Danio rerio

0 known processes

hspa4b

heat shock protein 4b

(Aliases: wu:fi30e11,fi30e11,zgc:77413,zgc:55743,hspa4)

hspa4b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.772
larval development GO:0002164 2 0.676
Worm
proteasomal protein catabolic process GO:0010498 2 0.554
aging GO:0007568 2 0.517
Worm
ubiquitin dependent protein catabolic process GO:0006511 3 0.412
embryo development ending in birth or egg hatching GO:0009792 271 0.406
Worm
cellular macromolecule metabolic process GO:0044260 391 0.307
Yeast Rat
modification dependent macromolecule catabolic process GO:0043632 3 0.301
nucleoside monophosphate catabolic process GO:0009125 4 0.293
Yeast
cellular protein catabolic process GO:0044257 4 0.255
modification dependent protein catabolic process GO:0019941 3 0.249
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.248
establishment of localization GO:0051234 244 0.215
Human Worm
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.213
regulation of macromolecule metabolic process GO:0060255 317 0.208
Rat
regulation of cellular metabolic process GO:0031323 320 0.205
Rat
regulation of protein catabolic process GO:0042176 1 0.198
cellular protein metabolic process GO:0044267 129 0.176
Yeast Rat
nucleic acid templated transcription GO:0097659 181 0.173
gene expression GO:0010467 252 0.173
Rat
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.161
Yeast
ribonucleoside monophosphate catabolic process GO:0009158 4 0.153
Yeast
small molecule metabolic process GO:0044281 77 0.149
Yeast
regulation of establishment of protein localization GO:0070201 4 0.148
mitotic g2 m transition checkpoint GO:0044818 3 0.146
cellular macromolecule biosynthetic process GO:0034645 224 0.138
regulation of macromolecule biosynthetic process GO:0010556 225 0.131
protein metabolic process GO:0019538 183 0.128
Yeast Rat
nucleobase containing compound biosynthetic process GO:0034654 205 0.126
atp catabolic process GO:0006200 4 0.123
Yeast
multicellular organism growth GO:0035264 4 0.114
locomotion GO:0040011 313 0.106
Worm
cell death GO:0008219 121 0.104
Rat
rna biosynthetic process GO:0032774 181 0.103
heterocycle metabolic process GO:0046483 290 0.099
Yeast
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.097
regulation of cellular protein catabolic process GO:1903362 1 0.096
response to stress GO:0006950 263 0.090
Rat Worm
protein modification by small protein removal GO:0070646 1 0.089
mitotic g2 dna damage checkpoint GO:0007095 3 0.087
transcription from rna polymerase ii promoter GO:0006366 80 0.085
regulation of protein metabolic process GO:0051246 56 0.079
Rat
negative regulation of protein phosphorylation GO:0001933 4 0.076
Rat
single organism localization GO:1902578 225 0.075
Human
carbohydrate derivative metabolic process GO:1901135 61 0.072
Yeast
regulation of biosynthetic process GO:0009889 250 0.071
regulation of gene expression GO:0010468 265 0.071
Rat
nucleic acid metabolic process GO:0090304 244 0.070
cellular response to stress GO:0033554 62 0.069
programmed cell death GO:0012501 119 0.069
Rat
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.068
organic substance biosynthetic process GO:1901576 289 0.066
cellular nitrogen compound metabolic process GO:0034641 290 0.065
Yeast
tube morphogenesis GO:0035239 349 0.065
biosynthetic process GO:0009058 294 0.064
transport GO:0006810 220 0.063
Human Worm
regulation of metabolic process GO:0019222 359 0.062
Yeast Rat
positive regulation of gene expression GO:0010628 71 0.062
Rat
digestive tract morphogenesis GO:0048546 231 0.061
regulation of transcription dna templated GO:0006355 213 0.060
positive regulation of transcription dna templated GO:0045893 57 0.060
regulation of protein transport GO:0051223 3 0.060
regulation of cellular biosynthetic process GO:0031326 245 0.058
regulation of multicellular organism growth GO:0040014 4 0.057
positive regulation of cellular biosynthetic process GO:0031328 68 0.057
cellular nitrogen compound biosynthetic process GO:0044271 218 0.057
organic cyclic compound metabolic process GO:1901360 301 0.056
Yeast
protein complex assembly GO:0006461 30 0.055
Human
positive regulation of biosynthetic process GO:0009891 68 0.055
maintenance of location GO:0051235 4 0.055
heterocycle biosynthetic process GO:0018130 215 0.054
nuclear transport GO:0051169 4 0.053
regulation of biological quality GO:0065008 263 0.053
positive regulation of biological process GO:0048518 253 0.053
Rat
macromolecule modification GO:0043412 111 0.053
Rat
