Danio rerio

0 known processes

lgi2b

leucine-rich repeat LGI family, member 2b

lgi2b biological process predictions


Filter by process size:
Biological process GO term ID Process size Probability Func Analog Org
aging GO:0007568 2 0.062
cognition GO:0050890 1 0.062
maintenance of location GO:0051235 4 0.054
phagocytosis GO:0006909 3 0.052
larval development GO:0002164 2 0.044
multicellular organism growth GO:0035264 4 0.042
embryonic organ development GO:0048568 381 0.041
generation of neurons GO:0048699 385 0.041
response to external stimulus GO:0009605 264 0.041
tube morphogenesis GO:0035239 349 0.039
morphogenesis of an epithelium GO:0002009 333 0.037
cell projection morphogenesis GO:0048858 244 0.037
neuron development GO:0048666 262 0.036
response to stress GO:0006950 263 0.036
cell projection organization GO:0030030 284 0.035
amine metabolic process GO:0009308 2 0.035
axonogenesis GO:0007409 152 0.035
cell part morphogenesis GO:0032990 246 0.034
regulation of multicellular organism growth GO:0040014 4 0.034
embryonic organ morphogenesis GO:0048562 274 0.034
signal transduction GO:0007165 455 0.033
chordate embryonic development GO:0043009 271 0.033
central nervous system development GO:0007417 387 0.032
Zebrafish
cellular amine metabolic process GO:0044106 2 0.032
positive regulation of transport GO:0051050 2 0.032
guanosine containing compound metabolic process GO:1901068 4 0.031
cellular protein catabolic process GO:0044257 4 0.031
sensory organ development GO:0007423 393 0.030
cell morphogenesis involved in differentiation GO:0000904 195 0.030
gtp metabolic process GO:0046039 4 0.030
regulation of cellular amino acid metabolic process GO:0006521 0 0.030
regulation of binding GO:0051098 3 0.030
chemosensory behavior GO:0007635 1 0.029
response to chemical GO:0042221 320 0.029
digestive tract development GO:0048565 265 0.029
regulation of cellular amine metabolic process GO:0033238 0 0.029
proteolysis involved in cellular protein catabolic process GO:0051603 3 0.029
cell morphogenesis GO:0000902 289 0.029
regulation of macromolecule metabolic process GO:0060255 317 0.028
regulation of metal ion transport GO:0010959 4 0.028
guanosine containing compound catabolic process GO:1901069 2 0.028
cellular macromolecule metabolic process GO:0044260 391 0.028
cellular component morphogenesis GO:0032989 336 0.028
locomotion GO:0040011 313 0.028
cellular component movement GO:0006928 335 0.028
positive regulation of cellular amino acid metabolic process GO:0045764 0 0.027
autophagy GO:0006914 4 0.027
inorganic ion transmembrane transport GO:0098660 57 0.027
neuron differentiation GO:0030182 353 0.027
vasculature development GO:0001944 278 0.027
cell migration GO:0016477 237 0.027
heart development GO:0007507 313 0.027
regulation of multicellular organismal process GO:0051239 277 0.026
regulation of cell communication GO:0010646 232 0.026
gtp catabolic process GO:0006184 2 0.026
digestive system development GO:0055123 289 0.026
axon development GO:0061564 166 0.026
establishment of localization GO:0051234 244 0.025
embryonic skeletal system development GO:0048706 97 0.025
regulation of establishment of protein localization GO:0070201 4 0.025
adult behavior GO:0030534 2 0.025
cation transport GO:0006812 81 0.025
positive regulation of catabolic process GO:0009896 4 0.025
nitrogen compound metabolic process GO:0006807 319 0.025
inorganic cation transmembrane transport GO:0098662 50 0.024
cell motility GO:0048870 244 0.024
positive regulation of cellular amine metabolic process GO:0033240 0 0.024
digestive tract morphogenesis GO:0048546 231 0.024
regulation of metabolic process GO:0019222 359 0.024
immune system process GO:0002376 241 0.024
ion transport GO:0006811 114 0.023
neuron projection development GO:0031175 180 0.023
