Danio rerio

18 known processes

tcf4

transcription factor 4

tcf4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
central nervous system development GO:0007417 387 0.871
skeletal system development GO:0001501 181 0.430
rna biosynthetic process GO:0032774 181 0.372
locomotion GO:0040011 313 0.371
cell motility GO:0048870 244 0.317
brain development GO:0007420 293 0.269
stem cell development GO:0048864 82 0.238
cell projection organization GO:0030030 284 0.238
nucleic acid templated transcription GO:0097659 181 0.237
head development GO:0060322 303 0.227
cellular macromolecule metabolic process GO:0044260 391 0.225
cellular nitrogen compound metabolic process GO:0034641 290 0.222
regulation of rna biosynthetic process GO:2001141 213 0.203
hematopoietic or lymphoid organ development GO:0048534 191 0.202
cellular component morphogenesis GO:0032989 336 0.182
ameboidal type cell migration GO:0001667 143 0.176
nitrogen compound metabolic process GO:0006807 319 0.172
organic cyclic compound biosynthetic process GO:1901362 223 0.165
regulation of transcription dna templated GO:0006355 213 0.160
embryonic organ development GO:0048568 381 0.154
embryonic skeletal joint development GO:0072498 3 0.154
cellular aromatic compound metabolic process GO:0006725 295 0.150
localization of cell GO:0051674 244 0.148
cell morphogenesis involved in differentiation GO:0000904 195 0.142
regionalization GO:0003002 274 0.140
regulation of macromolecule metabolic process GO:0060255 317 0.136
cell migration GO:0016477 237 0.136
nucleobase containing compound biosynthetic process GO:0034654 205 0.130
regulation of primary metabolic process GO:0080090 311 0.128
regulation of gene expression GO:0010468 265 0.125
heart development GO:0007507 313 0.121
immune system process GO:0002376 241 0.120
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.120
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.116
vasculature development GO:0001944 278 0.115
gene expression GO:0010467 252 0.114
tissue remodeling GO:0048771 4 0.113
muscle organ development GO:0007517 101 0.113
axon development GO:0061564 166 0.113
regulation of nitrogen compound metabolic process GO:0051171 251 0.110
regulation of cellular metabolic process GO:0031323 320 0.106
cellular component movement GO:0006928 335 0.106
heterocycle metabolic process GO:0046483 290 0.105
chordate embryonic development GO:0043009 271 0.104
catechol containing compound biosynthetic process GO:0009713 2 0.101
organic cyclic compound metabolic process GO:1901360 301 0.101
heterocycle biosynthetic process GO:0018130 215 0.100
mesenchymal cell development GO:0014031 78 0.100
neuron differentiation GO:0030182 353 0.098
somitogenesis GO:0001756 87 0.097
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.095
embryonic organ morphogenesis GO:0048562 274 0.088
rna metabolic process GO:0016070 219 0.087
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.085
cellular nitrogen compound biosynthetic process GO:0044271 218 0.085
signal transduction GO:0007165 455 0.084
nucleobase containing compound metabolic process GO:0006139 274 0.084
immune system development GO:0002520 191 0.081
regulation of cell communication GO:0010646 232 0.081
regulation of rna metabolic process GO:0051252 224 0.081
mesenchymal cell differentiation GO:0048762 87 0.080
cell morphogenesis GO:0000902 289 0.079
embryonic skeletal system development GO:0048706 97 0.079
skeletal muscle organ development GO:0060538 78 0.078
regulation of macromolecule biosynthetic process GO:0010556 225 0.078
urogenital system development GO:0001655 97 0.078
regulation of cellular biosynthetic process GO:0031326 245 0.078
skeletal system morphogenesis GO:0048705 102 0.078
central nervous system neuron differentiation GO:0021953 74 0.077
adult behavior GO:0030534 2 0.076
response to chemical GO:0042221 320 0.075
neural crest cell differentiation GO:0014033 72 0.075
central nervous system neuron axonogenesis GO:0021955 18 0.075
regulation of metabolic process GO:0019222 359 0.074
negative regulation of axon guidance GO:1902668 1 0.072
mesenchyme development GO:0060485 127 0.071
transcription dna templated GO:0006351 181 0.071
amine metabolic process GO:0009308 2 0.071
organelle organization GO:0006996 227 0.070
muscle structure development GO:0061061 196 0.067
nucleic acid metabolic process GO:0090304 244 0.067
stem cell differentiation GO:0048863 117 0.067
larval development GO:0002164 2 0.066
