Danio rerio

46 known processes

mapk3

mitogen-activated protein kinase 3

(Aliases: ERK1,zERK1,fi06b09,wu:fi06b09)

mapk3 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
brain development GO:0007420 293 0.875
digestive tract development GO:0048565 265 0.856
Zebrafish
head development GO:0060322 303 0.822
ameboidal type cell migration GO:0001667 143 0.771
central nervous system development GO:0007417 387 0.752
cell part morphogenesis GO:0032990 246 0.731
negative regulation of mitotic cell cycle GO:0045930 11 0.729
Worm
establishment of protein localization to organelle GO:0072594 4 0.672
Rat
larval development GO:0002164 2 0.659
Worm
nuclear transport GO:0051169 4 0.649
Yeast Rat
nucleocytoplasmic transport GO:0006913 4 0.646
Yeast Rat
protein localization to nucleus GO:0034504 3 0.623
Rat
regulation of macromolecule metabolic process GO:0060255 317 0.618
Human Yeast Mouse Rat
neuron development GO:0048666 262 0.587
single organism organelle organization GO:1902589 199 0.579
Human Fly
regionalization GO:0003002 274 0.579
Fly
regulation of cell cycle GO:0051726 52 0.575
Yeast Worm
regulation of metabolic process GO:0019222 359 0.573
Human Yeast Mouse Rat Fly
cellular nitrogen compound metabolic process GO:0034641 290 0.551
Human Yeast Mouse Rat
axonogenesis GO:0007409 152 0.544
signal transduction GO:0007165 455 0.543
Human Yeast Mouse Rat Worm Fly
axon development GO:0061564 166 0.540
regulation of response to nutrient levels GO:0032107 1 0.538
Fly
negative regulation of response to stimulus GO:0048585 104 0.534
Yeast Fly
cellular response to nutrient levels GO:0031669 2 0.532
Fly
protein import GO:0017038 3 0.532
Rat
regulation of developmental process GO:0050793 247 0.529
Worm Fly
regulation of signaling GO:0023051 235 0.523
Human Yeast Fly
central nervous system neuron axonogenesis GO:0021955 18 0.503
regulation of wound healing GO:0061041 2 0.501
Fly
cell projection morphogenesis GO:0048858 244 0.489
cell morphogenesis involved in differentiation GO:0000904 195 0.476
regulation of establishment of protein localization GO:0070201 4 0.469
Yeast
stem cell maintenance GO:0019827 4 0.452
regulation of photoreceptor cell differentiation GO:0046532 2 0.450
Fly
positive regulation of biological process GO:0048518 253 0.430
Human Yeast Rat Worm Fly
negative regulation of biological process GO:0048519 304 0.429
Yeast Worm Fly
organelle organization GO:0006996 227 0.428
Human Fly
chordate embryonic development GO:0043009 271 0.427
positive regulation of cellular process GO:0048522 201 0.425
Human Rat Worm Fly
digestive system development GO:0055123 289 0.424
Zebrafish
cell projection organization GO:0030030 284 0.420
aging GO:0007568 2 0.417
Worm
cellular macromolecule metabolic process GO:0044260 391 0.411
Human Yeast Mouse Rat Worm Fly
peptidyl serine phosphorylation GO:0018105 1 0.407
Rat Worm
neuron projection development GO:0031175 180 0.405
cell cycle GO:0007049 93 0.400
Yeast Worm Fly
cellular component biogenesis GO:0044085 178 0.397
Rat
cellular protein metabolic process GO:0044267 129 0.397
Human Yeast Mouse Rat Worm Fly
cell migration involved in gastrulation GO:0042074 79 0.391
locomotion GO:0040011 313 0.389
cellular response to extracellular stimulus GO:0031668 2 0.384
Fly
negative regulation of signal transduction GO:0009968 94 0.383
Yeast
single organism nuclear import GO:1902593 3 0.374
Rat
cellular response to external stimulus GO:0071496 2 0.372
Human Fly
stem cell proliferation GO:0072089 4 0.370
central nervous system neuron development GO:0021954 29 0.369
regulation of protein localization to nucleus GO:1900180 2 0.359
sensory organ development GO:0007423 393 0.353
negative regulation of cellular process GO:0048523 283 0.350