gastrulation GO:0007369 208 0.023
regulation of cellular ketone metabolic process GO:0010565 7 0.023
response to carbohydrate GO:0009743 3 0.023
organic cyclic compound metabolic process GO:1901360 301 0.023
eye development GO:0001654 277 0.023
head development GO:0060322 303 0.023
Zebrafish
endocrine process GO:0050886 2 0.023
regulation of calcium ion transport GO:0051924 2 0.023
regulation of response to stimulus GO:0048583 269 0.023
regulation of multicellular organismal development GO:2000026 223 0.023
positive regulation of cellular catabolic process GO:0031331 3 0.023
transmembrane transport GO:0055085 120 0.023
regulation of biological quality GO:0065008 263 0.023
Zebrafish
negative regulation of sequence specific dna binding transcription factor activity GO:0043433 2 0.023
ion transmembrane transport GO:0034220 91 0.022
regulation of nitrogen compound metabolic process GO:0051171 251 0.022
positive regulation of cellular component biogenesis GO:0044089 3 0.022
protein metabolic process GO:0019538 183 0.022
regulation of protein transport GO:0051223 3 0.022
positive regulation of extrinsic apoptotic signaling pathway GO:2001238 1 0.022
membrane invagination GO:0010324 1 0.022
organonitrogen compound metabolic process GO:1901564 74 0.022
modification dependent protein catabolic process GO:0019941 3 0.022
cation transmembrane transport GO:0098655 65 0.022
skeletal system development GO:0001501 181 0.022
cell surface receptor signaling pathway GO:0007166 325 0.022
cellular response to external stimulus GO:0071496 2 0.022
phagocytosis engulfment GO:0006911 1 0.022
single organism metabolic process GO:0044710 217 0.022
single organism localization GO:1902578 225 0.022
regulation of peptidyl tyrosine phosphorylation GO:0050730 1 0.021
regulation of reproductive process GO:2000241 4 0.021
neurological system process GO:0050877 62 0.021
Zebrafish
neuron neuron synaptic transmission GO:0007270 1 0.021
metal ion transport GO:0030001 58 0.021
positive regulation of cell cycle GO:0045787 3 0.021
ubiquitin dependent protein catabolic process GO:0006511 3 0.021
proteasome mediated ubiquitin dependent protein catabolic process GO:0043161 2 0.020
brain development GO:0007420 293 0.020
Zebrafish
cellular amide metabolic process GO:0043603 4 0.020
extrinsic apoptotic signaling pathway GO:0097191 3 0.020
positive regulation of biological process GO:0048518 253 0.020
cellular ketone metabolic process GO:0042180 11 0.020
heterocycle metabolic process GO:0046483 290 0.020
gene expression GO:0010467 252 0.020
stem cell proliferation GO:0072089 4 0.020
regulation of synaptic plasticity GO:0048167 1 0.020
cell morphogenesis involved in neuron differentiation GO:0048667 163 0.020
negative regulation of biological process GO:0048519 304 0.020
regulation of extrinsic apoptotic signaling pathway GO:2001236 3 0.020
response to uv GO:0009411 3 0.019
regulation of signaling GO:0023051 235 0.019
synaptic growth at neuromuscular junction GO:0051124 2 0.019
regulation of cytoplasmic transport GO:1903649 4 0.019
regulation of programmed cell death GO:0043067 101 0.019
regulation of dendrite development GO:0050773 3 0.019
mitochondrion organization GO:0007005 4 0.019
sensory perception of chemical stimulus GO:0007606 3 0.019
regulation of reactive oxygen species metabolic process GO:2000377 2 0.019
negative regulation of protein kinase activity GO:0006469 4 0.019
proteasomal protein catabolic process GO:0010498 2 0.019
localization of cell GO:0051674 244 0.019
single fertilization GO:0007338 3 0.019
neuron projection morphogenesis GO:0048812 161 0.018
establishment of protein localization to organelle GO:0072594 4 0.018
modification dependent macromolecule catabolic process GO:0043632 3 0.018
rna metabolic process GO:0016070 219 0.018
