Danio rerio

22 known processes

pold1

polymerase (DNA directed), delta 1, catalytic subunit

(Aliases: MGC152688,fla,zgc:152688,im:7139126)

pold1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
embryo development ending in birth or egg hatching GO:0009792 271 0.852
Worm
meiotic cell cycle process GO:1903046 3 0.775
meiotic chromosome segregation GO:0045132 3 0.580
meiosis i GO:0007127 1 0.512
biosynthetic process GO:0009058 294 0.506
locomotion GO:0040011 313 0.487
skeletal system development GO:0001501 181 0.445
cell cycle process GO:0022402 53 0.435
single organism biosynthetic process GO:0044711 71 0.382
cell cycle GO:0007049 93 0.377
cellular biosynthetic process GO:0044249 286 0.355
chordate embryonic development GO:0043009 271 0.339
camera type eye development GO:0043010 222 0.338
single organism organelle organization GO:1902589 199 0.317
larval development GO:0002164 2 0.314
Worm
retina development in camera type eye GO:0060041 146 0.313
mitotic dna integrity checkpoint GO:0044774 4 0.295
nucleic acid metabolic process GO:0090304 244 0.281
double strand break repair GO:0006302 3 0.267
meiotic nuclear division GO:0007126 4 0.262
heterocycle metabolic process GO:0046483 290 0.257
chromosome organization GO:0051276 31 0.253
cellular protein catabolic process GO:0044257 4 0.246
cellular aromatic compound metabolic process GO:0006725 295 0.241
organic substance biosynthetic process GO:1901576 289 0.237
neuron differentiation GO:0030182 353 0.233
mitotic cell cycle GO:0000278 64 0.225
cell projection organization GO:0030030 284 0.217
dna metabolic process GO:0006259 27 0.215
regulation of dna replication GO:0006275 3 0.195
double strand break repair via homologous recombination GO:0000724 1 0.185
connective tissue development GO:0061448 99 0.183
cellular macromolecule metabolic process GO:0044260 391 0.179
nitrogen compound metabolic process GO:0006807 319 0.177
macromolecule biosynthetic process GO:0009059 227 0.168
sensory organ development GO:0007423 393 0.166
nucleobase containing compound metabolic process GO:0006139 274 0.163
negative regulation of chromosome organization GO:2001251 1 0.152
embryonic organ morphogenesis GO:0048562 274 0.151
neuron development GO:0048666 262 0.147
organonitrogen compound metabolic process GO:1901564 74 0.146
retina layer formation GO:0010842 24 0.144
aromatic compound biosynthetic process GO:0019438 217 0.141
Human Yeast
negative regulation of histone methylation GO:0031061 1 0.141
regulation of protein catabolic process GO:0042176 1 0.139
eye development GO:0001654 277 0.139
organic cyclic compound biosynthetic process GO:1901362 223 0.139
Human Yeast
negative regulation of cell cycle process GO:0010948 9 0.134
negative regulation of cellular process GO:0048523 283 0.133
cellular nitrogen compound metabolic process GO:0034641 290 0.126
recombinational repair GO:0000725 1 0.119
male meiosis GO:0007140 2 0.116
sister chromatid cohesion GO:0007062 2 0.116
maintenance of location GO:0051235 4 0.109
rna biosynthetic process GO:0032774 181 0.106
regulation of transcription dna templated GO:0006355 213 0.106
response to stress GO:0006950 263 0.105
Human Mouse
apoptotic process GO:0006915 116 0.105
regulation of histone h3 k9 methylation GO:0051570 2 0.104
generation of neurons GO:0048699 385 0.104
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.102
cell projection morphogenesis GO:0048858 244 0.101
nucleobase containing compound biosynthetic process GO:0034654 205 0.093
Human Yeast
cellular response to endogenous stimulus GO:0071495 68 0.092
dna methylation on cytosine GO:0032776 3 0.092
regulation of meiotic cell cycle GO:0051445 1 0.091
embryonic cranial skeleton morphogenesis GO:0048701 90 0.090