Yeast Worm Fly
embryonic heart tube development GO:0035050 133 0.349
single organism localization GO:1902578 225 0.332
Yeast Rat
response to organic substance GO:0010033 153 0.327
Human Yeast Mouse Fly
generation of neurons GO:0048699 385 0.325
neuron differentiation GO:0030182 353 0.324
negative regulation of signaling GO:0023057 96 0.324
Yeast
positive regulation of translation GO:0045727 1 0.317
Rat
cell migration GO:0016477 237 0.317
organonitrogen compound metabolic process GO:1901564 74 0.313
response to lipid GO:0033993 60 0.308
Mouse
heart morphogenesis GO:0003007 156 0.303
cellular macromolecule biosynthetic process GO:0034645 224 0.302
Human Yeast Mouse Rat
regulation of protein transport GO:0051223 3 0.300
Yeast
gastrulation GO:0007369 208 0.300
Zebrafish
positive regulation of transport GO:0051050 2 0.288
Yeast
protein targeting to nucleus GO:0044744 3 0.285
Rat
localization of cell GO:0051674 244 0.284
regulation of cellular metabolic process GO:0031323 320 0.281
Human Yeast Mouse Rat Fly
enzyme linked receptor protein signaling pathway GO:0007167 106 0.272
Human Fly
positive regulation of epithelial cell proliferation GO:0050679 1 0.270
regulation of gene expression GO:0010468 265 0.266
Human Yeast Mouse Rat
regulation of epithelial cell proliferation GO:0050678 3 0.266
glucose homeostasis GO:0042593 1 0.262
cellular amino acid metabolic process GO:0006520 7 0.260
cellular response to lipopolysaccharide GO:0071222 3 0.259
Mouse
mitotic nuclear division GO:0007067 18 0.259
Fly
negative regulation of cellular catabolic process GO:0031330 3 0.258
Fly
peptidyl threonine phosphorylation GO:0018107 1 0.251
regulation of dna replication GO:0006275 3 0.250
amine metabolic process GO:0009308 2 0.250
regulation of neurogenesis GO:0050767 87 0.249
Fly
cell motility GO:0048870 244 0.248
cellular amine metabolic process GO:0044106 2 0.248
cognition GO:0050890 1 0.247
regulation of multicellular organismal development GO:2000026 223 0.246
Worm Fly
response to external stimulus GO:0009605 264 0.244
Human Mouse Fly
negative regulation of phosphate metabolic process GO:0045936 13 0.242
Yeast
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.241
Fly
organelle localization GO:0051640 49 0.237
regulation of signal transduction GO:0009966 225 0.227
Human Yeast Fly
response to stress GO:0006950 263 0.227
Human Mouse Worm Fly
negative regulation of autophagy GO:0010507 1 0.226
Fly
protein modification process GO:0036211 100 0.226
Human Yeast Mouse Rat Worm Fly
nuclear export GO:0051168 1 0.225
Yeast
nuclear import GO:0051170 3 0.222
Rat
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.222
Human Yeast Mouse Rat
cellular component movement GO:0006928 335 0.221
transport GO:0006810 220 0.221
Yeast Rat
cell fate specification GO:0001708 68 0.217
regulation of immune system process GO:0002682 34 0.217
adherens junction organization GO:0034332 4 0.215
Fly
cellular extravasation GO:0045123 1 0.215
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.212
Human Rat
bmp signaling pathway GO:0030509 52 0.209
Human
nitric oxide metabolic process GO:0046209 2 0.209
regulation of intracellular protein transport GO:0033157 3 0.206
Yeast
cell cycle process GO:0022402 53 0.200
Yeast Worm Fly
cellular response to molecule of bacterial origin GO:0071219 3 0.198
Mouse
regulation of primary metabolic process GO:0080090 311 0.197
Human Yeast Mouse Rat
regulation of anatomical structure morphogenesis GO:0022603 130 0.197
regulation of multicellular organismal process GO:0051239 277 0.194
Worm Fly
cellular ketone metabolic process GO:0042180 11 0.192
regulation of protein import into nucleus GO:0042306 2 0.192
regulation of synapse assembly GO:0051963 3 0.191