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.065
negative regulation of biological process GO:0048519 304 0.065
organic substance biosynthetic process GO:1901576 289 0.062
phagocytosis GO:0006909 3 0.062
response to drug GO:0042493 3 0.061
morphogenesis of an epithelium GO:0002009 333 0.059
cellular biosynthetic process GO:0044249 286 0.059
cell death GO:0008219 121 0.058
nuclear transport GO:0051169 4 0.058
catechol containing compound metabolic process GO:0009712 2 0.058
regulation of biosynthetic process GO:0009889 250 0.058
positive regulation of cellular process GO:0048522 201 0.057
axonogenesis GO:0007409 152 0.057
regulation of multicellular organismal process GO:0051239 277 0.057
aging GO:0007568 2 0.057
connective tissue development GO:0061448 99 0.056
sensory organ development GO:0007423 393 0.056
stem cell proliferation GO:0072089 4 0.056
larval heart development GO:0007508 2 0.055
negative regulation of axon extension involved in axon guidance GO:0048843 1 0.054
neural crest cell development GO:0014032 62 0.054
transcription from rna polymerase ii promoter GO:0006366 80 0.053
generation of neurons GO:0048699 385 0.053
embryo development ending in birth or egg hatching GO:0009792 271 0.052
regulation of reproductive process GO:2000241 4 0.051
forebrain development GO:0030900 96 0.051
sprouting angiogenesis GO:0002040 53 0.051
aromatic compound biosynthetic process GO:0019438 217 0.051
single organism metabolic process GO:0044710 217 0.049
peptidyl serine phosphorylation GO:0018105 1 0.048
small molecule metabolic process GO:0044281 77 0.047
hemopoiesis GO:0030097 183 0.047
macromolecule biosynthetic process GO:0009059 227 0.045
neural crest cell migration GO:0001755 42 0.045
maintenance of location GO:0051235 4 0.045
organonitrogen compound metabolic process GO:1901564 74 0.044
cell projection morphogenesis GO:0048858 244 0.044
cartilage development GO:0051216 96 0.044
central nervous system neuron development GO:0021954 29 0.043
neuron projection development GO:0031175 180 0.043
bmp signaling pathway GO:0030509 52 0.042
axonal defasciculation GO:0007414 2 0.042
striated muscle tissue development GO:0014706 110 0.040
cognition GO:0050890 1 0.040
embryonic skeletal joint morphogenesis GO:0060272 3 0.039
cellular amine metabolic process GO:0044106 2 0.039
regulation of intracellular protein transport GO:0033157 3 0.039
developmental growth GO:0048589 166 0.038
establishment of protein localization to organelle GO:0072594 4 0.038
regulation of cellular amine metabolic process GO:0033238 0 0.038
regulation of cell death GO:0010941 103 0.038
stem cell maintenance GO:0019827 4 0.038
renal system development GO:0072001 94 0.038
somatic stem cell maintenance GO:0035019 1 0.037
death GO:0016265 121 0.037
nucleocytoplasmic transport GO:0006913 4 0.037
response to stress GO:0006950 263 0.037
gastrulation GO:0007369 208 0.036
neurological system process GO:0050877 62 0.036
regulation of signal transduction GO:0009966 225 0.036
regulation of nucleic acid templated transcription GO:1903506 213 0.036
notochord development GO:0030903 54 0.036
positive regulation of cellular biosynthetic process GO:0031328 68 0.035
biological adhesion GO:0022610 40 0.035
blood vessel development GO:0001568 246 0.035
muscle cell differentiation GO:0042692 139 0.035
developmental growth involved in morphogenesis GO:0060560 86 0.034
central nervous system projection neuron axonogenesis GO:0021952 15 0.033
biosynthetic process GO:0009058 294 0.033
kidney development GO:0001822 92 0.033
eye development GO:0001654 277 0.033
regulation of cell activation GO:0050865 1 0.033
neuron projection extension GO:1990138 45 0.033
negative regulation of cellular process GO:0048523 283 0.032
regulation of cellular amino acid metabolic process GO:0006521 0 0.032
response to external stimulus GO:0009605 264 0.032
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.032
cell part morphogenesis GO:0032990 246 0.031
positive regulation of transport GO:0051050 2 0.031
digestive system development GO:0055123 289 0.031
epithelial tube morphogenesis GO:0060562 148 0.030
positive regulation of transcription dna templated GO:0045893 57 0.030
cellular localization GO:0051641 97 0.029
forebrain generation of neurons GO:0021872 14 0.029
cellular amino acid metabolic process GO:0006520 7 0.029
eye morphogenesis GO:0048592 144 0.028
positive regulation of biological process GO:0048518 253 0.028
