Danio rerio

0 known processes

idh2

isocitrate dehydrogenase 2 (NADP+), mitochondrial

(Aliases: zgc:55485,wu:fb33c06,wu:fq43b01,wu:fk31e05)

idh2 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
larval development GO:0002164 2 0.619
embryo development ending in birth or egg hatching GO:0009792 271 0.413
mitochondrion organization GO:0007005 4 0.277
nitrogen compound metabolic process GO:0006807 319 0.251
aging GO:0007568 2 0.189
carbohydrate derivative metabolic process GO:1901135 61 0.173
nucleobase containing compound metabolic process GO:0006139 274 0.162
organophosphate metabolic process GO:0019637 37 0.159
atp synthesis coupled electron transport GO:0042773 1 0.151
ribonucleotide metabolic process GO:0009259 27 0.149
single organism organelle organization GO:1902589 199 0.132
ribose phosphate metabolic process GO:0019693 27 0.127
maintenance of location GO:0051235 4 0.122
response to drug GO:0042493 3 0.122
establishment of localization GO:0051234 244 0.119
ribonucleotide biosynthetic process GO:0009260 20 0.119
heterocycle metabolic process GO:0046483 290 0.110
small molecule metabolic process GO:0044281 77 0.110
purine ribonucleoside monophosphate metabolic process GO:0009167 5 0.110
purine nucleotide metabolic process GO:0006163 27 0.106
ribonucleoside metabolic process GO:0009119 11 0.105
organonitrogen compound metabolic process GO:1901564 74 0.104
cellular nitrogen compound metabolic process GO:0034641 290 0.098
carbohydrate derivative biosynthetic process GO:1901137 43 0.091
cellular aromatic compound metabolic process GO:0006725 295 0.087
lipid storage GO:0019915 1 0.086
purine nucleoside monophosphate catabolic process GO:0009128 4 0.085
mitochondrial atp synthesis coupled electron transport GO:0042775 1 0.084
single organism metabolic process GO:0044710 217 0.083
cellular biosynthetic process GO:0044249 286 0.082
response to chemical GO:0042221 320 0.081
organic cyclic compound metabolic process GO:1901360 301 0.080
transport GO:0006810 220 0.079
central nervous system development GO:0007417 387 0.075
organophosphate biosynthetic process GO:0090407 23 0.075
atp catabolic process GO:0006200 4 0.069
reactive oxygen species metabolic process GO:0072593 6 0.066
organic substance biosynthetic process GO:1901576 289 0.064
regulation of metabolic process GO:0019222 359 0.064
oxidative phosphorylation GO:0006119 1 0.064
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.064
positive regulation of transport GO:0051050 2 0.063
biosynthetic process GO:0009058 294 0.062
phototransduction GO:0007602 2 0.062
single organism localization GO:1902578 225 0.062
oocyte anterior posterior axis specification GO:0007314 4 0.061
phosphate containing compound metabolic process GO:0006796 108 0.059
gtp metabolic process GO:0046039 4 0.058
nucleoside phosphate metabolic process GO:0006753 28 0.057
electron transport chain GO:0022900 2 0.057
nucleoside monophosphate catabolic process GO:0009125 4 0.056
spermatid development GO:0007286 2 0.053
response to stress GO:0006950 263 0.052
reproduction GO:0000003 40 0.051
organic acid metabolic process GO:0006082 31 0.051
regulation of biological quality GO:0065008 263 0.047
spermatid differentiation GO:0048515 2 0.047
phosphorus metabolic process GO:0006793 109 0.045
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.044
response to external stimulus GO:0009605 264 0.043
regulation of protein transport GO:0051223 3 0.042
nucleobase containing small molecule metabolic process GO:0055086 32 0.042
regulation of gene expression GO:0010468 265 0.042
ribonucleoside monophosphate catabolic process GO:0009158 4 0.041
purine containing compound biosynthetic process GO:0072522 20 0.041
guanosine containing compound metabolic process GO:1901068 4 0.041
phosphorylation GO:0016310 69 0.041
negative regulation of protein phosphorylation GO:0001933 4 0.040
ribose phosphate biosynthetic process GO:0046390 20 0.039
organic cyclic compound biosynthetic process GO:1901362 223 0.039
multi organism process GO:0051704 134 0.038
regulation of establishment of protein localization GO:0070201 4 0.038
single fertilization GO:0007338 3 0.038
amine metabolic process GO:0009308 2 0.037
locomotion GO:0040011 313 0.037
negative regulation of biological process GO:0048519 304 0.037
response to organic substance GO:0010033 153 0.036
response to abiotic stimulus GO:0009628 122 0.036
phagocytosis GO:0006909 3 0.036
regulation of binding GO:0051098 3 0.035
head development GO:0060322 303 0.035