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.018
nuclear transport GO:0051169 4 0.018
regulation of cell activation GO:0050865 1 0.018
cytokinesis GO:0000910 3 0.018
response to glucocorticoid GO:0051384 1 0.018
response to drug GO:0042493 3 0.018
cellular amino acid metabolic process GO:0006520 7 0.018
determination of bilateral symmetry GO:0009855 204 0.018
growth GO:0040007 174 0.018
response to wounding GO:0009611 116 0.018
fertilization GO:0009566 3 0.018
protein localization to nucleus GO:0034504 3 0.018
centrosome organization GO:0051297 1 0.018
peptide metabolic process GO:0006518 1 0.018
cellular aromatic compound metabolic process GO:0006725 295 0.017
positive regulation of cellular process GO:0048522 201 0.017
camera type eye development GO:0043010 222 0.017
response to corticosteroid GO:0031960 1 0.017
negative regulation of protein phosphorylation GO:0001933 4 0.017
system process GO:0003008 185 0.017
Zebrafish
single organism transport GO:0044765 206 0.017
regulation of cell death GO:0010941 103 0.017
immune system development GO:0002520 191 0.017
regulation of cellular metabolic process GO:0031323 320 0.017
regulation of synapse organization GO:0050807 3 0.017
determination of left right symmetry GO:0007368 179 0.017
embryonic skeletal system morphogenesis GO:0048704 93 0.017
skeletal system morphogenesis GO:0048705 102 0.017
regionalization GO:0003002 274 0.017
transport GO:0006810 220 0.017
carboxylic acid metabolic process GO:0019752 22 0.016
sensory perception of pain GO:0019233 1 0.016
regulation of gene expression GO:0010468 265 0.016
cellular response to extracellular stimulus GO:0031668 2 0.016
blood vessel morphogenesis GO:0048514 216 0.016
smooth muscle contraction GO:0006939 2 0.016
oxoacid metabolic process GO:0043436 31 0.016
specification of symmetry GO:0009799 204 0.016
multi organism process GO:0051704 134 0.016
leukocyte proliferation GO:0070661 1 0.016
response to monosaccharide GO:0034284 3 0.016
protein localization to plasma membrane GO:0072659 1 0.016
mechanosensory behavior GO:0007638 2 0.016
regulation of synapse assembly GO:0051963 3 0.016
regulation of signal transduction GO:0009966 225 0.016
muscle organ development GO:0007517 101 0.016
regulation of cell shape GO:0008360 1 0.016
cell substrate adhesion GO:0031589 4 0.016
regulation of primary metabolic process GO:0080090 311 0.016
muscle structure development GO:0061061 196 0.016
exocytosis GO:0006887 1 0.016
antimicrobial humoral response GO:0019730 2 0.016
regulation of cytokine production GO:0001817 3 0.016
organic substance biosynthetic process GO:1901576 289 0.016
regulation of dendrite morphogenesis GO:0048814 3 0.015
regulation of blood pressure GO:0008217 1 0.015
negative regulation of cellular process GO:0048523 283 0.015
positive regulation of cytokine production GO:0001819 2 0.015
protein targeting to nucleus GO:0044744 3 0.015
cellular protein metabolic process GO:0044267 129 0.015
neuromuscular synaptic transmission GO:0007274 2 0.015
positive regulation of immune effector process GO:0002699 3 0.015
protein secretion GO:0009306 1 0.015
stem cell maintenance GO:0019827 4 0.015
anterior posterior pattern specification GO:0009952 152 0.015
cellular component biogenesis GO:0044085 178 0.015
production of molecular mediator of immune response GO:0002440 2 0.015
homeostatic process GO:0042592 142 0.015
hemopoiesis GO:0030097 183 0.015
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.015
response to other organism GO:0051707 97 0.015
protein dephosphorylation GO:0006470 3 0.015
regulation of circadian rhythm GO:0042752 4 0.015
small molecule metabolic process GO:0044281 77 0.015
multicellular organismal response to stress GO:0033555 2 0.015
response to nutrient GO:0007584 3 0.015
