Danio rerio

31 known processes

numb

numb homolog (Drosophila)

numb biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
nitrogen compound metabolic process GO:0006807 319 0.078
larval development GO:0002164 2 0.070
sensory organ development GO:0007423 393 0.063
Fly
regulation of gene expression GO:0010468 265 0.057
positive regulation of transport GO:0051050 2 0.049
Fly
eye development GO:0001654 277 0.049
cellular nitrogen compound metabolic process GO:0034641 290 0.048
neuron differentiation GO:0030182 353 0.048
Mouse
ameboidal type cell migration GO:0001667 143 0.047
blood vessel development GO:0001568 246 0.045
vasculature development GO:0001944 278 0.043
Zebrafish
embryonic organ development GO:0048568 381 0.042
regulation of epithelial cell proliferation GO:0050678 3 0.042
single organism metabolic process GO:0044710 217 0.042
macromolecule biosynthetic process GO:0009059 227 0.042
sensory organ morphogenesis GO:0090596 200 0.041
head development GO:0060322 303 0.041
Mouse
transcription dna templated GO:0006351 181 0.038
cellular macromolecule biosynthetic process GO:0034645 224 0.037
exocytosis GO:0006887 1 0.037
aging GO:0007568 2 0.037
camera type eye development GO:0043010 222 0.035
brain development GO:0007420 293 0.035
Mouse
cellular biosynthetic process GO:0044249 286 0.034
cell surface receptor signaling pathway GO:0007166 325 0.034
Zebrafish Mouse Worm
cellular nitrogen compound biosynthetic process GO:0044271 218 0.032
gene expression GO:0010467 252 0.032
regulation of synapse organization GO:0050807 3 0.032
cellular aromatic compound metabolic process GO:0006725 295 0.032
response to stress GO:0006950 263 0.031
response to carbohydrate GO:0009743 3 0.030
cellular component movement GO:0006928 335 0.030
Fly
heterocycle metabolic process GO:0046483 290 0.030
positive regulation of catabolic process GO:0009896 4 0.030
signal transduction GO:0007165 455 0.028
Zebrafish Mouse Worm
organonitrogen compound metabolic process GO:1901564 74 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.028
cellular carbohydrate metabolic process GO:0044262 4 0.027
neurotransmitter transport GO:0006836 2 0.027
regulation of biological quality GO:0065008 263 0.027
cellular response to external stimulus GO:0071496 2 0.027
fertilization GO:0009566 3 0.027
regulation of metabolic process GO:0019222 359 0.027
small molecule metabolic process GO:0044281 77 0.027
stem cell proliferation GO:0072089 4 0.026
Mouse Fly
heart development GO:0007507 313 0.026
Fly
positive regulation of cellular catabolic process GO:0031331 3 0.026
organic acid metabolic process GO:0006082 31 0.025
regulation of synapse assembly GO:0051963 3 0.025
protein metabolic process GO:0019538 183 0.025
rna metabolic process GO:0016070 219 0.025
aromatic compound biosynthetic process GO:0019438 217 0.025
guanosine containing compound metabolic process GO:1901068 4 0.024
embryonic organ morphogenesis GO:0048562 274 0.024
ear development GO:0043583 127 0.024
regulation of reproductive process GO:2000241 4 0.024
regulation of transcription dna templated GO:0006355 213 0.024
carboxylic acid metabolic process GO:0019752 22 0.024
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.024
synaptic growth at neuromuscular junction GO:0051124 2 0.024
mitochondrion organization GO:0007005 4 0.024
organic cyclic compound metabolic process GO:1901360 301 0.023
blood vessel morphogenesis GO:0048514 216 0.023
oxoacid metabolic process GO:0043436 31 0.023
response to alkaloid GO:0043279 2 0.023
nucleocytoplasmic transport GO:0006913 4 0.023
guanosine containing compound catabolic process GO:1901069 2 0.023
tube morphogenesis GO:0035239 349 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
protein dephosphorylation GO:0006470 3 0.023
adult behavior GO:0030534 2 0.022
maintenance of location GO:0051235 4 0.022
camera type eye morphogenesis GO:0048593 108 0.022
generation of neurons GO:0048699 385 0.022
Mouse Fly
