Danio rerio

71 known processes

tef

thyrotroph embryonic factor

(Aliases: tefb,tefa,wu:fb11h02,tefbeta,wu:fa12f02,zTEF[a])

tef biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
steroid hormone secretion GO:0035929 1 0.929
regulation of endocrine process GO:0044060 2 0.810
circadian regulation of gene expression GO:0032922 8 0.734
endocrine process GO:0050886 2 0.678
regulation of circadian rhythm GO:0042752 4 0.663
entrainment of circadian clock by photoperiod GO:0043153 1 0.534
endocrine hormone secretion GO:0060986 2 0.477
regulation of hormone secretion GO:0046883 2 0.468
entrainment of circadian clock GO:0009649 2 0.465
hormone transport GO:0009914 2 0.372
macromolecule biosynthetic process GO:0009059 227 0.337
response to stress GO:0006950 263 0.313
regulation of nucleic acid templated transcription GO:1903506 213 0.303
defense response GO:0006952 47 0.290
cellular aromatic compound metabolic process GO:0006725 295 0.263
hormone secretion GO:0046879 2 0.256
nucleobase containing compound metabolic process GO:0006139 274 0.249
regulation of gene expression GO:0010468 265 0.241
regulation of macromolecule biosynthetic process GO:0010556 225 0.207
multicellular organism growth GO:0035264 4 0.191
photoperiodism GO:0009648 11 0.185
organic substance biosynthetic process GO:1901576 289 0.168
regulation of metabolic process GO:0019222 359 0.165
immune response GO:0006955 28 0.156
heterocycle metabolic process GO:0046483 290 0.149
larval development GO:0002164 2 0.145
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.143
organic cyclic compound biosynthetic process GO:1901362 223 0.143
response to bacterium GO:0009617 58 0.141
response to external stimulus GO:0009605 264 0.141
Fly
transport GO:0006810 220 0.139
nucleic acid templated transcription GO:0097659 181 0.137
cellular macromolecule biosynthetic process GO:0034645 224 0.133
positive regulation of biological process GO:0048518 253 0.131
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.129
regulation of multicellular organism growth GO:0040014 4 0.123
response to biotic stimulus GO:0009607 97 0.123
negative regulation of secretion GO:0051048 2 0.122
regulation of nitrogen compound metabolic process GO:0051171 251 0.121
regulation of hormone levels GO:0010817 21 0.120
heterocycle biosynthetic process GO:0018130 215 0.118
response to other organism GO:0051707 97 0.116
regulation of transcription dna templated GO:0006355 213 0.113
regulation of multicellular organismal process GO:0051239 277 0.106
cellular nitrogen compound metabolic process GO:0034641 290 0.105
biosynthetic process GO:0009058 294 0.099
circadian rhythm GO:0007623 19 0.099
Fly
cell surface receptor signaling pathway GO:0007166 325 0.095
nucleobase containing compound biosynthetic process GO:0034654 205 0.095
rna metabolic process GO:0016070 219 0.094
multi organism process GO:0051704 134 0.093
cellular nitrogen compound biosynthetic process GO:0044271 218 0.089
lipid homeostasis GO:0055088 3 0.087
organic cyclic compound metabolic process GO:1901360 301 0.087
single organism metabolic process GO:0044710 217 0.085
Fly
response to uv GO:0009411 3 0.085
regulation of cellular biosynthetic process GO:0031326 245 0.081
rna biosynthetic process GO:0032774 181 0.081
cellular macromolecule metabolic process GO:0044260 391 0.080
gene expression GO:0010467 252 0.080
locomotor rhythm GO:0045475 3 0.080
nucleic acid metabolic process GO:0090304 244 0.076
establishment of localization GO:0051234 244 0.075
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.075
Mouse Rat Fly
negative regulation of hormone secretion GO:0046888 2 0.074
regulation of steroid hormone secretion GO:2000831 1 0.073
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.072
regulation of developmental process GO:0050793 247 0.070
nitrogen compound metabolic process GO:0006807 319 0.069
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.068
hematopoietic or lymphoid organ development GO:0048534 191 0.067
system process GO:0003008 185 0.063
regulation of biological quality GO:0065008 263 0.063
transcription dna templated GO:0006351 181 0.061
regulation of biosynthetic process GO:0009889 250 0.061
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.060
negative regulation of biological process GO:0048519 304 0.060
regulation of response to stimulus GO:0048583 269 0.059
