Danio rerio

0 known processes

ern1

endoplasmic reticulum to nucleus signaling 1

(Aliases: MGC109932,zgc:109932)

ern1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.072
proteasomal protein catabolic process GO:0010498 2 0.066
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.061
cellular protein catabolic process GO:0044257 4 0.054
positive regulation of cellular component biogenesis GO:0044089 3 0.051
gene expression GO:0010467 252 0.051
negative regulation of nuclear division GO:0051784 3 0.049
positive regulation of transport GO:0051050 2 0.048
response to stress GO:0006950 263 0.048
modification dependent protein catabolic process GO:0019941 3 0.048
regulation of protein complex assembly GO:0043254 3 0.047
ubiquitin dependent protein catabolic process GO:0006511 3 0.044
rna metabolic process GO:0016070 219 0.042
meiotic nuclear division GO:0007126 4 0.040
regulation of establishment of protein localization GO:0070201 4 0.039
modification dependent macromolecule catabolic process GO:0043632 3 0.038
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.038
sequestering of metal ion GO:0051238 3 0.036
negative regulation of mitosis GO:0045839 3 0.036
aging GO:0007568 2 0.036
female gonad development GO:0008585 4 0.034
female sex differentiation GO:0046660 4 0.033
cellular response to nutrient levels GO:0031669 2 0.033
negative regulation of protein phosphorylation GO:0001933 4 0.032
positive regulation of protein complex assembly GO:0031334 2 0.032
maintenance of location GO:0051235 4 0.032
mitochondrion organization GO:0007005 4 0.031
regulation of cellular metabolic process GO:0031323 320 0.031
establishment of protein localization to organelle GO:0072594 4 0.031
negative regulation of cellular process GO:0048523 283 0.030
regulation of protein catabolic process GO:0042176 1 0.030
regulation of cytoplasmic transport GO:1903649 4 0.030
regulation of cellular ketone metabolic process GO:0010565 7 0.029
positive regulation of secretion by cell GO:1903532 1 0.029
regulation of sequestering of calcium ion GO:0051282 4 0.028
sequestering of calcium ion GO:0051208 3 0.028
signal transduction GO:0007165 455 0.028
cell surface receptor signaling pathway GO:0007166 325 0.028
negative regulation of sequestering of calcium ion GO:0051283 4 0.028
protein import GO:0017038 3 0.028
nucleobase containing compound metabolic process GO:0006139 274 0.027
regulation of metal ion transport GO:0010959 4 0.027
cellular nitrogen compound biosynthetic process GO:0044271 218 0.027
regulation of protein transport GO:0051223 3 0.027
regulation of macromolecule metabolic process GO:0060255 317 0.027
extrinsic apoptotic signaling pathway GO:0097191 3 0.026
positive regulation of cell cycle GO:0045787 3 0.026
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.026
single organism nuclear import GO:1902593 3 0.026
cellular macromolecule metabolic process GO:0044260 391 0.026
rna localization GO:0006403 4 0.026
cellular nitrogen compound metabolic process GO:0034641 290 0.026
release of sequestered calcium ion into cytosol GO:0051209 3 0.025
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.025
protein metabolic process GO:0019538 183 0.025
nucleic acid metabolic process GO:0090304 244 0.024
cellular component assembly GO:0022607 170 0.024
embryonic organ development GO:0048568 381 0.024
leukocyte proliferation GO:0070661 1 0.023
cell migration GO:0016477 237 0.023
erk1 and erk2 cascade GO:0070371 4 0.023
regulation of erk1 and erk2 cascade GO:0070372 4 0.023
response to chemical GO:0042221 320 0.023
phagocytosis GO:0006909 3 0.023
nucleocytoplasmic transport GO:0006913 4 0.023
response to organic substance GO:0010033 153 0.023
positive regulation of secretion GO:0051047 1 0.023
regulation of metabolic process GO:0019222 359 0.023
regulation of macromolecule biosynthetic process GO:0010556 225 0.023
response to topologically incorrect protein GO:0035966 2 0.022
amine metabolic process GO:0009308 2 0.022
autophagy GO:0006914 4 0.022
negative regulation of protein transport GO:0051224 3 0.022
biosynthetic process GO:0009058 294 0.022
mitochondrial transport GO:0006839 2 0.022
cellular component movement GO:0006928 335 0.022
organic cyclic compound metabolic process GO:1901360 301 0.022