regulation of binding GO:0051098 3 0.022
nuclear transport GO:0051169 4 0.022
startle response GO:0001964 4 0.022
regulation of rna metabolic process GO:0051252 224 0.022
regulation of ion transmembrane transporter activity GO:0032412 2 0.022
amine metabolic process GO:0009308 2 0.022
chordate embryonic development GO:0043009 271 0.022
response to glucose GO:0009749 3 0.021
phagocytosis GO:0006909 3 0.021
cellular component morphogenesis GO:0032989 336 0.021
Mouse
regulation of multicellular organism growth GO:0040014 4 0.021
regulation of macromolecule biosynthetic process GO:0010556 225 0.021
embryonic skeletal system morphogenesis GO:0048704 93 0.021
gtp metabolic process GO:0046039 4 0.021
single organism membrane fusion GO:0044801 2 0.021
stem cell maintenance GO:0019827 4 0.021
protein localization to nucleus GO:0034504 3 0.021
locomotion GO:0040011 313 0.020
Fly
protein import GO:0017038 3 0.020
response to external stimulus GO:0009605 264 0.020
response to hexose GO:0009746 3 0.020
cell part morphogenesis GO:0032990 246 0.020
Mouse
response to uv GO:0009411 3 0.020
regulation of signaling GO:0023051 235 0.020
Zebrafish Mouse Worm
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.020
regulation of cell shape GO:0008360 1 0.020
cellular amine metabolic process GO:0044106 2 0.020
gtp catabolic process GO:0006184 2 0.020
regulation of nucleocytoplasmic transport GO:0046822 2 0.020
cellular amino acid metabolic process GO:0006520 7 0.020
response to chemical GO:0042221 320 0.020
central nervous system development GO:0007417 387 0.020
Mouse
eye morphogenesis GO:0048592 144 0.020
negative regulation of biological process GO:0048519 304 0.020
Zebrafish Mouse
interspecies interaction between organisms GO:0044419 4 0.019
regulation of macromolecule metabolic process GO:0060255 317 0.019
compound eye development GO:0048749 2 0.019
death GO:0016265 121 0.019
positive regulation of cell cycle GO:0045787 3 0.019
retina development in camera type eye GO:0060041 146 0.019
organic substance biosynthetic process GO:1901576 289 0.019
macromolecule modification GO:0043412 111 0.019
cell morphogenesis involved in differentiation GO:0000904 195 0.019
Mouse
regulation of primary metabolic process GO:0080090 311 0.019
regulation of nucleotide catabolic process GO:0030811 2 0.019
muscle structure development GO:0061061 196 0.019
Fly
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.019
regulation of nucleoside metabolic process GO:0009118 2 0.019
regulation of cellular amine metabolic process GO:0033238 0 0.018
mesenchyme development GO:0060485 127 0.018
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.018
Mouse
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.018
neuron development GO:0048666 262 0.018
Mouse
regulation of cytoplasmic transport GO:1903649 4 0.018
regulation of multicellular organismal process GO:0051239 277 0.018
Mouse Fly
actin polymerization or depolymerization GO:0008154 2 0.018
angiogenesis GO:0001525 158 0.018
digestive tract morphogenesis GO:0048546 231 0.018
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.018
sensory perception of pain GO:0019233 1 0.018
synaptic vesicle localization GO:0097479 1 0.018
cellular macromolecule metabolic process GO:0044260 391 0.018
cell projection organization GO:0030030 284 0.018
Mouse
rna biosynthetic process GO:0032774 181 0.017
protein import into nucleus GO:0006606 3 0.017
cellular ketone metabolic process GO:0042180 11 0.017
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.017
neural crest cell migration GO:0001755 42 0.017
single organism nuclear import GO:1902593 3 0.017
regulation of protein transport GO:0051223 3 0.017
morphogenesis of an epithelium GO:0002009 333 0.017
Mouse
autophagy GO:0006914 4 0.017
cell substrate adhesion GO:0031589 4 0.017
regulation of glucose import GO:0046324 1 0.017
protein targeting to nucleus GO:0044744 3 0.017
membrane fusion GO:0061025 2 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.017