gene expression GO:0010467 252 0.090
pyrimidine containing compound metabolic process GO:0072527 3 0.089
cellular macromolecule biosynthetic process GO:0034645 224 0.089
camera type eye morphogenesis GO:0048593 108 0.086
positive regulation of catabolic process GO:0009896 4 0.085
response to organic substance GO:0010033 153 0.085
neural retina development GO:0003407 49 0.084
organic acid metabolic process GO:0006082 31 0.081
small molecule metabolic process GO:0044281 77 0.080
digestive tract development GO:0048565 265 0.080
regulation of cellular biosynthetic process GO:0031326 245 0.079
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.079
cellular component movement GO:0006928 335 0.079
negative regulation of nuclear division GO:0051784 3 0.077
ubiquitin dependent protein catabolic process GO:0006511 3 0.073
cellular response to chemical stimulus GO:0070887 157 0.072
cell morphogenesis GO:0000902 289 0.072
regulation of nucleic acid templated transcription GO:1903506 213 0.071
cellular component morphogenesis GO:0032989 336 0.070
organelle organization GO:0006996 227 0.070
microtubule based process GO:0007017 60 0.069
mesenchymal cell differentiation GO:0048762 87 0.068
regulation of nitrogen compound metabolic process GO:0051171 251 0.067
reproductive process GO:0022414 40 0.067
regulation of macromolecule metabolic process GO:0060255 317 0.065
pharyngeal system development GO:0060037 18 0.065
cell part morphogenesis GO:0032990 246 0.065
positive regulation of histone modification GO:0031058 1 0.064
chromosome organization involved in meiosis GO:0070192 1 0.064
macromolecular complex subunit organization GO:0043933 74 0.063
reciprocal meiotic recombination GO:0007131 1 0.062
sex determination GO:0007530 1 0.059
zymogen activation GO:0031638 3 0.058
negative regulation of cellular biosynthetic process GO:0031327 55 0.058
retina morphogenesis in camera type eye GO:0060042 79 0.058
regulation of cell cycle GO:0051726 52 0.058
negative regulation of metabolic process GO:0009892 86 0.057
multicellular organism reproduction GO:0032504 35 0.057
gland development GO:0048732 143 0.056
positive regulation of chromatin modification GO:1903310 1 0.056
pancreas development GO:0031016 84 0.056
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.056
mitotic nuclear division GO:0007067 18 0.056
cellular component biogenesis GO:0044085 178 0.056
negative regulation of macromolecule metabolic process GO:0010605 76 0.056
negative regulation of biosynthetic process GO:0009890 55 0.054
negative regulation of mitotic cell cycle GO:0045930 11 0.054
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.054
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.051
negative regulation of cellular metabolic process GO:0031324 77 0.051
embryonic skeletal system morphogenesis GO:0048704 93 0.050
regulation of cellular metabolic process GO:0031323 320 0.048
neuron projection morphogenesis GO:0048812 161 0.048
multicellular organismal reproductive process GO:0048609 35 0.046
cellular response to stress GO:0033554 62 0.046
Human Mouse
modification dependent protein catabolic process GO:0019941 3 0.046
embryonic skeletal system development GO:0048706 97 0.046
homeostatic process GO:0042592 142 0.045
Human
carbohydrate derivative metabolic process GO:1901135 61 0.044
cell motility GO:0048870 244 0.044
immune system process GO:0002376 241 0.044
modification dependent macromolecule catabolic process GO:0043632 3 0.044
embryonic viscerocranium morphogenesis GO:0048703 52 0.043
regulation of chromosome segregation GO:0051983 1 0.042
peptidyl serine modification GO:0018209 2 0.042
protein complex subunit organization GO:0071822 46 0.042
negative regulation of mitotic cell cycle phase transition GO:1901991 5 0.040
