0031344 44 0.016
cellular component biogenesis GO:0044085 178 0.016
positive regulation of biological process GO:0048518 253 0.016
cellular response to nutrient levels GO:0031669 2 0.016
modification dependent macromolecule catabolic process GO:0043632 3 0.016
cell part morphogenesis GO:0032990 246 0.016
negative regulation of purine nucleotide biosynthetic process GO:1900372 7 0.016
regulation of intracellular ph GO:0051453 1 0.016
nucleotide metabolic process GO:0009117 28 0.015
long chain fatty acid transport GO:0015909 1 0.015
modification dependent protein catabolic process GO:0019941 3 0.015
phosphate containing compound metabolic process GO:0006796 108 0.015
response to nitrogen compound GO:1901698 19 0.015
cell surface receptor signaling pathway GO:0007166 325 0.015
transcription dna templated GO:0006351 181 0.015
cellular component maintenance GO:0043954 3 0.015
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.015
negative regulation of gliogenesis GO:0014014 1 0.015
cell morphogenesis involved in differentiation GO:0000904 195 0.015
response to endogenous stimulus GO:0009719 83 0.015
sensory perception of chemical stimulus GO:0007606 3 0.014
response to monosaccharide GO:0034284 3 0.014
regulation of rna biosynthetic process GO:2001141 213 0.014
regulation of cellular ketone metabolic process GO:0010565 7 0.014
negative regulation of reproductive process GO:2000242 3 0.014
single organism metabolic process GO:0044710 217 0.014
cell morphogenesis GO:0000902 289 0.013
germ cell development GO:0007281 22 0.013
smooth muscle contraction GO:0006939 2 0.013
biological adhesion GO:0022610 40 0.013
synapse organization GO:0050808 21 0.013
regulation of primary metabolic process GO:0080090 311 0.013
carbohydrate derivative biosynthetic process GO:1901137 43 0.013
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.013
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.013
oocyte maturation GO:0001556 4 0.013
cellular protein modification process GO:0006464 100 0.013
regulation of macromolecule biosynthetic process GO:0010556 225 0.013
multicellular organismal reproductive process GO:0048609 35 0.012
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.012
positive regulation of cell division GO:0051781 2 0.012
regulation of blood pressure GO:0008217 1 0.012
lipid catabolic process GO:0016042 4 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
anterior posterior pattern specification GO:0009952 152 0.012
response to hormone GO:0009725 48 0.012
embryonic organ development GO:0048568 381 0.012
protein oligomerization GO:0051259 7 0.012
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.012
regulation of nucleotide biosynthetic process GO:0030808 15 0.012
protein metabolic process GO:0019538 183 0.012
nephron tubule morphogenesis GO:0072078 1 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
organophosphate metabolic process GO:0019637 37 0.012
cell adhesion GO:0007155 40 0.012
transmission of nerve impulse GO:0019226 19 0.012
macromolecular complex assembly GO:0065003 35 0.012
regulation of response to stimulus GO:0048583 269 0.012
regulation of cellular biosynthetic process GO:0031326 245 0.012
central nervous system development GO:0007417 387 0.012
cellular protein catabolic process GO:0044257 4 0.012
organelle fusion GO:0048284 3 0.012
pigmentation GO:0043473 85 0.012
regulation of localization GO:0032879 104 0.011
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.011
regulation of fatty acid metabolic process GO:0019217 1 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.011
heart development GO:0007507 313 0.011
cellular response to external stimulus GO:0071496 2 0.011
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.011
carbohydrate derivative metabolic process GO:1901135 61 0.011
synapse assembly GO:0007416 9 0.011
protein complex subunit organization GO:0071822 46 0.011
response to organic substance GO:0010033 153 0.011
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
cellular ketone metabolic process GO:0042180 11 0.010
negative regulation of secretion GO:0051048 2 0.010
aromatic compound biosynthetic process GO:0019438 217 0.010
reciprocal dna recombination GO:0035825 1 0.010
phototransduction GO:0007602 2 0.010
lipid metabolic process GO:0006629 52 0.010
signal transduction GO:0007165 455 0.010
synaptic vesicle localization GO:0097479 1 0.010
regulation of rna metabolic process GO:0051252 224 0.010
gastrulation GO:0007369 208 0.010
anion transport GO:0006820 38 0.010
neuromuscular synaptic transmission GO:0007274 2 0.010
negative regulation of multi organism process GO:0043901 3 0.010

nlgn4a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
autistic disorder DOID:12849 0 0.074
pervasive developmental disorder DOID:0060040 0 0.074
autism spectrum disorder DOID:0060041 0 0.074
disease of mental health DOID:150 0 0.074
developmental disorder of mental health DOID:0060037 0 0.074