cellular amine metabolic process GO:0044106 2 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
response to uv GO:0009411 3 0.022
cellular response to biotic stimulus GO:0071216 3 0.022
mononuclear cell proliferation GO:0032943 1 0.021
regulation of rna biosynthetic process GO:2001141 213 0.021
morphogenesis of an epithelium GO:0002009 333 0.021
cytokinesis GO:0000910 3 0.021
cellular amino acid metabolic process GO:0006520 7 0.021
heterocycle biosynthetic process GO:0018130 215 0.021
cellular response to extracellular stimulus GO:0031668 2 0.021
regulation of meiotic cell cycle GO:0051445 1 0.021
membrane fusion GO:0061025 2 0.021
regulation of cellular amine metabolic process GO:0033238 0 0.021
g1 s transition of mitotic cell cycle GO:0000082 1 0.020
positive regulation of catabolic process GO:0009896 4 0.020
regulation of biosynthetic process GO:0009889 250 0.020
regulation of gene expression GO:0010468 265 0.020
calcium ion transport into cytosol GO:0060402 3 0.020
regulation of multicellular organism growth GO:0040014 4 0.020
cellular response to external stimulus GO:0071496 2 0.020
nitrogen compound metabolic process GO:0006807 319 0.020
regulation of cytokine production GO:0001817 3 0.020
cellular response to molecule of bacterial origin GO:0071219 3 0.020
digestive system development GO:0055123 289 0.020
multicellular organism growth GO:0035264 4 0.020
regulation of biological quality GO:0065008 263 0.020
organic substance biosynthetic process GO:1901576 289 0.020
regulation of protein localization to nucleus GO:1900180 2 0.020
heterocycle metabolic process GO:0046483 290 0.020
tissue remodeling GO:0048771 4 0.020
regulation of reactive oxygen species metabolic process GO:2000377 2 0.020
regulation of synapse organization GO:0050807 3 0.020
regulation of protein import into nucleus GO:0042306 2 0.020
protein secretion GO:0009306 1 0.019
cellular component disassembly GO:0022411 1 0.019
organelle organization GO:0006996 227 0.019
development of primary female sexual characteristics GO:0046545 4 0.019
blood vessel development GO:0001568 246 0.019
vasculature development GO:0001944 278 0.019
lipid storage GO:0019915 1 0.019
cellular ketone metabolic process GO:0042180 11 0.019
regulation of wound healing GO:0061041 2 0.019
regulation of primary metabolic process GO:0080090 311 0.019
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.019
tube morphogenesis GO:0035239 349 0.019
cellular component biogenesis GO:0044085 178 0.019
protein targeting to nucleus GO:0044744 3 0.018
positive regulation of chromatin modification GO:1903310 1 0.018
embryo development ending in birth or egg hatching GO:0009792 271 0.018
regulation of cellular amino acid metabolic process GO:0006521 0 0.018
cellular response to starvation GO:0009267 1 0.018
synaptic growth at neuromuscular junction GO:0051124 2 0.018
nucleic acid templated transcription GO:0097659 181 0.018
nuclear transport GO:0051169 4 0.018
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.018
nucleobase containing compound biosynthetic process GO:0034654 205 0.018
neuron differentiation GO:0030182 353 0.018
regulation of calcium ion transport GO:0051924 2 0.018
positive regulation of cellular process GO:0048522 201 0.018
gtp catabolic process GO:0006184 2 0.018
protein dephosphorylation GO:0006470 3 0.018
regulation of transcription dna templated GO:0006355 213 0.018
protein import into nucleus GO:0006606 3 0.018
cellular aromatic compound metabolic process GO:0006725 295 0.018
cell cycle g1 s phase transition GO:0044843 1 0.017
protein localization to nucleus GO:0034504 3 0.017
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.017
negative regulation of cytoplasmic transport GO:1903650 2 0.017
stem cell maintenance GO:0019827 4 0.017
chordate embryonic development GO:0043009 271 0.017
double strand break repair GO:0006302 3 0.017
regulation of protein targeting GO:1903533 2 0.017
positive regulation of cytoskeleton organization GO:0051495 3 0.017
negative regulation of biological process GO:0048519 304 0.017
positive regulation of dna metabolic process GO:0051054 1 0.017
positive regulation of cellular catabolic process GO:0031331 3 0.017
regulation of binding GO:0051098 3 0.017
