Danio rerio

84 known processes

pink1

PTEN induced putative kinase 1

(Aliases: wu:fc39e12,zgc:101729)

pink1 biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
cell projection organization GO:0030030 284 0.774
Worm
g protein coupled receptor signaling pathway GO:0007186 74 0.465
positive regulation of biological process GO:0048518 253 0.462
Human Mouse Fly
brain development GO:0007420 293 0.452
response to external stimulus GO:0009605 264 0.433
Worm
single organism transport GO:0044765 206 0.404
Mouse
regulation of homeostatic process GO:0032844 9 0.350
adult behavior GO:0030534 2 0.346
positive regulation of transport GO:0051050 2 0.332
Mouse
sequestering of metal ion GO:0051238 3 0.283
ion transport GO:0006811 114 0.279
Mouse
startle response GO:0001964 4 0.274
cognition GO:0050890 1 0.233
neuron projection development GO:0031175 180 0.226
Worm
positive regulation of cellular process GO:0048522 201 0.201
Human Mouse Fly
regulation of biological quality GO:0065008 263 0.200
cytoskeleton organization GO:0007010 96 0.195
signal transduction GO:0007165 455 0.193
neuron differentiation GO:0030182 353 0.185
response to abiotic stimulus GO:0009628 122 0.175
Human Mouse
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.167
regulation of sequestering of calcium ion GO:0051282 4 0.167
macromolecular complex subunit organization GO:0043933 74 0.164
Human
organic substance transport GO:0071702 58 0.155
Mouse
blood vessel morphogenesis GO:0048514 216 0.150
response to oxygen levels GO:0070482 25 0.150
Human Mouse
positive regulation of camp biosynthetic process GO:0030819 2 0.148
cellular component assembly GO:0022607 170 0.146
Human
vasculature development GO:0001944 278 0.145
cell morphogenesis GO:0000902 289 0.142
Worm
angiogenesis GO:0001525 158 0.139
cell migration GO:0016477 237 0.132
transmembrane transport GO:0055085 120 0.128
central nervous system neuron axonogenesis GO:0021955 18 0.124
anion transport GO:0006820 38 0.114
glucose import GO:0046323 2 0.114
neuron neuron synaptic transmission GO:0007270 1 0.113
Mouse
head development GO:0060322 303 0.113
cytosolic calcium ion transport GO:0060401 3 0.110
calcium ion transport into cytosol GO:0060402 3 0.107
detection of stimulus GO:0051606 29 0.107
regulation of synaptic plasticity GO:0048167 1 0.105
neuron projection extension GO:1990138 45 0.103
Worm
regulation of dendrite development GO:0050773 3 0.101
cellular response to decreased oxygen levels GO:0036294 1 0.097
Human Mouse
establishment of localization GO:0051234 244 0.095
Mouse
transport GO:0006810 220 0.093
Mouse
generation of neurons GO:0048699 385 0.093
regulation of receptor activity GO:0010469 2 0.092
positive regulation of cellular component biogenesis GO:0044089 3 0.087
regulation of fatty acid metabolic process GO:0019217 1 0.085
spermatid development GO:0007286 2 0.085
behavior GO:0007610 74 0.083
negative regulation of sequestering of calcium ion GO:0051283 4 0.080
organelle transport along microtubule GO:0072384 1 0.079
response to osmotic stress GO:0006970 11 0.077
positive regulation of secretion by cell GO:1903532 1 0.076
Mouse
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.074
single organism metabolic process GO:0044710 217 0.073
Mouse
actin filament based process GO:0030029 64 0.073
regulation of signaling GO:0023051 235 0.071
cell part morphogenesis GO:0032990 246 0.071
Worm
neurological system process GO:0050877 62 0.071
sequestering of calcium ion GO:0051208 3 0.070
negative regulation of cellular process GO:0048523 283 0.069
Human Mouse Fly
receptor internalization GO:0031623 2 0.069
cell surface receptor signaling pathway GO:0007166 325 0.069
single organism localization GO:1902578 225 0.066
Mouse
peptidyl serine phosphorylation GO:0018105 1 0.065
Human
reactive nitrogen species metabolic process GO:2001057 0 0.065
cerebellum vasculature development GO:0061300 1 0.064
regulation of postsynaptic membrane potential GO:0060078 1 0.062
cellular component morphogenesis GO:0032989 336 0.061
Worm
detection of abiotic stimulus GO:0009582 24 0.061
localization of cell GO:0051674 244 0.061
inner ear development GO:0048839 126 0.060
regulation of cell communication GO:0010646 232 0.060