regulation of purine nucleotide catabolic process GO:0033121 2 0.015
behavior GO:0007610 74 0.015
Zebrafish
regeneration GO:0031099 91 0.015
blood vessel development GO:0001568 246 0.015
cellular component assembly GO:0022607 170 0.015
transcription dna templated GO:0006351 181 0.015
meiotic cell cycle process GO:1903046 3 0.015
programmed cell death GO:0012501 119 0.015
phosphorus metabolic process GO:0006793 109 0.014
response to hexose GO:0009746 3 0.014
cellular biosynthetic process GO:0044249 286 0.014
b cell activation GO:0042113 2 0.014
regulation of protein complex assembly GO:0043254 3 0.014
liver development GO:0001889 96 0.014
regulation of autophagy GO:0010506 3 0.014
hormone secretion GO:0046879 2 0.014
adherens junction organization GO:0034332 4 0.014
regulation of developmental process GO:0050793 247 0.014
phototransduction GO:0007602 2 0.014
regulation of localization GO:0032879 104 0.014
embryonic cranial skeleton morphogenesis GO:0048701 90 0.014
epithelial tube morphogenesis GO:0060562 148 0.014
peptide transport GO:0015833 1 0.014
rna localization GO:0006403 4 0.014
regulation of neural precursor cell proliferation GO:2000177 3 0.014
positive regulation of peptidyl tyrosine phosphorylation GO:0050731 1 0.014
female gonad development GO:0008585 4 0.014
cellular response to chemical stimulus GO:0070887 157 0.014
embryonic heart tube development GO:0035050 133 0.014
carbohydrate homeostasis GO:0033500 1 0.014
regulation of tube size GO:0035150 2 0.014
nuclear import GO:0051170 3 0.014
positive regulation of cell activation GO:0050867 1 0.014
regulation of stem cell proliferation GO:0072091 2 0.014
taxis GO:0042330 109 0.014
regulation of ion transmembrane transporter activity GO:0032412 2 0.014
negative regulation of kinase activity GO:0033673 4 0.014
cellular nitrogen compound metabolic process GO:0034641 290 0.014
response to glucose GO:0009749 3 0.014
organic acid metabolic process GO:0006082 31 0.014
regulation of protein binding GO:0043393 3 0.014
development of primary female sexual characteristics GO:0046545 4 0.014
sensory organ morphogenesis GO:0090596 200 0.014
nucleobase containing compound biosynthetic process GO:0034654 205 0.014
biosynthetic process GO:0009058 294 0.014
meiotic nuclear division GO:0007126 4 0.014
glucose homeostasis GO:0042593 1 0.014
organic cyclic compound biosynthetic process GO:1901362 223 0.013
protein stabilization GO:0050821 2 0.013
neurotransmitter secretion GO:0007269 2 0.013
regulation of protein catabolic process GO:0042176 1 0.013
positive regulation of secretion GO:0051047 1 0.013
positive regulation of protein complex assembly GO:0031334 2 0.013
stem cell division GO:0017145 1 0.013
positive regulation of leukocyte differentiation GO:1902107 1 0.013
cellular response to nutrient levels GO:0031669 2 0.013
regulation of nucleoside metabolic process GO:0009118 2 0.013
protein modification process GO:0036211 100 0.013
hepaticobiliary system development GO:0061008 98 0.013
transcription from rna polymerase ii promoter GO:0006366 80 0.013
female sex differentiation GO:0046660 4 0.013
maternal determination of anterior posterior axis embryo GO:0008358 4 0.013
microtubule organizing center organization GO:0031023 1 0.013
heterocycle biosynthetic process GO:0018130 215 0.013
apoptotic process GO:0006915 116 0.013
carbohydrate biosynthetic process GO:0016051 1 0.013
macromolecule biosynthetic process GO:0009059 227 0.013
outflow tract morphogenesis GO:0003151 1 0.013
regulation of protein modification by small protein conjugation or removal GO:1903320 3 0.013
cellular protein modification process GO:0006464 100 0.013
neurotransmitter transport GO:0006836 2 0.013
regulation of sequestering of calcium ion GO:0051282 4 0.013
positive regulation of dna metabolic process GO:0051054 1 0.013
