Danio rerio

0 known processes

thoc4

THO complex 4

(Aliases: zgc:171753,tho4,MGC171753)

thoc4 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
alternative mrna splicing via spliceosome GO:0000380 1 0.393
regulation of mrna processing GO:0050684 3 0.382
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.300
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.213
regulation of rna metabolic process GO:0051252 224 0.187
regulation of nitrogen compound metabolic process GO:0051171 251 0.178
nucleobase containing compound metabolic process GO:0006139 274 0.145
regulation of mrna splicing via spliceosome GO:0048024 3 0.128
multi organism reproductive process GO:0044703 36 0.102
macromolecule biosynthetic process GO:0009059 227 0.102
regulation of cellular metabolic process GO:0031323 320 0.092
regulation of metabolic process GO:0019222 359 0.082
cellular aromatic compound metabolic process GO:0006725 295 0.082
cellular biosynthetic process GO:0044249 286 0.076
heterocycle metabolic process GO:0046483 290 0.067
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.063
negative regulation of rna splicing GO:0033119 1 0.062
cellular macromolecule metabolic process GO:0044260 391 0.059
neuron differentiation GO:0030182 353 0.057
regulation of macromolecule biosynthetic process GO:0010556 225 0.055
immune system process GO:0002376 241 0.052
negative regulation of gene expression GO:0010629 65 0.052
regulation of macromolecule metabolic process GO:0060255 317 0.051
nitrogen compound metabolic process GO:0006807 319 0.049
rna metabolic process GO:0016070 219 0.049
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.049
rna localization GO:0006403 4 0.048
cellular nitrogen compound metabolic process GO:0034641 290 0.048
cellular nitrogen compound biosynthetic process GO:0044271 218 0.046
negative regulation of biological process GO:0048519 304 0.046
nucleic acid templated transcription GO:0097659 181 0.044
regulation of nucleic acid templated transcription GO:1903506 213 0.044
aging GO:0007568 2 0.043
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.040
response to stress GO:0006950 263 0.040
intracellular mrna localization GO:0008298 1 0.037
negative regulation of cellular process GO:0048523 283 0.036
regulation of primary metabolic process GO:0080090 311 0.035
regulation of gene expression GO:0010468 265 0.035
generation of neurons GO:0048699 385 0.035
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.035
positive regulation of biological process GO:0048518 253 0.034
neuron development GO:0048666 262 0.034
regionalization GO:0003002 274 0.034
multi organism process GO:0051704 134 0.034
locomotion GO:0040011 313 0.033
response to external stimulus GO:0009605 264 0.033
negative regulation of catabolic process GO:0009895 3 0.031
regulation of protein complex assembly GO:0043254 3 0.031
gene expression GO:0010467 252 0.030
vasculature development GO:0001944 278 0.030
organic cyclic compound metabolic process GO:1901360 301 0.029
multicellular organism reproduction GO:0032504 35 0.029
organic substance biosynthetic process GO:1901576 289 0.028
cellular component assembly GO:0022607 170 0.028
positive regulation of mrna splicing via spliceosome GO:0048026 1 0.028
rna splicing GO:0008380 16 0.027
amine metabolic process GO:0009308 2 0.027
regulation of cellular biosynthetic process GO:0031326 245 0.027
pole plasm assembly GO:0007315 4 0.027
regulation of erk1 and erk2 cascade GO:0070372 4 0.026
axon development GO:0061564 166 0.026
negative regulation of mitosis GO:0045839 3 0.026
regulation of rna biosynthetic process GO:2001141 213 0.025
regulation of epithelial cell proliferation GO:0050678 3 0.025
axonogenesis GO:0007409 152 0.025
positive regulation of metabolic process GO:0009893 108 0.025
nucleic acid metabolic process GO:0090304 244 0.025
spermatid development GO:0007286 2 0.024
cellular carbohydrate metabolic process GO:0044262 4 0.024
positive regulation of gene expression GO:0010628 71 0.024
protein complex disassembly GO:0043241 1 0.023
cellular amine metabolic process GO:0044106 2 0.023
organelle organization GO:0006996 227 0.022
transcription from rna polymerase ii promoter GO:0006366 80 0.022
female gonad development GO:0008585 4 0.022
maternal determination of anterior posterior axis embryo GO:0008358 4 0.022
organic cyclic compound biosynthetic process GO:1901362 223 0.022
developmental cell growth GO:0048588 52 0.022
rna processing GO:0006396 25 0.021
aromatic compound biosynthetic process GO:0019438 217 0.021
cellular macromolecule biosynthetic process GO:0034645 224 0.021
positive regulation of macromolecule metabolic process GO:0010604 93 0.021
response to organic substance GO:0010033 153 0.021
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.020
larval development GO:0002164 2 0.020
oocyte anterior posterior axis specification GO:0007314 4 0.020
spermatid differentiation GO:0048515 2 0.020
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
regulation of cell differentiation GO:0045595 142 0.019
regulation of biosynthetic process GO:0009889 250 0.019
meiotic nuclear division GO:0007126 4 0.019
behavior GO:0007610 74 0.019
single organism metabolic process GO:0044710 217 0.019
negative regulation of metabolic process GO:0009892 86 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.019