response to organic substance GO:0010033 153 0.028
embryonic skeletal system morphogenesis GO:0048704 93 0.028
cell substrate adhesion GO:0031589 4 0.028
lateral inhibition GO:0046331 1 0.028
centrosome cycle GO:0007098 1 0.027
microtubule organizing center organization GO:0031023 1 0.027
system process GO:0003008 185 0.026
regulation of establishment of protein localization GO:0070201 4 0.026
regulation of cell shape GO:0008360 1 0.026
regulation of anatomical structure morphogenesis GO:0022603 130 0.026
regulation of signaling GO:0023051 235 0.026
cellular macromolecule biosynthetic process GO:0034645 224 0.026
specification of symmetry GO:0009799 204 0.026
regulation of skeletal muscle fiber development GO:0048742 2 0.025
smoothened signaling pathway GO:0007224 30 0.025
neuron development GO:0048666 262 0.025
blood vessel morphogenesis GO:0048514 216 0.025
extrinsic apoptotic signaling pathway GO:0097191 3 0.025
hypothalamus cell differentiation GO:0021979 4 0.025
post embryonic organ development GO:0048569 4 0.025
protein secretion GO:0009306 1 0.025
cellular ketone metabolic process GO:0042180 11 0.025
regulation of rho protein signal transduction GO:0035023 2 0.025
programmed cell death GO:0012501 119 0.024
cellular response to extracellular stimulus GO:0031668 2 0.024
single organism nuclear import GO:1902593 3 0.024
cell proliferation in hindbrain GO:0021534 4 0.024
positive regulation of striated muscle cell differentiation GO:0051155 1 0.023
cellular protein catabolic process GO:0044257 4 0.023
regulation of response to biotic stimulus GO:0002831 2 0.023
protein import GO:0017038 3 0.023
anterior posterior pattern specification GO:0009952 152 0.023
mitochondrion organization GO:0007005 4 0.023
proteasomal protein catabolic process GO:0010498 2 0.023
sensory perception of chemical stimulus GO:0007606 3 0.023
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.023
mesoderm development GO:0007498 88 0.023
regulation of nucleotide catabolic process GO:0030811 2 0.023
single organism organelle organization GO:1902589 199 0.022
regulation of collateral sprouting in absence of injury GO:0048696 4 0.022
odontogenesis of dentin containing tooth GO:0042475 1 0.022
segmentation GO:0035282 97 0.022
positive regulation of cellular amine metabolic process GO:0033240 0 0.022
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.022
positive regulation of mesenchymal cell proliferation GO:0002053 1 0.022
regulation of localization GO:0032879 104 0.021
regulation of myotube differentiation GO:0010830 2 0.021
regulation of neurotransmitter transport GO:0051588 1 0.021
camera type eye morphogenesis GO:0048593 108 0.021
regulation of protein transport GO:0051223 3 0.021
lipid storage GO:0019915 1 0.021
regulation of developmental process GO:0050793 247 0.021
cell migration involved in vasculogenesis GO:0035441 1 0.021
embryonic cranial skeleton morphogenesis GO:0048701 90 0.021
regulation of cytoplasmic transport GO:1903649 4 0.021
response to corticosteroid GO:0031960 1 0.021
regulation of nucleoside metabolic process GO:0009118 2 0.021
determination of bilateral symmetry GO:0009855 204 0.020
cell matrix adhesion GO:0007160 4 0.020
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.020
regulation of production of molecular mediator of immune response GO:0002700 1 0.020
positive regulation of rna metabolic process GO:0051254 59 0.020
cellular component biogenesis GO:0044085 178 0.020
dopaminergic neuron differentiation GO:0071542 14 0.020
stem cell division GO:0017145 1 0.020
cellular response to external stimulus GO:0071496 2 0.020
dorsal ventral pattern formation GO:0009953 125 0.019
positive regulation of dna templated transcription elongation GO:0032786 1 0.019
regulation of protein binding GO:0043393 3 0.019
nuclear import GO:0051170 3 0.019
dopamine biosynthetic process GO:0042416 2 0.019
reproductive process GO:0022414 40 0.019
protein import into nucleus GO:0006606 3 0.019
regulation of cellular component movement GO:0051270 55 0.019
regulation of gtp catabolic process GO:0033124 2 0.019
single organism localization GO:1902578 225 0.019
regulation of epithelial cell proliferation GO:0050678 3 0.019
regulation of protein targeting GO:1903533 2 0.019
renal tubule morphogenesis GO:0061333 1 0.019
convergent extension GO:0060026 118 0.018
muscle tissue development GO:0060537 110 0.018
guanosine containing compound metabolic process GO:1901068 4 0.018