mitotic cell cycle process GO:1903047 48 0.040
cellular component assembly GO:0022607 170 0.040
carboxylic acid metabolic process GO:0019752 22 0.040
dna biosynthetic process GO:0071897 3 0.040
Human Yeast
negative regulation of biological process GO:0048519 304 0.040
regulation of stem cell proliferation GO:0072091 2 0.039
negative regulation of cell division GO:0051782 4 0.039
tube morphogenesis GO:0035239 349 0.038
cell migration GO:0016477 237 0.038
single organism metabolic process GO:0044710 217 0.037
Human Mouse
transcription from rna polymerase ii promoter GO:0006366 80 0.037
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.037
regulation of endopeptidase activity GO:0052548 23 0.036
cell fate commitment GO:0045165 99 0.036
protein metabolic process GO:0019538 183 0.035
ribonucleoside monophosphate catabolic process GO:0009158 4 0.035
nucleic acid phosphodiester bond hydrolysis GO:0090305 6 0.035
Yeast Mouse
covalent chromatin modification GO:0016569 20 0.034
cellular catabolic process GO:0044248 27 0.034
Yeast
transcription dna templated GO:0006351 181 0.034
negative regulation of cell cycle phase transition GO:1901988 5 0.034
photoreceptor cell differentiation GO:0046530 55 0.034
dna damage checkpoint GO:0000077 6 0.033
regulation of proteolysis GO:0030162 24 0.033
regulation of gene expression GO:0010468 265 0.033
response to chemical GO:0042221 320 0.033
programmed cell death GO:0012501 119 0.033
meiosis ii GO:0007135 1 0.032
phosphate containing compound metabolic process GO:0006796 108 0.032
peptidyl serine phosphorylation GO:0018105 1 0.032
regulation of cysteine type endopeptidase activity involved in apoptotic process GO:0043281 20 0.032
b cell activation GO:0042113 2 0.032
nucleoside monophosphate catabolic process GO:0009125 4 0.032
death GO:0016265 121 0.031
neuron projection development GO:0031175 180 0.031
proteasomal protein catabolic process GO:0010498 2 0.031
regulation of histone methylation GO:0031060 3 0.031
cartilage development GO:0051216 96 0.031
multicellular organism growth GO:0035264 4 0.030
regulation of macromolecule biosynthetic process GO:0010556 225 0.030
response to endogenous stimulus GO:0009719 83 0.030
digestive system development GO:0055123 289 0.030
regulation of cellular protein catabolic process GO:1903362 1 0.030
protein import GO:0017038 3 0.030
mitotic spindle organization GO:0007052 5 0.030
organic cyclic compound metabolic process GO:1901360 301 0.029
oxoacid metabolic process GO:0043436 31 0.029
aging GO:0007568 2 0.029
rna metabolic process GO:0016070 219 0.029
Yeast
peptidyl threonine phosphorylation GO:0018107 1 0.029
regulation of purine nucleotide catabolic process GO:0033121 2 0.028
dna catabolic process GO:0006308 1 0.028
Yeast
phosphorus metabolic process GO:0006793 109 0.027
negative regulation of nucleic acid templated transcription GO:1903507 45 0.027
chromatin organization GO:0006325 22 0.027
germ cell development GO:0007281 22 0.027
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.027
regulation of nucleotide catabolic process GO:0030811 2 0.026
positive regulation of chromosome organization GO:2001252 1 0.026
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.026
dna recombination GO:0006310 5 0.026
hematopoietic or lymphoid organ development GO:0048534 191 0.026
liver development GO:0001889 96 0.026
exocrine pancreas development GO:0031017 28 0.026
regulation of cellular ketone metabolic process GO:0010565 7 0.026
mesenchyme development GO:0060485 127 0.026
macromolecule methylation GO:0043414 19 0.026
eye photoreceptor cell differentiation GO:0001754 45 0.026
negative regulation of transcription dna templated GO:0045892 45 0.026
cell cycle g2 m phase transition GO:0044839 4 0.025
