Danio rerio

0 known processes

fkbp4

FK506 binding protein 4

(Aliases: wu:fb34f09)

fkbp4 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
negative regulation of cellular process GO:0048523 283 0.264
Rat
organelle organization GO:0006996 227 0.222
Rat
regulation of cellular metabolic process GO:0031323 320 0.188
regulation of macromolecule metabolic process GO:0060255 317 0.185
cellular nitrogen compound metabolic process GO:0034641 290 0.183
regulation of metabolic process GO:0019222 359 0.181
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.175
larval development GO:0002164 2 0.173
nucleobase containing compound metabolic process GO:0006139 274 0.171
nitrogen compound metabolic process GO:0006807 319 0.159
single organism organelle organization GO:1902589 199 0.140
Rat
cellular protein metabolic process GO:0044267 129 0.135
Human
heterocycle metabolic process GO:0046483 290 0.131
cellular macromolecule metabolic process GO:0044260 391 0.123
Human
organic acid metabolic process GO:0006082 31 0.114
organic cyclic compound metabolic process GO:1901360 301 0.112
embryo development ending in birth or egg hatching GO:0009792 271 0.101
atp catabolic process GO:0006200 4 0.097
nucleoside monophosphate catabolic process GO:0009125 4 0.094
regulation of biological quality GO:0065008 263 0.090
response to chemical GO:0042221 320 0.086
mitochondrion organization GO:0007005 4 0.083
protein metabolic process GO:0019538 183 0.081
Human
cellular ketone metabolic process GO:0042180 11 0.080
oxoacid metabolic process GO:0043436 31 0.078
negative regulation of biological process GO:0048519 304 0.078
Rat
cellular aromatic compound metabolic process GO:0006725 295 0.077
carboxylic acid metabolic process GO:0019752 22 0.076
small molecule metabolic process GO:0044281 77 0.072
single organism metabolic process GO:0044710 217 0.070
regionalization GO:0003002 274 0.068
regulation of primary metabolic process GO:0080090 311 0.066
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.064
macromolecular complex subunit organization GO:0043933 74 0.064
Rat
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.063
regulation of protein complex assembly GO:0043254 3 0.062
Rat
cellular component assembly GO:0022607 170 0.061
Rat
protein import GO:0017038 3 0.061
modification dependent macromolecule catabolic process GO:0043632 3 0.061
nucleocytoplasmic transport GO:0006913 4 0.060
immune system process GO:0002376 241 0.059
regulation of cellular amino acid metabolic process GO:0006521 0 0.059
purine nucleoside monophosphate catabolic process GO:0009128 4 0.058
sensory perception GO:0007600 39 0.058
Fly
regulation of cellular amine metabolic process GO:0033238 0 0.055
establishment of protein localization to organelle GO:0072594 4 0.055
aging GO:0007568 2 0.055
positive regulation of cellular component biogenesis GO:0044089 3 0.054
amine metabolic process GO:0009308 2 0.053
locomotion GO:0040011 313 0.052
cellular amino acid metabolic process GO:0006520 7 0.051
organonitrogen compound metabolic process GO:1901564 74 0.050
regulation of protein ubiquitination GO:0031396 3 0.049
positive regulation of small gtpase mediated signal transduction GO:0051057 1 0.048
response to stress GO:0006950 263 0.048
cellular amine metabolic process GO:0044106 2 0.046
nuclear transport GO:0051169 4 0.046
positive regulation of cellular amine metabolic process GO:0033240 0 0.046
erk1 and erk2 cascade GO:0070371 4 0.046
ribonucleoside monophosphate catabolic process GO:0009158 4 0.045
single organism localization GO:1902578 225 0.045
Rat Fly
ubiquitin dependent protein catabolic process GO:0006511 3 0.042
phosphorus metabolic process GO:0006793 109 0.041
regulation of cell death GO:0010941 103 0.041