establishment of localization in cell GO:0051649 77 0.059
central nervous system development GO:0007417 387 0.057
regulation of cell communication GO:0010646 232 0.057
regulation of rna biosynthetic process GO:2001141 213 0.056
regulation of rna metabolic process GO:0051252 224 0.056
regulation of cell differentiation GO:0045595 142 0.056
glucose homeostasis GO:0042593 1 0.056
response to external biotic stimulus GO:0043207 97 0.056
regulation of system process GO:0044057 40 0.055
protein targeting to nucleus GO:0044744 3 0.053
immune system process GO:0002376 241 0.052
mesoderm development GO:0007498 88 0.049
nuclear transport GO:0051169 4 0.048
cellular protein catabolic process GO:0044257 4 0.045
response to radiation GO:0009314 51 0.045
intestinal absorption GO:0050892 2 0.045
lipid metabolic process GO:0006629 52 0.044
Fly
negative regulation of protein kinase activity GO:0006469 4 0.044
regulation of macromolecule metabolic process GO:0060255 317 0.044
negative regulation of cellular biosynthetic process GO:0031327 55 0.043
regulation of signal transduction GO:0009966 225 0.043
regulation of tube size GO:0035150 2 0.043
negative regulation of metabolic process GO:0009892 86 0.043
signal transduction GO:0007165 455 0.041
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.041
carboxylic acid metabolic process GO:0019752 22 0.041
response to alkaloid GO:0043279 2 0.041
ubiquitin dependent protein catabolic process GO:0006511 3 0.040
maintenance of location GO:0051235 4 0.039
mitochondrion organization GO:0007005 4 0.039
positive regulation of cellular process GO:0048522 201 0.039
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.039
meiotic chromosome segregation GO:0045132 3 0.038
negative regulation of mitosis GO:0045839 3 0.038
response to chemical GO:0042221 320 0.038
Fly
negative regulation of gene expression GO:0010629 65 0.037
rhythmic process GO:0048511 21 0.037
Fly
protein import GO:0017038 3 0.037
bmp signaling pathway GO:0030509 52 0.037
response to organic substance GO:0010033 153 0.037
cellular ketone metabolic process GO:0042180 11 0.037
aging GO:0007568 2 0.036
single organism transport GO:0044765 206 0.036
regulation of protein ubiquitination GO:0031396 3 0.035
negative regulation of rna metabolic process GO:0051253 48 0.035
amine metabolic process GO:0009308 2 0.035
regulation of primary metabolic process GO:0080090 311 0.034
homeostatic process GO:0042592 142 0.034
photoreceptor cell development GO:0042461 40 0.034
neuron differentiation GO:0030182 353 0.034
liver development GO:0001889 96 0.033
negative regulation of secretion by cell GO:1903531 2 0.033
cellular biosynthetic process GO:0044249 286 0.032
carbohydrate homeostasis GO:0033500 1 0.032
chordate embryonic development GO:0043009 271 0.032
protein metabolic process GO:0019538 183 0.032
regulation of blood vessel size GO:0050880 2 0.032
germ line stem cell maintenance GO:0030718 2 0.031
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.031
oxoacid metabolic process GO:0043436 31 0.031
hepatocyte proliferation GO:0072574 2 0.031
regulation of signaling GO:0023051 235 0.031
modification dependent macromolecule catabolic process GO:0043632 3 0.031
neuron development GO:0048666 262 0.030
response to inorganic substance GO:0010035 38 0.030
peptide transport GO:0015833 1 0.030
negative regulation of cellular metabolic process GO:0031324 77 0.030
regulation of skeletal muscle cell differentiation GO:2001014 1 0.030
muscle organ development GO:0007517 101 0.030
circadian sleep wake cycle sleep GO:0050802 1 0.030
negative regulation of transcription dna templated GO:0045892 45 0.029
cellular protein metabolic process GO:0044267 129 0.029
ribosomal small subunit biogenesis GO:0042274 2 0.028
circadian sleep wake cycle GO:0042745 2 0.028
dna metabolic process GO:0006259 27 0.028
Fly
regulation of cytokine production GO:0001817 3 0.028
embryo development ending in birth or egg hatching GO:0009792 271 0.028
ion transport GO:0006811 114 0.028
aromatic compound biosynthetic process GO:0019438 217 0.027
stem cell maintenance GO:0019827 4 0.027
cellular amine metabolic process GO:0044106 2 0.027
organic acid metabolic process GO:0006082 31 0.027
negative regulation of protein phosphorylation GO:0001933 4 0.027
regulation of cellular metabolic process GO:0031323 320 0.027
protein import into nucleus GO:0006606 3 0.027