protein acetylation GO:0006473 2 0.053
cell cell recognition GO:0009988 1 0.052
cellular component disassembly GO:0022411 1 0.052
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.051
mitotic dna integrity checkpoint GO:0044774 4 0.051
response to organic substance GO:0010033 153 0.050
Worm
embryonic organ development GO:0048568 381 0.048
cellular component assembly GO:0022607 170 0.046
Human
toxin transport GO:1901998 2 0.046
nitrogen compound metabolic process GO:0006807 319 0.045
Yeast
rna metabolic process GO:0016070 219 0.045
fertilization GO:0009566 3 0.045
single organism transport GO:0044765 206 0.045
Human
regulation of molecular function GO:0065009 70 0.044
Yeast Rat
death GO:0016265 121 0.044
Rat
oxoacid metabolic process GO:0043436 31 0.044
macromolecule biosynthetic process GO:0009059 227 0.044
purine nucleoside monophosphate catabolic process GO:0009128 4 0.044
Yeast
positive regulation of cellular metabolic process GO:0031325 94 0.043
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.043
regulation of inflammatory response GO:0050727 2 0.042
cell type specific apoptotic process GO:0097285 22 0.042
nucleocytoplasmic transport GO:0006913 4 0.042
dna templated transcription initiation GO:0006352 1 0.041
positive regulation of rna biosynthetic process GO:1902680 57 0.040
regulation of proteolysis GO:0030162 24 0.040
negative regulation of cellular protein metabolic process GO:0032269 16 0.040
Rat
regulation of primary metabolic process GO:0080090 311 0.039
Rat
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.039
organic cyclic compound biosynthetic process GO:1901362 223 0.038
positive regulation of nucleic acid templated transcription GO:1903508 57 0.038
single fertilization GO:0007338 3 0.038
establishment of localization in cell GO:0051649 77 0.037
Human
cellular biosynthetic process GO:0044249 286 0.036
regulation of cytokine production GO:0001817 3 0.036
head development GO:0060322 303 0.036
cell fate commitment GO:0045165 99 0.036
organonitrogen compound metabolic process GO:1901564 74 0.035
Yeast
determination of bilateral symmetry GO:0009855 204 0.035
single organism metabolic process GO:0044710 217 0.035
Yeast
positive regulation of protein complex assembly GO:0031334 2 0.035
protein import GO:0017038 3 0.035
Human
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.035
transcription dna templated GO:0006351 181 0.034
single organism nuclear import GO:1902593 3 0.034
protein localization to nucleus GO:0034504 3 0.034
mitotic dna damage checkpoint GO:0044773 4 0.034
positive regulation of rna metabolic process GO:0051254 59 0.033
regulation of programmed cell death GO:0043067 101 0.033
Rat
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.033
positive regulation of cellular process GO:0048522 201 0.033
nuclear import GO:0051170 3 0.033
regulation of cell death GO:0010941 103 0.033
Rat
carboxylic acid metabolic process GO:0019752 22 0.032
heart development GO:0007507 313 0.032
central nervous system development GO:0007417 387 0.031
negative regulation of cytokine production GO:0001818 1 0.031
regulation of protein binding GO:0043393 3 0.031
Rat
organic acid metabolic process GO:0006082 31 0.031
digestive system development GO:0055123 289 0.030
cellular macromolecular complex assembly GO:0034622 24 0.030
Human
negative regulation of biological process GO:0048519 304 0.030
Rat
positive regulation of macromolecule metabolic process GO:0010604 93 0.030
Rat
protein complex subunit organization GO:0071822 46 0.030
Human
embryonic digestive tract morphogenesis GO:0048557 3 0.029
proteolysis GO:0006508 38 0.029
cellular amine metabolic process GO:0044106 2 0.029
regulation of protein complex assembly GO:0043254 3 0.029
immune system process GO:0002376 241 0.029
specification of symmetry GO:0009799 204 0.029
negative regulation of cytoplasmic transport GO:1903650 2 0.029
regulation of immune response GO:0050776 14 0.029
cellular response to chemical stimulus GO:0070887 157 0.029
negative regulation of cellular process GO:0048523 283 0.028
Rat
regulation of nucleic acid templated transcription GO:1903506 213 0.027
aromatic compound biosynthetic process GO:0019438 217 0.027
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.027
response to biotic stimulus GO:0009607 97 0.027
chromatin modification GO:0016568 21 0.026
regulation of nitrogen compound metabolic process GO:0051171 251 0.026
protein modification process GO:0036211 100 0.026
Rat