dorsal convergence GO:0060030 14 0.190
regulation of cellular amino acid metabolic process GO:0006521 0 0.188
organic acid metabolic process GO:0006082 31 0.187
Rat
regulation of cytoplasmic transport GO:1903649 4 0.186
Yeast
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.186
tube morphogenesis GO:0035239 349 0.185
Zebrafish
regulation of cell communication GO:0010646 232 0.184
Human Yeast Fly
organic cyclic compound biosynthetic process GO:1901362 223 0.184
Human Yeast Mouse Rat
negative regulation of protein localization to nucleus GO:1900181 2 0.183
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.182
cellular respiration GO:0045333 3 0.181
phosphorus metabolic process GO:0006793 109 0.181
Human Yeast Mouse Rat Worm Fly
central nervous system neuron differentiation GO:0021953 74 0.181
regulation of protein catabolic process GO:0042176 1 0.180
single organism metabolic process GO:0044710 217 0.179
Human Yeast Mouse Rat Worm Fly
synaptic growth at neuromuscular junction GO:0051124 2 0.177
response to oxidative stress GO:0006979 11 0.176
Fly
oxoacid metabolic process GO:0043436 31 0.176
Rat
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.175
Yeast
regulation of apoptotic process GO:0042981 98 0.175
reciprocal dna recombination GO:0035825 1 0.174
regulation of cellular amine metabolic process GO:0033238 0 0.172
positive regulation of secretion by cell GO:1903532 1 0.172
neuron projection morphogenesis GO:0048812 161 0.170
autophagy GO:0006914 4 0.169
Fly
nucleobase containing compound metabolic process GO:0006139 274 0.166
Human Yeast Mouse Rat
meiotic nuclear division GO:0007126 4 0.165
response to bacterium GO:0009617 58 0.165
Mouse
negative regulation of catabolic process GO:0009895 3 0.165
Fly
phosphate containing compound metabolic process GO:0006796 108 0.162
Human Yeast Mouse Rat Worm Fly
regulation of response to stimulus GO:0048583 269 0.161
Human Yeast Fly
rna biosynthetic process GO:0032774 181 0.160
Human Yeast Mouse Rat
cytoskeleton organization GO:0007010 96 0.160
convergent extension involved in gastrulation GO:0060027 71 0.159
locomotor rhythm GO:0045475 3 0.157
response to drug GO:0042493 3 0.155
Fly
hexose transport GO:0008645 6 0.155
protein import into nucleus GO:0006606 3 0.149
Rat
negative regulation of protein kinase activity GO:0006469 4 0.148
protein metabolic process GO:0019538 183 0.148
Human Yeast Mouse Rat Worm Fly
cellular response to starvation GO:0009267 1 0.147
Fly
regulation of response to cytokine stimulus GO:0060759 3 0.146
response to fluid shear stress GO:0034405 2 0.146
defense response GO:0006952 47 0.146
regulation of nucleocytoplasmic transport GO:0046822 2 0.144
Yeast
biosynthetic process GO:0009058 294 0.144
Human Yeast Mouse Rat
regulation of response to oxidative stress GO:1902882 2 0.144
macromolecule biosynthetic process GO:0009059 227 0.143
Human Yeast Mouse Rat
multicellular organism growth GO:0035264 4 0.143
positive regulation of striated muscle tissue development GO:0045844 1 0.143
positive regulation of muscle cell differentiation GO:0051149 1 0.141
negative regulation of map kinase activity GO:0043407 2 0.140
midbrain development GO:0030901 28 0.139
macromolecular complex subunit organization GO:0043933 74 0.139
Human Rat
cellular aromatic compound metabolic process GO:0006725 295 0.138
Human Yeast Mouse Rat
organic cyclic compound metabolic process GO:1901360 301 0.137
Human Yeast Mouse Rat
cell morphogenesis GO:0000902 289 0.137
positive regulation of cellular amine metabolic process GO:0033240 0 0.136
regulation of synapse organization GO:0050807 3 0.136
organic substance biosynthetic process GO:1901576 289 0.136
Human Yeast Mouse Rat
