Danio rerio

54 known processes

gpc3

glypican 3

gpc3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular macromolecule metabolic process GO:0044260 391 0.078
aging GO:0007568 2 0.069
generation of neurons GO:0048699 385 0.064
larval development GO:0002164 2 0.058
embryonic organ development GO:0048568 381 0.056
nucleobase containing compound metabolic process GO:0006139 274 0.054
macromolecule biosynthetic process GO:0009059 227 0.054
sensory organ development GO:0007423 393 0.053
cell projection morphogenesis GO:0048858 244 0.053
signal transduction GO:0007165 455 0.050
neuron development GO:0048666 262 0.049
multicellular organism growth GO:0035264 4 0.048
regulation of synapse organization GO:0050807 3 0.047
cell projection organization GO:0030030 284 0.047
heterocycle metabolic process GO:0046483 290 0.045
protein localization to nucleus GO:0034504 3 0.045
cell part morphogenesis GO:0032990 246 0.043
biosynthetic process GO:0009058 294 0.043
embryonic organ morphogenesis GO:0048562 274 0.042
rna metabolic process GO:0016070 219 0.042
organic substance biosynthetic process GO:1901576 289 0.042
cell morphogenesis GO:0000902 289 0.041
nucleic acid metabolic process GO:0090304 244 0.039
nitrogen compound metabolic process GO:0006807 319 0.039
response to external stimulus GO:0009605 264 0.038
neuron differentiation GO:0030182 353 0.038
cell surface receptor signaling pathway GO:0007166 325 0.038
gene expression GO:0010467 252 0.038
positive regulation of biological process GO:0048518 253 0.038
cellular amine metabolic process GO:0044106 2 0.037
head development GO:0060322 303 0.037
cellular nitrogen compound metabolic process GO:0034641 290 0.037
single organism localization GO:1902578 225 0.037
regulation of biological quality GO:0065008 263 0.036
locomotion GO:0040011 313 0.035
morphogenesis of an epithelium GO:0002009 333 0.035
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.035
protein metabolic process GO:0019538 183 0.035
organic cyclic compound metabolic process GO:1901360 301 0.035
gastrulation GO:0007369 208 0.035
tube morphogenesis GO:0035239 349 0.035
regulation of metabolic process GO:0019222 359 0.035
transcription dna templated GO:0006351 181 0.035
cellular biosynthetic process GO:0044249 286 0.034
aromatic compound biosynthetic process GO:0019438 217 0.034
amine metabolic process GO:0009308 2 0.034
heterocycle biosynthetic process GO:0018130 215 0.034
regulation of synapse assembly GO:0051963 3 0.034
cellular protein modification process GO:0006464 100 0.033
sensory organ morphogenesis GO:0090596 200 0.033
cellular component movement GO:0006928 335 0.033
regulation of gene expression GO:0010468 265 0.033
cellular protein metabolic process GO:0044267 129 0.033
response to stress GO:0006950 263 0.033
cellular component morphogenesis GO:0032989 336 0.033
regulation of nucleic acid templated transcription GO:1903506 213 0.032
single fertilization GO:0007338 3 0.032
regulation of macromolecule biosynthetic process GO:0010556 225 0.032
localization of cell GO:0051674 244 0.032
nuclear transport GO:0051169 4 0.032
establishment of protein localization to organelle GO:0072594 4 0.032
cognition GO:0050890 1 0.031
regulation of multicellular organismal development GO:2000026 223 0.031
embryo development ending in birth or egg hatching GO:0009792 271 0.031
brain development GO:0007420 293 0.031
regulation of signaling GO:0023051 235 0.031
adult behavior GO:0030534 2 0.031
negative regulation of cellular process GO:0048523 283 0.031
regulation of biosynthetic process GO:0009889 250 0.030
regionalization GO:0003002 274 0.030
positive regulation of transport GO:0051050 2 0.030
rna biosynthetic process GO:0032774 181 0.030
cell migration GO:0016477 237 0.030
cellular macromolecule biosynthetic process GO:0034645 224 0.030
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.029
cellular ketone metabolic process GO:0042180 11 0.029
regulation of nitrogen compound metabolic process GO:0051171 251 0.029
immune system process GO:0002376 241 0.028
response to chemical GO:0042221 320 0.028
digestive system development GO:0055123 289 0.028
nucleobase containing compound biosynthetic process GO:0034654 205 0.028
regulation of response to stimulus GO:0048583 269 0.028