regulation of biosynthetic process GO:0009889 250 0.017
negative regulation of metabolic process GO:0009892 86 0.017
transport GO:0006810 220 0.017
Worm Fly
homeostatic process GO:0042592 142 0.017
positive regulation of secretion by cell GO:1903532 1 0.017
post embryonic organ development GO:0048569 4 0.017
multi organism cellular process GO:0044764 2 0.017
cellular response to extracellular stimulus GO:0031668 2 0.017
nucleobase containing compound biosynthetic process GO:0034654 205 0.017
inner ear development GO:0048839 126 0.017
establishment of protein localization to organelle GO:0072594 4 0.017
anterior posterior pattern specification GO:0009952 152 0.016
regulation of circadian rhythm GO:0042752 4 0.016
regulation of neuronal synaptic plasticity GO:0048168 1 0.016
ubiquitin dependent protein catabolic process GO:0006511 3 0.016
positive regulation of secretion GO:0051047 1 0.016
cell migration GO:0016477 237 0.016
Fly
mesoderm development GO:0007498 88 0.016
cranial nerve development GO:0021545 42 0.016
negative regulation of catabolic process GO:0009895 3 0.016
neuron projection development GO:0031175 180 0.016
Mouse
adherens junction organization GO:0034332 4 0.016
Mouse
cellular response to biotic stimulus GO:0071216 3 0.016
embryo development ending in birth or egg hatching GO:0009792 271 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
modification dependent protein catabolic process GO:0019941 3 0.016
embryonic cranial skeleton morphogenesis GO:0048701 90 0.016
lipid storage GO:0019915 1 0.016
digestive system development GO:0055123 289 0.016
nucleic acid metabolic process GO:0090304 244 0.016
regulation of nitrogen compound metabolic process GO:0051171 251 0.016
epithelial tube morphogenesis GO:0060562 148 0.016
regulation of cellular biosynthetic process GO:0031326 245 0.016
cellular response to lipopolysaccharide GO:0071222 3 0.016
regulation of mrna processing GO:0050684 3 0.016
regulation of blood pressure GO:0008217 1 0.016
somatic muscle development GO:0007525 4 0.016
immune system development GO:0002520 191 0.016
nuclear migration GO:0007097 3 0.015
spermatid differentiation GO:0048515 2 0.015
endosomal transport GO:0016197 2 0.015
Worm
regulation of developmental process GO:0050793 247 0.015
Mouse Fly
multicellular organism growth GO:0035264 4 0.015
organic cyclic compound biosynthetic process GO:1901362 223 0.015
immune system process GO:0002376 241 0.015
cellular component disassembly GO:0022411 1 0.015
positive regulation of biological process GO:0048518 253 0.015
Mouse Worm Fly
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.015
regulation of synaptic plasticity GO:0048167 1 0.015
regulation of rna biosynthetic process GO:2001141 213 0.015
carbohydrate derivative metabolic process GO:1901135 61 0.015
cognition GO:0050890 1 0.015
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.015
skeletal system morphogenesis GO:0048705 102 0.015
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.015
regulation of gtpase activity GO:0043087 2 0.015
regulation of protein catabolic process GO:0042176 1 0.015
digestive tract development GO:0048565 265 0.015
nucleoside monophosphate catabolic process GO:0009125 4 0.015
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
regulation of gtp catabolic process GO:0033124 2 0.015
wound healing GO:0042060 90 0.015
chemosensory behavior GO:0007635 1 0.015
regulation of cellular amino acid metabolic process GO:0006521 0 0.014
regulation of purine nucleotide catabolic process GO:0033121 2 0.014
epidermis development GO:0008544 48 0.014
synaptic vesicle transport GO:0048489 1 0.014
neuronal action potential GO:0019228 18 0.014
heterocycle biosynthetic process GO:0018130 215 0.014
response to monosaccharide GO:0034284 3 0.014
cellular protein catabolic process GO:0044257 4 0.014
regulation of cytokine production GO:0001817 3 0.014
multicellular organismal metabolic process GO:0044236 2 0.014