regulation of nucleocytoplasmic transport GO:0046822 2 0.017
lymphocyte proliferation GO:0046651 1 0.017
atp catabolic process GO:0006200 4 0.017
internal peptidyl lysine acetylation GO:0018393 2 0.017
intracellular mrna localization GO:0008298 1 0.017
regulation of rna metabolic process GO:0051252 224 0.016
negative regulation of catabolic process GO:0009895 3 0.016
neurotransmitter transport GO:0006836 2 0.016
digestive tract development GO:0048565 265 0.016
ovulation cycle GO:0042698 2 0.016
organelle fusion GO:0048284 3 0.016
ovulation cycle process GO:0022602 2 0.016
response to unfolded protein GO:0006986 2 0.016
single organism metabolic process GO:0044710 217 0.016
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.016
exocytosis GO:0006887 1 0.016
positive regulation of apoptotic signaling pathway GO:2001235 1 0.016
peptidyl serine phosphorylation GO:0018105 1 0.016
cellular response to organic substance GO:0071310 105 0.016
ribonucleoside monophosphate catabolic process GO:0009158 4 0.016
positive regulation of biological process GO:0048518 253 0.016
regulation of cell activation GO:0050865 1 0.016
rna biosynthetic process GO:0032774 181 0.016
peptidyl lysine acetylation GO:0018394 2 0.016
negative regulation of kinase activity GO:0033673 4 0.016
regulation of mitochondrion organization GO:0010821 1 0.016
cellular response to oxygen levels GO:0071453 1 0.016
protein acetylation GO:0006473 2 0.016
spermatid differentiation GO:0048515 2 0.016
regulation of purine nucleotide catabolic process GO:0033121 2 0.016
rna transport GO:0050658 2 0.016
negative regulation of metabolic process GO:0009892 86 0.016
nuclear import GO:0051170 3 0.016
regulation of synapse assembly GO:0051963 3 0.016
purine nucleoside monophosphate catabolic process GO:0009128 4 0.015
nuclear export GO:0051168 1 0.015
organelle assembly GO:0070925 110 0.015
i kappab kinase nf kappab signaling GO:0007249 4 0.015
cellular response to light stimulus GO:0071482 4 0.015
central nervous system development GO:0007417 387 0.015
nucleic acid transport GO:0050657 2 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
system process GO:0003008 185 0.015
single organism localization GO:1902578 225 0.015
establishment of rna localization GO:0051236 3 0.015
translational initiation GO:0006413 3 0.015
inositol lipid mediated signaling GO:0048017 2 0.015
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.015
single organism membrane fusion GO:0044801 2 0.015
cellular response to unfolded protein GO:0034620 2 0.015
locomotion GO:0040011 313 0.015
guanosine containing compound catabolic process GO:1901069 2 0.015
negative regulation of protein kinase activity GO:0006469 4 0.015
endosomal transport GO:0016197 2 0.014
regulation of chromosome segregation GO:0051983 1 0.014
localization of cell GO:0051674 244 0.014
endoplasmic reticulum unfolded protein response GO:0030968 2 0.014
positive regulation of chromosome organization GO:2001252 1 0.014
peptidyl serine modification GO:0018209 2 0.014
guanosine containing compound metabolic process GO:1901068 4 0.014
neuron neuron synaptic transmission GO:0007270 1 0.014
cellular response to topologically incorrect protein GO:0035967 2 0.014
aromatic compound biosynthetic process GO:0019438 217 0.014
cell projection morphogenesis GO:0048858 244 0.014
antimicrobial humoral response GO:0019730 2 0.014
transcription dna templated GO:0006351 181 0.014
meiotic cell cycle process GO:1903046 3 0.014
negative regulation of map kinase activity GO:0043407 2 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.014
negative regulation of mapk cascade GO:0043409 4 0.014
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.014
mitotic dna integrity checkpoint GO:0044774 4 0.014
interspecies interaction between organisms GO:0044419 4 0.014
response to antibiotic GO:0046677 1 0.014
nucleobase containing compound transport GO:0015931 2 0.014
mrna stabilization GO:0048255 4 0.014
developmental growth GO:0048589 166 0.014
ameboidal type cell migration GO:0001667 143 0.014
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.014
positive regulation of cytokine production GO:0001819 2 0.014
regulation of inflammatory response GO:0050727 2 0.014
post embryonic organ development GO:0048569 4 0.014