protein complex biogenesis GO:0070271 30 0.058
Human
cell projection assembly GO:0030031 64 0.057
neuron development GO:0048666 262 0.056
Worm
axon guidance GO:0007411 86 0.054
Worm
positive regulation of epithelial cell proliferation GO:0050679 1 0.054
maintenance of location GO:0051235 4 0.054
central nervous system development GO:0007417 387 0.053
cellular localization GO:0051641 97 0.053
Mouse
synaptic transmission GO:0007268 35 0.052
Mouse Fly
regulation of filopodium assembly GO:0051489 2 0.051
positive regulation of secretion GO:0051047 1 0.051
Mouse
amine metabolic process GO:0009308 2 0.050
macromolecular complex disassembly GO:0032984 1 0.049
regulation of cell projection organization GO:0031344 44 0.049
cation homeostasis GO:0055080 33 0.046
cell motility GO:0048870 244 0.046
locomotory behavior GO:0007626 34 0.045
central nervous system neuron differentiation GO:0021953 74 0.045
cellular response to hypoxia GO:0071456 1 0.042
Human Mouse
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.042
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.041
Mouse
regulation of rac protein signal transduction GO:0035020 1 0.041
cellular component biogenesis GO:0044085 178 0.040
Human
cell proliferation GO:0008283 80 0.040
aromatic compound biosynthetic process GO:0019438 217 0.039
Mouse
hydrogen peroxide metabolic process GO:0042743 2 0.039
Mouse
regulation of neuron projection development GO:0010975 40 0.039
positive regulation of striated muscle tissue development GO:0045844 1 0.039
osteoclast development GO:0036035 1 0.038
regulation of membrane potential GO:0042391 23 0.038
Human
locomotion GO:0040011 313 0.038
Worm
nuclear migration GO:0007097 3 0.038
regulation of dendrite morphogenesis GO:0048814 3 0.038
bicarbonate transport GO:0015701 4 0.038
brain morphogenesis GO:0048854 18 0.038
carbohydrate transport GO:0008643 13 0.037
protein complex subunit organization GO:0071822 46 0.037
Human
semicircular canal development GO:0060872 24 0.037
muscle cell migration GO:0014812 4 0.037
organic substance biosynthetic process GO:1901576 289 0.036
Mouse
embryonic skeletal joint development GO:0072498 3 0.036
response to chemical GO:0042221 320 0.035
actin polymerization or depolymerization GO:0008154 2 0.035
positive regulation of muscle organ development GO:0048636 1 0.034
regulation of cellular component organization GO:0051128 86 0.033
Human Fly
ras protein signal transduction GO:0007265 7 0.033
cell death GO:0008219 121 0.033
response to dexamethasone GO:0071548 1 0.033
cellular response to external stimulus GO:0071496 2 0.032
growth GO:0040007 174 0.032
Worm
regulation of reproductive process GO:2000241 4 0.031
establishment of localization in cell GO:0051649 77 0.031
Mouse
synapsis GO:0007129 1 0.031
cellular component movement GO:0006928 335 0.031
Worm
dopaminergic neuron differentiation GO:0071542 14 0.030
microtubule based movement GO:0007018 33 0.030
multicellular organism growth GO:0035264 4 0.030
protein import GO:0017038 3 0.029
cellular component disassembly GO:0022411 1 0.029
actin filament polymerization GO:0030041 2 0.029
regulation of cyclin dependent protein serine threonine kinase activity GO:0000079 1 0.029
positive regulation of exocytosis GO:0045921 1 0.029
cellular response to chemical stimulus GO:0070887 157 0.028
regulation of glucose import GO:0046324 1 0.028
erk1 and erk2 cascade GO:0070371 4 0.028
death GO:0016265 121 0.028
blood vessel development GO:0001568 246 0.028
purine ribonucleoside monophosphate catabolic process GO:0009169 4 0.028
developmental growth GO:0048589 166 0.027
Worm
multicellular organismal metabolic process GO:0044236 2 0.027
centrosome organization GO:0051297 1 0.027
cellular carbohydrate metabolic process GO:0044262 4 0.027
nitric oxide biosynthetic process GO:0006809 2 0.027
positive regulation of metabolic process GO:0009893 108 0.026
Human Mouse
positive regulation of catabolic process GO:0009896 4 0.026
central nervous system projection neuron axonogenesis GO:0021952 15 0.026
circadian sleep wake cycle process GO:0022410 2 0.026
regulation of transporter activity GO:0032409 2 0.026
calcium mediated signaling GO:0019722 2 0.026
