Danio rerio

0 known processes

acta1a

actin, alpha 1a, skeletal muscle

(Aliases: hm:zeh0293,zgc:112098)

acta1a biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular component morphogenesis GO:0032989 336 0.688
Mouse
striated muscle contraction GO:0006941 12 0.680
striated muscle cell differentiation GO:0051146 129 0.607
Mouse
muscle cell development GO:0055001 115 0.515
Mouse
ventricular cardiac myofibril assembly GO:0055005 4 0.416
muscle tissue development GO:0060537 110 0.388
Mouse
reactive nitrogen species metabolic process GO:2001057 0 0.378
lymphoid lineage cell migration GO:0097534 4 0.374
lymphoid lineage cell migration into thymus GO:0097535 4 0.356
skeletal muscle organ development GO:0060538 78 0.342
heart development GO:0007507 313 0.332
Zebrafish Mouse
nitric oxide biosynthetic process GO:0006809 2 0.301
muscle organ development GO:0007517 101 0.289
Mouse
regionalization GO:0003002 274 0.284
striated muscle cell development GO:0055002 108 0.263
Mouse
muscle structure development GO:0061061 196 0.248
Mouse
sarcomere organization GO:0045214 26 0.226
muscle cell differentiation GO:0042692 139 0.219
Mouse
cellular aromatic compound metabolic process GO:0006725 295 0.218
myotube cell development GO:0014904 35 0.215
regulation of circadian rhythm GO:0042752 4 0.201
muscle fiber development GO:0048747 52 0.176
locomotion GO:0040011 313 0.176
rna metabolic process GO:0016070 219 0.176
post embryonic organ development GO:0048569 4 0.172
regulation of rna biosynthetic process GO:2001141 213 0.167
cellular biosynthetic process GO:0044249 286 0.164
nucleic acid metabolic process GO:0090304 244 0.155
muscle system process GO:0003012 20 0.154
cellular component biogenesis GO:0044085 178 0.144
Mouse
muscle contraction GO:0006936 18 0.142
organic cyclic compound metabolic process GO:1901360 301 0.140
system process GO:0003008 185 0.135
connective tissue development GO:0061448 99 0.132
cellular nitrogen compound biosynthetic process GO:0044271 218 0.130
organic substance biosynthetic process GO:1901576 289 0.129
biosynthetic process GO:0009058 294 0.125
nitrogen compound metabolic process GO:0006807 319 0.124
nitric oxide metabolic process GO:0046209 2 0.124
skeletal muscle thin filament assembly GO:0030240 4 0.123
Mouse
neuron projection development GO:0031175 180 0.121
taxis GO:0042330 109 0.120
regulation of gene expression GO:0010468 265 0.115
lipid storage GO:0019915 1 0.114
neuron development GO:0048666 262 0.113
maintenance of location GO:0051235 4 0.109
vasculature development GO:0001944 278 0.109
ventricular cardiac muscle tissue morphogenesis GO:0055010 2 0.104
immune system process GO:0002376 241 0.102
positive regulation of blood circulation GO:1903524 2 0.101
cell migration GO:0016477 237 0.097
cellular component assembly GO:0022607 170 0.095
Mouse
cardiac muscle tissue development GO:0048738 48 0.093
Mouse
regulation of muscle contraction GO:0006937 3 0.091
nucleobase containing compound biosynthetic process GO:0034654 205 0.091
cellular component assembly involved in morphogenesis GO:0010927 107 0.090
Mouse
heterocycle metabolic process GO:0046483 290 0.090
skeletal muscle fiber development GO:0048741 35 0.087
localization of cell GO:0051674 244 0.087
nucleobase containing compound metabolic process GO:0006139 274 0.087
venous blood vessel morphogenesis GO:0048845 3 0.087
regulation of myotube differentiation GO:0010830 2 0.087
organelle organization GO:0006996 227 0.085
Mouse
cellular macromolecule biosynthetic process GO:0034645 224 0.083
reactive oxygen species metabolic process GO:0072593 6 0.083
signal transduction GO:0007165 455 0.082
response to external stimulus GO:0009605 264 0.081
regulation of nitrogen compound metabolic process GO:0051171 251 0.080
regulation of cell shape GO:0008360 1 0.080
meiotic nuclear division GO:0007126 4 0.080
regulation of cell communication GO:0010646 232 0.078
negative regulation of biological process GO:0048519 304 0.077
Mouse
angiogenesis GO:0001525 158 0.075
blood vessel development GO:0001568 246 0.073
regulation of ion transmembrane transporter activity GO:0032412 2 0.072
skeletal system development GO:0001501 181 0.071
positive regulation of cellular component biogenesis GO:0044089 3 0.071
