Danio rerio

19 known processes

fgf21

fibroblast growth factor 21

fgf21 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
positive regulation of transport GO:0051050 2 0.071
cellular component morphogenesis GO:0032989 336 0.058
generation of neurons GO:0048699 385 0.050
single organism metabolic process GO:0044710 217 0.050
camera type eye development GO:0043010 222 0.048
exocytosis GO:0006887 1 0.046
regulation of establishment of protein localization GO:0070201 4 0.046
eye development GO:0001654 277 0.045
aging GO:0007568 2 0.042
regulation of protein transport GO:0051223 3 0.041
larval development GO:0002164 2 0.038
signal transduction GO:0007165 455 0.038
transport GO:0006810 220 0.036
sensory organ development GO:0007423 393 0.036
microtubule based movement GO:0007018 33 0.035
regulation of synapse organization GO:0050807 3 0.034
cellular component movement GO:0006928 335 0.034
blood vessel development GO:0001568 246 0.034
regulation of cell communication GO:0010646 232 0.034
heterocycle metabolic process GO:0046483 290 0.033
positive regulation of biological process GO:0048518 253 0.033
positive regulation of cellular component biogenesis GO:0044089 3 0.033
regulation of cellular metabolic process GO:0031323 320 0.031
guanosine containing compound catabolic process GO:1901069 2 0.031
single organism localization GO:1902578 225 0.031
establishment of localization GO:0051234 244 0.031
cilium organization GO:0044782 71 0.031
single fertilization GO:0007338 3 0.030
fertilization GO:0009566 3 0.030
regulation of primary metabolic process GO:0080090 311 0.030
cilium morphogenesis GO:0060271 85 0.030
cell part morphogenesis GO:0032990 246 0.029
positive regulation of catabolic process GO:0009896 4 0.028
response to stress GO:0006950 263 0.028
regulation of carbohydrate metabolic process GO:0006109 4 0.028
amine metabolic process GO:0009308 2 0.028
biosynthetic process GO:0009058 294 0.028
guanosine containing compound metabolic process GO:1901068 4 0.027
maintenance of location GO:0051235 4 0.027
cellular amine metabolic process GO:0044106 2 0.027
regulation of synaptic plasticity GO:0048167 1 0.027
protein polymerization GO:0051258 4 0.027
retina development in camera type eye GO:0060041 146 0.027
positive regulation of cellular catabolic process GO:0031331 3 0.027
cellular carbohydrate metabolic process GO:0044262 4 0.026
positive regulation of secretion by cell GO:1903532 1 0.026
stem cell maintenance GO:0019827 4 0.026
regulation of metabolic process GO:0019222 359 0.026
regulation of intracellular protein transport GO:0033157 3 0.025
positive regulation of cytokine production GO:0001819 2 0.025
regulation of protein localization to nucleus GO:1900180 2 0.025
cellular protein catabolic process GO:0044257 4 0.025
blood vessel morphogenesis GO:0048514 216 0.025
neuron differentiation GO:0030182 353 0.025
adult behavior GO:0030534 2 0.024
regulation of cellular amino acid metabolic process GO:0006521 0 0.024
camera type eye morphogenesis GO:0048593 108 0.024
positive regulation of secretion GO:0051047 1 0.024
multicellular organism growth GO:0035264 4 0.024
lipid storage GO:0019915 1 0.024
response to chemical GO:0042221 320 0.024
developmental growth GO:0048589 166 0.024
modification dependent protein catabolic process GO:0019941 3 0.024
regulation of synapse assembly GO:0051963 3 0.024
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.023
cell migration GO:0016477 237 0.023
positive regulation of i kappab kinase nf kappab signaling GO:0043123 3 0.023
cell surface receptor signaling pathway GO:0007166 325 0.023
system process GO:0003008 185 0.023
positive regulation of cell cycle GO:0045787 3 0.023
protein localization to nucleus GO:0034504 3 0.023
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.022
macromolecule biosynthetic process GO:0009059 227 0.022
ubiquitin dependent protein catabolic process GO:0006511 3 0.022