signal transduction GO:0007165 455 0.025
reproduction GO:0000003 40 0.025
camera type eye photoreceptor cell differentiation GO:0060219 19 0.025
regulation of synapse organization GO:0050807 3 0.025
guanosine containing compound metabolic process GO:1901068 4 0.025
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.025
thymus development GO:0048538 10 0.025
regulation of biological quality GO:0065008 263 0.025
Human
negative regulation of catabolic process GO:0009895 3 0.025
negative regulation of dna metabolic process GO:0051053 4 0.024
purine nucleoside monophosphate catabolic process GO:0009128 4 0.024
developmental process involved in reproduction GO:0003006 27 0.024
regulation of catalytic activity GO:0050790 55 0.024
regionalization GO:0003002 274 0.024
cellular nitrogen compound biosynthetic process GO:0044271 218 0.024
Human Yeast
positive regulation of metabolic process GO:0009893 108 0.024
oocyte maturation GO:0001556 4 0.024
growth GO:0040007 174 0.024
g1 s transition of mitotic cell cycle GO:0000082 1 0.024
regulation of biosynthetic process GO:0009889 250 0.023
hatching GO:0035188 4 0.023
Worm
muscle structure development GO:0061061 196 0.023
cellular modified amino acid metabolic process GO:0006575 3 0.023
hepaticobiliary system development GO:0061008 98 0.023
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.023
sexual reproduction GO:0019953 36 0.023
heterocycle biosynthetic process GO:0018130 215 0.023
Human Yeast
positive regulation of cellular catabolic process GO:0031331 3 0.022
mitotic metaphase plate congression GO:0007080 1 0.022
regulation of peptidase activity GO:0052547 23 0.022
negative regulation of cell cycle GO:0045786 14 0.022
mitotic recombination GO:0006312 2 0.022
methylation GO:0032259 22 0.022
cell death GO:0008219 121 0.022
proteolysis GO:0006508 38 0.022
chromosome segregation GO:0007059 12 0.022
carbohydrate derivative biosynthetic process GO:1901137 43 0.021
atp catabolic process GO:0006200 4 0.021
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.021
negative regulation of gene expression GO:0010629 65 0.021
nucleic acid templated transcription GO:0097659 181 0.021
spindle assembly GO:0051225 2 0.021
nuclear import GO:0051170 3 0.021
female meiotic division GO:0007143 2 0.020
cell morphogenesis involved in differentiation GO:0000904 195 0.020
gtp metabolic process GO:0046039 4 0.020
sister chromatid segregation GO:0000819 6 0.020
dna alkylation GO:0006305 8 0.020
negative regulation of rna metabolic process GO:0051253 48 0.020
blood vessel morphogenesis GO:0048514 216 0.020
cellular amino acid metabolic process GO:0006520 7 0.019
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.019
axis specification GO:0009798 43 0.019
intracellular signal transduction GO:0035556 85 0.019
phagocytosis GO:0006909 3 0.019
multi organism process GO:0051704 134 0.019
angiogenesis GO:0001525 158 0.019
lymphocyte proliferation GO:0046651 1 0.019
lateral inhibition GO:0046331 1 0.019
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.019
protein localization to nucleus GO:0034504 3 0.019
cellular component assembly involved in morphogenesis GO:0010927 107 0.019
nucleobase containing small molecule metabolic process GO:0055086 32 0.019
extracellular structure organization GO:0043062 27 0.019
microtubule polymerization GO:0046785 2 0.019
negative regulation of histone modification GO:0031057 1 0.019
response to abiotic stimulus GO:0009628 122 0.019
immunoglobulin production GO:0002377 1 0.018
guanosine containing compound catabolic process GO:1901069 2 0.018
neuroblast fate determination GO:0007400 1 0.018
regulation of metabolic process GO:0019222 359 0.018
regulation of cell cycle phase transition GO:1901987 8 0.018