single organism nuclear import GO:1902593 3 0.027
i kappab kinase nf kappab signaling GO:0007249 4 0.027
regulation of epithelial cell proliferation GO:0050678 3 0.026
regulation of multicellular organismal development GO:2000026 223 0.026
spindle assembly GO:0051225 2 0.026
defense response to bacterium GO:0042742 22 0.025
cell substrate adhesion GO:0031589 4 0.025
protein modification process GO:0036211 100 0.025
intracellular receptor signaling pathway GO:0030522 30 0.025
b cell activation GO:0042113 2 0.025
antimicrobial humoral response GO:0019730 2 0.025
negative regulation of cellular process GO:0048523 283 0.025
positive regulation of cell division GO:0051781 2 0.025
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.025
response to endogenous stimulus GO:0009719 83 0.025
single organism localization GO:1902578 225 0.025
determination of bilateral symmetry GO:0009855 204 0.025
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.025
peptidyl serine phosphorylation GO:0018105 1 0.024
female sex differentiation GO:0046660 4 0.024
negative regulation of signal transduction GO:0009968 94 0.024
homologous chromosome segregation GO:0045143 1 0.024
nuclear import GO:0051170 3 0.024
regulation of intracellular signal transduction GO:1902531 57 0.024
generation of neurons GO:0048699 385 0.024
negative regulation of macromolecule metabolic process GO:0010605 76 0.023
response to copper ion GO:0046688 13 0.023
regulation of reproductive process GO:2000241 4 0.023
negative regulation of rna biosynthetic process GO:1902679 45 0.023
lipid storage GO:0019915 1 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
chemical homeostasis GO:0048878 49 0.023
positive regulation of catabolic process GO:0009896 4 0.023
regulation of cellular amine metabolic process GO:0033238 0 0.022
regulation of skeletal muscle tissue development GO:0048641 4 0.022
transcription from rna polymerase ii promoter GO:0006366 80 0.022
Mouse Rat Fly
regulation of lipid transport GO:0032368 4 0.022
response to ketone GO:1901654 1 0.022
enzyme linked receptor protein signaling pathway GO:0007167 106 0.022
toll like receptor signaling pathway GO:0002224 4 0.022
regulation of stem cell differentiation GO:2000736 4 0.022
eye development GO:0001654 277 0.022
dna repair GO:0006281 6 0.021
hepaticobiliary system development GO:0061008 98 0.021
growth GO:0040007 174 0.021
Fly
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.021
response to topologically incorrect protein GO:0035966 2 0.021
carbohydrate biosynthetic process GO:0016051 1 0.021
negative regulation of steroid hormone secretion GO:2000832 1 0.021
protein localization to nucleus GO:0034504 3 0.020
regulation of receptor mediated endocytosis GO:0048259 4 0.020
positive regulation of multicellular organismal process GO:0051240 52 0.020
response to hydrogen peroxide GO:0042542 3 0.020
transmembrane transport GO:0055085 120 0.020
blood circulation GO:0008015 87 0.020
negative regulation of kinase activity GO:0033673 4 0.020
digestive system development GO:0055123 289 0.020
negative regulation of biosynthetic process GO:0009890 55 0.019
nucleocytoplasmic transport GO:0006913 4 0.019
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
response to oxygen radical GO:0000305 2 0.019
regulation of cell activation GO:0050865 1 0.019
cellular response to starvation GO:0009267 1 0.019
cellular lipid metabolic process GO:0044255 36 0.019
establishment of protein localization to organelle GO:0072594 4 0.019
negative regulation of response to stimulus GO:0048585 104 0.019
innate immune response activating signal transduction GO:0002758 5 0.019
multicellular organismal metabolic process GO:0044236 2 0.019
regulation of localization GO:0032879 104 0.019
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.019
response to hormone GO:0009725 48 0.019
neurotransmitter transport GO:0006836 2 0.019
regulation of systemic arterial blood pressure GO:0003073 1 0.019
regulation of circadian sleep wake cycle GO:0042749 1 0.019
cellular response to stress GO:0033554 62 0.019
developmental growth GO:0048589 166 0.019
modification dependent protein catabolic process GO:0019941 3 0.018
regulation of nucleoside metabolic process GO:0009118 2 0.018
heart development GO:0007507 313 0.018
regulation of wnt signaling pathway GO:0030111 53 0.018