purine nucleoside triphosphate biosynthetic process GO:0009145 2 0.034
mitochondrial electron transport nadh to ubiquinone GO:0006120 1 0.033
striated muscle cell differentiation GO:0051146 129 0.032
gene expression GO:0010467 252 0.032
nucleobase containing compound biosynthetic process GO:0034654 205 0.031
regulation of biosynthetic process GO:0009889 250 0.030
cellular amine metabolic process GO:0044106 2 0.030
nucleotide metabolic process GO:0009117 28 0.030
purine ribonucleoside biosynthetic process GO:0046129 2 0.030
cellular respiration GO:0045333 3 0.030
cellular nitrogen compound biosynthetic process GO:0044271 218 0.030
regulation of cellular amine metabolic process GO:0033238 0 0.029
cell cell recognition GO:0009988 1 0.029
cell cycle GO:0007049 93 0.029
regulation of blood pressure GO:0008217 1 0.029
atp metabolic process GO:0046034 5 0.028
muscle structure development GO:0061061 196 0.028
organelle organization GO:0006996 227 0.028
establishment of protein localization to organelle GO:0072594 4 0.028
cellular protein complex assembly GO:0043623 19 0.027
positive regulation of catabolic process GO:0009896 4 0.027
cell death GO:0008219 121 0.027
growth GO:0040007 174 0.026
single organism transport GO:0044765 206 0.026
cellular macromolecule metabolic process GO:0044260 391 0.026
regulation of intracellular protein transport GO:0033157 3 0.025
protein secretion GO:0009306 1 0.025
nucleoside biosynthetic process GO:0009163 2 0.025
nucleoside phosphate biosynthetic process GO:1901293 21 0.024
nucleoside triphosphate biosynthetic process GO:0009142 2 0.024
purine containing compound metabolic process GO:0072521 29 0.024
nucleotide biosynthetic process GO:0009165 21 0.024
nitric oxide metabolic process GO:0046209 2 0.023
regulation of developmental process GO:0050793 247 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.023
transmembrane transport GO:0055085 120 0.023
purine nucleotide biosynthetic process GO:0006164 20 0.023
positive regulation of apoptotic signaling pathway GO:2001235 1 0.023
macromolecule modification GO:0043412 111 0.023
protein polymerization GO:0051258 4 0.023
ion transport GO:0006811 114 0.022
macromolecule biosynthetic process GO:0009059 227 0.022
protein complex subunit organization GO:0071822 46 0.022
cellular macromolecule biosynthetic process GO:0034645 224 0.022
regulation of cellular ketone metabolic process GO:0010565 7 0.022
cellular component assembly GO:0022607 170 0.022
nucleoside metabolic process GO:0009116 11 0.022
cell surface receptor signaling pathway GO:0007166 325 0.022
regulation of membrane potential GO:0042391 23 0.022
embryonic organ morphogenesis GO:0048562 274 0.022
apoptotic process GO:0006915 116 0.021
membrane fusion GO:0061025 2 0.021
regulation of endothelial cell proliferation GO:0001936 1 0.021
translational initiation GO:0006413 3 0.021
negative regulation of kinase activity GO:0033673 4 0.021
microtubule based process GO:0007017 60 0.021
regulation of mrna splicing via spliceosome GO:0048024 3 0.021
purine ribonucleoside triphosphate metabolic process GO:0009205 9 0.021
regulation of cell activation GO:0050865 1 0.021
brain development GO:0007420 293 0.021
protein import GO:0017038 3 0.020
striated muscle cell development GO:0055002 108 0.020
chordate embryonic development GO:0043009 271 0.020
negative regulation of protein kinase activity GO:0006469 4 0.020
oxoacid metabolic process GO:0043436 31 0.020
positive regulation of secretion GO:0051047 1 0.020
cellular component morphogenesis GO:0032989 336 0.020
regulation of cellular amino acid metabolic process GO:0006521 0 0.019
embryonic organ development GO:0048568 381 0.019
cellular response to biotic stimulus GO:0071216 3 0.019
multicellular organism growth GO:0035264 4 0.019
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.019
programmed cell death GO:0012501 119 0.019
tissue regeneration GO:0042246 74 0.019
organonitrogen compound biosynthetic process GO:1901566 47 0.018
cellular ketone metabolic process GO:0042180 11 0.018
purine ribonucleoside metabolic process GO:0046128 10 0.018
nuclear migration GO:0007097 3 0.018
purine ribonucleotide metabolic process GO:0009150 27 0.018
regulation of alternative mrna splicing via spliceosome GO:0000381 1 0.018
internal protein amino acid acetylation GO:0006475 2 0.017
determination of bilateral symmetry GO:0009855 204 0.017
immune system process GO:0002376 241 0.017
positive regulation of secretion by cell GO:1903532 1 0.017