cellular biosynthetic process GO:0044249 286 0.022
gtp catabolic process GO:0006184 2 0.022
muscle cell differentiation GO:0042692 139 0.022
regulation of macromolecule metabolic process GO:0060255 317 0.022
carboxylic acid metabolic process GO:0019752 22 0.021
single organism transport GO:0044765 206 0.021
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
heart development GO:0007507 313 0.021
positive regulation of exocytosis GO:0045921 1 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.021
establishment of protein localization to organelle GO:0072594 4 0.021
vasculature development GO:0001944 278 0.021
regulation of signaling GO:0023051 235 0.021
protein import into nucleus GO:0006606 3 0.021
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.021
neuron development GO:0048666 262 0.021
localization of cell GO:0051674 244 0.021
gtp metabolic process GO:0046039 4 0.021
stem cell division GO:0017145 1 0.021
protein secretion GO:0009306 1 0.020
nuclear transport GO:0051169 4 0.020
carbohydrate derivative biosynthetic process GO:1901137 43 0.020
stem cell proliferation GO:0072089 4 0.020
positive regulation of cytoskeleton organization GO:0051495 3 0.020
nitrogen compound metabolic process GO:0006807 319 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
regulation of protein catabolic process GO:0042176 1 0.020
positive regulation of blood circulation GO:1903524 2 0.020
cellular ketone metabolic process GO:0042180 11 0.020
regulation of nitrogen compound metabolic process GO:0051171 251 0.020
positive regulation of cellular amine metabolic process GO:0033240 0 0.020
pigmentation GO:0043473 85 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.020
golgi vesicle transport GO:0048193 3 0.020
regulation of protein import into nucleus GO:0042306 2 0.020
organelle organization GO:0006996 227 0.020
nuclear migration GO:0007097 3 0.020
embryonic organ morphogenesis GO:0048562 274 0.020
organic cyclic compound biosynthetic process GO:1901362 223 0.019
nucleocytoplasmic transport GO:0006913 4 0.019
ameboidal type cell migration GO:0001667 143 0.019
regulation of multicellular organism growth GO:0040014 4 0.019
adherens junction organization GO:0034332 4 0.019
regulation of erk1 and erk2 cascade GO:0070372 4 0.019
inner ear development GO:0048839 126 0.019
muscle structure development GO:0061061 196 0.019
extrinsic apoptotic signaling pathway GO:0097191 3 0.019
protein metabolic process GO:0019538 183 0.019
rna localization GO:0006403 4 0.019
embryonic organ development GO:0048568 381 0.019
ear development GO:0043583 127 0.019
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.018
cell motility GO:0048870 244 0.018
cellular localization GO:0051641 97 0.018
cellular aromatic compound metabolic process GO:0006725 295 0.018
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.018
hormone secretion GO:0046879 2 0.018
response to drug GO:0042493 3 0.018
protein import GO:0017038 3 0.018
intracellular signal transduction GO:0035556 85 0.018
eye morphogenesis GO:0048592 144 0.018
cytokinesis GO:0000910 3 0.018
regulation of binding GO:0051098 3 0.018
modification dependent macromolecule catabolic process GO:0043632 3 0.018
phototransduction GO:0007602 2 0.018
regulation of cell death GO:0010941 103 0.018
membrane invagination GO:0010324 1 0.018
single organism organelle organization GO:1902589 199 0.018
somatic muscle development GO:0007525 4 0.018
i kappab kinase nf kappab signaling GO:0007249 4 0.018
positive regulation of nucleoside metabolic process GO:0045979 1 0.018
germ line stem cell maintenance GO:0030718 2 0.018
phagocytosis GO:0006909 3 0.018
regulation of protein complex assembly GO:0043254 3 0.018
organic cyclic compound metabolic process GO:1901360 301 0.018
cell morphogenesis GO:0000902 289 0.017
regulation of purine nucleotide catabolic process GO:0033121 2 0.017
protein targeting to nucleus GO:0044744 3 0.017
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.017