central nervous system development GO:0007417 387 0.028
regulation of rna metabolic process GO:0051252 224 0.028
pigmentation GO:0043473 85 0.027
vasculature development GO:0001944 278 0.027
single organism metabolic process GO:0044710 217 0.027
nucleic acid templated transcription GO:0097659 181 0.027
digestive tract development GO:0048565 265 0.027
regulation of macromolecule metabolic process GO:0060255 317 0.027
regulation of cellular metabolic process GO:0031323 320 0.027
carboxylic acid metabolic process GO:0019752 22 0.026
organic cyclic compound biosynthetic process GO:1901362 223 0.026
oxoacid metabolic process GO:0043436 31 0.026
regulation of cellular biosynthetic process GO:0031326 245 0.026
mitochondrion organization GO:0007005 4 0.026
cell morphogenesis involved in differentiation GO:0000904 195 0.026
protein import into nucleus GO:0006606 3 0.026
regulation of multicellular organism growth GO:0040014 4 0.026
regulation of protein transport GO:0051223 3 0.026
regulation of cellular amine metabolic process GO:0033238 0 0.026
positive regulation of cellular process GO:0048522 201 0.025
protein targeting to nucleus GO:0044744 3 0.025
regulation of developmental process GO:0050793 247 0.025
eye development GO:0001654 277 0.025
cellular amide metabolic process GO:0043603 4 0.025
transport GO:0006810 220 0.025
regulation of cellular amino acid metabolic process GO:0006521 0 0.025
regulation of cellular ketone metabolic process GO:0010565 7 0.025
cell motility GO:0048870 244 0.025
organic acid metabolic process GO:0006082 31 0.024
cellular aromatic compound metabolic process GO:0006725 295 0.024
skeletal system development GO:0001501 181 0.024
growth GO:0040007 174 0.024
cellular nitrogen compound biosynthetic process GO:0044271 218 0.024
macromolecule modification GO:0043412 111 0.024
cellular response to external stimulus GO:0071496 2 0.024
positive regulation of cellular catabolic process GO:0031331 3 0.024
protein import GO:0017038 3 0.024
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.024
regulation of cytoplasmic transport GO:1903649 4 0.024
transcription from rna polymerase ii promoter GO:0006366 80 0.023
single organism nuclear import GO:1902593 3 0.023
phagocytosis GO:0006909 3 0.023
cellular response to extracellular stimulus GO:0031668 2 0.023
stem cell proliferation GO:0072089 4 0.023
response to carbohydrate GO:0009743 3 0.023
heart development GO:0007507 313 0.023
hemopoiesis GO:0030097 183 0.023
regulation of multicellular organismal process GO:0051239 277 0.023
regulation of primary metabolic process GO:0080090 311 0.023
regulation of transcription dna templated GO:0006355 213 0.023
exocytosis GO:0006887 1 0.023
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.022
regulation of establishment of protein localization GO:0070201 4 0.022
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.022
cytokinesis GO:0000910 3 0.022
nucleocytoplasmic transport GO:0006913 4 0.022
development of primary female sexual characteristics GO:0046545 4 0.022
stem cell maintenance GO:0019827 4 0.022
positive regulation of catabolic process GO:0009896 4 0.022
somatic muscle development GO:0007525 4 0.022
maintenance of location GO:0051235 4 0.022
alcohol biosynthetic process GO:0046165 2 0.022
nuclear import GO:0051170 3 0.022
regulation of cytokine production GO:0001817 3 0.022
regulation of intracellular protein transport GO:0033157 3 0.021
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.021
ubiquitin dependent protein catabolic process GO:0006511 3 0.021
single organism transport GO:0044765 206 0.021
synaptic growth at neuromuscular junction GO:0051124 2 0.021
system process GO:0003008 185 0.021
compound eye development GO:0048749 2 0.021
endosomal transport GO:0016197 2 0.021
autophagy GO:0006914 4 0.021
neuron projection development GO:0031175 180 0.021
cellular amino acid metabolic process GO:0006520 7 0.020
atp catabolic process GO:0006200 4 0.020
anterior posterior pattern specification GO:0009952 152 0.020
periodic partitioning GO:0007365 1 0.020
eye morphogenesis GO:0048592 144 0.020
organonitrogen compound metabolic process GO:1901564 74 0.020
lipid storage GO:0019915 1 0.020
taxis GO:0042330 109 0.020
guanosine containing compound catabolic process GO:1901069 2 0.020