energy reserve metabolic process GO:0006112 2 0.018
purine nucleoside monophosphate catabolic process GO:0009128 4 0.018
regulation of synaptic plasticity GO:0048167 1 0.018
extrinsic apoptotic signaling pathway GO:0097191 3 0.018
behavior GO:0007610 74 0.018
cellular amide metabolic process GO:0043603 4 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.018
neurotransmitter secretion GO:0007269 2 0.018
regulation of protein catabolic process GO:0042176 1 0.018
cellular protein modification process GO:0006464 100 0.017
regulation of defense response GO:0031347 14 0.017
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.017
pharyngeal system development GO:0060037 18 0.017
autophagy GO:0006914 4 0.017
regulation of cellular ketone metabolic process GO:0010565 7 0.017
regulation of response to external stimulus GO:0032101 31 0.017
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.017
mitochondrial transport GO:0006839 2 0.017
circulatory system process GO:0003013 87 0.017
leukocyte proliferation GO:0070661 1 0.017
cell cell signaling GO:0007267 52 0.017
alternative mrna splicing via spliceosome GO:0000380 1 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.016
regulation of blood pressure GO:0008217 1 0.016
protein polyubiquitination GO:0000209 4 0.016
receptor internalization GO:0031623 2 0.016
organic substance transport GO:0071702 58 0.016
regulation of mrna splicing via spliceosome GO:0048024 3 0.016
brain development GO:0007420 293 0.016
defense response to other organism GO:0098542 33 0.016
negative regulation of signaling GO:0023057 96 0.016
common bile duct development GO:0061009 13 0.016
cell aging GO:0007569 2 0.015
rna modification GO:0009451 2 0.015
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.015
regulation of ion transmembrane transporter activity GO:0032412 2 0.015
pancreas development GO:0031016 84 0.015
guanosine containing compound metabolic process GO:1901068 4 0.015
regulation of cellular protein catabolic process GO:1903362 1 0.015
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.015
fin development GO:0033333 77 0.015
multicellular organismal homeostasis GO:0048871 29 0.015
cellular response to dna damage stimulus GO:0006974 24 0.015
mononuclear cell proliferation GO:0032943 1 0.015
response to lipid GO:0033993 60 0.015
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.015
regulation of inflammatory response GO:0050727 2 0.014
head development GO:0060322 303 0.014
negative regulation of multicellular organismal process GO:0051241 69 0.014
regulation of receptor internalization GO:0002090 2 0.014
cellular response to nutrient levels GO:0031669 2 0.014
iron ion homeostasis GO:0055072 4 0.014
positive regulation of multi organism process GO:0043902 3 0.014
negative regulation of epithelial cell proliferation GO:0050680 1 0.014
camera type eye development GO:0043010 222 0.014
macromolecule modification GO:0043412 111 0.014
regulation of neurotransmitter transport GO:0051588 1 0.014
regulation of gtpase activity GO:0043087 2 0.014
negative regulation of autophagy GO:0010507 1 0.014
meiotic cell cycle process GO:1903046 3 0.014
negative regulation of defense response GO:0031348 2 0.014
cell growth GO:0016049 57 0.014
cellular response to radiation GO:0071478 4 0.014
anion transport GO:0006820 38 0.014
negative regulation of cell communication GO:0010648 96 0.013
cellular amino acid metabolic process GO:0006520 7 0.013
positive regulation of cell death GO:0010942 29 0.013
Worm
response to light stimulus GO:0009416 46 0.013
one carbon compound transport GO:0019755 14 0.013
mesenchyme development GO:0060485 127 0.013
negative regulation of map kinase activity GO:0043407 2 0.013
regulation of protein complex assembly GO:0043254 3 0.013
positive regulation of muscle tissue development GO:1901863 1 0.013
response to oxidative stress GO:0006979 11 0.013
response to wounding GO:0009611 116 0.013
locomotory behavior GO:0007626 34 0.013
positive regulation of secretion GO:0051047 1 0.013
locomotion GO:0040011 313 0.013
b cell differentiation GO:0030183 1 0.013
oxidation reduction process GO:0055114 41 0.013
regulation of binding GO:0051098 3 0.012
cellular component disassembly GO:0022411 1 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.012
regulation of epithelial to mesenchymal transition GO:0010717 3 0.012
rhythmic behavior GO:0007622 5 0.012