cellular response to extracellular stimulus GO:0031668 2 0.026
neural nucleus development GO:0048857 15 0.025
ribose phosphate metabolic process GO:0019693 27 0.025
microtubule organizing center organization GO:0031023 1 0.025
negative regulation of dna metabolic process GO:0051053 4 0.025
response to ketone GO:1901654 1 0.025
spermatid differentiation GO:0048515 2 0.025
locus ceruleus development GO:0021703 3 0.024
centrosome cycle GO:0007098 1 0.024
regulation of exocytosis GO:0017157 1 0.024
regulation of multicellular organismal process GO:0051239 277 0.024
glial cell proliferation GO:0014009 4 0.024
positive regulation of cytoskeleton organization GO:0051495 3 0.024
cell cell signaling GO:0007267 52 0.024
Mouse Fly
peptidyl serine modification GO:0018209 2 0.023
Human
multi organism process GO:0051704 134 0.023
pronuclear migration GO:0035046 1 0.023
regulation of ion homeostasis GO:2000021 7 0.023
regulation of ion transmembrane transporter activity GO:0032412 2 0.023
cellular cation homeostasis GO:0030003 17 0.023
response to stress GO:0006950 263 0.023
Human Mouse Worm Fly
system process GO:0003008 185 0.023
synaptic growth at neuromuscular junction GO:0051124 2 0.023
reactive oxygen species biosynthetic process GO:1903409 1 0.023
organic cyclic compound metabolic process GO:1901360 301 0.023
Mouse
cellular response to nutrient levels GO:0031669 2 0.022
neuropeptide signaling pathway GO:0007218 11 0.022
establishment of synaptic vesicle localization GO:0097480 1 0.022
retrograde axon cargo transport GO:0008090 1 0.022
developmental maturation GO:0021700 34 0.022
regulation of camp biosynthetic process GO:0030817 9 0.022
regulation of cell shape GO:0008360 1 0.022
cellular macromolecule biosynthetic process GO:0034645 224 0.022
Mouse
regulation of neurogenesis GO:0050767 87 0.022
regulation of cellular amine metabolic process GO:0033238 0 0.022
mrna 3 end processing GO:0031124 2 0.022
organic acid metabolic process GO:0006082 31 0.021
neurotransmitter secretion GO:0007269 2 0.021
cell projection morphogenesis GO:0048858 244 0.021
Worm
organelle organization GO:0006996 227 0.021
negative regulation of signal transduction in absence of ligand GO:1901099 1 0.021
cellular response to stress GO:0033554 62 0.021
Human Mouse Worm
hexose transport GO:0008645 6 0.020
ear development GO:0043583 127 0.020
cerebellum morphogenesis GO:0021587 10 0.020
regulation of neurological system process GO:0031644 2 0.020
regulation of ph GO:0006885 3 0.020
nucleobase containing small molecule metabolic process GO:0055086 32 0.020
phototransduction visible light GO:0007603 2 0.020
intracellular transport GO:0046907 32 0.020
cellular response to organic substance GO:0071310 105 0.020
cell maturation GO:0048469 23 0.020
regulation of molecular function GO:0065009 70 0.019
Mouse
regulation of developmental process GO:0050793 247 0.019
Fly
larval development GO:0002164 2 0.019
single organism organelle organization GO:1902589 199 0.019
Fly
regulation of localization GO:0032879 104 0.019
Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.019
Mouse
regulation of cellular component size GO:0032535 30 0.019
response to light stimulus GO:0009416 46 0.019
chemotaxis GO:0006935 104 0.019
Worm
centrosome localization GO:0051642 1 0.019
cellular ion homeostasis GO:0006873 17 0.019
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.019
regulation of meiotic cell cycle GO:0051445 1 0.019
heterocycle metabolic process GO:0046483 290 0.018
Mouse
dicarboxylic acid transport GO:0006835 1 0.018
negative regulation of biological process GO:0048519 304 0.018
Human Mouse Fly
taste bud morphogenesis GO:0061194 3 0.018
regulation of cellular biosynthetic process GO:0031326 245 0.018
Mouse
metencephalon development GO:0022037 27 0.018
nitric oxide metabolic process GO:0046209 2 0.018
cellular amine metabolic process GO:0044106 2 0.017
mitotic cell cycle GO:0000278 64 0.017
regulation of circadian rhythm GO:0042752 4 0.017
steroid hormone mediated signaling pathway GO:0043401 9 0.017
regulation of cell migration GO:0030334 40 0.017
cellular component maintenance GO:0043954 3 0.017
fatty acid biosynthetic process GO:0006633 4 0.017