small molecule metabolic process GO:0044281 77 0.136
Rat
regulation of neuron differentiation GO:0045664 56 0.136
Fly
response to chemical GO:0042221 320 0.135
Human Yeast Mouse Rat Fly
heart development GO:0007507 313 0.135
negative regulation of cellular metabolic process GO:0031324 77 0.134
Yeast Fly
intracellular transport GO:0046907 32 0.134
Yeast Rat
digestive tract morphogenesis GO:0048546 231 0.133
Zebrafish
developmental maturation GO:0021700 34 0.133
Worm
regulation of cellular ketone metabolic process GO:0010565 7 0.133
cellular response to organic substance GO:0071310 105 0.133
Human Yeast Mouse
adherens junction maintenance GO:0034334 2 0.132
Fly
regulation of synaptic plasticity GO:0048167 1 0.132
protein complex assembly GO:0006461 30 0.131
Rat
intracellular signal transduction GO:0035556 85 0.131
Human Yeast Mouse Rat Worm Fly
cell fate commitment GO:0045165 99 0.131
cellular response to biotic stimulus GO:0071216 3 0.130
Mouse
cellular response to growth factor stimulus GO:0071363 39 0.127
regulation of meiotic cell cycle GO:0051445 1 0.125
Worm
germ line stem cell division GO:0042078 1 0.125
positive regulation of response to stimulus GO:0048584 80 0.124
Human Fly
mesodermal cell migration GO:0008078 12 0.123
embryonic heart tube morphogenesis GO:0003143 108 0.123
positive regulation of macromolecule metabolic process GO:0010604 93 0.123
Human Rat
regulation of cellular protein metabolic process GO:0032268 52 0.123
Human Rat
negative regulation of cell differentiation GO:0045596 46 0.122
regulation of autophagy GO:0010506 3 0.122
Fly
regulation of protein targeting GO:1903533 2 0.120
response to exogenous dsrna GO:0043330 6 0.120
Mouse
negative regulation of protein phosphorylation GO:0001933 4 0.119
regulation of cellular response to oxidative stress GO:1900407 2 0.119
nuclear division GO:0000280 23 0.119
Fly
heart looping GO:0001947 94 0.118
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.118
Human Yeast Mouse Rat
regulation of cell differentiation GO:0045595 142 0.117
Fly
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.116
central nervous system projection neuron axonogenesis GO:0021952 15 0.116
positive regulation of muscle organ development GO:0048636 1 0.115
immune system process GO:0002376 241 0.115
embryonic organ morphogenesis GO:0048562 274 0.114
pathway restricted smad protein phosphorylation GO:0060389 1 0.114
regulation of response to stress GO:0080134 36 0.113
Fly
spindle assembly GO:0051225 2 0.112
negative regulation of cell communication GO:0010648 96 0.112
Yeast Fly
response to dsrna GO:0043331 7 0.111
Mouse
regulation of macromolecule biosynthetic process GO:0010556 225 0.111
Human Yeast Mouse Rat
regulation of bmp signaling pathway GO:0030510 39 0.111
negative regulation of mapk cascade GO:0043409 4 0.111
Yeast
carbohydrate homeostasis GO:0033500 1 0.111
cellular response to dna damage stimulus GO:0006974 24 0.110
Human Mouse Fly
cellular localization GO:0051641 97 0.109
Yeast Rat
positive regulation of wound healing GO:0090303 1 0.108
Fly
rna metabolic process GO:0016070 219 0.107
Human Yeast Mouse Rat
dna metabolic process GO:0006259 27 0.107
regulation of response to extracellular stimulus GO:0032104 1 0.107
Fly
positive regulation of signal transduction GO:0009967 56 0.106
Human Fly
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.106
regulation of localization GO:0032879 104 0.105
Yeast
regulation of calcium dependent cell cell adhesion GO:0046586 1 0.104
protein phosphorylation GO:0006468 47 0.104
Human Yeast Mouse Rat Worm Fly
regulation of nucleic acid templated transcription GO:1903506 213 0.103
Human Yeast Mouse Rat
positive regulation of cell cycle GO:0045787 3 0.103
Worm