regulation of bmp signaling pathway GO:0030510 39 0.018
cellular response to nutrient levels GO:0031669 2 0.018
growth GO:0040007 174 0.018
regulation of neuron migration GO:2001222 2 0.018
lipid homeostasis GO:0055088 3 0.018
negative regulation of cell communication GO:0010648 96 0.018
somite development GO:0061053 96 0.018
regulation of gtpase activity GO:0043087 2 0.018
regulation of cytokine production GO:0001817 3 0.017
positive regulation of rna biosynthetic process GO:1902680 57 0.017
regulation of heart growth GO:0060420 2 0.017
b cell activation GO:0042113 2 0.017
epithalamus development GO:0021538 10 0.017
chemotaxis GO:0006935 104 0.017
tube morphogenesis GO:0035239 349 0.017
cellular protein modification process GO:0006464 100 0.017
positive regulation of multicellular organismal process GO:0051240 52 0.017
production of molecular mediator of immune response GO:0002440 2 0.017
digestive tract morphogenesis GO:0048546 231 0.017
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.017
sensory organ morphogenesis GO:0090596 200 0.017
cell migration involved in gastrulation GO:0042074 79 0.017
regulation of cell differentiation GO:0045595 142 0.016
regulation of organ growth GO:0046620 3 0.016
cellular component assembly GO:0022607 170 0.016
regulation of glial cell differentiation GO:0045685 4 0.016
cell recognition GO:0008037 19 0.016
developmental cell growth GO:0048588 52 0.016
protein localization to nucleus GO:0034504 3 0.016
axon extension GO:0048675 45 0.016
positive regulation of biosynthetic process GO:0009891 68 0.016
extracellular structure organization GO:0043062 27 0.016
negative chemotaxis GO:0050919 1 0.016
g1 s transition of mitotic cell cycle GO:0000082 1 0.016
positive regulation of epithelial cell proliferation GO:0050679 1 0.016
cell adhesion GO:0007155 40 0.016
branching morphogenesis of a nerve GO:0048755 4 0.015
negative regulation of signal transduction GO:0009968 94 0.015
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.015
ear development GO:0043583 127 0.015
regulation of neurogenesis GO:0050767 87 0.015
endoderm development GO:0007492 49 0.015
protein polymerization GO:0051258 4 0.015
positive regulation of nucleic acid templated transcription GO:1903508 57 0.015
response to endogenous stimulus GO:0009719 83 0.015
centrosome organization GO:0051297 1 0.015
meiotic nuclear division GO:0007126 4 0.014
gland development GO:0048732 143 0.014
ear morphogenesis GO:0042471 64 0.014
astrocyte differentiation GO:0048708 1 0.014
forebrain neuron development GO:0021884 7 0.014
sympathetic ganglion development GO:0061549 2 0.014
regulation of mechanoreceptor differentiation GO:0045631 1 0.014
regulation of stem cell differentiation GO:2000736 4 0.014
heart morphogenesis GO:0003007 156 0.014
cell proliferation GO:0008283 80 0.014
regulation of response to stimulus GO:0048583 269 0.014
morphogenesis of embryonic epithelium GO:0016331 30 0.014
camera type eye development GO:0043010 222 0.014
phosphate containing compound metabolic process GO:0006796 108 0.014
regulation of cellular protein catabolic process GO:1903362 1 0.013
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.013
telencephalon development GO:0021537 14 0.013
regulation of tube size GO:0035150 2 0.013
protein targeting to nucleus GO:0044744 3 0.013
cellular response to starvation GO:0009267 1 0.013
regulation of dendrite development GO:0050773 3 0.013
phenol containing compound biosynthetic process GO:0046189 4 0.013
antimicrobial humoral response GO:0019730 2 0.013
embryonic heart tube development GO:0035050 133 0.013
positive regulation of translation GO:0045727 1 0.013
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.013
heart looping GO:0001947 94 0.013
mesenchymal cell proliferation GO:0010463 1 0.013
regulation of biomineral tissue development GO:0070167 2 0.013
negative regulation of cellular biosynthetic process GO:0031327 55 0.013
regulation of molecular function GO:0065009 70 0.013
negative regulation of leukocyte differentiation GO:1902106 1 0.013
muscle fiber development GO:0048747 52 0.013
cellular component assembly involved in morphogenesis GO:0010927 107 0.012
neuron projection guidance GO:0097485 86 0.012
positive regulation of macromolecule metabolic process GO:0010604 93 0.012
positive regulation of muscle organ development GO:0048636 1 0.012
cell growth GO:0016049 57 0.012
response to organic cyclic compound GO:0014070 51 0.012