cellular modified amino acid metabolic process GO:0006575 3 0.014
developmental programmed cell death GO:0010623 4 0.014
establishment of localization GO:0051234 244 0.014
peptide metabolic process GO:0006518 1 0.014
response to abiotic stimulus GO:0009628 122 0.013
cell motility GO:0048870 244 0.013
chemosensory behavior GO:0007635 1 0.013
homeostatic process GO:0042592 142 0.013
oxoacid metabolic process GO:0043436 31 0.013
gtp metabolic process GO:0046039 4 0.013
negative regulation of protein import into nucleus GO:0042308 2 0.013
regulation of nucleoside metabolic process GO:0009118 2 0.013
single organism organelle organization GO:1902589 199 0.013
regulation of reproductive process GO:2000241 4 0.013
mitotic dna damage checkpoint GO:0044773 4 0.013
cellular biosynthetic process GO:0044249 286 0.013
positive regulation of cell activation GO:0050867 1 0.013
protein modification process GO:0036211 100 0.013
regulation of signal transduction GO:0009966 225 0.013
regulation of epithelial cell proliferation GO:0050678 3 0.013
regulation of transporter activity GO:0032409 2 0.013
macromolecule modification GO:0043412 111 0.013
regulation of nucleic acid templated transcription GO:1903506 213 0.013
embryonic organ morphogenesis GO:0048562 274 0.013
b cell activation GO:0042113 2 0.013
regulation of organelle assembly GO:1902115 4 0.013
cellular carbohydrate metabolic process GO:0044262 4 0.013
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.013
regulation of localization GO:0032879 104 0.013
cellular macromolecule biosynthetic process GO:0034645 224 0.013
regulation of microtubule cytoskeleton organization GO:0070507 3 0.013
protein polymerization GO:0051258 4 0.013
internal protein amino acid acetylation GO:0006475 2 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
fertilization GO:0009566 3 0.013
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.012
negative regulation of intracellular transport GO:0032387 3 0.012
regulation of gtpase activity GO:0043087 2 0.012
regulation of stem cell proliferation GO:0072091 2 0.012
organonitrogen compound metabolic process GO:1901564 74 0.012
er nucleus signaling pathway GO:0006984 2 0.012
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.012
organic acid metabolic process GO:0006082 31 0.012
mesenchymal cell differentiation GO:0048762 87 0.012
rna modification GO:0009451 2 0.012
cell matrix adhesion GO:0007160 4 0.012
rna polyadenylation GO:0043631 2 0.012
cellular protein metabolic process GO:0044267 129 0.012
regulation of synaptic plasticity GO:0048167 1 0.012
regulation of nucleotide catabolic process GO:0030811 2 0.012
negative regulation of secretion GO:0051048 2 0.012
neuroblast proliferation GO:0007405 2 0.012
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.012
heart development GO:0007507 313 0.012
axon development GO:0061564 166 0.012
negative regulation of signal transduction GO:0009968 94 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
spindle assembly GO:0051225 2 0.012
phosphatidylinositol mediated signaling GO:0048015 2 0.012
cellular response to decreased oxygen levels GO:0036294 1 0.012
regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001239 1 0.012
generation of neurons GO:0048699 385 0.012
negative regulation of defense response GO:0031348 2 0.012
regulation of protein polymerization GO:0032271 2 0.012
cell substrate adhesion GO:0031589 4 0.012
blood vessel morphogenesis GO:0048514 216 0.012
positive regulation of jnk cascade GO:0046330 3 0.012
nucleoside monophosphate catabolic process GO:0009125 4 0.012
stem cell proliferation GO:0072089 4 0.012
positive regulation of cell division GO:0051781 2 0.012
negative regulation of epithelial cell proliferation GO:0050680 1 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
negative regulation of cellular catabolic process GO:0031330 3 0.012
cellular amide metabolic process GO:0043603 4 0.012
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.012
positive regulation of protein polymerization GO:0032273 2 0.012
negative regulation of signaling GO:0023057 96 0.012
organic cyclic compound biosynthetic process GO:1901362 223 0.012
regulation of dna replication GO:0006275 3 0.012
protein localization to plasma membrane GO:0072659 1 0.012