regulation of cellular ketone metabolic process GO:0010565 7 0.041
regulation of nitrogen compound metabolic process GO:0051171 251 0.040
mitotic cell cycle GO:0000278 64 0.040
signal transduction GO:0007165 455 0.040
response to external stimulus GO:0009605 264 0.039
Fly
regulation of establishment of protein localization GO:0070201 4 0.039
phagocytosis GO:0006909 3 0.039
protein stabilization GO:0050821 2 0.039
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.039
negative regulation of catabolic process GO:0009895 3 0.039
regulation of protein transport GO:0051223 3 0.038
gene expression GO:0010467 252 0.038
regulation of purine nucleotide catabolic process GO:0033121 2 0.038
maintenance of location GO:0051235 4 0.038
negative regulation of protein phosphorylation GO:0001933 4 0.037
regulation of response to stimulus GO:0048583 269 0.037
positive regulation of map kinase activity GO:0043406 3 0.037
cellular macromolecule biosynthetic process GO:0034645 224 0.036
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.036
cell surface receptor signaling pathway GO:0007166 325 0.036
macromolecule biosynthetic process GO:0009059 227 0.035
nucleic acid metabolic process GO:0090304 244 0.035
regulation of protein metabolic process GO:0051246 56 0.035
nuclear import GO:0051170 3 0.035
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.035
organic substance biosynthetic process GO:1901576 289 0.034
protein polymerization GO:0051258 4 0.034
Rat
regulation of protein catabolic process GO:0042176 1 0.034
meiosis i GO:0007127 1 0.033
regulation of multicellular organismal process GO:0051239 277 0.033
tube morphogenesis GO:0035239 349 0.033
negative regulation of protein transport GO:0051224 3 0.033
transport GO:0006810 220 0.033
Rat Fly
system process GO:0003008 185 0.033
Fly
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.032
positive regulation of catabolic process GO:0009896 4 0.032
negative regulation of cellular metabolic process GO:0031324 77 0.031
protein dephosphorylation GO:0006470 3 0.031
actin filament polymerization GO:0030041 2 0.031
regulation of erk1 and erk2 cascade GO:0070372 4 0.031
chordate embryonic development GO:0043009 271 0.031
blood vessel development GO:0001568 246 0.030
cellular respiration GO:0045333 3 0.030
regulation of cell communication GO:0010646 232 0.030
extrinsic apoptotic signaling pathway GO:0097191 3 0.029
establishment of localization GO:0051234 244 0.028
Rat Fly
cytoskeleton organization GO:0007010 96 0.028
Rat
protein import into nucleus GO:0006606 3 0.028
regulation of gene expression GO:0010468 265 0.028
modification dependent protein catabolic process GO:0019941 3 0.028
central nervous system development GO:0007417 387 0.027
positive regulation of stress activated mapk cascade GO:0032874 3 0.027
heart development GO:0007507 313 0.027
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.027
rna biosynthetic process GO:0032774 181 0.027
stem cell division GO:0017145 1 0.027
digestive system development GO:0055123 289 0.027
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.026
microtubule based process GO:0007017 60 0.026
Rat
energy reserve metabolic process GO:0006112 2 0.026
cellular component biogenesis GO:0044085 178 0.026
Rat
negative regulation of metabolic process GO:0009892 86 0.026
single organism nuclear import GO:1902593 3 0.026
regulation of reproductive process GO:2000241 4 0.026
regulation of cellular biosynthetic process GO:0031326 245 0.025
positive regulation of jnk cascade GO:0046330 3 0.025
positive regulation of biological process GO:0048518 253 0.025
phosphate containing compound metabolic process GO:0006796 108 0.025
intracellular signal transduction GO:0035556 85 0.025