regulation of rna biosynthetic process GO:2001141 213 0.020
regulation of protein targeting GO:1903533 2 0.020
axonogenesis GO:0007409 152 0.020
cellular component biogenesis GO:0044085 178 0.020
developmental growth GO:0048589 166 0.020
cell substrate adhesion GO:0031589 4 0.020
positive regulation of cell cycle GO:0045787 3 0.020
post embryonic organ development GO:0048569 4 0.020
organelle organization GO:0006996 227 0.020
regulation of nucleocytoplasmic transport GO:0046822 2 0.020
negative regulation of protein phosphorylation GO:0001933 4 0.019
response to drug GO:0042493 3 0.019
positive regulation of immune effector process GO:0002699 3 0.019
gtp catabolic process GO:0006184 2 0.019
peptide transport GO:0015833 1 0.019
regulation of binding GO:0051098 3 0.019
cilium organization GO:0044782 71 0.019
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.019
chordate embryonic development GO:0043009 271 0.019
hematopoietic or lymphoid organ development GO:0048534 191 0.019
positive regulation of macromolecule metabolic process GO:0010604 93 0.019
neuron projection morphogenesis GO:0048812 161 0.019
negative regulation of cytoplasmic transport GO:1903650 2 0.018
embryonic skeletal system development GO:0048706 97 0.018
cellular protein catabolic process GO:0044257 4 0.018
protein modification process GO:0036211 100 0.018
establishment of localization GO:0051234 244 0.018
digestive tract morphogenesis GO:0048546 231 0.018
dicarboxylic acid transport GO:0006835 1 0.018
small molecule metabolic process GO:0044281 77 0.018
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.018
regulation of purine nucleotide catabolic process GO:0033121 2 0.018
regulation of reproductive process GO:2000241 4 0.018
regulation of cell activation GO:0050865 1 0.018
blood vessel morphogenesis GO:0048514 216 0.018
female sex differentiation GO:0046660 4 0.018
regulation of cell death GO:0010941 103 0.018
positive regulation of cellular amine metabolic process GO:0033240 0 0.018
cell death GO:0008219 121 0.018
inner ear morphogenesis GO:0042472 63 0.018
ribonucleoside monophosphate catabolic process GO:0009158 4 0.018
positive regulation of cellular component biogenesis GO:0044089 3 0.018
epithelial cell differentiation GO:0030855 116 0.018
specification of symmetry GO:0009799 204 0.017
liver development GO:0001889 96 0.017
actin filament based movement GO:0030048 1 0.017
gland development GO:0048732 143 0.017
cellular response to starvation GO:0009267 1 0.017
negative regulation of intracellular transport GO:0032387 3 0.017
regulation of protein import into nucleus GO:0042306 2 0.017
negative regulation of protein kinase activity GO:0006469 4 0.017
response to glucose GO:0009749 3 0.017
regulation of cell differentiation GO:0045595 142 0.017
negative regulation of biological process GO:0048519 304 0.017
modification dependent protein catabolic process GO:0019941 3 0.017
embryonic skeletal system morphogenesis GO:0048704 93 0.017
camera type eye development GO:0043010 222 0.017
axon development GO:0061564 166 0.017
guanosine containing compound metabolic process GO:1901068 4 0.017
apoptotic process GO:0006915 116 0.017
cilium assembly GO:0042384 58 0.017
tube closure GO:0060606 1 0.017
cilium morphogenesis GO:0060271 85 0.017
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.017
regulation of nucleoside metabolic process GO:0009118 2 0.017
neuroblast proliferation GO:0007405 2 0.017
glucose homeostasis GO:0042593 1 0.017
regulation of protein localization to nucleus GO:1900180 2 0.017
ear development GO:0043583 127 0.017
muscle structure development GO:0061061 196 0.016
synaptic vesicle localization GO:0097479 1 0.016
ameboidal type cell migration GO:0001667 143 0.016
blood vessel development GO:0001568 246 0.016
neurological system process GO:0050877 62 0.016
myeloid cell differentiation GO:0030099 86 0.016
cell matrix adhesion GO:0007160 4 0.016
epithelial tube morphogenesis GO:0060562 148 0.016
determination of bilateral symmetry GO:0009855 204 0.016
response to glucocorticoid GO:0051384 1 0.016
carbohydrate homeostasis GO:0033500 1 0.016
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.016
response to monosaccharide GO:0034284 3 0.016
positive regulation of secretion by cell GO:1903532 1 0.016