regulation of oocyte development GO:0060281 3 0.102
forebrain development GO:0030900 96 0.101
cellular component assembly GO:0022607 170 0.101
Rat
aromatic compound biosynthetic process GO:0019438 217 0.100
Human Yeast Mouse Rat
response to metal ion GO:0010038 34 0.100
Fly
positive regulation of cellular metabolic process GO:0031325 94 0.098
Human Rat Fly
muscle tissue development GO:0060537 110 0.098
response to lipopolysaccharide GO:0032496 13 0.098
Mouse
establishment of mitotic spindle orientation GO:0000132 10 0.098
cell death GO:0008219 121 0.098
Worm
extrinsic apoptotic signaling pathway GO:0097191 3 0.097
regulation of cell morphogenesis GO:0022604 42 0.097
cell junction maintenance GO:0034331 2 0.096
Fly
regulation of multicellular organism growth GO:0040014 4 0.095
negative regulation of protein import into nucleus GO:0042308 2 0.093
response to growth factor GO:0070848 39 0.093
Human
lipid metabolic process GO:0006629 52 0.093
Rat
regulation of cell migration GO:0030334 40 0.092
wound healing GO:0042060 90 0.092
Fly
cell cycle g1 s phase transition GO:0044843 1 0.092
maintenance of location GO:0051235 4 0.092
gene expression GO:0010467 252 0.091
Human Yeast Mouse Rat
nitrogen compound metabolic process GO:0006807 319 0.091
Human Yeast Mouse Rat
taxis GO:0042330 109 0.091
protein localization GO:0008104 40 0.091
Yeast Rat
pronuclear migration GO:0035046 1 0.090
cellular component maintenance GO:0043954 3 0.090
Fly
germ line stem cell maintenance GO:0030718 2 0.090
mitotic cell cycle process GO:1903047 48 0.089
Fly
biological adhesion GO:0022610 40 0.089
negative regulation of kinase activity GO:0033673 4 0.089
regulation of reactive oxygen species metabolic process GO:2000377 2 0.089
cellular response to chemical stimulus GO:0070887 157 0.088
Human Yeast Mouse Fly
reactive oxygen species biosynthetic process GO:1903409 1 0.087
chemotaxis GO:0006935 104 0.087
regulation of anatomical structure size GO:0090066 33 0.087
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.086
positive regulation of cellular component movement GO:0051272 11 0.086
regulation of dna templated transcription in response to stress GO:0043620 0 0.086
apoptotic process GO:0006915 116 0.085
Worm
positive regulation of cellular component biogenesis GO:0044089 3 0.084
positive regulation of secretion GO:0051047 1 0.084
phosphorylation GO:0016310 69 0.084
Human Yeast Mouse Rat Worm Fly
cell cell signaling involved in cell fate commitment GO:0045168 12 0.083
response to arsenic containing substance GO:0046685 5 0.083
Fly
regulation of blood circulation GO:1903522 32 0.083
actin filament based process GO:0030029 64 0.082
positive regulation of response to wounding GO:1903036 5 0.082
Fly
single organism cellular localization GO:1902580 46 0.082
Rat
regulation of neurological system process GO:0031644 2 0.082
regulation of protein binding GO:0043393 3 0.081
Mouse
regulation of protein metabolic process GO:0051246 56 0.081
Human Rat
ear development GO:0043583 127 0.080
cellular response to oxidative stress GO:0034599 5 0.080
Fly
regulation of transport GO:0051049 45 0.080
Yeast
negative regulation of multicellular organismal process GO:0051241 69 0.079
Worm
single organism intracellular transport GO:1902582 25 0.079
Yeast Rat
regulation of cellular biosynthetic process GO:0031326 245 0.078
Human Yeast Mouse Rat
epithelial tube morphogenesis GO:0060562 148 0.078
nucleobase containing compound biosynthetic process GO:0034654 205 0.078
Human Yeast Mouse Rat
myeloid cell differentiation GO:0030099 86 0.078
small gtpase mediated signal transduction GO:0007264 8 0.078
Worm Fly
protein demethylation GO:0006482 2 0.078
nucleic acid metabolic process GO:0090304 244 0.077