positive regulation of cellular amine metabolic process GO:0033240 0 0.012
positive regulation of immune effector process GO:0002699 3 0.012
response to organic cyclic compound GO:0014070 51 0.012
positive regulation of ras protein signal transduction GO:0046579 1 0.012
g protein coupled receptor signaling pathway GO:0007186 74 0.012
gtp catabolic process GO:0006184 2 0.012
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.012
phagocytosis engulfment GO:0006911 1 0.012
muscle structure development GO:0061061 196 0.012
response to oxygen containing compound GO:1901700 55 0.012
cellular localization GO:0051641 97 0.012
single organism biosynthetic process GO:0044711 71 0.012
Fly
response to glucose GO:0009749 3 0.012
microtubule based process GO:0007017 60 0.012
regulation of jun kinase activity GO:0043506 3 0.012
insulin like growth factor receptor signaling pathway GO:0048009 4 0.012
renal system process involved in regulation of systemic arterial blood pressure GO:0003071 1 0.011
apoptotic process GO:0006915 116 0.011
Worm
mitotic dna integrity checkpoint GO:0044774 4 0.011
circadian sleep wake cycle process GO:0022410 2 0.011
positive regulation of developmental process GO:0051094 50 0.011
positive regulation of macromolecule metabolic process GO:0010604 93 0.011
protein stabilization GO:0050821 2 0.011
positive regulation of transport GO:0051050 2 0.011
meiotic nuclear division GO:0007126 4 0.011
regulation of bmp signaling pathway GO:0030510 39 0.011
protein dephosphorylation GO:0006470 3 0.011
energy homeostasis GO:0097009 3 0.011
regulation of carbohydrate metabolic process GO:0006109 4 0.011
developmental cell growth GO:0048588 52 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
negative regulation of immune response GO:0050777 2 0.011
regulation of canonical wnt signaling pathway GO:0060828 34 0.011
determination of left right asymmetry in lateral mesoderm GO:0003140 20 0.011
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.011
positive regulation of metabolic process GO:0009893 108 0.011
regulation of receptor activity GO:0010469 2 0.011
positive regulation of cellular biosynthetic process GO:0031328 68 0.011
cytokinesis GO:0000910 3 0.011
response to steroid hormone GO:0048545 35 0.011
regulation of wnt signaling pathway calcium modulating pathway GO:0008591 3 0.011
regulation of calcium ion transport GO:0051924 2 0.011
programmed cell death GO:0012501 119 0.011
Worm
mitotic dna damage checkpoint GO:0044773 4 0.011
negative regulation of mapk cascade GO:0043409 4 0.011
ovulation cycle process GO:0022602 2 0.011
positive regulation of leukocyte mediated cytotoxicity GO:0001912 1 0.011
notochord development GO:0030903 54 0.011
regulation of epidermis development GO:0045682 2 0.011
cellular response to decreased oxygen levels GO:0036294 1 0.010
skeletal muscle organ development GO:0060538 78 0.010
regulation of microtubule cytoskeleton organization GO:0070507 3 0.010
regulation of cardiac muscle tissue development GO:0055024 1 0.010
regulation of purine nucleotide catabolic process GO:0033121 2 0.010
atp catabolic process GO:0006200 4 0.010
regulation of protein metabolic process GO:0051246 56 0.010
negative regulation of nuclear division GO:0051784 3 0.010
erk1 and erk2 cascade GO:0070371 4 0.010
regulation of autophagy GO:0010506 3 0.010
protein localization to plasma membrane GO:0072659 1 0.010
membrane repolarization GO:0086009 2 0.010
striated muscle tissue development GO:0014706 110 0.010
positive regulation of cell killing GO:0031343 2 0.010
positive regulation of cytoskeleton organization GO:0051495 3 0.010
inositol lipid mediated signaling GO:0048017 2 0.010
specification of symmetry GO:0009799 204 0.010
gtp metabolic process GO:0046039 4 0.010
lymphocyte proliferation GO:0046651 1 0.010
positive regulation of cell cycle GO:0045787 3 0.010

tef disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.026
inherited metabolic disorder DOID:655 0 0.020
retinal disease DOID:5679 0 0.013
sensory system disease DOID:0050155 0 0.013
disease of anatomical entity DOID:7 0 0.013
eye and adnexa disease DOID:1492 0 0.013
nervous system disease DOID:863 0 0.013
eye disease DOID:5614 0 0.013
gastrointestinal system cancer DOID:3119 0 0.011
cancer DOID:162 0 0.011
disease of cellular proliferation DOID:14566 0 0.011
organ system cancer DOID:0050686 0 0.011