cellular response to oxygen levels GO:0071453 1 0.014
regulation of intracellular protein transport GO:0033157 3 0.014
g protein coupled receptor signaling pathway GO:0007186 74 0.014
regulation of response to stimulus GO:0048583 269 0.014
Zebrafish Mouse Worm
regulation of carbohydrate metabolic process GO:0006109 4 0.014
regulation of inflammatory response GO:0050727 2 0.014
negative regulation of gene expression GO:0010629 65 0.014
spermatid development GO:0007286 2 0.014
cellular response to lipid GO:0071396 39 0.014
alcohol biosynthetic process GO:0046165 2 0.014
positive regulation of cellular amine metabolic process GO:0033240 0 0.014
regulation of erk1 and erk2 cascade GO:0070372 4 0.014
protein localization to plasma membrane GO:0072659 1 0.014
i kappab kinase nf kappab signaling GO:0007249 4 0.014
atp catabolic process GO:0006200 4 0.013
regulation of multicellular organismal development GO:2000026 223 0.013
Mouse Fly
establishment of synaptic vesicle localization GO:0097480 1 0.013
neurotransmitter secretion GO:0007269 2 0.013
lipid homeostasis GO:0055088 3 0.013
biosynthetic process GO:0009058 294 0.013
erythrocyte differentiation GO:0030218 54 0.013
response to drug GO:0042493 3 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
hindbrain development GO:0030902 91 0.013
lateral line system development GO:0048925 76 0.013
erythrocyte homeostasis GO:0034101 55 0.013
regulation of transmembrane transporter activity GO:0022898 2 0.013
peptidyl serine phosphorylation GO:0018105 1 0.013
positive regulation of epithelial cell proliferation GO:0050679 1 0.013
cellular response to molecule of bacterial origin GO:0071219 3 0.013
ribonucleoside monophosphate catabolic process GO:0009158 4 0.013
regulation of tube size GO:0035150 2 0.013
protein polymerization GO:0051258 4 0.013
establishment of localization GO:0051234 244 0.013
Worm Fly
rna localization GO:0006403 4 0.013
cytokinesis GO:0000910 3 0.013
single organism localization GO:1902578 225 0.013
Worm
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.013
retina morphogenesis in camera type eye GO:0060042 79 0.013
peptidyl serine modification GO:0018209 2 0.013
chemotaxis GO:0006935 104 0.013
regulation of protein import into nucleus GO:0042306 2 0.013
regulation of blood vessel size GO:0050880 2 0.013
regulation of protein binding GO:0043393 3 0.013
connective tissue development GO:0061448 99 0.012
cell death GO:0008219 121 0.012
nuclear import GO:0051170 3 0.012
negative regulation of protein phosphorylation GO:0001933 4 0.012
neuroblast proliferation GO:0007405 2 0.012
Mouse Fly
regulation of neurogenesis GO:0050767 87 0.012
Mouse Fly
proteasomal protein catabolic process GO:0010498 2 0.012
regulation of cell activation GO:0050865 1 0.012
protein complex disassembly GO:0043241 1 0.012
cellular response to organic substance GO:0071310 105 0.012
single fertilization GO:0007338 3 0.012
gland development GO:0048732 143 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
regulation of glucose transport GO:0010827 1 0.012
antimicrobial humoral response GO:0019730 2 0.012
protein acetylation GO:0006473 2 0.012
glucose import GO:0046323 2 0.012
organelle organization GO:0006996 227 0.012
cellular component assembly GO:0022607 170 0.012
forebrain development GO:0030900 96 0.012
Mouse
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.012
multicellular organismal signaling GO:0035637 22 0.012
tissue migration GO:0090130 37 0.012
medulla oblongata development GO:0021550 4 0.012
gastrulation GO:0007369 208 0.012
neural crest cell differentiation GO:0014033 72 0.012
macromolecular complex disassembly GO:0032984 1 0.012
amino acid transport GO:0006865 2 0.012
cell projection morphogenesis GO:0048858 244 0.012
Mouse
regulation of nucleic acid templated transcription GO:1903506 213 0.012
embryonic skeletal system development GO:0048706 97 0.012
hemopoiesis GO:0030097 183 0.012