b cell mediated immunity GO:0019724 3 0.017
cell proliferation GO:0008283 80 0.017
catabolic process GO:0009056 32 0.017
Yeast
reciprocal dna recombination GO:0035825 1 0.017
positive regulation of molecular function GO:0044093 33 0.017
meiotic spindle organization GO:0000212 1 0.017
gene silencing GO:0016458 4 0.017
spindle assembly involved in mitosis GO:0090307 1 0.017
cytoskeleton organization GO:0007010 96 0.017
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.017
negative regulation of cytoplasmic transport GO:1903650 2 0.017
immunoglobulin mediated immune response GO:0016064 3 0.016
regulation of rna biosynthetic process GO:2001141 213 0.016
negative regulation of organelle organization GO:0010639 4 0.016
ribonucleotide metabolic process GO:0009259 27 0.016
developmental growth involved in morphogenesis GO:0060560 86 0.016
vesicle mediated transport GO:0016192 22 0.016
Worm
regulation of response to stimulus GO:0048583 269 0.016
cellular response to organic substance GO:0071310 105 0.016
protein complex assembly GO:0006461 30 0.016
g2 m transition of mitotic cell cycle GO:0000086 4 0.016
establishment of protein localization to organelle GO:0072594 4 0.016
response to oxygen containing compound GO:1901700 55 0.016
female meiosis chromosome segregation GO:0016321 1 0.016
nerve development GO:0021675 45 0.016
regulation of establishment of protein localization GO:0070201 4 0.016
cellular amine metabolic process GO:0044106 2 0.016
regulation of chromatin organization GO:1902275 5 0.016
single organism nuclear import GO:1902593 3 0.016
organic substance catabolic process GO:1901575 28 0.016
Yeast
protein polymerization GO:0051258 4 0.016
positive regulation of apoptotic process GO:0043065 29 0.015
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.015
dna replication GO:0006260 6 0.015
common bile duct development GO:0061009 13 0.015
macromolecular complex assembly GO:0065003 35 0.015
cell migration involved in gastrulation GO:0042074 79 0.015
purine nucleotide metabolic process GO:0006163 27 0.015
lens development in camera type eye GO:0002088 22 0.015
cytokinesis GO:0000910 3 0.015
meiotic cell cycle GO:0051321 5 0.015
heterocycle catabolic process GO:0046700 15 0.015
Yeast
regulation of apoptotic process GO:0042981 98 0.015
regulation of anatomical structure morphogenesis GO:0022603 130 0.015
mitotic cell cycle phase transition GO:0044772 9 0.015
response to antibiotic GO:0046677 1 0.015
organonitrogen compound biosynthetic process GO:1901566 47 0.015
regulation of mitotic cell cycle GO:0007346 25 0.015
regulation of nucleocytoplasmic transport GO:0046822 2 0.015
stem cell differentiation GO:0048863 117 0.014
dna methylation or demethylation GO:0044728 8 0.014
negative regulation of rna biosynthetic process GO:1902679 45 0.014
regulation of dendrite development GO:0050773 3 0.014
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.014
regulation of cellular protein metabolic process GO:0032268 52 0.014
response to uv GO:0009411 3 0.014
autonomic nervous system development GO:0048483 19 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
response to wounding GO:0009611 116 0.014
somatic cell dna recombination GO:0016444 1 0.014
regulation of primary metabolic process GO:0080090 311 0.014
regulation of multicellular organismal process GO:0051239 277 0.014
peptidyl threonine modification GO:0018210 1 0.014
single organism reproductive process GO:0044702 40 0.013
brain development GO:0007420 293 0.013
negative regulation of mitosis GO:0045839 3 0.013
oocyte development GO:0048599 14 0.013
regulation of dna metabolic process GO:0051052 11 0.013
heart development GO:0007507 313 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