cell part morphogenesis GO:0032990 246 0.012
positive regulation of histone modification GO:0031058 1 0.012
regulation of intracellular protein transport GO:0033157 3 0.011
negative regulation of cytokine production GO:0001818 1 0.011
regulation of dendrite morphogenesis GO:0048814 3 0.011
cell morphogenesis GO:0000902 289 0.011
protein homooligomerization GO:0051260 3 0.011
regulation of developmental process GO:0050793 247 0.011
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.011
regulation of response to stimulus GO:0048583 269 0.011
macromolecule biosynthetic process GO:0009059 227 0.011
negative regulation of gene expression GO:0010629 65 0.011
regulation of signaling GO:0023051 235 0.011
regulation of autophagy GO:0010506 3 0.011
rna stabilization GO:0043489 4 0.011
regulation of multicellular organismal process GO:0051239 277 0.011
protein heterooligomerization GO:0051291 1 0.011
protein acylation GO:0043543 3 0.011
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.011
regulation of cellular component organization GO:0051128 86 0.011
cellular response to hypoxia GO:0071456 1 0.011
regulation of response to biotic stimulus GO:0002831 2 0.011
stem cell division GO:0017145 1 0.011
negative regulation of response to stimulus GO:0048585 104 0.011
regulation of protein metabolic process GO:0051246 56 0.011
mrna transport GO:0051028 2 0.011
cognition GO:0050890 1 0.011
cytoplasm organization GO:0007028 4 0.011
protein polyubiquitination GO:0000209 4 0.011
cell cycle arrest GO:0007050 1 0.011
negative regulation of intracellular protein transport GO:0090317 3 0.011
cytosolic calcium ion transport GO:0060401 3 0.011
neurotransmitter secretion GO:0007269 2 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
positive regulation of nucleotide catabolic process GO:0030813 1 0.011
regulation of ion transmembrane transporter activity GO:0032412 2 0.011
cell projection organization GO:0030030 284 0.011
eye development GO:0001654 277 0.011
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.011
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.011
regulation of mrna processing GO:0050684 3 0.011
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.011
regulation of stem cell differentiation GO:2000736 4 0.011
double strand break repair via homologous recombination GO:0000724 1 0.011
immune system process GO:0002376 241 0.011
adherens junction organization GO:0034332 4 0.011
negative regulation of protein complex assembly GO:0031333 1 0.011
compound eye development GO:0048749 2 0.011
dna templated transcription elongation GO:0006354 3 0.011
carboxylic acid metabolic process GO:0019752 22 0.010
regulation of cellular biosynthetic process GO:0031326 245 0.010
secondary metabolic process GO:0019748 3 0.010
positive regulation of lymphocyte mediated immunity GO:0002708 1 0.010
adult behavior GO:0030534 2 0.010
negative regulation of secretion by cell GO:1903531 2 0.010
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.010
signal transduction in absence of ligand GO:0038034 1 0.010
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.010
negative regulation of macromolecule metabolic process GO:0010605 76 0.010
synaptic vesicle localization GO:0097479 1 0.010
macromolecular complex disassembly GO:0032984 1 0.010
positive regulation of immune effector process GO:0002699 3 0.010
positive regulation of nucleoside metabolic process GO:0045979 1 0.010
regulation of exocytosis GO:0017157 1 0.010
ncrna catabolic process GO:0034661 1 0.010
xenobiotic metabolic process GO:0006805 4 0.010
response to wounding GO:0009611 116 0.010
germ line stem cell maintenance GO:0030718 2 0.010
transport GO:0006810 220 0.010
phosphate containing compound metabolic process GO:0006796 108 0.010

ern1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.066
disease of metabolism DOID:0014667 0 0.021
nervous system disease DOID:863 0 0.019
immune system disease DOID:2914 0 0.019
cancer DOID:162 0 0.015
disease of cellular proliferation DOID:14566 0 0.015
musculoskeletal system disease DOID:17 0 0.015
organ system cancer DOID:0050686 0 0.014
cardiovascular system disease DOID:1287 0 0.012
inherited metabolic disorder DOID:655 0 0.011
muscular disease DOID:0080000 0 0.010