positive regulation of cell activation GO:0050867 1 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.026
single organism intracellular transport GO:1902582 25 0.025
Human
establishment of protein localization to organelle GO:0072594 4 0.025
Human
protein import into nucleus GO:0006606 3 0.025
positive regulation of chromosome organization GO:2001252 1 0.025
positive regulation of molecular function GO:0044093 33 0.025
Rat
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.024
protein targeting to nucleus GO:0044744 3 0.024
negative regulation of apoptotic process GO:0043066 55 0.024
Rat
chordate embryonic development GO:0043009 271 0.023
spindle assembly GO:0051225 2 0.023
negative regulation of cellular catabolic process GO:0031330 3 0.023
amine metabolic process GO:0009308 2 0.023
dna biosynthetic process GO:0071897 3 0.023
embryonic cranial skeleton morphogenesis GO:0048701 90 0.023
lipid storage GO:0019915 1 0.023
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.022
regulation of cytoplasmic transport GO:1903649 4 0.022
protein polymerization GO:0051258 4 0.022
developmental growth GO:0048589 166 0.022
positive regulation of cellular component biogenesis GO:0044089 3 0.021
phagocytosis GO:0006909 3 0.021
negative regulation of response to stimulus GO:0048585 104 0.021
regulation of immune system process GO:0002682 34 0.021
positive regulation of transport GO:0051050 2 0.021
negative regulation of cellular metabolic process GO:0031324 77 0.021
Rat
b cell activation GO:0042113 2 0.021
protein stabilization GO:0050821 2 0.021
regulation of protein targeting GO:1903533 2 0.021
positive regulation of secretion by cell GO:1903532 1 0.020
positive regulation of lipid metabolic process GO:0045834 1 0.020
cellular response to organic substance GO:0071310 105 0.020
negative regulation of signal transduction GO:0009968 94 0.020
regulation of rna metabolic process GO:0051252 224 0.020
regulation of multicellular organismal process GO:0051239 277 0.019
Rat
positive regulation of chromatin modification GO:1903310 1 0.019
protein acylation GO:0043543 3 0.019
chromatin organization GO:0006325 22 0.019
single organism organelle organization GO:1902589 199 0.019
Human
connective tissue development GO:0061448 99 0.019
phosphate containing compound metabolic process GO:0006796 108 0.019
Yeast Rat
regulation of response to stimulus GO:0048583 269 0.019
cellular macromolecule catabolic process GO:0044265 12 0.019
regulation of protein localization to nucleus GO:1900180 2 0.019
vesicle mediated transport GO:0016192 22 0.019
Worm
muscle organ development GO:0007517 101 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
production of molecular mediator of immune response GO:0002440 2 0.018
regulation of intracellular protein transport GO:0033157 3 0.018
g2 dna damage checkpoint GO:0031572 3 0.018
angiogenesis GO:0001525 158 0.018
Rat
nucleobase containing compound metabolic process GO:0006139 274 0.018
Yeast
camera type eye development GO:0043010 222 0.018
negative regulation of cell communication GO:0010648 96 0.017
spindle assembly involved in mitosis GO:0090307 1 0.017
apoptotic process GO:0006915 116 0.017
Rat
catabolic process GO:0009056 32 0.017
Yeast
response to endogenous stimulus GO:0009719 83 0.017
ribonucleotide metabolic process GO:0009259 27 0.017
Yeast
macromolecule localization GO:0033036 54 0.017
Human
cellular protein modification process GO:0006464 100 0.017
Rat
growth GO:0040007 174 0.017
mitotic cell cycle GO:0000278 64 0.017
vasculature development GO:0001944 278 0.017
Rat
macromolecular complex assembly GO:0065003 35 0.016
Human
determination of left right symmetry GO:0007368 179 0.016
regulation of rna biosynthetic process GO:2001141 213 0.016
regulation of chromosome segregation GO:0051983 1 0.016
phosphorus metabolic process GO:0006793 109 0.016
Yeast Rat
cellular response to extracellular stimulus GO:0031668 2 0.016
negative regulation of macromolecule metabolic process GO:0010605 76 0.016
Rat
negative regulation of defense response GO:0031348 2 0.015
regulation of protein import into nucleus GO:0042306 2 0.015
regulation of binding GO:0051098 3 0.015
Rat
tissue regeneration GO:0042246 74 0.015
response to organic cyclic compound GO:0014070 51 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
response to abiotic stimulus GO:0009628 122 0.015
Rat
negative regulation of gene expression GO:0010629 65 0.015
Rat
internal peptidyl lysine acetylation GO:0018393 2 0.015
translational initiation GO:0006413 3 0.015
aromatic compound catabolic process GO:0019439 15 0.015