negative regulation of chromatin modification GO:1903309 1 0.013
regulation of rna metabolic process GO:0051252 224 0.013
regulation of organelle assembly GO:1902115 4 0.013
regulation of protein binding GO:0043393 3 0.013
multi organism reproductive process GO:0044703 36 0.013
mitotic sister chromatid segregation GO:0000070 6 0.013
response to amino acid GO:0043200 2 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
positive regulation of hydrolase activity GO:0051345 13 0.013
astral microtubule organization GO:0030953 1 0.012
cellular response to dna damage stimulus GO:0006974 24 0.012
Human Mouse
endocytosis GO:0006897 16 0.012
Worm
positive regulation of rna biosynthetic process GO:1902680 57 0.012
regulation of cysteine type endopeptidase activity GO:2000116 21 0.012
ribose phosphate metabolic process GO:0019693 27 0.012
eye photoreceptor cell development GO:0042462 30 0.012
regulation of mitotic cell cycle phase transition GO:1901990 8 0.012
stem cell development GO:0048864 82 0.012
macromolecule modification GO:0043412 111 0.012
cellular response to biotic stimulus GO:0071216 3 0.012
positive regulation of cell cycle GO:0045787 3 0.012
tissue regeneration GO:0042246 74 0.012
mononuclear cell proliferation GO:0032943 1 0.012
photoreceptor cell development GO:0042461 40 0.012
localization of cell GO:0051674 244 0.012
nucleoside phosphate metabolic process GO:0006753 28 0.012
regulation of binding GO:0051098 3 0.012
chromatin modification GO:0016568 21 0.011
telomere maintenance GO:0000723 1 0.011
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
gtp catabolic process GO:0006184 2 0.011
regulation of programmed cell death GO:0043067 101 0.011
immune system development GO:0002520 191 0.011
mucopolysaccharide metabolic process GO:1903510 2 0.011
cell cycle g1 s phase transition GO:0044843 1 0.011
regulation of cellular component organization GO:0051128 86 0.011
protein targeting to nucleus GO:0044744 3 0.011
glycosaminoglycan metabolic process GO:0030203 9 0.011
positive regulation of programmed cell death GO:0043068 29 0.011
protein import into nucleus GO:0006606 3 0.011
cell division GO:0051301 20 0.011
Worm
posttranscriptional gene silencing by rna GO:0035194 3 0.011
regulation of protein import into nucleus GO:0042306 2 0.011
regulation of chromatin modification GO:1903308 5 0.011
regulation of multicellular organism growth GO:0040014 4 0.011
g2 dna damage checkpoint GO:0031572 3 0.011
polarized epithelial cell differentiation GO:0030859 4 0.011
developmental growth GO:0048589 166 0.011
response to external stimulus GO:0009605 264 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
stem cell maintenance GO:0019827 4 0.011
dna methylation GO:0006306 8 0.011
pronuclear migration GO:0035046 1 0.011
establishment of localization in cell GO:0051649 77 0.011
positive regulation of nucleic acid templated transcription GO:1903508 57 0.010
b cell differentiation GO:0030183 1 0.010
regulation of cellular amine metabolic process GO:0033238 0 0.010
gastrulation GO:0007369 208 0.010
microtubule organizing center organization GO:0031023 1 0.010
organelle fission GO:0048285 23 0.010
response to growth factor GO:0070848 39 0.010
negative regulation of cell death GO:0060548 60 0.010
negative regulation of cellular catabolic process GO:0031330 3 0.010
cilium morphogenesis GO:0060271 85 0.010

pold1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.042
Human
disease of cellular proliferation DOID:14566 0 0.042
Human
organ system cancer DOID:0050686 0 0.042
Human
disease of anatomical entity DOID:7 0 0.025
thoracic cancer DOID:5093 0 0.023
nervous system disease DOID:863 0 0.018
disease of mental health DOID:150 0 0.012
developmental disorder of mental health DOID:0060037 0 0.012