Danio rerio

12 known processes

gfra1a

gdnf family receptor alpha 1a

(Aliases: MGC162478,gfralpha1a,zgc:110129)

gfra1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
enteric nervous system development GO:0048484 12 0.759
cognition GO:0050890 1 0.694
positive regulation of cellular process GO:0048522 201 0.645
head development GO:0060322 303 0.520
macromolecule biosynthetic process GO:0009059 227 0.476
response to chemical GO:0042221 320 0.407
autonomic nervous system development GO:0048483 19 0.395
single organism localization GO:1902578 225 0.388
adult behavior GO:0030534 2 0.383
regulation of biological quality GO:0065008 263 0.364
regulation of ion transport GO:0043269 22 0.316
regulation of heart rate GO:0002027 5 0.287
embryonic organ development GO:0048568 381 0.274
smooth muscle contraction GO:0006939 2 0.271
response to stress GO:0006950 263 0.251
negative regulation of multicellular organismal process GO:0051241 69 0.242
cellular component movement GO:0006928 335 0.236
cellular component morphogenesis GO:0032989 336 0.231
system process GO:0003008 185 0.223
neural crest cell differentiation GO:0014033 72 0.216
regulation of macromolecule biosynthetic process GO:0010556 225 0.210
generation of neurons GO:0048699 385 0.209
regulation of cell communication GO:0010646 232 0.208
regulation of molecular function GO:0065009 70 0.200
axon development GO:0061564 166 0.199
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.188
negative regulation of camp metabolic process GO:0030815 7 0.183
developmental growth GO:0048589 166 0.182
cell morphogenesis involved in differentiation GO:0000904 195 0.178
cell projection morphogenesis GO:0048858 244 0.177
negative regulation of hormone secretion GO:0046888 2 0.177
axon extension GO:0048675 45 0.174
regulation of signal transduction GO:0009966 225 0.171
facial nerve morphogenesis GO:0021610 1 0.166
localization of cell GO:0051674 244 0.166
regulation of axon extension GO:0030516 24 0.161
gene expression GO:0010467 252 0.157
central nervous system development GO:0007417 387 0.154
cellular response to organic cyclic compound GO:0071407 38 0.153
response to external stimulus GO:0009605 264 0.150
cell morphogenesis GO:0000902 289 0.145
neuron differentiation GO:0030182 353 0.144
positive regulation of biological process GO:0048518 253 0.144
female gonad development GO:0008585 4 0.141
negative regulation of cellular process GO:0048523 283 0.137
signal transduction GO:0007165 455 0.132
regulation of multicellular organismal process GO:0051239 277 0.127
development of primary female sexual characteristics GO:0046545 4 0.124
neuron projection morphogenesis GO:0048812 161 0.123
regulation of anatomical structure size GO:0090066 33 0.122
cellular nitrogen compound biosynthetic process GO:0044271 218 0.122
regulation of blood pressure GO:0008217 1 0.120
organic acid metabolic process GO:0006082 31 0.118
mesenchyme development GO:0060485 127 0.117
regulation of cell development GO:0060284 100 0.116
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.116
positive regulation of transport GO:0051050 2 0.114
cellular biosynthetic process GO:0044249 286 0.111
regulation of response to stimulus GO:0048583 269 0.110
larval development GO:0002164 2 0.110
regulation of developmental process GO:0050793 247 0.109
sensory perception GO:0007600 39 0.106
mechanosensory lateral line system development GO:0048881 49 0.104
metal ion transport GO:0030001 58 0.102
single organism behavior GO:0044708 24 0.100
regulation of inner ear receptor cell differentiation GO:2000980 1 0.099
regulation of cell morphogenesis GO:0022604 42 0.098
regulation of metal ion transport GO:0010959 4 0.097
organic substance biosynthetic process GO:1901576 289 0.096
diencephalon development GO:0021536 58 0.096
response to alkaloid GO:0043279 2 0.095
branching morphogenesis of a nerve GO:0048755 4 0.094
response to organic substance GO:0010033 153 0.094
cellular macromolecule biosynthetic process GO:0034645 224 0.094
heterocycle biosynthetic process GO:0018130 215 0.094
regulation of axonogenesis GO:0050770 32 0.093
peristalsis GO:0030432 1 0.092
regulation of tube size GO:0035150 2 0.091
regulation of primary metabolic process GO:0080090 311 0.090
regulation of reproductive process GO:2000241 4 0.088
cellular response to steroid hormone stimulus GO:0071383 31 0.088
regulation of multicellular organismal development GO:2000026 223 0.084
