Danio rerio

18 known processes

manf

mesencephalic astrocyte-derived neurotrophic factor

(Aliases: im:6909481,MGC153327,zgc:153327)

manf biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cellular response to topologically incorrect protein GO:0035967 2 0.976
response to unfolded protein GO:0006986 2 0.918
cellular response to unfolded protein GO:0034620 2 0.877
endoplasmic reticulum unfolded protein response GO:0030968 2 0.856
er nucleus signaling pathway GO:0006984 2 0.837
response to topologically incorrect protein GO:0035966 2 0.681
regulation of nuclease activity GO:0032069 1 0.585
response to endoplasmic reticulum stress GO:0034976 6 0.428
protein n linked glycosylation GO:0006487 1 0.341
cellular response to organic substance GO:0071310 105 0.340
larval development GO:0002164 2 0.304
positive regulation of apoptotic signaling pathway GO:2001235 1 0.299
response to organic substance GO:0010033 153 0.265
ceramide biosynthetic process GO:0046513 1 0.251
locomotion GO:0040011 313 0.202
regulation of multicellular organismal process GO:0051239 277 0.170
aging GO:0007568 2 0.161
chromosome organization involved in meiosis GO:0070192 1 0.148
response to amine GO:0014075 1 0.139
programmed cell death GO:0012501 119 0.122
positive regulation of nuclease activity GO:0032075 1 0.119
signal transduction GO:0007165 455 0.118
cellular response to chemical stimulus GO:0070887 157 0.115
hydrogen peroxide metabolic process GO:0042743 2 0.113
cellular response to stress GO:0033554 62 0.106
response to abiotic stimulus GO:0009628 122 0.102
embryonic organ development GO:0048568 381 0.101
cellular response to antibiotic GO:0071236 1 0.100
membrane lipid biosynthetic process GO:0046467 2 0.097
regulation of dna catabolic process GO:1903624 1 0.095
positive regulation of biological process GO:0048518 253 0.087
cellular component assembly GO:0022607 170 0.084
dicarboxylic acid metabolic process GO:0043648 1 0.083
cellular protein metabolic process GO:0044267 129 0.082
maintenance of location GO:0051235 4 0.081
cell proliferation GO:0008283 80 0.080
response to chemical GO:0042221 320 0.074
cell death GO:0008219 121 0.072
cell migration GO:0016477 237 0.070
extrinsic apoptotic signaling pathway GO:0097191 3 0.068
regulation of cell death GO:0010941 103 0.065
protein metabolic process GO:0019538 183 0.064
regulation of signaling GO:0023051 235 0.062
regulation of protein ubiquitination GO:0031396 3 0.059
response to temperature stimulus GO:0009266 15 0.057
regulation of developmental process GO:0050793 247 0.054
morphogenesis of an epithelium GO:0002009 333 0.053
cell substrate junction assembly GO:0007044 2 0.052
modification dependent macromolecule catabolic process GO:0043632 3 0.052
single organism localization GO:1902578 225 0.051
digestive tract morphogenesis GO:0048546 231 0.050
cellular response to toxic substance GO:0097237 1 0.048
response to stress GO:0006950 263 0.042
regulation of molecular function GO:0065009 70 0.042
spindle assembly GO:0051225 2 0.041
multicellular organism growth GO:0035264 4 0.040
endodermal digestive tract morphogenesis GO:0061031 2 0.039
positive regulation of cellular process GO:0048522 201 0.039
death GO:0016265 121 0.036
central nervous system development GO:0007417 387 0.036
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.036
cellular protein catabolic process GO:0044257 4 0.035
regulation of nucleotide catabolic process GO:0030811 2 0.034
embryo development ending in birth or egg hatching GO:0009792 271 0.034
phosphorylation GO:0016310 69 0.033
response to heat GO:0009408 6 0.033
embryonic organ morphogenesis GO:0048562 274 0.033
extrinsic apoptotic signaling pathway via death domain receptors GO:0008625 1 0.033
regulation of nucleoside metabolic process GO:0009118 2 0.032
organic substance catabolic process GO:1901575 28 0.031
retina homeostasis GO:0001895 12 0.030
modification dependent protein catabolic process GO:0019941 3 0.030
regulation of epithelial cell proliferation GO:0050678 3 0.030
single organism transport GO:0044765 206 0.030
sphingolipid biosynthetic process GO:0030148 2 0.029
cellular component morphogenesis GO:0032989 336 0.028
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.028
cellular localization GO:0051641 97 0.027
retrograde axon cargo transport GO:0008090 1 0.026
cellular component biogenesis GO:0044085 178 0.026
cellular response to extracellular stimulus GO:0031668 2 0.025
regulation of apoptotic process GO:0042981 98 0.025
regulation of gtp catabolic process GO:0033124 2 0.025
sensory organ development GO:0007423 393 0.025
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.024
chordate embryonic development GO:0043009 271 0.024
cellular response to nutrient levels GO:0031669 2 0.024
regulation of cell communication GO:0010646 232 0.024
regulation of purine nucleotide catabolic process GO:0033121 2 0.023
immune system development GO:0002520 191 0.023
heart development GO:0007507 313 0.023
transport GO:0006810 220 0.023
digestive system development GO:0055123 289 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
positive regulation of cytokine production GO:0001819 2 0.022
regulation of cell activation GO:0050865 1 0.022
lipid homeostasis GO:0055088 3 0.022
lipid storage GO:0019915 1 0.022