regulation of macromolecule biosynthetic process GO:0010556 225 0.017
nucleoside monophosphate metabolic process GO:0009123 6 0.017
muscle cell development GO:0055001 115 0.017
regulation of protein catabolic process GO:0042176 1 0.017
organelle fusion GO:0048284 3 0.017
leukocyte proliferation GO:0070661 1 0.017
guanosine containing compound catabolic process GO:1901069 2 0.017
regulation of protein localization to nucleus GO:1900180 2 0.017
protein acetylation GO:0006473 2 0.016
regulation of primary metabolic process GO:0080090 311 0.016
developmental growth GO:0048589 166 0.016
negative regulation of macromolecule metabolic process GO:0010605 76 0.016
rna metabolic process GO:0016070 219 0.016
stem cell maintenance GO:0019827 4 0.016
sexual reproduction GO:0019953 36 0.016
multi organism reproductive process GO:0044703 36 0.016
apical junction assembly GO:0043297 1 0.016
heterocycle biosynthetic process GO:0018130 215 0.016
heart development GO:0007507 313 0.016
positive regulation of nucleoside metabolic process GO:0045979 1 0.016
purine ribonucleotide biosynthetic process GO:0009152 20 0.016
regulation of receptor activity GO:0010469 2 0.016
regulation of nucleoside metabolic process GO:0009118 2 0.016
regulation of protein targeting GO:1903533 2 0.016
ribonucleoside triphosphate biosynthetic process GO:0009201 2 0.016
single organism biosynthetic process GO:0044711 71 0.015
regulation of protein complex assembly GO:0043254 3 0.015
cytokinesis GO:0000910 3 0.015
mitotic dna damage checkpoint GO:0044773 4 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
action potential GO:0001508 19 0.015
regulation of multicellular organismal process GO:0051239 277 0.015
aromatic compound biosynthetic process GO:0019438 217 0.015
nuclear transport GO:0051169 4 0.015
inner ear development GO:0048839 126 0.015
dorsal ventral pattern formation GO:0009953 125 0.015
regulation of circadian rhythm GO:0042752 4 0.015
carboxylic acid metabolic process GO:0019752 22 0.015
germ line stem cell maintenance GO:0030718 2 0.015
muscle tissue development GO:0060537 110 0.015
carbohydrate biosynthetic process GO:0016051 1 0.015
regulation of purine nucleotide catabolic process GO:0033121 2 0.015
regulation of cytokine production GO:0001817 3 0.015
multicellular organismal reproductive process GO:0048609 35 0.015
ribonucleoside biosynthetic process GO:0042455 2 0.014
regulation of gtp catabolic process GO:0033124 2 0.014
positive regulation of nucleotide catabolic process GO:0030813 1 0.014
regulation of metal ion transport GO:0010959 4 0.014
negative regulation of metabolic process GO:0009892 86 0.014
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.014
adult behavior GO:0030534 2 0.014
reactive nitrogen species metabolic process GO:2001057 0 0.014
protein stabilization GO:0050821 2 0.014
purine nucleoside monophosphate metabolic process GO:0009126 5 0.014
rna localization GO:0006403 4 0.014
angiogenesis GO:0001525 158 0.014
regulation of mrna processing GO:0050684 3 0.014
gtp catabolic process GO:0006184 2 0.014
cytoskeleton organization GO:0007010 96 0.014
regulation of multicellular organism growth GO:0040014 4 0.014
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.014
response to hypoxia GO:0001666 25 0.014
neurotransmitter transport GO:0006836 2 0.014
regulation of reproductive process GO:2000241 4 0.014
multicellular organismal signaling GO:0035637 22 0.014
single organism membrane fusion GO:0044801 2 0.014
cellular amino acid metabolic process GO:0006520 7 0.014
fertilization GO:0009566 3 0.014
macromolecule localization GO:0033036 54 0.014
regulation of protein binding GO:0043393 3 0.014
macromolecular complex subunit organization GO:0043933 74 0.013
response to cold GO:0009409 4 0.013
multicellular organismal metabolic process GO:0044236 2 0.013
regulation of nitrogen compound metabolic process GO:0051171 251 0.013
multicellular organism reproduction GO:0032504 35 0.013
cellular protein metabolic process GO:0044267 129 0.013
cell migration GO:0016477 237 0.013
response to wounding GO:0009611 116 0.013
microtubule cytoskeleton organization involved in mitosis GO:1902850 1 0.013
purine ribonucleoside triphosphate biosynthetic process GO:0009206 2 0.013
ribonucleoside monophosphate metabolic process GO:0009161 5 0.013
cellular component disassembly GO:0022411 1 0.013
regulation of apoptotic process GO:0042981 98 0.013
positive regulation of cellular amine metabolic process GO:0033240 0 0.013