Human Yeast Mouse Rat
growth GO:0040007 174 0.077
Yeast
specification of symmetry GO:0009799 204 0.076
hematopoietic or lymphoid organ development GO:0048534 191 0.076
cellular lipid metabolic process GO:0044255 36 0.075
Rat
positive regulation of cell adhesion GO:0045785 1 0.075
nucleic acid templated transcription GO:0097659 181 0.075
Human Yeast Mouse Rat
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.075
meiotic cell cycle process GO:1903046 3 0.075
glucose import GO:0046323 2 0.074
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.073
Human Fly
positive regulation of cell communication GO:0010647 56 0.073
Human Fly
cellular carbohydrate metabolic process GO:0044262 4 0.073
somatic muscle development GO:0007525 4 0.073
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.073
cell aging GO:0007569 2 0.073
anterior posterior pattern specification GO:0009952 152 0.073
regulation of phosphorus metabolic process GO:0051174 43 0.073
Human Yeast Fly
cellular response to stress GO:0033554 62 0.072
Human Mouse Fly
regulation of binding GO:0051098 3 0.072
Mouse
neuron projection extension GO:1990138 45 0.072
response to cadmium ion GO:0046686 14 0.072
Fly
determination of dorsal ventral asymmetry GO:0048262 34 0.072
response to external biotic stimulus GO:0043207 97 0.072
Mouse
organelle assembly GO:0070925 110 0.072
cellular component disassembly GO:0022411 1 0.071
pyrimidine containing compound metabolic process GO:0072527 3 0.071
regulation of cardiac muscle cell differentiation GO:2000725 1 0.071
regulation of mitotic cell cycle phase transition GO:1901990 8 0.071
regulation of developmental growth GO:0048638 38 0.070
positive regulation of muscle tissue development GO:1901863 1 0.070
negative regulation of developmental process GO:0051093 65 0.070
Worm
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.070
regulation of protein ubiquitination GO:0031396 3 0.070
establishment of localization in cell GO:0051649 77 0.070
Yeast Rat
nuclear migration GO:0007097 3 0.069
axis specification GO:0009798 43 0.069
regulation of axon extension GO:0030516 24 0.069
positive regulation of ras protein signal transduction GO:0046579 1 0.069
Fly
positive regulation of axon extension GO:0045773 5 0.068
response to starvation GO:0042594 5 0.068
Fly
regulation of rna metabolic process GO:0051252 224 0.068
Human Yeast Mouse Rat
organelle fission GO:0048285 23 0.067
Fly
cell adhesion GO:0007155 40 0.066
positive regulation of striated muscle cell differentiation GO:0051155 1 0.066
regulation of biological quality GO:0065008 263 0.065
cell proliferation GO:0008283 80 0.065
Fly
protein complex biogenesis GO:0070271 30 0.064
Rat
transcription dna templated GO:0006351 181 0.064
Human Yeast Mouse Rat
response to endogenous stimulus GO:0009719 83 0.064
Human
stem cell division GO:0017145 1 0.064
ras protein signal transduction GO:0007265 7 0.064
Worm Fly
response to reactive oxygen species GO:0000302 5 0.063
Fly
neuroblast proliferation GO:0007405 2 0.063
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.063
regulation of cell cycle process GO:0010564 20 0.063
negative regulation of cell cycle process GO:0010948 9 0.063
carboxylic acid metabolic process GO:0019752 22 0.062
Rat
peptidyl threonine modification GO:0018210 1 0.062
determination of bilateral symmetry GO:0009855 204 0.062
positive regulation of apoptotic signaling pathway GO:2001235 1 0.062
establishment of organelle localization GO:0051656 45 0.061
oocyte maturation GO:0001556 4 0.061
Worm
regulation of extent of cell growth GO:0061387 29 0.060
response to superoxide GO:0000303 2 0.060
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.060
regulation of organ growth GO:0046620 3 0.060