oxoacid metabolic process GO:0043436 31 0.017
synaptic growth at neuromuscular junction GO:0051124 2 0.017
cellular nitrogen compound metabolic process GO:0034641 290 0.017
protein localization to plasma membrane GO:0072659 1 0.017
regulation of cytokine production GO:0001817 3 0.017
regulation of protein targeting GO:1903533 2 0.017
nuclear import GO:0051170 3 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
positive regulation of epithelial cell differentiation GO:0030858 2 0.017
organic acid metabolic process GO:0006082 31 0.017
meiotic nuclear division GO:0007126 4 0.017
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.017
compound eye development GO:0048749 2 0.016
brain development GO:0007420 293 0.016
negative regulation of catabolic process GO:0009895 3 0.016
cellular component disassembly GO:0022411 1 0.016
regulation of nucleotide catabolic process GO:0030811 2 0.016
negative regulation of biological process GO:0048519 304 0.016
regulation of response to stimulus GO:0048583 269 0.016
mitochondrion organization GO:0007005 4 0.016
cilium movement GO:0003341 26 0.016
hormone transport GO:0009914 2 0.016
autophagy GO:0006914 4 0.016
regulation of signal transduction GO:0009966 225 0.016
establishment of localization in cell GO:0051649 77 0.016
regulation of programmed cell death GO:0043067 101 0.016
regulation of biological quality GO:0065008 263 0.016
positive regulation of cell activation GO:0050867 1 0.016
interspecies interaction between organisms GO:0044419 4 0.016
cellular nitrogen compound biosynthetic process GO:0044271 218 0.016
antimicrobial humoral response GO:0019730 2 0.016
regulation of cell activation GO:0050865 1 0.015
negative regulation of protein transport GO:0051224 3 0.015
neurotransmitter transport GO:0006836 2 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
cellular response to external stimulus GO:0071496 2 0.015
actin polymerization or depolymerization GO:0008154 2 0.015
regulation of ion transmembrane transporter activity GO:0032412 2 0.015
organic substance biosynthetic process GO:1901576 289 0.015
cellular protein metabolic process GO:0044267 129 0.015
cognition GO:0050890 1 0.015
intracellular mrna localization GO:0008298 1 0.015
response to uv GO:0009411 3 0.015
morphogenesis of an epithelium GO:0002009 333 0.015
muscle cell development GO:0055001 115 0.015
positive regulation of immune effector process GO:0002699 3 0.015
single organism membrane fusion GO:0044801 2 0.015
ribonucleoside monophosphate catabolic process GO:0009158 4 0.015
neuron projection development GO:0031175 180 0.015
single organism nuclear import GO:1902593 3 0.015
regulation of tube size GO:0035150 2 0.015
neuroblast proliferation GO:0007405 2 0.015
proteasomal protein catabolic process GO:0010498 2 0.015
positive regulation of protein complex assembly GO:0031334 2 0.015
glycosylation GO:0070085 11 0.015
regulation of biosynthetic process GO:0009889 250 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
oocyte anterior posterior axis specification GO:0007314 4 0.015
transcription dna templated GO:0006351 181 0.015
negative regulation of mapk cascade GO:0043409 4 0.015
sensory organ morphogenesis GO:0090596 200 0.015
phagocytosis engulfment GO:0006911 1 0.014
organonitrogen compound metabolic process GO:1901564 74 0.014
macromolecule modification GO:0043412 111 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
cell projection organization GO:0030030 284 0.014
membrane fusion GO:0061025 2 0.014
regulation of cytoplasmic transport GO:1903649 4 0.014
secondary metabolic process GO:0019748 3 0.014
regulation of macromolecule biosynthetic process GO:0010556 225 0.014
gene expression GO:0010467 252 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.014
regulation of production of molecular mediator of immune response GO:0002700 1 0.014
death GO:0016265 121 0.014