cognition GO:0050890 1 0.071
regulation of metabolic process GO:0019222 359 0.070
nuclear transport GO:0051169 4 0.070
cell projection organization GO:0030030 284 0.069
myotube differentiation GO:0014902 45 0.068
regulation of system process GO:0044057 40 0.068
regulation of nucleic acid templated transcription GO:1903506 213 0.066
organelle assembly GO:0070925 110 0.065
Mouse
lamellipodium assembly GO:0030032 1 0.065
larval development GO:0002164 2 0.064
cardiac muscle cell development GO:0055013 20 0.063
Mouse
macromolecule biosynthetic process GO:0009059 227 0.063
reactive oxygen species biosynthetic process GO:1903409 1 0.062
regulation of cellular metabolic process GO:0031323 320 0.061
intracellular signal transduction GO:0035556 85 0.060
regulation of macromolecule metabolic process GO:0060255 317 0.059
transport GO:0006810 220 0.056
cell motility GO:0048870 244 0.055
rna biosynthetic process GO:0032774 181 0.055
anatomical structure homeostasis GO:0060249 36 0.054
artery development GO:0060840 22 0.054
cell morphogenesis GO:0000902 289 0.054
blood vessel morphogenesis GO:0048514 216 0.053
neuron projection morphogenesis GO:0048812 161 0.053
positive regulation of transcription dna templated GO:0045893 57 0.052
positive regulation of biological process GO:0048518 253 0.052
regulation of biological quality GO:0065008 263 0.052
mitotic cell cycle GO:0000278 64 0.052
protein localization to nucleus GO:0034504 3 0.052
gene expression GO:0010467 252 0.051
organic cyclic compound biosynthetic process GO:1901362 223 0.051
regulation of macromolecule biosynthetic process GO:0010556 225 0.047
nucleic acid templated transcription GO:0097659 181 0.047
cytoskeleton organization GO:0007010 96 0.047
Mouse
mitochondrion organization GO:0007005 4 0.047
neuron differentiation GO:0030182 353 0.046
homeostatic process GO:0042592 142 0.046
regulation of multicellular organismal process GO:0051239 277 0.046
adult behavior GO:0030534 2 0.046
regulation of epithelial cell proliferation GO:0050678 3 0.046
actin filament organization GO:0007015 15 0.045
Mouse
patterning of blood vessels GO:0001569 15 0.045
positive regulation of transport GO:0051050 2 0.045
pronephros development GO:0048793 69 0.044
cellular nitrogen compound metabolic process GO:0034641 290 0.044
positive regulation of heart contraction GO:0045823 2 0.044
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.043
oxoacid metabolic process GO:0043436 31 0.043
regulation of cellular component organization GO:0051128 86 0.042
renal system development GO:0072001 94 0.042
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.041
actomyosin structure organization GO:0031032 53 0.040
Mouse
mitotic cell cycle process GO:1903047 48 0.040
muscle cell cellular homeostasis GO:0046716 5 0.040
positive regulation of cellular process GO:0048522 201 0.039
kidney development GO:0001822 92 0.039
regulation of nitric oxide mediated signal transduction GO:0010749 1 0.039
negative regulation of cellular process GO:0048523 283 0.038
Mouse
blood circulation GO:0008015 87 0.038
myofibril assembly GO:0030239 48 0.038
Mouse
mesoderm development GO:0007498 88 0.037
atrial cardiac myofibril assembly GO:0055004 2 0.037
regulation of metal ion transport GO:0010959 4 0.036
regulation of transcription dna templated GO:0006355 213 0.036
segmentation GO:0035282 97 0.036
regulation of cell projection assembly GO:0060491 4 0.036
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.036
proximal distal pattern formation GO:0009954 1 0.035
reproductive process GO:0022414 40 0.035
heart process GO:0003015 71 0.035
central nervous system development GO:0007417 387 0.035
hematopoietic or lymphoid organ development GO:0048534 191 0.035
cell projection morphogenesis GO:0048858 244 0.035
regulation of response to stimulus GO:0048583 269 0.034
skeletal muscle tissue development GO:0007519 67 0.034
actin cytoskeleton organization GO:0030036 63 0.034
Mouse
multi organism process GO:0051704 134 0.034
pigmentation GO:0043473 85 0.033
regulation of biosynthetic process GO:0009889 250 0.033
transcription dna templated GO:0006351 181 0.033
heart morphogenesis GO:0003007 156 0.032
Zebrafish Mouse