negative regulation of cell cycle GO:0045786 14 0.060
Yeast Worm
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.060
regulation of axonogenesis GO:0050770 32 0.060
regulation of cell motility GO:2000145 46 0.059
jnk cascade GO:0007254 7 0.059
Fly
actin polymerization or depolymerization GO:0008154 2 0.059
regulation of cell development GO:0060284 100 0.059
Fly
wnt signaling pathway GO:0016055 80 0.059
negative regulation of extrinsic apoptotic signaling pathway GO:2001237 2 0.059
synaptic vesicle localization GO:0097479 1 0.058
negative regulation of intracellular protein transport GO:0090317 3 0.058
microtubule based process GO:0007017 60 0.057
development of primary female sexual characteristics GO:0046545 4 0.057
peptidyl serine modification GO:0018209 2 0.057
Rat Worm
synapse assembly GO:0007416 9 0.057
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.056
Human
regulation of mitotic cell cycle GO:0007346 25 0.056
Worm
positive regulation of multicellular organismal process GO:0051240 52 0.056
Fly
developmental growth GO:0048589 166 0.056
regulation of cell adhesion GO:0030155 15 0.055
heterocycle metabolic process GO:0046483 290 0.055
Human Yeast Mouse Rat
establishment of spindle localization GO:0051293 12 0.055
positive regulation of cell proliferation GO:0008284 15 0.055
Fly
protein polymerization GO:0051258 4 0.055
positive regulation of signaling GO:0023056 56 0.055
Human Fly
positive regulation of oocyte development GO:0060282 1 0.055
regulation of cellular extravasation GO:0002691 1 0.055
cellular nitrogen compound biosynthetic process GO:0044271 218 0.054
Human Yeast Mouse Rat
negative regulation of macromolecule metabolic process GO:0010605 76 0.054
apoptotic signaling pathway GO:0097190 23 0.054
cell surface receptor signaling pathway GO:0007166 325 0.054
Human Yeast Mouse Fly
system process GO:0003008 185 0.054
Mouse
pigment granule localization GO:0051875 25 0.054
positive regulation of metabolic process GO:0009893 108 0.053
Human Rat Fly
regulation of organ morphogenesis GO:2000027 35 0.053
limbic system development GO:0021761 16 0.052
regulation of dna metabolic process GO:0051052 11 0.052
cell division GO:0051301 20 0.052
negative regulation of cellular biosynthetic process GO:0031327 55 0.051
cellular protein catabolic process GO:0044257 4 0.051
regulation of cellular localization GO:0060341 12 0.051
Yeast
regulation of reproductive process GO:2000241 4 0.051
negative regulation of apoptotic process GO:0043066 55 0.051
positive regulation of cell development GO:0010720 25 0.051
Fly
synaptic transmission GO:0007268 35 0.051
Fly
somatic stem cell maintenance GO:0035019 1 0.051
cellular biosynthetic process GO:0044249 286 0.050
Human Yeast Mouse Rat
synapsis GO:0007129 1 0.050
photoreceptor cell differentiation GO:0046530 55 0.050
Fly
negative regulation of dna replication GO:0008156 2 0.050
cell surface receptor signaling pathway involved in heart development GO:0061311 20 0.050
intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 2 0.049
cell death in response to oxidative stress GO:0036473 2 0.049
immune system development GO:0002520 191 0.049
actin cytoskeleton organization GO:0030036 63 0.049
myeloid cell development GO:0061515 32 0.048
reactive nitrogen species metabolic process GO:2001057 0 0.048
negative regulation of biosynthetic process GO:0009890 55 0.048
glial cell migration GO:0008347 3 0.048
lateral inhibition GO:0046331 1 0.048
convergent extension GO:0060026 118 0.048
immune response GO:0006955 28 0.048
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.047
Human Rat
signal transduction in absence of ligand GO:0038034 1 0.047
negative regulation of cell cycle phase transition GO:1901988 5 0.047