cellular response to nutrient levels GO:0031669 2 0.016
response to corticosteroid GO:0031960 1 0.016
negative regulation of intracellular protein transport GO:0090317 3 0.016
regulation of response to biotic stimulus GO:0002831 2 0.016
response to nutrient GO:0007584 3 0.016
fat soluble vitamin metabolic process GO:0006775 4 0.016
cellular localization GO:0051641 97 0.016
embryonic heart tube development GO:0035050 133 0.015
regulation of epithelial cell proliferation GO:0050678 3 0.015
extrinsic apoptotic signaling pathway GO:0097191 3 0.015
positive regulation of secretion GO:0051047 1 0.015
centrosome localization GO:0051642 1 0.015
antimicrobial humoral response GO:0019730 2 0.015
response to hexose GO:0009746 3 0.015
hormone secretion GO:0046879 2 0.015
neural crest cell development GO:0014032 62 0.015
single organism organelle organization GO:1902589 199 0.015
regulation of protein complex assembly GO:0043254 3 0.015
death GO:0016265 121 0.015
lipid catabolic process GO:0016042 4 0.015
secondary metabolic process GO:0019748 3 0.015
regulation of cell shape GO:0008360 1 0.015
hepaticobiliary system development GO:0061008 98 0.015
regulation of autophagy GO:0010506 3 0.015
response to wounding GO:0009611 116 0.015
gtp metabolic process GO:0046039 4 0.015
female gonad development GO:0008585 4 0.014
neuron neuron synaptic transmission GO:0007270 1 0.014
positive regulation of transcription dna templated GO:0045893 57 0.014
regulation of dendrite development GO:0050773 3 0.014
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.014
response to organic substance GO:0010033 153 0.014
nuclear migration GO:0007097 3 0.014
response to alkaloid GO:0043279 2 0.014
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.014
urogenital system development GO:0001655 97 0.014
leukocyte proliferation GO:0070661 1 0.014
regulation of exocytosis GO:0017157 1 0.014
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.014
heart morphogenesis GO:0003007 156 0.014
negative regulation of signaling GO:0023057 96 0.014
modification dependent macromolecule catabolic process GO:0043632 3 0.014
microtubule based movement GO:0007018 33 0.013
negative regulation of kinase activity GO:0033673 4 0.013
ear morphogenesis GO:0042471 64 0.013
fertilization GO:0009566 3 0.013
positive regulation of cell adhesion GO:0045785 1 0.013
rna localization GO:0006403 4 0.013
regulation of protein catabolic process GO:0042176 1 0.013
nucleoside monophosphate catabolic process GO:0009125 4 0.013
production of molecular mediator of immune response GO:0002440 2 0.013
ion transport GO:0006811 114 0.013
negative regulation of epithelial cell proliferation GO:0050680 1 0.013
cellular component disassembly GO:0022411 1 0.013
regulation of signal transduction GO:0009966 225 0.013
programmed cell death GO:0012501 119 0.013
primary neural tube formation GO:0014020 1 0.013
chemosensory behavior GO:0007635 1 0.013
regulation of nucleotide catabolic process GO:0030811 2 0.013
homeostatic process GO:0042592 142 0.013
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.013
interspecies interaction between organisms GO:0044419 4 0.013
regulation of inflammatory response GO:0050727 2 0.013
purine nucleoside monophosphate catabolic process GO:0009128 4 0.013
hormone transport GO:0009914 2 0.013
embryonic cranial skeleton morphogenesis GO:0048701 90 0.013
inner ear development GO:0048839 126 0.013
positive regulation of metabolic process GO:0009893 108 0.013
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.013
protein dephosphorylation GO:0006470 3 0.013
cellular component assembly GO:0022607 170 0.012
chemotaxis GO:0006935 104 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
regulation of molecular function GO:0065009 70 0.012
embryonic heart tube morphogenesis GO:0003143 108 0.012
golgi vesicle transport GO:0048193 3 0.012
convergent extension GO:0060026 118 0.012
peptidyl serine modification GO:0018209 2 0.012
microtubule organizing center organization GO:0031023 1 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
regulation of gtp catabolic process GO:0033124 2 0.012
regulation of cell communication GO:0010646 232 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
centrosome organization GO:0051297 1 0.012
regulation of cell substrate adhesion GO:0010810 1 0.012