digestive tract development GO:0048565 265 0.025
cellular carbohydrate metabolic process GO:0044262 4 0.024
antimicrobial humoral response GO:0019730 2 0.024
regulation of cytokine production GO:0001817 3 0.024
protein complex biogenesis GO:0070271 30 0.024
Rat
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.024
cellular component disassembly GO:0022411 1 0.024
regulation of catalytic activity GO:0050790 55 0.023
sensory perception of pain GO:0019233 1 0.023
protein targeting to nucleus GO:0044744 3 0.023
positive regulation of ras protein signal transduction GO:0046579 1 0.023
protein homooligomerization GO:0051260 3 0.023
head development GO:0060322 303 0.023
negative regulation of protein kinase activity GO:0006469 4 0.023
cellular response to radiation GO:0071478 4 0.023
positive regulation of transport GO:0051050 2 0.023
neurological system process GO:0050877 62 0.023
Fly
positive regulation of cellular catabolic process GO:0031331 3 0.023
cell death GO:0008219 121 0.022
regulation of nucleotide catabolic process GO:0030811 2 0.022
regulation of rna metabolic process GO:0051252 224 0.022
macromolecular complex assembly GO:0065003 35 0.022
Rat
proteasomal protein catabolic process GO:0010498 2 0.022
peptidyl serine phosphorylation GO:0018105 1 0.022
alternative mrna splicing via spliceosome GO:0000380 1 0.022
oocyte anterior posterior axis specification GO:0007314 4 0.022
cell cycle g1 s phase transition GO:0044843 1 0.021
negative regulation of protein serine threonine kinase activity GO:0071901 2 0.021
skin development GO:0043588 54 0.021
autophagy GO:0006914 4 0.021
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.021
regulation of mrna processing GO:0050684 3 0.021
regulation of synapse assembly GO:0051963 3 0.021
response to wounding GO:0009611 116 0.021
cellular response to organic substance GO:0071310 105 0.021
regulation of nucleoside metabolic process GO:0009118 2 0.021
meiotic nuclear division GO:0007126 4 0.021
cellular catabolic process GO:0044248 27 0.020
cell cycle GO:0007049 93 0.020
regulation of cytoplasmic transport GO:1903649 4 0.020
peptidyl threonine phosphorylation GO:0018107 1 0.020
cell motility GO:0048870 244 0.020
regulation of cytoskeleton organization GO:0051493 11 0.020
Rat
regulation of binding GO:0051098 3 0.020
centrosome organization GO:0051297 1 0.020
rna splicing GO:0008380 16 0.019
negative regulation of intracellular transport GO:0032387 3 0.019
carbohydrate homeostasis GO:0033500 1 0.019
cell proliferation GO:0008283 80 0.019
positive regulation of apoptotic signaling pathway GO:2001235 1 0.019
positive regulation of protein complex assembly GO:0031334 2 0.019
regulation of cellular protein catabolic process GO:1903362 1 0.019
regulation of protein polymerization GO:0032271 2 0.019
Rat
immune system development GO:0002520 191 0.019
nuclear export GO:0051168 1 0.019
regulation of cellular response to growth factor stimulus GO:0090287 35 0.019
positive regulation of cytoskeleton organization GO:0051495 3 0.018
regulation of dna replication GO:0006275 3 0.018
growth GO:0040007 174 0.018
leukocyte proliferation GO:0070661 1 0.018
axonogenesis GO:0007409 152 0.018
rna metabolic process GO:0016070 219 0.018
multicellular organism growth GO:0035264 4 0.018
regulation of intracellular protein transport GO:0033157 3 0.018
cellular biosynthetic process GO:0044249 286 0.018
cellular nitrogen compound biosynthetic process GO:0044271 218 0.018
cellular amide metabolic process GO:0043603 4 0.018
cellular component morphogenesis GO:0032989 336 0.018
regulation of response to biotic stimulus GO:0002831 2 0.018
meiotic cell cycle process GO:1903046 3 0.018
positive regulation of cell cycle GO:0045787 3 0.018