lymphocyte proliferation GO:0046651 1 0.013
phosphate containing compound metabolic process GO:0006796 108 0.013
hematopoietic or lymphoid organ development GO:0048534 191 0.013
regulation of jak stat cascade GO:0046425 3 0.013
nucleocytoplasmic transport GO:0006913 4 0.013
cell death GO:0008219 121 0.013
hormone transport GO:0009914 2 0.013
cellular nitrogen compound biosynthetic process GO:0044271 218 0.013
erk1 and erk2 cascade GO:0070371 4 0.013
negative regulation of catabolic process GO:0009895 3 0.013
peptidyl serine modification GO:0018209 2 0.013
nuclear migration GO:0007097 3 0.013
positive regulation of nucleoside metabolic process GO:0045979 1 0.013
positive regulation of apoptotic signaling pathway GO:2001235 1 0.013
death GO:0016265 121 0.013
sequestering of calcium ion GO:0051208 3 0.013
regulation of apoptotic process GO:0042981 98 0.012
negative regulation of map kinase activity GO:0043407 2 0.012
nucleic acid metabolic process GO:0090304 244 0.012
chemotaxis GO:0006935 104 0.012
organism emergence from protective structure GO:0071684 4 0.012
compound eye development GO:0048749 2 0.012
eye morphogenesis GO:0048592 144 0.012
cellular response to starvation GO:0009267 1 0.012
regulation of inflammatory response GO:0050727 2 0.012
wound healing GO:0042060 90 0.012
lipid storage GO:0019915 1 0.012
macromolecule modification GO:0043412 111 0.012
regulation of cellular biosynthetic process GO:0031326 245 0.012
embryo development ending in birth or egg hatching GO:0009792 271 0.012
response to biotic stimulus GO:0009607 97 0.012
regulation of protein ubiquitination GO:0031396 3 0.012
regulation of synaptic growth at neuromuscular junction GO:0008582 1 0.012
regulation of cell projection assembly GO:0060491 4 0.012
protein import GO:0017038 3 0.012
developmental growth involved in morphogenesis GO:0060560 86 0.012
golgi vesicle transport GO:0048193 3 0.012
peptidyl threonine phosphorylation GO:0018107 1 0.012
neuron projection guidance GO:0097485 86 0.012
regulation of erk1 and erk2 cascade GO:0070372 4 0.012
peptidyl threonine modification GO:0018210 1 0.012
angiogenesis GO:0001525 158 0.012
positive regulation of cytoskeleton organization GO:0051495 3 0.012
endosomal transport GO:0016197 2 0.012
positive regulation of gtpase activity GO:0043547 1 0.012
response to alkaloid GO:0043279 2 0.012
regulation of proteolysis involved in cellular protein catabolic process GO:1903050 1 0.012
nucleic acid templated transcription GO:0097659 181 0.012
regulation of blood vessel size GO:0050880 2 0.012
protein import into nucleus GO:0006606 3 0.012
somite development GO:0061053 96 0.012
response to external biotic stimulus GO:0043207 97 0.012
calcium ion transport into cytosol GO:0060402 3 0.011
intracellular signal transduction GO:0035556 85 0.011
protein heterooligomerization GO:0051291 1 0.011
neuroblast proliferation GO:0007405 2 0.011
regulation of cell differentiation GO:0045595 142 0.011
retina development in camera type eye GO:0060041 146 0.011
convergent extension GO:0060026 118 0.011
mononuclear cell proliferation GO:0032943 1 0.011
embryonic heart tube morphogenesis GO:0003143 108 0.011
gland development GO:0048732 143 0.011
positive regulation of map kinase activity GO:0043406 3 0.011
mitochondrial transport GO:0006839 2 0.011
olfactory lobe development GO:0021988 4 0.011
spermatid differentiation GO:0048515 2 0.011
germ line stem cell maintenance GO:0030718 2 0.011
lateral inhibition GO:0046331 1 0.011
central nervous system neuron differentiation GO:0021953 74 0.011
cellular component disassembly GO:0022411 1 0.011
water homeostasis GO:0030104 4 0.011
nucleobase containing compound metabolic process GO:0006139 274 0.011
energy reserve metabolic process GO:0006112 2 0.011