photoreceptor cell differentiation GO:0046530 55 0.021
regulation of biological quality GO:0065008 263 0.021
Mouse
response to amphetamine GO:0001975 1 0.021
cellular response to oxygen radical GO:0071450 2 0.021
specification of symmetry GO:0009799 204 0.021
regulation of cytokine production GO:0001817 3 0.021
regulation of gtpase activity GO:0043087 2 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.020
brain development GO:0007420 293 0.020
regulation of nucleotide metabolic process GO:0006140 17 0.020
meiotic nuclear division GO:0007126 4 0.020
regulation of catalytic activity GO:0050790 55 0.019
regulation of signal transduction GO:0009966 225 0.019
peptide transport GO:0015833 1 0.018
regulation of microtubule based movement GO:0060632 3 0.018
cell morphogenesis GO:0000902 289 0.018
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.018
amine metabolic process GO:0009308 2 0.018
regulation of programmed cell death GO:0043067 101 0.017
negative regulation of cellular process GO:0048523 283 0.017
ubiquitin dependent protein catabolic process GO:0006511 3 0.017
protein targeting to membrane GO:0006612 1 0.017
regulation of phosphorus metabolic process GO:0051174 43 0.017
cellular response to starvation GO:0009267 1 0.017
cellular protein modification process GO:0006464 100 0.016
regulation of cytokine mediated signaling pathway GO:0001959 3 0.016
skeletal system development GO:0001501 181 0.016
transmembrane transport GO:0055085 120 0.016
negative regulation of biological process GO:0048519 304 0.016
toxin transport GO:1901998 2 0.016
regulation of phosphate metabolic process GO:0019220 43 0.016
ceramide metabolic process GO:0006672 5 0.016
golgi vesicle transport GO:0048193 3 0.016
negative regulation of programmed cell death GO:0043069 58 0.015
negative regulation of apoptotic process GO:0043066 55 0.015
epithelial cell differentiation GO:0030855 116 0.015
oocyte maturation GO:0001556 4 0.015
guanosine containing compound catabolic process GO:1901069 2 0.015
leukocyte proliferation GO:0070661 1 0.015
apoptotic process GO:0006915 116 0.015
regulation of primary metabolic process GO:0080090 311 0.015
regulation of multicellular organism growth GO:0040014 4 0.015
gtp metabolic process GO:0046039 4 0.015
stem cell maintenance GO:0019827 4 0.015
catechol containing compound metabolic process GO:0009712 2 0.014
homeostatic process GO:0042592 142 0.014
adult behavior GO:0030534 2 0.014
growth GO:0040007 174 0.014
regulation of macromolecule metabolic process GO:0060255 317 0.014
regulation of metabolic process GO:0019222 359 0.014
response to metal ion GO:0010038 34 0.014
regulation of organ growth GO:0046620 3 0.013
neurological system process GO:0050877 62 0.013
Mouse
cell motility GO:0048870 244 0.013
ear development GO:0043583 127 0.013
protein modification by small protein conjugation GO:0032446 13 0.013
establishment of localization in cell GO:0051649 77 0.013
multicellular organismal response to stress GO:0033555 2 0.012
cellular catabolic process GO:0044248 27 0.012
water homeostasis GO:0030104 4 0.012
negative regulation of cell death GO:0060548 60 0.012
regulation of phosphorylation GO:0042325 26 0.012
kidney development GO:0001822 92 0.012
reactive oxygen species biosynthetic process GO:1903409 1 0.012
cell projection organization GO:0030030 284 0.012
multicellular organism reproduction GO:0032504 35 0.012
regulation of protein metabolic process GO:0051246 56 0.012
positive regulation of secretion by cell GO:1903532 1 0.012
macromolecule localization GO:0033036 54 0.012
regulation of nitrogen compound metabolic process GO:0051171 251 0.012
regulation of reproductive process GO:2000241 4 0.012
nucleocytoplasmic transport GO:0006913 4 0.012
purine nucleoside monophosphate catabolic process GO:0009128 4 0.011
cellular amine metabolic process GO:0044106 2 0.011
hepatocyte proliferation GO:0072574 2 0.011
removal of superoxide radicals GO:0019430 2 0.011
cell aging GO:0007569 2 0.011
protein import GO:0017038 3 0.011
positive regulation of cellular metabolic process GO:0031325 94 0.011
positive regulation of cell activation GO:0050867 1 0.011
system process GO:0003008 185 0.011
Mouse
proteasomal protein catabolic process GO:0010498 2 0.011
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.011
cellular nitrogen compound metabolic process GO:0034641 290 0.011
protein modification by small protein conjugation or removal GO:0070647 14 0.011
cell surface receptor signaling pathway GO:0007166 325 0.011
regulation of cellular amine metabolic process GO:0033238 0 0.010
regulation of localization GO:0032879 104 0.010
response to oxygen radical GO:0000305 2 0.010
cellular response to superoxide GO:0071451 2 0.010
cellular response to external stimulus GO:0071496 2 0.010
epidermis morphogenesis GO:0048730 4 0.010
lymphocyte proliferation GO:0046651 1 0.010
rna localization GO:0006403 4 0.010
response to estrogen GO:0043627 27 0.010
response to ethanol GO:0045471 6 0.010
phosphorus metabolic process GO:0006793 109 0.010
otolith development GO:0048840 32 0.010

manf disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.022
musculoskeletal system disease DOID:17 0 0.012
myopathy DOID:423 0 0.010
muscular disease DOID:0080000 0 0.010
muscle tissue disease DOID:66 0 0.010