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.032
cytokinesis GO:0000910 3 0.032
regulation of cellular biosynthetic process GO:0031326 245 0.031
musculoskeletal movement GO:0050881 8 0.031
regulation of heart contraction GO:0008016 32 0.031
nucleocytoplasmic transport GO:0006913 4 0.031
skeletal muscle contraction GO:0003009 5 0.030
regulation of blood pressure GO:0008217 1 0.030
cardiac muscle cell differentiation GO:0055007 30 0.030
Mouse
cellular macromolecule metabolic process GO:0044260 391 0.030
morphogenesis of an epithelium GO:0002009 333 0.030
hematopoietic progenitor cell differentiation GO:0002244 23 0.030
regulation of purine nucleotide catabolic process GO:0033121 2 0.030
striated muscle tissue development GO:0014706 110 0.029
Mouse
establishment of localization GO:0051234 244 0.029
proteasomal protein catabolic process GO:0010498 2 0.029
cardiac muscle contraction GO:0060048 6 0.029
rna localization GO:0006403 4 0.029
regulation of protein polymerization GO:0032271 2 0.029
regulation of intracellular signal transduction GO:1902531 57 0.029
generation of neurons GO:0048699 385 0.029
chordate embryonic development GO:0043009 271 0.029
nuclear import GO:0051170 3 0.028
response to stress GO:0006950 263 0.028
regulation of primary metabolic process GO:0080090 311 0.028
regulation of multicellular organism growth GO:0040014 4 0.028
cardiac chamber development GO:0003205 19 0.028
aromatic compound biosynthetic process GO:0019438 217 0.028
regulation of signal transduction GO:0009966 225 0.027
response to nutrient GO:0007584 3 0.027
negative regulation of cell growth GO:0030308 7 0.027
positive regulation of rna biosynthetic process GO:1902680 57 0.027
regulation of nucleotide catabolic process GO:0030811 2 0.027
modification dependent protein catabolic process GO:0019941 3 0.027
mesenchyme development GO:0060485 127 0.027
Zebrafish
basement membrane assembly GO:0070831 3 0.026
intracellular mrna localization GO:0008298 1 0.026
growth GO:0040007 174 0.026
cell cycle GO:0007049 93 0.026
cardiac muscle fiber development GO:0048739 3 0.026
sleep GO:0030431 1 0.026
cardiocyte differentiation GO:0035051 44 0.025
Mouse
negative regulation of rna biosynthetic process GO:1902679 45 0.025
regulation of transporter activity GO:0032409 2 0.025
regulation of nucleoside metabolic process GO:0009118 2 0.025
regulation of calcium ion transport GO:0051924 2 0.024
chemical homeostasis GO:0048878 49 0.024
catabolic process GO:0009056 32 0.024
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.024
somatic muscle development GO:0007525 4 0.024
single organism organelle organization GO:1902589 199 0.024
Mouse
voluntary skeletal muscle contraction GO:0003010 4 0.024
positive regulation of macromolecule metabolic process GO:0010604 93 0.024
regulation of developmental process GO:0050793 247 0.024
phosphorus metabolic process GO:0006793 109 0.023
regulation of synapse assembly GO:0051963 3 0.023
response to organic cyclic compound GO:0014070 51 0.023
cell morphogenesis involved in differentiation GO:0000904 195 0.023
negative regulation of sequestering of calcium ion GO:0051283 4 0.023
cellular amino acid metabolic process GO:0006520 7 0.023
regulation of anatomical structure morphogenesis GO:0022603 130 0.023
cytoskeleton dependent cytokinesis GO:0061640 3 0.023
protein polymerization GO:0051258 4 0.022
carboxylic acid metabolic process GO:0019752 22 0.022
outflow tract morphogenesis GO:0003151 1 0.022
regulation of transport GO:0051049 45 0.022
growth plate cartilage development GO:0003417 2 0.022
cell substrate adhesion GO:0031589 4 0.021
lipid homeostasis GO:0055088 3 0.021
positive regulation of nucleic acid templated transcription GO:1903508 57 0.021
regulation of sarcomere organization GO:0060297 2 0.021
protein complex assembly GO:0006461 30 0.021
chemosensory behavior GO:0007635 1 0.021
regulation of protein targeting GO:1903533 2 0.020
response to drug GO:0042493 3 0.020
cardiac ventricle development GO:0003231 9 0.020
regulation of transmembrane transporter activity GO:0022898 2 0.020
cellular amino acid biosynthetic process GO:0008652 2 0.020
organic substance catabolic process GO:1901575 28 0.020