regulation of nervous system development GO:0051960 90 0.017
fertilization GO:0009566 3 0.017
cellular monovalent inorganic cation homeostasis GO:0030004 2 0.017
indole containing compound biosynthetic process GO:0042435 1 0.017
positive regulation of wound healing GO:0090303 1 0.017
purine nucleotide metabolic process GO:0006163 27 0.017
regulation of cytoplasmic transport GO:1903649 4 0.016
heterocycle biosynthetic process GO:0018130 215 0.016
Mouse
regulation of locomotion GO:0040012 55 0.016
rna 3 end processing GO:0031123 2 0.016
peripheral nervous system neuron axonogenesis GO:0048936 13 0.016
cellular protein catabolic process GO:0044257 4 0.016
Fly
regulation of neuron differentiation GO:0045664 56 0.016
regulation of multicellular organism growth GO:0040014 4 0.016
regulation of intracellular protein transport GO:0033157 3 0.016
nuclear envelope organization GO:0006998 2 0.016
striated muscle cell differentiation GO:0051146 129 0.016
metal ion homeostasis GO:0055065 26 0.016
hindbrain development GO:0030902 91 0.016
reproductive process GO:0022414 40 0.016
Fly
multicellular organismal water homeostasis GO:0050891 1 0.016
cellular respiration GO:0045333 3 0.016
Mouse
cellular response to topologically incorrect protein GO:0035967 2 0.016
neuron projection guidance GO:0097485 86 0.016
Worm
vasculogenesis GO:0001570 41 0.016
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.015
Human
regulation of heart growth GO:0060420 2 0.015
regulation of metal ion transport GO:0010959 4 0.015
small gtpase mediated signal transduction GO:0007264 8 0.015
regulation of extent of cell growth GO:0061387 29 0.015
muscle structure development GO:0061061 196 0.015
regulation of multicellular organismal development GO:2000026 223 0.015
regulation of protein ubiquitination GO:0031396 3 0.015
Human
regulation of phospholipase activity GO:0010517 2 0.015
regulation of calcium ion transport GO:0051924 2 0.015
small molecule metabolic process GO:0044281 77 0.015
organelle localization GO:0051640 49 0.014
locomotor rhythm GO:0045475 3 0.014
regulation of n methyl d aspartate selective glutamate receptor activity GO:2000310 1 0.014
positive regulation of striated muscle cell differentiation GO:0051155 1 0.014
response to organic substance GO:0010033 153 0.014
negative regulation of signaling GO:0023057 96 0.014
Human Mouse
regulation of rho protein signal transduction GO:0035023 2 0.014
response to amphetamine GO:0001975 1 0.014
regulation of signal transduction GO:0009966 225 0.014
protein complex disassembly GO:0043241 1 0.014
cerebellum development GO:0021549 17 0.014
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.014
regulation of purine nucleotide biosynthetic process GO:1900371 15 0.014
regulation of erk1 and erk2 cascade GO:0070372 4 0.014
purine ribonucleotide metabolic process GO:0009150 27 0.014
regulation of glutamate receptor signaling pathway GO:1900449 1 0.014
protein metabolic process GO:0019538 183 0.014
Human Mouse Fly
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 8 0.014
positive regulation of muscle tissue development GO:1901863 1 0.013
regulation of transmembrane transporter activity GO:0022898 2 0.013
circadian sleep wake cycle GO:0042745 2 0.013
regulation of primary metabolic process GO:0080090 311 0.013
Human Mouse
microtubule based transport GO:0010970 10 0.013
single organism nuclear import GO:1902593 3 0.013
negative regulation of dna replication GO:0008156 2 0.013
regulation of endothelial cell proliferation GO:0001936 1 0.013
negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:2001240 1 0.013
response to cortisol GO:0051414 1 0.013
organonitrogen compound biosynthetic process GO:1901566 47 0.013
regulation of developmental growth GO:0048638 38 0.013
toxin transport GO:1901998 2 0.013
single organism intracellular transport GO:1902582 25 0.013
regulation of phosphorus metabolic process GO:0051174 43 0.013
Human Mouse
neural tube patterning GO:0021532 33 0.013
establishment of protein localization to organelle GO:0072594 4 0.013
organonitrogen compound metabolic process GO:1901564 74 0.013
sensory organ development GO:0007423 393 0.013
negative regulation of catabolic process GO:0009895 3 0.013