negative regulation of mapk cascade GO:0043409 4 0.018
rho protein signal transduction GO:0007266 5 0.017
regulation of biosynthetic process GO:0009889 250 0.017
production of molecular mediator of immune response GO:0002440 2 0.017
negative regulation of macromolecule metabolic process GO:0010605 76 0.017
negative regulation of cytoplasmic transport GO:1903650 2 0.017
morphogenesis of an epithelium GO:0002009 333 0.017
microtubule organizing center organization GO:0031023 1 0.017
regulation of microtubule cytoskeleton organization GO:0070507 3 0.017
Rat
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.017
germ line stem cell maintenance GO:0030718 2 0.017
organic cyclic compound biosynthetic process GO:1901362 223 0.017
pole plasm assembly GO:0007315 4 0.017
cellular protein catabolic process GO:0044257 4 0.017
muscle cell differentiation GO:0042692 139 0.017
negative regulation of cellular catabolic process GO:0031330 3 0.016
lipid storage GO:0019915 1 0.016
developmental programmed cell death GO:0010623 4 0.016
single organism transport GO:0044765 206 0.016
Rat Fly
nuclear transcribed mrna catabolic process nonsense mediated decay GO:0000184 4 0.016
circulatory system process GO:0003013 87 0.016
negative regulation of kinase activity GO:0033673 4 0.016
regulation of phosphate metabolic process GO:0019220 43 0.016
protein localization to nucleus GO:0034504 3 0.016
reactive oxygen species metabolic process GO:0072593 6 0.016
death GO:0016265 121 0.016
stem cell proliferation GO:0072089 4 0.016
reactive oxygen species biosynthetic process GO:1903409 1 0.016
biosynthetic process GO:0009058 294 0.016
regulation of protein binding GO:0043393 3 0.016
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.016
negative regulation of protein metabolic process GO:0051248 16 0.016
meiotic chromosome segregation GO:0045132 3 0.016
digestive tract morphogenesis GO:0048546 231 0.015
regulation of protein localization to nucleus GO:1900180 2 0.015
regulation of gene silencing GO:0060968 1 0.015
regulation of mrna splicing via spliceosome GO:0048024 3 0.015
regulation of cell shape GO:0008360 1 0.015
g1 s transition of mitotic cell cycle GO:0000082 1 0.015
negative regulation of dna metabolic process GO:0051053 4 0.015
regulation of signaling GO:0023051 235 0.015
rna modification GO:0009451 2 0.015
response to drug GO:0042493 3 0.015
carbohydrate biosynthetic process GO:0016051 1 0.015
transcription from rna polymerase ii promoter GO:0006366 80 0.015
cellular protein modification process GO:0006464 100 0.015
Human
regulation of oocyte development GO:0060281 3 0.015
stem cell development GO:0048864 82 0.015
positive regulation of nucleoside metabolic process GO:0045979 1 0.015
muscle structure development GO:0061061 196 0.015
catabolic process GO:0009056 32 0.015
transcription dna templated GO:0006351 181 0.015
organelle assembly GO:0070925 110 0.015
cellular modified amino acid metabolic process GO:0006575 3 0.014
synaptic growth at neuromuscular junction GO:0051124 2 0.014
regulation of response to cytokine stimulus GO:0060759 3 0.014
positive regulation of metabolic process GO:0009893 108 0.014
positive regulation of molecular function GO:0044093 33 0.014
multicellular organismal reproductive process GO:0048609 35 0.014
positive regulation of dna metabolic process GO:0051054 1 0.014
protein complex subunit organization GO:0071822 46 0.014
Rat
protein acylation GO:0043543 3 0.014
regulation of localization GO:0032879 104 0.014
Fly
hematopoietic or lymphoid organ development GO:0048534 191 0.014
eye development GO:0001654 277 0.014
cellular localization GO:0051641 97 0.014
protein phosphorylation GO:0006468 47 0.014