response to organic substance GO:0010033 153 0.019
cell projection assembly GO:0030031 64 0.019
cell part morphogenesis GO:0032990 246 0.019
negative regulation of macromolecule metabolic process GO:0010605 76 0.019
atp catabolic process GO:0006200 4 0.019
protein stabilization GO:0050821 2 0.019
muscle cell migration GO:0014812 4 0.019
digestive system development GO:0055123 289 0.019
maternal determination of anterior posterior axis embryo GO:0008358 4 0.019
regulation of molecular function GO:0065009 70 0.018
regulation of blood vessel size GO:0050880 2 0.018
multicellular organismal movement GO:0050879 8 0.018
olfactory bulb axon guidance GO:0071678 3 0.018
regulation of protein complex assembly GO:0043254 3 0.018
actin filament based movement GO:0030048 1 0.018
Mouse
regulation of cell development GO:0060284 100 0.018
regulation of nucleocytoplasmic transport GO:0046822 2 0.018
anterior commissure morphogenesis GO:0021960 3 0.018
regulation of cytoplasmic transport GO:1903649 4 0.018
regulation of rna metabolic process GO:0051252 224 0.017
positive regulation of rna metabolic process GO:0051254 59 0.017
circadian sleep wake cycle process GO:0022410 2 0.017
regulation of striated muscle contraction GO:0006942 2 0.017
enzyme linked receptor protein signaling pathway GO:0007167 106 0.017
circulatory system process GO:0003013 87 0.017
cellular component movement GO:0006928 335 0.017
Mouse
alternative mrna splicing via spliceosome GO:0000380 1 0.017
regulation of cellular amine metabolic process GO:0033238 0 0.017
regulation of establishment of protein localization GO:0070201 4 0.017
negative regulation of gene expression GO:0010629 65 0.017
protein import GO:0017038 3 0.017
small molecule metabolic process GO:0044281 77 0.017
embryonic organ development GO:0048568 381 0.017
Zebrafish
pole plasm assembly GO:0007315 4 0.016
response to alkaloid GO:0043279 2 0.016
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.016
negative regulation of metabolic process GO:0009892 86 0.016
ventricular cardiac muscle tissue development GO:0003229 3 0.016
tissue regeneration GO:0042246 74 0.016
endocardial cushion formation GO:0003272 2 0.016
Zebrafish
heterocycle biosynthetic process GO:0018130 215 0.016
myoblast fusion GO:0007520 10 0.016
regulation of reproductive process GO:2000241 4 0.016
response to wounding GO:0009611 116 0.016
organonitrogen compound metabolic process GO:1901564 74 0.016
regulation of protein import into nucleus GO:0042306 2 0.015
multicellular organismal reproductive process GO:0048609 35 0.015
positive regulation of cytoskeleton organization GO:0051495 3 0.015
regulation of intracellular protein transport GO:0033157 3 0.015
regulation of cell motility GO:2000145 46 0.015
purine nucleoside monophosphate catabolic process GO:0009128 4 0.015
ubiquitin dependent protein catabolic process GO:0006511 3 0.015
establishment of protein localization to organelle GO:0072594 4 0.014
lipid localization GO:0010876 11 0.014
cellular response to external stimulus GO:0071496 2 0.014
negative regulation of cellular metabolic process GO:0031324 77 0.014
multicellular organism growth GO:0035264 4 0.014
behavior GO:0007610 74 0.014
somite development GO:0061053 96 0.014
single organism localization GO:1902578 225 0.014
amine metabolic process GO:0009308 2 0.014
protein localization to plasma membrane GO:0072659 1 0.014
microtubule organizing center organization GO:0031023 1 0.014
somitogenesis GO:0001756 87 0.014
positive regulation of wound healing GO:0090303 1 0.014
regulation of cardiac muscle contraction GO:0055117 2 0.013
regulation of multicellular organismal development GO:2000026 223 0.013
dendrite guidance GO:0070983 0 0.013
cellular amine metabolic process GO:0044106 2 0.013
macromolecular complex subunit organization GO:0043933 74 0.013
Mouse
fertilization GO:0009566 3 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
cardiac chamber morphogenesis GO:0003206 12 0.013
anterior posterior pattern specification GO:0009952 152 0.013
regulation of protein transport GO:0051223 3 0.013
cell growth GO:0016049 57 0.013
regulation of cell cycle GO:0051726 52 0.013
regulation of cell projection organization GO:0031344 44 0.013