positive regulation of dna metabolic process GO:0051054 1 0.013
nucleic acid metabolic process GO:0090304 244 0.013
reactive oxygen species biosynthetic process GO:1903409 1 0.012
glial cell differentiation GO:0010001 42 0.012
regulation of cellular protein catabolic process GO:1903362 1 0.012
regulation of cell shape GO:0008360 1 0.012
pole plasm assembly GO:0007315 4 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
stem cell proliferation GO:0072089 4 0.012
transcription dna templated GO:0006351 181 0.012
protein complex assembly GO:0006461 30 0.012
mitotic dna integrity checkpoint GO:0044774 4 0.012
nuclear export GO:0051168 1 0.012
negative regulation of molecular function GO:0044092 23 0.012
purine nucleoside biosynthetic process GO:0042451 2 0.012
regulation of sodium ion transport GO:0002028 2 0.012
cellular protein modification process GO:0006464 100 0.012
negative regulation of catalytic activity GO:0043086 21 0.012
system process GO:0003008 185 0.012
regulation of macromolecule metabolic process GO:0060255 317 0.012
nucleic acid transport GO:0050657 2 0.011
regulation of programmed cell death GO:0043067 101 0.011
regeneration GO:0031099 91 0.011
response to endogenous stimulus GO:0009719 83 0.011
spindle assembly involved in mitosis GO:0090307 1 0.011
neuronal action potential GO:0019228 18 0.011
regulation of cytoplasmic transport GO:1903649 4 0.011
activation of mapk activity GO:0000187 3 0.011
protein complex biogenesis GO:0070271 30 0.011
b cell activation GO:0042113 2 0.011
glycosyl compound biosynthetic process GO:1901659 2 0.011
cell motility GO:0048870 244 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
muscle cell differentiation GO:0042692 139 0.011
response to lipid GO:0033993 60 0.011
eye development GO:0001654 277 0.011
insulin like growth factor receptor signaling pathway GO:0048009 4 0.011
reproductive process GO:0022414 40 0.011
response to external biotic stimulus GO:0043207 97 0.011
regulation of reactive oxygen species metabolic process GO:2000377 2 0.011
g protein coupled receptor signaling pathway GO:0007186 74 0.011
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.011
organelle assembly GO:0070925 110 0.011
signal transduction GO:0007165 455 0.011
negative regulation of epithelial cell proliferation GO:0050680 1 0.011
mitotic cell cycle GO:0000278 64 0.011
mononuclear cell proliferation GO:0032943 1 0.011
cell migration involved in gastrulation GO:0042074 79 0.011
death GO:0016265 121 0.011
establishment of rna localization GO:0051236 3 0.011
macromolecular complex disassembly GO:0032984 1 0.011
regulation of actin filament based movement GO:1903115 1 0.011
cellular response to external stimulus GO:0071496 2 0.011
cellular carbohydrate metabolic process GO:0044262 4 0.011
striated muscle tissue development GO:0014706 110 0.011
determination of left right symmetry GO:0007368 179 0.011
response to decreased oxygen levels GO:0036293 25 0.011
regulation of cell death GO:0010941 103 0.011
wound healing GO:0042060 90 0.011
nitric oxide biosynthetic process GO:0006809 2 0.011
response to organic cyclic compound GO:0014070 51 0.011
carbohydrate homeostasis GO:0033500 1 0.010
response to oxygen levels GO:0070482 25 0.010
connective tissue development GO:0061448 99 0.010
transmission of nerve impulse GO:0019226 19 0.010
regulation of muscle contraction GO:0006937 3 0.010
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
maternal determination of anterior posterior axis embryo GO:0008358 4 0.010
circulatory system process GO:0003013 87 0.010
response to biotic stimulus GO:0009607 97 0.010
adherens junction organization GO:0034332 4 0.010
posttranscriptional regulation of gene expression GO:0010608 14 0.010
rna transport GO:0050658 2 0.010
regulation of gtpase activity GO:0043087 2 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.010
developmental process involved in reproduction GO:0003006 27 0.010
regionalization GO:0003002 274 0.010
cell cycle g2 m phase transition GO:0044839 4 0.010
glial cell proliferation GO:0014009 4 0.010
proepicardium development GO:0003342 4 0.010
cytoplasm organization GO:0007028 4 0.010
regulation of wound healing GO:0061041 2 0.010
regulation of epithelial cell proliferation GO:0050678 3 0.010

idh2 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
cancer DOID:162 0 0.017
disease of cellular proliferation DOID:14566 0 0.017
organ system cancer DOID:0050686 0 0.017
disease of anatomical entity DOID:7 0 0.014