Yeast
macromolecular complex disassembly GO:0032984 1 0.015
positive regulation of translation GO:0045727 1 0.015
negative regulation of metabolic process GO:0009892 86 0.014
Rat
organelle organization GO:0006996 227 0.014
Human
negative regulation of signaling GO:0023057 96 0.014
regulation of organelle organization GO:0033043 29 0.014
protein secretion GO:0009306 1 0.014
macromolecular complex subunit organization GO:0043933 74 0.014
Human
nucleobase containing small molecule metabolic process GO:0055086 32 0.014
Yeast
embryonic heart tube development GO:0035050 133 0.014
cellular response to external stimulus GO:0071496 2 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
response to chemical GO:0042221 320 0.013
Worm
developmental programmed cell death GO:0010623 4 0.013
negative regulation of biosynthetic process GO:0009890 55 0.013
cell migration GO:0016477 237 0.013
negative regulation of cellular biosynthetic process GO:0031327 55 0.013
regulation of developmental process GO:0050793 247 0.013
Rat
erk1 and erk2 cascade GO:0070371 4 0.013
protein complex biogenesis GO:0070271 30 0.013
Human
ion homeostasis GO:0050801 41 0.013
regulation of erk1 and erk2 cascade GO:0070372 4 0.013
cellular aromatic compound metabolic process GO:0006725 295 0.013
Yeast
signal transduction GO:0007165 455 0.013
muscle structure development GO:0061061 196 0.013
response to oxygen levels GO:0070482 25 0.012
protein complex disassembly GO:0043241 1 0.012
negative regulation of transcription dna templated GO:0045892 45 0.012
response to other organism GO:0051707 97 0.012
regulation of cellular amino acid metabolic process GO:0006521 0 0.012
system process GO:0003008 185 0.012
reproduction GO:0000003 40 0.012
Worm
regulation of signal transduction GO:0009966 225 0.012
mononuclear cell proliferation GO:0032943 1 0.012
positive regulation of catabolic process GO:0009896 4 0.012
organic substance catabolic process GO:1901575 28 0.012
Yeast
positive regulation of cellular catabolic process GO:0031331 3 0.012
cellular response to nutrient levels GO:0031669 2 0.012
negative regulation of protein metabolic process GO:0051248 16 0.012
Rat
regulation of vasculature development GO:1901342 33 0.012
Rat
digestive tract development GO:0048565 265 0.012
embryonic skeletal system morphogenesis GO:0048704 93 0.012
lymphocyte proliferation GO:0046651 1 0.012
zymogen activation GO:0031638 3 0.012
cellular ketone metabolic process GO:0042180 11 0.012
positive regulation of immune response GO:0050778 11 0.011
regulation of cytokine biosynthetic process GO:0042035 1 0.011
sister chromatid cohesion GO:0007062 2 0.011
skeletal system development GO:0001501 181 0.011
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.011
response to external biotic stimulus GO:0043207 97 0.011
regulation of cell activation GO:0050865 1 0.011
negative regulation of immune response GO:0050777 2 0.011
blood vessel morphogenesis GO:0048514 216 0.011
Rat
ribose phosphate metabolic process GO:0019693 27 0.011
Yeast
brain development GO:0007420 293 0.011
cytokinesis GO:0000910 3 0.011
eye morphogenesis GO:0048592 144 0.011
interspecies interaction between organisms GO:0044419 4 0.011
positive regulation of immune system process GO:0002684 17 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
sister chromatid segregation GO:0000819 6 0.011
post embryonic development GO:0009791 7 0.011
Worm
meiotic spindle organization GO:0000212 1 0.011
dna templated transcription elongation GO:0006354 3 0.010
cellular component biogenesis GO:0044085 178 0.010
Human
positive regulation of immune effector process GO:0002699 3 0.010
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.010
histone modification GO:0016570 20 0.010
modification of morphology or physiology of other organism involved in symbiotic interaction GO:0051817 4 0.010
cellular nitrogen compound catabolic process GO:0044270 15 0.010
Yeast
nucleoside phosphate metabolic process GO:0006753 28 0.010
Yeast
positive regulation of multicellular organismal process GO:0051240 52 0.010
Rat
organism emergence from protective structure GO:0071684 4 0.010
sensory organ development GO:0007423 393 0.010
cellular carbohydrate metabolic process GO:0044262 4 0.010

hspa4b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.201
nervous system disease DOID:863 0 0.160
central nervous system disease DOID:331 0 0.049
neurodegenerative disease DOID:1289 0 0.049
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011