regulation of microtubule cytoskeleton organization GO:0070507 3 0.011
negative regulation of protein transport GO:0051224 3 0.011
regulation of protein targeting GO:1903533 2 0.011
regulation of gtp catabolic process GO:0033124 2 0.011
protein polymerization GO:0051258 4 0.011
oocyte anterior posterior axis specification GO:0007314 4 0.011
aromatic compound biosynthetic process GO:0019438 217 0.011
intracellular mrna localization GO:0008298 1 0.011
adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains GO:0002460 4 0.011
regulation of nucleocytoplasmic transport GO:0046822 2 0.011
striated muscle tissue development GO:0014706 110 0.011
convergent extension involved in gastrulation GO:0060027 71 0.011
axon guidance GO:0007411 86 0.011
mitotic cell cycle embryonic GO:0045448 2 0.011
regulation of production of molecular mediator of immune response GO:0002700 1 0.011
regulation of protein localization to nucleus GO:1900180 2 0.011
cell matrix adhesion GO:0007160 4 0.011
cellular response to organic substance GO:0071310 105 0.011
regulation of protein polymerization GO:0032271 2 0.011
organelle fusion GO:0048284 3 0.011
cellular macromolecule biosynthetic process GO:0034645 224 0.011
positive regulation of secretion by cell GO:1903532 1 0.011
tissue remodeling GO:0048771 4 0.011
actin polymerization or depolymerization GO:0008154 2 0.011
positive regulation of cell adhesion GO:0045785 1 0.011
regulation of endocrine process GO:0044060 2 0.011
regulation of neuron differentiation GO:0045664 56 0.011
cilium organization GO:0044782 71 0.011
negative regulation of cytoplasmic transport GO:1903650 2 0.011
secondary metabolic process GO:0019748 3 0.011
negative regulation of multicellular organismal process GO:0051241 69 0.011
segmentation GO:0035282 97 0.011
regulation of gtpase activity GO:0043087 2 0.010
cellular response to molecule of bacterial origin GO:0071219 3 0.010
regulation of nucleotide catabolic process GO:0030811 2 0.010
regulation of protein import into nucleus GO:0042306 2 0.010
positive regulation of purine nucleotide catabolic process GO:0033123 1 0.010
forebrain development GO:0030900 96 0.010
regulation of response to biotic stimulus GO:0002831 2 0.010
thermosensory behavior GO:0040040 1 0.010
cytosolic calcium ion transport GO:0060401 3 0.010
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.010
cytoplasm organization GO:0007028 4 0.010
sequestering of metal ion GO:0051238 3 0.010
positive regulation of cell killing GO:0031343 2 0.010
cellular response to reactive oxygen species GO:0034614 2 0.010
interspecies interaction between organisms GO:0044419 4 0.010
single organism organelle organization GO:1902589 199 0.010
ameboidal type cell migration GO:0001667 143 0.010
dicarboxylic acid transport GO:0006835 1 0.010
negative regulation of defense response GO:0031348 2 0.010
positive regulation of nucleotide catabolic process GO:0030813 1 0.010
negative regulation of mapk cascade GO:0043409 4 0.010
negative regulation of nucleocytoplasmic transport GO:0046823 2 0.010
developmental cell growth GO:0048588 52 0.010
lateral line system development GO:0048925 76 0.010
regulation of systemic arterial blood pressure GO:0003073 1 0.010
tyrosine phosphorylation of stat protein GO:0007260 1 0.010
symbiosis encompassing mutualism through parasitism GO:0044403 4 0.010
regulation of mrna processing GO:0050684 3 0.010

lgi2b disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.029
immune system disease DOID:2914 0 0.020
nervous system disease DOID:863 0 0.015
disease of metabolism DOID:0014667 0 0.013
musculoskeletal system disease DOID:17 0 0.013
cancer DOID:162 0 0.013
disease of cellular proliferation DOID:14566 0 0.013
cardiovascular system disease DOID:1287 0 0.012
organ system cancer DOID:0050686 0 0.010