fatty acid biosynthetic process GO:0006633 4 0.014
reciprocal dna recombination GO:0035825 1 0.014
regulation of molecular function GO:0065009 70 0.014
internal peptidyl lysine acetylation GO:0018393 2 0.014
response to carbohydrate GO:0009743 3 0.014
retina development in camera type eye GO:0060041 146 0.014
peptidyl threonine modification GO:0018210 1 0.014
negative regulation of chromosome organization GO:2001251 1 0.013
rna localization GO:0006403 4 0.013
regulation of transcription elongation from rna polymerase ii promoter GO:0034243 3 0.013
regulation of protein targeting GO:1903533 2 0.013
mononuclear cell proliferation GO:0032943 1 0.013
negative regulation of protein complex assembly GO:0031333 1 0.013
Rat
lipid catabolic process GO:0016042 4 0.013
cell morphogenesis GO:0000902 289 0.013
mitotic cell cycle embryonic GO:0045448 2 0.013
regulation of jak stat cascade GO:0046425 3 0.013
telomere organization GO:0032200 1 0.013
protein complex assembly GO:0006461 30 0.013
Rat
vasculature development GO:0001944 278 0.013
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.013
small gtpase mediated signal transduction GO:0007264 8 0.013
peptidyl serine modification GO:0018209 2 0.013
positive regulation of muscle cell differentiation GO:0051149 1 0.013
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.013
protein secretion GO:0009306 1 0.013
regulation of oxidative stress induced cell death GO:1903201 2 0.013
alpha amino acid metabolic process GO:1901605 3 0.013
response to topologically incorrect protein GO:0035966 2 0.013
regulation of cell activation GO:0050865 1 0.013
regulation of carbohydrate metabolic process GO:0006109 4 0.013
actin polymerization or depolymerization GO:0008154 2 0.013
positive regulation of nucleotide catabolic process GO:0030813 1 0.013
aromatic compound biosynthetic process GO:0019438 217 0.013
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.013
mesenchymal cell development GO:0014031 78 0.013
regulation of reactive oxygen species metabolic process GO:2000377 2 0.013
cellular response to starvation GO:0009267 1 0.013
response to hypoxia GO:0001666 25 0.013
regulation of circadian rhythm GO:0042752 4 0.013
regulation of developmental process GO:0050793 247 0.013
cellular response to endogenous stimulus GO:0071495 68 0.013
response to glucose GO:0009749 3 0.013
cellular response to external stimulus GO:0071496 2 0.012
protein modification process GO:0036211 100 0.012
Human
kupffer s vesicle development GO:0070121 50 0.012
cellular response to nutrient levels GO:0031669 2 0.012
regulation of chromosome segregation GO:0051983 1 0.012
negative regulation of nuclear division GO:0051784 3 0.012
peptidyl lysine dimethylation GO:0018027 1 0.012
cellular response to chemical stimulus GO:0070887 157 0.012
internal protein amino acid acetylation GO:0006475 2 0.012
regulation of systemic arterial blood pressure GO:0003073 1 0.012
axon development GO:0061564 166 0.012
regulation of inflammatory response GO:0050727 2 0.012
positive regulation of canonical wnt signaling pathway GO:0090263 4 0.012
protein complex disassembly GO:0043241 1 0.012
regulation of phosphorus metabolic process GO:0051174 43 0.012
regulation of i kappab kinase nf kappab signaling GO:0043122 4 0.012
regulation of protein complex disassembly GO:0043244 1 0.012
ribose phosphate metabolic process GO:0019693 27 0.012
centrosome cycle GO:0007098 1 0.012
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.012
anterior posterior pattern specification GO:0009952 152 0.012
nucleobase containing compound biosynthetic process GO:0034654 205 0.012
skeletal system development GO:0001501 181 0.012
organic substance transport GO:0071702 58 0.012
gastrulation GO:0007369 208 0.012