cellular macromolecule metabolic process GO:0044260 391 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.014
positive regulation of gtpase activity GO:0043547 1 0.014
neurological system process GO:0050877 62 0.014
macromolecule glycosylation GO:0043413 9 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
negative regulation of cellular process GO:0048523 283 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.014
protein modification process GO:0036211 100 0.014
cell substrate adhesion GO:0031589 4 0.014
tissue remodeling GO:0048771 4 0.014
small molecule metabolic process GO:0044281 77 0.014
rna metabolic process GO:0016070 219 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
atp catabolic process GO:0006200 4 0.014
organelle fusion GO:0048284 3 0.014
leukocyte proliferation GO:0070661 1 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
cellular protein modification process GO:0006464 100 0.014
cellular macromolecule biosynthetic process GO:0034645 224 0.014
synaptic vesicle localization GO:0097479 1 0.014
cytoplasm organization GO:0007028 4 0.014
meiotic cell cycle process GO:1903046 3 0.014
regulation of reproductive process GO:2000241 4 0.013
negative regulation of kinase activity GO:0033673 4 0.013
xenobiotic metabolic process GO:0006805 4 0.013
negative regulation of protein kinase activity GO:0006469 4 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
myeloid cell differentiation GO:0030099 86 0.013
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.013
central nervous system development GO:0007417 387 0.013
spermatid development GO:0007286 2 0.013
regulation of circadian rhythm GO:0042752 4 0.013
cellular response to hypoxia GO:0071456 1 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
response to wounding GO:0009611 116 0.013
regulation of blood vessel size GO:0050880 2 0.013
apoptotic process GO:0006915 116 0.013
regulation of protein polymerization GO:0032271 2 0.013
immune system process GO:0002376 241 0.013
cell death GO:0008219 121 0.013
regulation of transmembrane transporter activity GO:0022898 2 0.013
phosphatidylinositol 3 kinase signaling GO:0014065 2 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
regulation of response to biotic stimulus GO:0002831 2 0.013
regulation of cell shape GO:0008360 1 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
response to alkaloid GO:0043279 2 0.013
regulation of neural precursor cell proliferation GO:2000177 3 0.013
cellular response to decreased oxygen levels GO:0036294 1 0.013
negative regulation of cell communication GO:0010648 96 0.012
multi organism cellular process GO:0044764 2 0.012
urogenital system development GO:0001655 97 0.012
developmental pigmentation GO:0048066 48 0.012
programmed cell death GO:0012501 119 0.012
negative regulation of signaling GO:0023057 96 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.012
regulation of metal ion transport GO:0010959 4 0.012
synaptic vesicle transport GO:0048489 1 0.012
wound healing GO:0042060 90 0.012
erythrocyte homeostasis GO:0034101 55 0.012
b cell activation GO:0042113 2 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
endosomal transport GO:0016197 2 0.012
positive regulation of gtp catabolic process GO:0033126 1 0.012
cell killing GO:0001906 2 0.012
regulation of multicellular organismal development GO:2000026 223 0.012
striated muscle cell development GO:0055002 108 0.012
transcription from rna polymerase ii promoter GO:0006366 80 0.012
determination of left right symmetry GO:0007368 179 0.012
alcohol biosynthetic process GO:0046165 2 0.012
cellular response to lipopolysaccharide GO:0071222 3 0.012
positive regulation of cell adhesion GO:0045785 1 0.012
cellular response to oxygen levels GO:0071453 1 0.012
regulation of mrna processing GO:0050684 3 0.012
aromatic compound biosynthetic process GO:0019438 217 0.012
energy reserve metabolic process GO:0006112 2 0.012
cellular response to molecule of bacterial origin GO:0071219 3 0.012