regulation of ras gtpase activity GO:0032318 2 0.012
regulation of dna replication GO:0006275 3 0.012
positive regulation of transcription dna templated GO:0045893 57 0.012
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.012
Fly
response to monosaccharide GO:0034284 3 0.012
growth plate cartilage morphogenesis GO:0003422 1 0.012
embryonic organ development GO:0048568 381 0.012
regulation of cardiac muscle cell contraction GO:0086004 1 0.012
gtp metabolic process GO:0046039 4 0.012
establishment of organelle localization GO:0051656 45 0.012
protein polymerization GO:0051258 4 0.012
cyclic nucleotide biosynthetic process GO:0009190 18 0.012
rac protein signal transduction GO:0016601 1 0.012
negative regulation of programmed cell death GO:0043069 58 0.012
Human Mouse Fly
regulation of behavior GO:0050795 24 0.012
nitrogen compound metabolic process GO:0006807 319 0.012
Mouse
neuromuscular synaptic transmission GO:0007274 2 0.012
Fly
light induced release of internally sequestered calcium ion GO:0008377 1 0.012
modification dependent macromolecule catabolic process GO:0043632 3 0.012
Fly
glucose transport GO:0015758 6 0.011
actin filament organization GO:0007015 15 0.011
microtubule depolymerization GO:0007019 1 0.011
protein targeting to nucleus GO:0044744 3 0.011
rna stabilization GO:0043489 4 0.011
rhodopsin mediated signaling pathway GO:0016056 1 0.011
phosphorylation GO:0016310 69 0.011
Human Mouse Fly
positive regulation of cellular amine metabolic process GO:0033240 0 0.011
positive regulation of nucleotide biosynthetic process GO:0030810 8 0.011
regulation of microtubule based movement GO:0060632 3 0.011
cerebellar granular layer formation GO:0021684 3 0.011
pyruvate metabolic process GO:0006090 1 0.011
osteoclast differentiation GO:0030316 1 0.011
cellular transition metal ion homeostasis GO:0046916 3 0.011
regulation of skeletal muscle tissue development GO:0048641 4 0.011
positive regulation of signal transduction GO:0009967 56 0.011
Human
sensory perception of pain GO:0019233 1 0.011
positive regulation of purine nucleotide biosynthetic process GO:1900373 8 0.011
organic cyclic compound biosynthetic process GO:1901362 223 0.011
Mouse
actin filament based movement GO:0030048 1 0.011
apoptotic process GO:0006915 116 0.011
synaptic transmission cholinergic GO:0007271 4 0.011
membrane repolarization GO:0086009 2 0.011
regulation of blood circulation GO:1903522 32 0.011
g1 s transition of mitotic cell cycle GO:0000082 1 0.011
cellular nitrogen compound metabolic process GO:0034641 290 0.011
Mouse
single organism cellular localization GO:1902580 46 0.011
negative regulation of locomotion GO:0040013 18 0.011
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.011
bone remodeling GO:0046849 2 0.011
single organism behavior GO:0044708 24 0.010
positive regulation of cell cycle GO:0045787 3 0.010
otolith development GO:0048840 32 0.010
regulation of organelle organization GO:0033043 29 0.010
Human Fly
intracellular signal transduction GO:0035556 85 0.010
Human Mouse
regulation of protein polymerization GO:0032271 2 0.010
primary neural tube formation GO:0014020 1 0.010
ubiquitin dependent protein catabolic process GO:0006511 3 0.010
Fly
muscle tissue development GO:0060537 110 0.010
negative regulation of mitosis GO:0045839 3 0.010
carbohydrate derivative biosynthetic process GO:1901137 43 0.010
carboxylic acid metabolic process GO:0019752 22 0.010
regulation of response to cytokine stimulus GO:0060759 3 0.010
spindle assembly GO:0051225 2 0.010
developmental cell growth GO:0048588 52 0.010
Worm
protein complex assembly GO:0006461 30 0.010
Human
negative regulation of secretion GO:0051048 2 0.010

pink1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of metabolism DOID:0014667 0 0.040
physical disorder DOID:0080015 0 0.027
lissencephaly DOID:0050453 0 0.027
congenital nervous system abnormality DOID:2490 0 0.027
disease of anatomical entity DOID:7 0 0.020
Human
nervous system disease DOID:863 0 0.020
Human
parkinson s disease DOID:14330 0 0.013
Human
synucleinopathy DOID:0050890 0 0.013
Human
central nervous system disease DOID:331 0 0.013
Human
neurodegenerative disease DOID:1289 0 0.013
Human