transport GO:0006810 220 0.084
regulation of cell morphogenesis involved in differentiation GO:0010769 38 0.083
transcription dna templated GO:0006351 181 0.082
regulation of ion transmembrane transporter activity GO:0032412 2 0.081
embryonic skeletal system development GO:0048706 97 0.080
neuron development GO:0048666 262 0.079
embryonic skeletal system morphogenesis GO:0048704 93 0.078
regulation of circadian sleep wake cycle GO:0042749 1 0.077
facial nerve development GO:0021561 3 0.076
primary amino compound metabolic process GO:1901160 1 0.076
regulation of signaling GO:0023051 235 0.076
negative regulation of signaling GO:0023057 96 0.074
regulation of neurological system process GO:0031644 2 0.074
nerve development GO:0021675 45 0.073
cell motility GO:0048870 244 0.073
rna metabolic process GO:0016070 219 0.072
small molecule metabolic process GO:0044281 77 0.072
peptide transport GO:0015833 1 0.071
regulation of system process GO:0044057 40 0.071
cranial nerve development GO:0021545 42 0.071
maintenance of location GO:0051235 4 0.070
monovalent inorganic cation transport GO:0015672 42 0.069
cation transport GO:0006812 81 0.068
embryo development ending in birth or egg hatching GO:0009792 271 0.067
sensory system development GO:0048880 76 0.066
response to lipid GO:0033993 60 0.066
oocyte maturation GO:0001556 4 0.066
neurological system process GO:0050877 62 0.066
cell recognition GO:0008037 19 0.064
regulation of transmembrane transport GO:0034762 18 0.063
regulation of circadian rhythm GO:0042752 4 0.061
striated muscle tissue development GO:0014706 110 0.061
regulation of localization GO:0032879 104 0.059
catecholamine metabolic process GO:0006584 2 0.059
peripheral nervous system neuron differentiation GO:0048934 28 0.058
regulation of gene expression GO:0010468 265 0.058
neural crest cell development GO:0014032 62 0.058
skeletal system morphogenesis GO:0048705 102 0.057
regulation of locomotion GO:0040012 55 0.057
brain development GO:0007420 293 0.057
cell projection organization GO:0030030 284 0.057
cellular response to organic substance GO:0071310 105 0.057
developmental growth involved in morphogenesis GO:0060560 86 0.056
regulation of transcription dna templated GO:0006355 213 0.055
regulation of protein complex assembly GO:0043254 3 0.055
oxoacid metabolic process GO:0043436 31 0.055
forebrain neuron development GO:0021884 7 0.054
cellular component assembly GO:0022607 170 0.054
regulation of ion transmembrane transport GO:0034765 18 0.054
homeostatic process GO:0042592 142 0.053
response to inorganic substance GO:0010035 38 0.053
organic cyclic compound metabolic process GO:1901360 301 0.052
regulation of neuron migration GO:2001222 2 0.052
response to wounding GO:0009611 116 0.052
negative regulation of secretion by cell GO:1903531 2 0.052
cellular response to hormone stimulus GO:0032870 39 0.052
aging GO:0007568 2 0.052
regulation of axon guidance GO:1902667 8 0.052
organonitrogen compound biosynthetic process GO:1901566 47 0.052
regulation of nitrogen compound metabolic process GO:0051171 251 0.051
establishment of localization GO:0051234 244 0.051
forebrain neuron differentiation GO:0021879 14 0.051
cell death GO:0008219 121 0.051
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.050
amine metabolic process GO:0009308 2 0.049
cation transmembrane transport GO:0098655 65 0.049
chemical homeostasis GO:0048878 49 0.049
cellular amine metabolic process GO:0044106 2 0.049
rna biosynthetic process GO:0032774 181 0.049
embryonic organ morphogenesis GO:0048562 274 0.049
axon guidance GO:0007411 86 0.049
response to nicotine GO:0035094 2 0.048
cell part morphogenesis GO:0032990 246 0.048
catechol containing compound metabolic process GO:0009712 2 0.048
neuron projection development GO:0031175 180 0.048
positive regulation of multicellular organismal process GO:0051240 52 0.047
carboxylic acid metabolic process GO:0019752 22 0.047
cellular response to lipid GO:0071396 39 0.046
regulation of transporter activity GO:0032409 2 0.046
inorganic cation transmembrane transport GO:0098662 50 0.045
positive regulation of neurogenesis GO:0050769 24 0.045
regulation of transmembrane transporter activity GO:0022898 2 0.045
synapse organization GO:0050808 21 0.045
regulation of biosynthetic process GO:0009889 250 0.045
locomotion GO:0040011 313 0.044
negative regulation of cyclic nucleotide metabolic process GO:0030800 7 0.044