negative regulation of map kinase activity GO:0043407 2 0.012
leukocyte mediated cytotoxicity GO:0001909 1 0.012
regulation of apoptotic process GO:0042981 98 0.012
locomotion GO:0040011 313 0.012
positive regulation of neuron death GO:1901216 1 0.012
nucleobase containing compound biosynthetic process GO:0034654 205 0.011
microtubule based process GO:0007017 60 0.011
nucleic acid metabolic process GO:0090304 244 0.011
regulation of exocytosis GO:0017157 1 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
nucleoside monophosphate catabolic process GO:0009125 4 0.011
positive regulation of protein polymerization GO:0032273 2 0.011
regulation of gtpase activity GO:0043087 2 0.011
viral process GO:0016032 1 0.011
pole plasm assembly GO:0007315 4 0.011
actin filament polymerization GO:0030041 2 0.011
macromolecular complex disassembly GO:0032984 1 0.011
protein complex disassembly GO:0043241 1 0.011
cell projection morphogenesis GO:0048858 244 0.011
carbohydrate derivative metabolic process GO:1901135 61 0.011
skeletal system development GO:0001501 181 0.011
nucleobase containing compound metabolic process GO:0006139 274 0.011
response to hexose GO:0009746 3 0.011
response to carbohydrate GO:0009743 3 0.011
digestive system development GO:0055123 289 0.011
regulation of cellular protein catabolic process GO:1903362 1 0.011
heme metabolic process GO:0042168 9 0.011
cell morphogenesis involved in differentiation GO:0000904 195 0.011
peptide metabolic process GO:0006518 1 0.011
post embryonic organ development GO:0048569 4 0.011
centrosome organization GO:0051297 1 0.011
regulation of cell projection assembly GO:0060491 4 0.011
maternal determination of anterior posterior axis embryo GO:0008358 4 0.011
multicellular organismal response to stress GO:0033555 2 0.011
tube morphogenesis GO:0035239 349 0.011
cellular response to starvation GO:0009267 1 0.011
liver development GO:0001889 96 0.011
protein dephosphorylation GO:0006470 3 0.011
establishment of synaptic vesicle localization GO:0097480 1 0.011
startle response GO:0001964 4 0.011
rna transport GO:0050658 2 0.011
sleep GO:0030431 1 0.011
positive regulation of epithelial cell migration GO:0010634 2 0.011
phosphatidylinositol mediated signaling GO:0048015 2 0.010
positive regulation of cell division GO:0051781 2 0.010
negative regulation of intracellular protein transport GO:0090317 3 0.010
response to corticosteroid GO:0031960 1 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
peptide transport GO:0015833 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
cellular response to extracellular stimulus GO:0031668 2 0.010
nucleic acid templated transcription GO:0097659 181 0.010
protein complex localization GO:0031503 1 0.010
regulation of calcium ion transport GO:0051924 2 0.010
establishment of protein localization to plasma membrane GO:0090002 1 0.010
regulation of neuronal synaptic plasticity GO:0048168 1 0.010
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.010
small molecule catabolic process GO:0044282 3 0.010
regulation of cellular biosynthetic process GO:0031326 245 0.010
regulation of dendrite morphogenesis GO:0048814 3 0.010
lateral inhibition GO:0046331 1 0.010
calcium ion dependent exocytosis GO:0017156 1 0.010
cell matrix adhesion GO:0007160 4 0.010
chordate embryonic development GO:0043009 271 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010

fgf21 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.061
immune system disease DOID:2914 0 0.027
musculoskeletal system disease DOID:17 0 0.017
disease of metabolism DOID:0014667 0 0.016
myopathy DOID:423 0 0.016
muscular disease DOID:0080000 0 0.016
muscle tissue disease DOID:66 0 0.016
nervous system disease DOID:863 0 0.015
disease of cellular proliferation DOID:14566 0 0.014
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.012
sensory system disease DOID:0050155 0 0.011
eye and adnexa disease DOID:1492 0 0.011