pancreas development GO:0031016 84 0.012
regulation of metal ion transport GO:0010959 4 0.012
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
negative regulation of response to stimulus GO:0048585 104 0.012
positive regulation of nucleoside metabolic process GO:0045979 1 0.012
stem cell division GO:0017145 1 0.012
negative regulation of defense response GO:0031348 2 0.012
regulation of organelle assembly GO:1902115 4 0.012
macroautophagy GO:0016236 1 0.012
muscle cell migration GO:0014812 4 0.012
regulation of ion transmembrane transporter activity GO:0032412 2 0.012
wound healing GO:0042060 90 0.012
lateral line development GO:0048882 66 0.012
regulation of tube size GO:0035150 2 0.012
spermatid development GO:0007286 2 0.012
negative regulation of secretion GO:0051048 2 0.012
regulation of gtpase activity GO:0043087 2 0.012
negative regulation of cell communication GO:0010648 96 0.012
meiotic nuclear division GO:0007126 4 0.012
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.012
determination of heart left right asymmetry GO:0061371 117 0.011
tissue remodeling GO:0048771 4 0.011
immune system development GO:0002520 191 0.011
regulation of transmembrane transporter activity GO:0022898 2 0.011
monoamine transport GO:0015844 1 0.011
peptide metabolic process GO:0006518 1 0.011
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.011
neurotransmitter transport GO:0006836 2 0.011
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.011
renal tubule morphogenesis GO:0061333 1 0.011
startle response GO:0001964 4 0.011
developmental growth involved in morphogenesis GO:0060560 86 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
negative regulation of cellular catabolic process GO:0031330 3 0.011
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.011
nephron tubule morphogenesis GO:0072078 1 0.011
peptidyl serine phosphorylation GO:0018105 1 0.011
fin development GO:0033333 77 0.011
membrane fusion GO:0061025 2 0.011
regulation of protein binding GO:0043393 3 0.011
meiotic cell cycle process GO:1903046 3 0.011
heart looping GO:0001947 94 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
sensory system development GO:0048880 76 0.011
macromolecule localization GO:0033036 54 0.011
skeletal system morphogenesis GO:0048705 102 0.011
regulation of anatomical structure morphogenesis GO:0022603 130 0.011
mononuclear cell proliferation GO:0032943 1 0.011
phosphate containing compound metabolic process GO:0006796 108 0.011
negative regulation of dna metabolic process GO:0051053 4 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
regulation of localization GO:0032879 104 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.011
response to abiotic stimulus GO:0009628 122 0.011
lateral inhibition GO:0046331 1 0.011
lymphocyte proliferation GO:0046651 1 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.010
protein localization to plasma membrane GO:0072659 1 0.010
skin development GO:0043588 54 0.010
regulation of transporter activity GO:0032409 2 0.010
negative regulation of multi organism process GO:0043901 3 0.010
protein secretion GO:0009306 1 0.010
regulation of cell projection assembly GO:0060491 4 0.010
negative regulation of cell death GO:0060548 60 0.010
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.010
regulation of dendrite morphogenesis GO:0048814 3 0.010
cell projection assembly GO:0030031 64 0.010
organelle fusion GO:0048284 3 0.010
renal system development GO:0072001 94 0.010
striated muscle tissue development GO:0014706 110 0.010
negative regulation of apoptotic process GO:0043066 55 0.010
positive regulation of cell activation GO:0050867 1 0.010
response to hydrogen peroxide GO:0042542 3 0.010
positive regulation of protein complex assembly GO:0031334 2 0.010

gpc3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.047
cardiovascular system disease DOID:1287 0 0.028
musculoskeletal system disease DOID:17 0 0.024
nervous system disease DOID:863 0 0.022
muscular disease DOID:0080000 0 0.018
disease of cellular proliferation DOID:14566 0 0.013
immune system disease DOID:2914 0 0.012
disease of metabolism DOID:0014667 0 0.011
organ system cancer DOID:0050686 0 0.011
cancer DOID:162 0 0.011
muscle tissue disease DOID:66 0 0.011