cellular response to extracellular stimulus GO:0031668 2 0.012
reactive nitrogen species metabolic process GO:2001057 0 0.012
cation transport GO:0006812 81 0.012
Rat Fly
cellular response to biotic stimulus GO:0071216 3 0.012
adult behavior GO:0030534 2 0.012
positive regulation of signal transduction GO:0009967 56 0.012
regulation of nucleic acid templated transcription GO:1903506 213 0.012
regulation of stem cell differentiation GO:2000736 4 0.012
mitotic g2 dna damage checkpoint GO:0007095 3 0.011
primary neural tube formation GO:0014020 1 0.011
stem cell maintenance GO:0019827 4 0.011
chemotaxis GO:0006935 104 0.011
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.011
lymphocyte proliferation GO:0046651 1 0.011
blood vessel morphogenesis GO:0048514 216 0.011
regulation of meiotic cell cycle GO:0051445 1 0.011
chromosome organization GO:0051276 31 0.011
positive regulation of multi organism process GO:0043902 3 0.011
nucleoside phosphate metabolic process GO:0006753 28 0.011
interspecies interaction between organisms GO:0044419 4 0.011
gtp metabolic process GO:0046039 4 0.011
determination of left right symmetry GO:0007368 179 0.011
phosphorylation GO:0016310 69 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
sister chromatid cohesion GO:0007062 2 0.011
glucose import GO:0046323 2 0.011
phagocytosis engulfment GO:0006911 1 0.011
positive regulation of cytokine production GO:0001819 2 0.011
mesenchyme development GO:0060485 127 0.011
negative regulation of secretion GO:0051048 2 0.011
oxidation reduction process GO:0055114 41 0.011
positive regulation of chromosome organization GO:2001252 1 0.011
brain development GO:0007420 293 0.011
regulation of cellular carbohydrate metabolic process GO:0010675 4 0.011
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.011
peptide metabolic process GO:0006518 1 0.011
programmed cell death GO:0012501 119 0.011
cell part morphogenesis GO:0032990 246 0.011
homeostatic process GO:0042592 142 0.011
regulation of rho protein signal transduction GO:0035023 2 0.011
regulation of multicellular organism growth GO:0040014 4 0.011
mrna processing GO:0006397 14 0.011
response to hexose GO:0009746 3 0.010
macromolecular complex disassembly GO:0032984 1 0.010
response to endogenous stimulus GO:0009719 83 0.010
single organism biosynthetic process GO:0044711 71 0.010
endoplasmic reticulum unfolded protein response GO:0030968 2 0.010
membrane invagination GO:0010324 1 0.010
cytokinesis GO:0000910 3 0.010
regulation of synapse organization GO:0050807 3 0.010
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.010
lateral inhibition GO:0046331 1 0.010
positive regulation of secretion GO:0051047 1 0.010
exocytosis GO:0006887 1 0.010
cell migration GO:0016477 237 0.010
enzyme linked receptor protein signaling pathway GO:0007167 106 0.010
angiogenesis GO:0001525 158 0.010
negative regulation of cytokine production GO:0001818 1 0.010
b cell activation GO:0042113 2 0.010
negative regulation of multi organism process GO:0043901 3 0.010
apoptotic process GO:0006915 116 0.010
negative regulation of defense response GO:0031348 2 0.010
toxin transport GO:1901998 2 0.010
positive regulation of immune effector process GO:0002699 3 0.010

fkbp4 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.074
disease of metabolism DOID:0014667 0 0.036
nervous system disease DOID:863 0 0.029
musculoskeletal system disease DOID:17 0 0.024
myopathy DOID:423 0 0.021
muscular disease DOID:0080000 0 0.021
muscle tissue disease DOID:66 0 0.021
inherited metabolic disorder DOID:655 0 0.013
synucleinopathy DOID:0050890 0 0.011
central nervous system disease DOID:331 0 0.011
neurodegenerative disease DOID:1289 0 0.011