signal transduction by phosphorylation GO:0023014 18 0.047
Human Yeast Mouse Rat Worm Fly
actin filament polymerization GO:0030041 2 0.047
modification dependent macromolecule catabolic process GO:0043632 3 0.047
blood vessel development GO:0001568 246 0.047
regulation of intracellular signal transduction GO:1902531 57 0.046
Human Yeast Fly
extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 1 0.046
programmed cell death GO:0012501 119 0.046
Worm
morphogenesis of an epithelium GO:0002009 333 0.046
neural tube development GO:0021915 62 0.046
regulation of rna biosynthetic process GO:2001141 213 0.046
Human Yeast Mouse Rat
single organism transport GO:0044765 206 0.045
Yeast Rat
regulation of erk1 and erk2 cascade GO:0070372 4 0.045
Human Fly
negative regulation of metabolic process GO:0009892 86 0.045
Yeast Fly
stem cell differentiation GO:0048863 117 0.045
regulation of cell cycle phase transition GO:1901987 8 0.045
death GO:0016265 121 0.045
Worm
nitric oxide biosynthetic process GO:0006809 2 0.045
macromolecule modification GO:0043412 111 0.045
Human Yeast Mouse Rat Worm Fly
axon extension GO:0048675 45 0.045
cardiac muscle tissue development GO:0048738 48 0.045
regulation of chromosome segregation GO:0051983 1 0.044
positive regulation of fibroblast growth factor receptor signaling pathway GO:0045743 9 0.044
embryonic limb morphogenesis GO:0030326 2 0.044
negative regulation of intracellular signal transduction GO:1902532 22 0.044
Yeast
single organismal cell cell adhesion GO:0016337 29 0.044
negative regulation of jnk cascade GO:0046329 1 0.044
regulation of nitrogen compound metabolic process GO:0051171 251 0.044
Human Yeast Mouse Rat
cellular process involved in reproduction in multicellular organism GO:0022412 28 0.044
Worm
negative regulation of epithelial cell proliferation GO:0050680 1 0.043
regulation of transcription dna templated GO:0006355 213 0.043
Human Yeast Mouse Rat
protein dephosphorylation GO:0006470 3 0.043
positive regulation of nervous system development GO:0051962 25 0.042
Fly
specification of organ identity GO:0010092 2 0.042
regulation of protein phosphorylation GO:0001932 18 0.042
Human
heart field specification GO:0003128 1 0.042
regulation of dendrite development GO:0050773 3 0.042
tissue remodeling GO:0048771 4 0.042
negative regulation of leukocyte differentiation GO:1902106 1 0.041
positive regulation of dna metabolic process GO:0051054 1 0.041
g1 s transition of mitotic cell cycle GO:0000082 1 0.041
regulation of phosphate metabolic process GO:0019220 43 0.041
Human Yeast Fly
regulation of bmp signaling pathway involved in heart jogging GO:2000223 12 0.041
sleep GO:0030431 1 0.041
fertilization GO:0009566 3 0.041
multicellular organism reproduction GO:0032504 35 0.041
Worm
regulation of hormone secretion GO:0046883 2 0.041
negative regulation of phosphorylation GO:0042326 6 0.040
Yeast
circulatory system process GO:0003013 87 0.040
regulation of cellular component movement GO:0051270 55 0.040
positive regulation of cellular catabolic process GO:0031331 3 0.040
protein complex disassembly GO:0043241 1 0.040
defense response to fungus GO:0050832 2 0.039
negative regulation of muscle tissue development GO:1901862 2 0.039
transcription from rna polymerase ii promoter GO:0006366 80 0.039
Human
regulation of cell death GO:0010941 103 0.039
regulation of heart growth GO:0060420 2 0.039
embryonic skeletal joint development GO:0072498 3 0.039
odontogenesis of dentin containing tooth GO:0042475 1 0.039
regulation of circadian sleep wake cycle GO:0042749 1 0.038
regulation of nervous system development GO:0051960 90 0.038
Fly

mapk3 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org