gamete generation GO:0007276 33 0.019
cellular response to extracellular stimulus GO:0031668 2 0.019
regulation of reproductive process GO:2000241 4 0.018
developmental growth GO:0048589 166 0.018
regulation of nucleocytoplasmic transport GO:0046822 2 0.018
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
cellular component biogenesis GO:0044085 178 0.018
regulation of cellular amine metabolic process GO:0033238 0 0.018
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.018
regulation of heart growth GO:0060420 2 0.017
dorsal ventral pattern formation GO:0009953 125 0.017
positive regulation of mrna processing GO:0050685 1 0.017
oxoacid metabolic process GO:0043436 31 0.017
regulation of protein metabolic process GO:0051246 56 0.017
response to biotic stimulus GO:0009607 97 0.016
regulation of mrna metabolic process GO:1903311 6 0.016
protein localization to nucleus GO:0034504 3 0.016
cytoplasm organization GO:0007028 4 0.016
blood vessel morphogenesis GO:0048514 216 0.016
biosynthetic process GO:0009058 294 0.015
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.015
positive regulation of chromatin modification GO:1903310 1 0.015
regulation of transcription dna templated GO:0006355 213 0.015
phosphate containing compound metabolic process GO:0006796 108 0.015
mrna metabolic process GO:0016071 20 0.015
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.015
autophagy GO:0006914 4 0.015
negative regulation of mrna processing GO:0050686 1 0.015
positive regulation of cellular metabolic process GO:0031325 94 0.014
cell maturation GO:0048469 23 0.014
regulation of response to stimulus GO:0048583 269 0.014
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.014
cellular response to organic substance GO:0071310 105 0.014
pore complex assembly GO:0046931 2 0.014
developmental process involved in reproduction GO:0003006 27 0.014
positive regulation of cellular component biogenesis GO:0044089 3 0.014
positive regulation of cellular process GO:0048522 201 0.014
anterior posterior pattern specification GO:0009952 152 0.014
maintenance of location GO:0051235 4 0.014
stem cell maintenance GO:0019827 4 0.013
carboxylic acid metabolic process GO:0019752 22 0.013
regulation of gene expression epigenetic GO:0040029 11 0.013
negative regulation of biosynthetic process GO:0009890 55 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
determination of bilateral symmetry GO:0009855 204 0.013
negative regulation of developmental process GO:0051093 65 0.013
positive regulation of biosynthetic process GO:0009891 68 0.013
mrna processing GO:0006397 14 0.013
aromatic compound catabolic process GO:0019439 15 0.012
organelle assembly GO:0070925 110 0.012
posttranscriptional gene silencing GO:0016441 3 0.012
regulation of localization GO:0032879 104 0.012
regulation of cytokine production GO:0001817 3 0.012
cytoskeleton organization GO:0007010 96 0.012
transcription dna templated GO:0006351 181 0.012
regulation of cellular protein metabolic process GO:0032268 52 0.012
single organism organelle organization GO:1902589 199 0.012
heterocycle biosynthetic process GO:0018130 215 0.012
zymogen activation GO:0031638 3 0.011
regulation of multicellular organismal development GO:2000026 223 0.011
germ cell development GO:0007281 22 0.011
muscle organ development GO:0007517 101 0.011
cellular response to starvation GO:0009267 1 0.011
response to chemical GO:0042221 320 0.011
system process GO:0003008 185 0.011
single organism cellular localization GO:1902580 46 0.011
cell projection organization GO:0030030 284 0.011
skeletal system development GO:0001501 181 0.011
rna catabolic process GO:0006401 7 0.011
response to carbohydrate GO:0009743 3 0.011
regulation of cellular amino acid metabolic process GO:0006521 0 0.011
small molecule metabolic process GO:0044281 77 0.011
spliceosomal complex assembly GO:0000245 1 0.011
muscle structure development GO:0061061 196 0.011
positive regulation of gliogenesis GO:0014015 2 0.011
neuron projection morphogenesis GO:0048812 161 0.011
rna splicing via transesterification reactions with bulged adenosine as nucleophile GO:0000377 10 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
axis specification GO:0009798 43 0.011
regulation of protein catabolic process GO:0042176 1 0.011
protein complex subunit organization GO:0071822 46 0.010
positive regulation of catabolic process GO:0009896 4 0.010
positive regulation of ras protein signal transduction GO:0046579 1 0.010
regulation of locomotion GO:0040012 55 0.010
positive regulation of cell cycle GO:0045787 3 0.010
embryo development ending in birth or egg hatching GO:0009792 271 0.010
wound healing GO:0042060 90 0.010
brain development GO:0007420 293 0.010
positive regulation of glial cell differentiation GO:0045687 1 0.010
regulation of response to stress GO:0080134 36 0.010

thoc4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of cellular proliferation DOID:14566 0 0.018
disease of anatomical entity DOID:7 0 0.015
cancer DOID:162 0 0.013
intestinal cancer DOID:10155 0 0.013
gastrointestinal system cancer DOID:3119 0 0.013
colon cancer DOID:219 0 0.013
large intestine cancer DOID:5672 0 0.013
colon carcinoma DOID:1520 0 0.013
colorectal cancer DOID:9256 0 0.013
organ system cancer DOID:0050686 0 0.013