forebrain cell migration GO:0021885 1 0.044
negative regulation of nucleotide biosynthetic process GO:0030809 7 0.044
adrenergic receptor signaling pathway GO:0071875 5 0.043
regulation of protein metabolic process GO:0051246 56 0.043
central nervous system neuron development GO:0021954 29 0.043
regulation of intracellular signal transduction GO:1902531 57 0.043
synaptic transmission GO:0007268 35 0.042
neuron recognition GO:0008038 18 0.042
regulation of rna metabolic process GO:0051252 224 0.041
glomerular epithelial cell fate commitment GO:0072314 4 0.041
female sex differentiation GO:0046660 4 0.041
monoamine transport GO:0015844 1 0.040
neuron neuron synaptic transmission GO:0007270 1 0.040
regulation of neuron projection development GO:0010975 40 0.039
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.039
cellular response to chemical stimulus GO:0070887 157 0.039
regulation of cellular biosynthetic process GO:0031326 245 0.038
nitrogen compound metabolic process GO:0006807 319 0.038
lateral line system development GO:0048925 76 0.038
cell surface receptor signaling pathway GO:0007166 325 0.038
cellular response to endogenous stimulus GO:0071495 68 0.037
regulation of cell proliferation GO:0042127 37 0.037
positive regulation of alcohol biosynthetic process GO:1902932 1 0.037
locomotory behavior GO:0007626 34 0.037
response to endogenous stimulus GO:0009719 83 0.037
heterocycle metabolic process GO:0046483 290 0.037
sequestering of metal ion GO:0051238 3 0.036
regulation of metabolic process GO:0019222 359 0.036
regulation of neuron differentiation GO:0045664 56 0.036
regulation of rna biosynthetic process GO:2001141 213 0.036
ion transport GO:0006811 114 0.035
ovulation cycle process GO:0022602 2 0.035
regulation of cellular metabolic process GO:0031323 320 0.035
intracellular signal transduction GO:0035556 85 0.035
positive regulation of gene expression GO:0010628 71 0.035
sensory organ development GO:0007423 393 0.034
negative regulation of biological process GO:0048519 304 0.034
nucleic acid templated transcription GO:0097659 181 0.034
regulation of cellular ketone metabolic process GO:0010565 7 0.034
negative regulation of reproductive process GO:2000242 3 0.034
carbohydrate homeostasis GO:0033500 1 0.033
negative regulation of secretion GO:0051048 2 0.033
extrinsic apoptotic signaling pathway GO:0097191 3 0.033
axonogenesis GO:0007409 152 0.033
regulation of blood vessel size GO:0050880 2 0.033
embryonic skeletal joint morphogenesis GO:0060272 3 0.032
cellular amino acid metabolic process GO:0006520 7 0.032
regulation of nervous system development GO:0051960 90 0.032
cell migration GO:0016477 237 0.032
regulation of neurotransmitter transport GO:0051588 1 0.032
neuron projection guidance GO:0097485 86 0.032
response to hormone GO:0009725 48 0.031
response to alcohol GO:0097305 14 0.031
positive regulation of secretion GO:0051047 1 0.031
multicellular organismal response to stress GO:0033555 2 0.030
positive regulation of protein metabolic process GO:0051247 23 0.030
action potential GO:0001508 19 0.030
forebrain generation of neurons GO:0021872 14 0.030
negative regulation of nervous system development GO:0051961 22 0.029
response to abiotic stimulus GO:0009628 122 0.029
aromatic compound biosynthetic process GO:0019438 217 0.029
transmembrane transport GO:0055085 120 0.029
regulation of macromolecule metabolic process GO:0060255 317 0.029
cellular response to estrogen stimulus GO:0071391 24 0.028
lateral line development GO:0048882 66 0.028
single organism metabolic process GO:0044710 217 0.028
heart contraction GO:0060047 71 0.028
regulation of cellular component organization GO:0051128 86 0.027
transmission of nerve impulse GO:0019226 19 0.027
cell migration in hindbrain GO:0021535 7 0.027
regulation of extent of cell growth GO:0061387 29 0.027
positive regulation of reproductive process GO:2000243 2 0.027
behavior GO:0007610 74 0.027
regulation of systemic arterial blood pressure GO:0003073 1 0.027
biological adhesion GO:0022610 40 0.026
ion homeostasis GO:0050801 41 0.026
sensory perception of pain GO:0019233 1 0.026
hormone transport GO:0009914 2 0.026
collateral sprouting GO:0048668 9 0.026
reproductive process GO:0022414 40 0.026
positive regulation of cell communication GO:0010647 56 0.026
negative regulation of catabolic process GO:0009895 3 0.026
ion transmembrane transport GO:0034220 91 0.026