catecholamine biosynthetic process GO:0042423 2 0.012
positive regulation of cellular component biogenesis GO:0044089 3 0.012
negative regulation of cell death GO:0060548 60 0.012
response to abiotic stimulus GO:0009628 122 0.012
carboxylic acid metabolic process GO:0019752 22 0.012
regulation of cardiac muscle tissue development GO:0055024 1 0.012
leukocyte proliferation GO:0070661 1 0.012
regulation of bone mineralization GO:0030500 2 0.012
regulation of hematopoietic progenitor cell differentiation GO:1901532 1 0.012
negative regulation of rna metabolic process GO:0051253 48 0.012
response to carbohydrate GO:0009743 3 0.012
regulation of transmembrane transporter activity GO:0022898 2 0.012
transport GO:0006810 220 0.012
guanosine containing compound catabolic process GO:1901069 2 0.012
cellular protein metabolic process GO:0044267 129 0.012
negative regulation of cellular metabolic process GO:0031324 77 0.012
forebrain cell migration GO:0021885 1 0.012
protein metabolic process GO:0019538 183 0.012
mitotic dna integrity checkpoint GO:0044774 4 0.012
bone remodeling GO:0046849 2 0.012
positive regulation of secretion GO:0051047 1 0.012
multi organism process GO:0051704 134 0.012
skeletal muscle tissue development GO:0007519 67 0.011
cell surface receptor signaling pathway GO:0007166 325 0.011
development of primary female sexual characteristics GO:0046545 4 0.011
positive regulation of cell cycle GO:0045787 3 0.011
gabaergic neuron differentiation GO:0097154 2 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
wound healing GO:0042060 90 0.011
response to glucose GO:0009749 3 0.011
angiogenesis GO:0001525 158 0.011
lymphocyte proliferation GO:0046651 1 0.011
nuclear export GO:0051168 1 0.011
establishment of localization in cell GO:0051649 77 0.011
regulation of protein complex assembly GO:0043254 3 0.011
collateral sprouting in absence of injury GO:0048669 4 0.011
forebrain neuron differentiation GO:0021879 14 0.011
spermatid development GO:0007286 2 0.011
single organism transport GO:0044765 206 0.011
anatomical structure arrangement GO:0048532 2 0.011
female gonad development GO:0008585 4 0.011
regulation of mrna splicing via spliceosome GO:0048024 3 0.011
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 1 0.011
sensory neuron axon guidance GO:0097374 3 0.011
negative regulation of biosynthetic process GO:0009890 55 0.011
positive regulation of muscle tissue development GO:1901863 1 0.011
regulation of mesenchymal cell proliferation GO:0010464 1 0.011
compound eye development GO:0048749 2 0.011
response to glucocorticoid GO:0051384 1 0.011
regulation of ras gtpase activity GO:0032318 2 0.011
regulation of purine nucleotide catabolic process GO:0033121 2 0.011
cell type specific apoptotic process GO:0097285 22 0.011
proximal distal pattern formation GO:0009954 1 0.011
intra s dna damage checkpoint GO:0031573 1 0.011
regulation of catalytic activity GO:0050790 55 0.011
taxis GO:0042330 109 0.011
negative regulation of chemotaxis GO:0050922 4 0.011
response to inorganic substance GO:0010035 38 0.011
regulation of neuron differentiation GO:0045664 56 0.010
peptidyl serine modification GO:0018209 2 0.010
negative regulation of programmed cell death GO:0043069 58 0.010
positive regulation of cell activation GO:0050867 1 0.010
pronephros development GO:0048793 69 0.010
circulatory system process GO:0003013 87 0.010
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
protein phosphorylation GO:0006468 47 0.010
protein modification process GO:0036211 100 0.010
synaptic target recognition GO:0008039 1 0.010
positive regulation of stem cell proliferation GO:2000648 1 0.010
striated muscle cell differentiation GO:0051146 129 0.010
cell fate commitment GO:0045165 99 0.010
regulation of blood vessel size GO:0050880 2 0.010
response to other organism GO:0051707 97 0.010
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.010
myoblast fusion GO:0007520 10 0.010
striated muscle cell development GO:0055002 108 0.010
neuron migration GO:0001764 22 0.010
negative regulation of gliogenesis GO:0014014 1 0.010
regulation of protein localization to nucleus GO:1900180 2 0.010
establishment of localization GO:0051234 244 0.010

tcf4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
organ system cancer DOID:0050686 0 0.018
cancer DOID:162 0 0.018
disease of cellular proliferation DOID:14566 0 0.018
disease of anatomical entity DOID:7 0 0.012
nervous system disease DOID:863 0 0.010