oocyte anterior posterior axis specification GO:0007314 4 0.013
response to alcohol GO:0097305 14 0.013
negative regulation of nucleic acid templated transcription GO:1903507 45 0.013
cellular protein catabolic process GO:0044257 4 0.013
cytoplasm organization GO:0007028 4 0.013
antimicrobial humoral response GO:0019730 2 0.013
regulation of binding GO:0051098 3 0.013
negative regulation of epithelial cell proliferation GO:0050680 1 0.013
regulation of tube size GO:0035150 2 0.013
organic acid metabolic process GO:0006082 31 0.013
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.013
positive regulation of cellular catabolic process GO:0031331 3 0.013
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.013
cellular response to estradiol stimulus GO:0071392 1 0.013
development of primary female sexual characteristics GO:0046545 4 0.013
cell cycle arrest GO:0007050 1 0.012
notochord development GO:0030903 54 0.012
negative regulation of kinase activity GO:0033673 4 0.012
regulation of protein complex disassembly GO:0043244 1 0.012
collagen biosynthetic process GO:0032964 2 0.012
negative regulation of protein kinase activity GO:0006469 4 0.012
convergent extension involved in gastrulation GO:0060027 71 0.012
positive regulation of gene expression GO:0010628 71 0.012
axon development GO:0061564 166 0.012
nitric oxide mediated signal transduction GO:0007263 2 0.012
circadian sleep wake cycle GO:0042745 2 0.012
glial cell migration GO:0008347 3 0.012
defense response GO:0006952 47 0.012
negative regulation of cytokine production GO:0001818 1 0.012
regulation of protein binding GO:0043393 3 0.012
regulation of ion transport GO:0043269 22 0.012
positive regulation of cellular metabolic process GO:0031325 94 0.012
regulation of protein kinase b signaling GO:0051896 8 0.012
stem cell differentiation GO:0048863 117 0.012
single organism nuclear import GO:1902593 3 0.012
protein complex disassembly GO:0043241 1 0.012
extrinsic apoptotic signaling pathway GO:0097191 3 0.011
regulation of bmp signaling pathway GO:0030510 39 0.011
urogenital system development GO:0001655 97 0.011
protein targeting to nucleus GO:0044744 3 0.011
regulation of cell activation GO:0050865 1 0.011
intracellular estrogen receptor signaling pathway GO:0030520 3 0.011
cellular divalent inorganic cation homeostasis GO:0072503 13 0.011
sequestering of calcium ion GO:0051208 3 0.011
spermatid development GO:0007286 2 0.011
calcium mediated signaling GO:0019722 2 0.011
regulation of signaling GO:0023051 235 0.011
brain development GO:0007420 293 0.011
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.011
endochondral bone growth GO:0003416 2 0.011
single organism transport GO:0044765 206 0.011
cardiac ventricle morphogenesis GO:0003208 7 0.011
female sex differentiation GO:0046660 4 0.010
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.010
cellular component disassembly GO:0022411 1 0.010
cell matrix adhesion GO:0007160 4 0.010
macromolecular complex disassembly GO:0032984 1 0.010
regulation of cellular ketone metabolic process GO:0010565 7 0.010
ras protein signal transduction GO:0007265 7 0.010
cellular calcium ion homeostasis GO:0006874 13 0.010
embryo development ending in birth or egg hatching GO:0009792 271 0.010
single organism reproductive process GO:0044702 40 0.010
response to ketone GO:1901654 1 0.010
actin polymerization or depolymerization GO:0008154 2 0.010
negative regulation of developmental process GO:0051093 65 0.010
negative regulation of jnk cascade GO:0046329 1 0.010
cellular catabolic process GO:0044248 27 0.010
regulation of p38mapk cascade GO:1900744 1 0.010
astrocyte differentiation GO:0048708 1 0.010
macromolecule localization GO:0033036 54 0.010

acta1a disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.315
musculoskeletal system disease DOID:17 0 0.112
hypertrophic cardiomyopathy DOID:11984 0 0.105
myopathy DOID:423 0 0.105
muscular disease DOID:0080000 0 0.105
heart disease DOID:114 0 0.105
cardiomyopathy DOID:0050700 0 0.105
intrinsic cardiomyopathy DOID:0060036 0 0.105
cardiovascular system disease DOID:1287 0 0.105
muscle tissue disease DOID:66 0 0.105
nervous system disease DOID:863 0 0.030
connective tissue disease DOID:65 0 0.010