taxis GO:0042330 109 0.025
regulation of collateral sprouting GO:0048670 7 0.025
single organism transport GO:0044765 206 0.025
phasic smooth muscle contraction GO:0014821 1 0.025
nitric oxide biosynthetic process GO:0006809 2 0.024
central nervous system myelination GO:0022010 2 0.024
parasympathetic nervous system development GO:0048486 6 0.024
hormone secretion GO:0046879 2 0.024
regulation of nucleic acid templated transcription GO:1903506 213 0.024
nitric oxide metabolic process GO:0046209 2 0.024
muscle contraction GO:0006936 18 0.024
olfactory lobe development GO:0021988 4 0.024
blood circulation GO:0008015 87 0.024
death GO:0016265 121 0.024
multicellular organism reproduction GO:0032504 35 0.023
cell cell signaling GO:0007267 52 0.023
regulation of hormone secretion GO:0046883 2 0.023
midbrain development GO:0030901 28 0.023
homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 4 0.023
regulation of cell shape GO:0008360 1 0.023
negative regulation of cell communication GO:0010648 96 0.023
negative regulation of adenylate cyclase activity GO:0007194 6 0.023
positive regulation of cellular component biogenesis GO:0044089 3 0.023
negative regulation of camp biosynthetic process GO:0030818 7 0.022
regulation of cell differentiation GO:0045595 142 0.022
biosynthetic process GO:0009058 294 0.022
ph reduction GO:0045851 1 0.022
ovulation cycle GO:0042698 2 0.022
regulation of nucleotide biosynthetic process GO:0030808 15 0.022
positive regulation of macromolecule metabolic process GO:0010604 93 0.022
otolith formation GO:0032475 2 0.022
regulation of axon extension involved in axon guidance GO:0048841 6 0.022
circadian sleep wake cycle process GO:0022410 2 0.022
eye development GO:0001654 277 0.022
positive regulation of developmental process GO:0051094 50 0.021
skeletal system development GO:0001501 181 0.021
defense response GO:0006952 47 0.021
gland development GO:0048732 143 0.021
positive regulation of signaling GO:0023056 56 0.021
multi organism process GO:0051704 134 0.021
cell growth GO:0016049 57 0.021
hindbrain development GO:0030902 91 0.020
anatomical structure arrangement GO:0048532 2 0.020
dorsal convergence GO:0060030 14 0.020
regulation of neuronal synaptic plasticity GO:0048168 1 0.019
catechol containing compound biosynthetic process GO:0009713 2 0.019
muscle structure development GO:0061061 196 0.019
cellular component biogenesis GO:0044085 178 0.019
embryonic skeletal joint development GO:0072498 3 0.019
divalent inorganic cation homeostasis GO:0072507 22 0.019
regulation of programmed cell death GO:0043067 101 0.019
negative regulation of response to stimulus GO:0048585 104 0.019
positive regulation of nervous system development GO:0051962 25 0.019
regulation of catalytic activity GO:0050790 55 0.019
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.019
response to glucose GO:0009749 3 0.018
regulation of calcium ion transport GO:0051924 2 0.018
axonal fasciculation GO:0007413 11 0.018
regulation of ph GO:0006885 3 0.018
transcription from rna polymerase ii promoter GO:0006366 80 0.018
regulation of apoptotic process GO:0042981 98 0.018
water homeostasis GO:0030104 4 0.018
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.018
nucleobase containing compound metabolic process GO:0006139 274 0.018
lipid metabolic process GO:0006629 52 0.018
regulation of cell size GO:0008361 29 0.018
g protein coupled receptor signaling pathway GO:0007186 74 0.018
morphogenesis of an epithelium GO:0002009 333 0.018
glucose homeostasis GO:0042593 1 0.017
cellular macromolecule metabolic process GO:0044260 391 0.017
metencephalon development GO:0022037 27 0.017
entrainment of circadian clock GO:0009649 2 0.017
intrinsic apoptotic signaling pathway in response to dna damage by p53 class mediator GO:0042771 2 0.017
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.017
response to organic cyclic compound GO:0014070 51 0.017
cellular response to oxygen containing compound GO:1901701 20 0.017
regulation of dna templated transcription elongation GO:0032784 3 0.017
synapse assembly GO:0007416 9 0.017
positive regulation of secretion by cell GO:1903532 1 0.016
cellular response to nitrogen compound GO:1901699 6 0.016
phenol containing compound biosynthetic process GO:0046189 4 0.016
neuron migration GO:0001764 22 0.016
positive regulation of cell adhesion GO:0045785 1 0.016