regulation of metal ion transport GO:0010959 4 0.012
response to abiotic stimulus GO:0009628 122 0.012
nucleic acid templated transcription GO:0097659 181 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
regulation of calcium ion transport GO:0051924 2 0.012
establishment of localization in cell GO:0051649 77 0.012
Worm
cellular protein metabolic process GO:0044267 129 0.011
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.011
cytoplasm organization GO:0007028 4 0.011
epithelial cell migration GO:0010631 25 0.011
system process GO:0003008 185 0.011
sensory system development GO:0048880 76 0.011
regulation of dendrite development GO:0050773 3 0.011
female gonad development GO:0008585 4 0.011
viral process GO:0016032 1 0.011
regulation of endothelial cell proliferation GO:0001936 1 0.011
cellular response to nutrient levels GO:0031669 2 0.011
nuclear export GO:0051168 1 0.011
regulation of transporter activity GO:0032409 2 0.011
negative regulation of synapse assembly GO:0051964 2 0.011
modification dependent macromolecule catabolic process GO:0043632 3 0.011
cartilage development GO:0051216 96 0.011
positive regulation of immune effector process GO:0002699 3 0.011
meiotic nuclear division GO:0007126 4 0.011
multicellular organismal response to stress GO:0033555 2 0.011
protein modification process GO:0036211 100 0.011
taxis GO:0042330 109 0.011
multi organism process GO:0051704 134 0.011
cellular component assembly involved in morphogenesis GO:0010927 107 0.011
neurological system process GO:0050877 62 0.011
cell morphogenesis GO:0000902 289 0.011
Mouse
negative regulation of cellular process GO:0048523 283 0.011
Zebrafish Mouse
localization of cell GO:0051674 244 0.011
Fly
peptidyl lysine acetylation GO:0018394 2 0.011
regulation of nervous system development GO:0051960 90 0.011
Mouse Fly
cell motility GO:0048870 244 0.011
Fly
embryonic viscerocranium morphogenesis GO:0048703 52 0.011
monoamine transport GO:0015844 1 0.011
regulation of cell projection assembly GO:0060491 4 0.011
muscle cell differentiation GO:0042692 139 0.011
Fly
regulation of protein ubiquitination GO:0031396 3 0.011
axon development GO:0061564 166 0.011
Mouse
reactive oxygen species biosynthetic process GO:1903409 1 0.011
cellular response to starvation GO:0009267 1 0.011
lipid catabolic process GO:0016042 4 0.011
cellular response to decreased oxygen levels GO:0036294 1 0.011
cellular response to chemical stimulus GO:0070887 157 0.011
regulation of protein localization to nucleus GO:1900180 2 0.010
regulation of membrane potential GO:0042391 23 0.010
single organism transport GO:0044765 206 0.010
Worm
neuron neuron synaptic transmission GO:0007270 1 0.010
peptide transport GO:0015833 1 0.010
negative regulation of multi organism process GO:0043901 3 0.010
organelle fusion GO:0048284 3 0.010
action potential GO:0001508 19 0.010
actin filament based movement GO:0030048 1 0.010
germ line stem cell maintenance GO:0030718 2 0.010
regulation of reactive oxygen species metabolic process GO:2000377 2 0.010
developmental pigmentation GO:0048066 48 0.010
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.010
positive regulation of protein complex assembly GO:0031334 2 0.010
regulation of filopodium assembly GO:0051489 2 0.010
cellular component maintenance GO:0043954 3 0.010
axonogenesis GO:0007409 152 0.010
Mouse
production of molecular mediator of immune response GO:0002440 2 0.010
protein stabilization GO:0050821 2 0.010
regulation of protein targeting GO:1903533 2 0.010

numb disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.079
nervous system disease DOID:863 0 0.027
disease of cellular proliferation DOID:14566 0 0.018
immune system disease DOID:2914 0 0.015
cancer DOID:162 0 0.014
organ system cancer DOID:0050686 0 0.014
musculoskeletal system disease DOID:17 0 0.013
disease of metabolism DOID:0014667 0 0.012
cardiovascular system disease DOID:1287 0 0.012
sensory system disease DOID:0050155 0 0.010