catecholamine biosynthetic process GO:0042423 2 0.016
regulation of sodium ion transport GO:0002028 2 0.016
cellular ketone metabolic process GO:0042180 11 0.016
regulation of cell growth GO:0001558 29 0.016
response to glucocorticoid GO:0051384 1 0.016
renal tubule morphogenesis GO:0061333 1 0.015
response to hexose GO:0009746 3 0.015
response to carbohydrate GO:0009743 3 0.015
rhombomere 6 development GO:0021572 4 0.015
negative regulation of feeding behavior GO:2000252 2 0.015
tube morphogenesis GO:0035239 349 0.015
response to osmotic stress GO:0006970 11 0.015
negative regulation of blood circulation GO:1903523 2 0.015
circadian sleep wake cycle GO:0042745 2 0.015
phagocytosis GO:0006909 3 0.015
central nervous system neuron differentiation GO:0021953 74 0.015
regulation of cellular amine metabolic process GO:0033238 0 0.015
cardiocyte differentiation GO:0035051 44 0.015
regulation of cellular component size GO:0032535 30 0.015
negative regulation of cell development GO:0010721 26 0.015
cellular biogenic amine metabolic process GO:0006576 2 0.014
response to oxygen containing compound GO:1901700 55 0.014
response to drug GO:0042493 3 0.014
regulation of cell projection organization GO:0031344 44 0.014
regulation of cytokine production GO:0001817 3 0.014
spinal cord development GO:0021510 46 0.014
regulation of synaptic plasticity GO:0048167 1 0.014
positive regulation of map kinase activity GO:0043406 3 0.014
response to amine GO:0014075 1 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.014
cellular localization GO:0051641 97 0.014
regulation of collateral sprouting in absence of injury GO:0048696 4 0.014
cation homeostasis GO:0055080 33 0.014
nucleic acid metabolic process GO:0090304 244 0.014
posterior lateral line system development GO:0048915 46 0.014
sodium ion transport GO:0006814 24 0.014
regulation of phosphate metabolic process GO:0019220 43 0.013
microtubule polymerization or depolymerization GO:0031109 3 0.013
response to amphetamine GO:0001975 1 0.013
segment polarity determination GO:0007367 1 0.013
regulation of nucleoside metabolic process GO:0009118 2 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
anterior lateral line development GO:0048899 5 0.013
growth GO:0040007 174 0.013
regulation of synapse organization GO:0050807 3 0.012
regulation of inflammatory response GO:0050727 2 0.012
cellular protein modification process GO:0006464 100 0.012
regulation of cellular component movement GO:0051270 55 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.012
vasculature development GO:0001944 278 0.012
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.012
regulation of heart growth GO:0060420 2 0.012
regulation of neurogenesis GO:0050767 87 0.012
sympathetic ganglion development GO:0061549 2 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
urogenital system development GO:0001655 97 0.012
signal transduction in absence of ligand GO:0038034 1 0.012
activation of mapk activity GO:0000187 3 0.011
metal ion homeostasis GO:0055065 26 0.011
neuron projection extension involved in neuron projection guidance GO:1902284 10 0.011
regulation of growth GO:0040008 42 0.011
response to temperature stimulus GO:0009266 15 0.011
renal system development GO:0072001 94 0.011
nephron tubule morphogenesis GO:0072078 1 0.011
cellular nitrogen compound metabolic process GO:0034641 290 0.011
single organism reproductive process GO:0044702 40 0.011
regulation of membrane potential GO:0042391 23 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
programmed cell death GO:0012501 119 0.011
cardiac cell fate commitment GO:0060911 1 0.011
negative regulation of purine nucleotide biosynthetic process GO:1900372 7 0.011
multicellular organismal signaling GO:0035637 22 0.010
cellular amide metabolic process GO:0043603 4 0.010
neuron death GO:0070997 21 0.010
cellular homeostasis GO:0019725 26 0.010
regulation of protein catabolic process GO:0042176 1 0.010
cellular protein metabolic process GO:0044267 129 0.010
regulation of fatty acid metabolic process GO:0019217 1 0.010
post embryonic organ development GO:0048569 4 0.010
regulation of phosphorus metabolic process GO:0051174 43 0.010
neurotransmitter biosynthetic process GO:0042136 2 0.010

gfra1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.093
urinary system disease DOID:18 0 0.093
nervous system disease DOID:863 0 0.026
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.010