Danio rerio

105 known processes

esr1

estrogen receptor 1

(Aliases: zfER[a],eralpha,NR3A1,ESR,ER[a])

esr1 biological process predictions


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Biological process GO term ID Process size Probability Func Analog Org
cellular response to estrogen stimulus GO:0071391 24 0.914
cellular aromatic compound metabolic process GO:0006725 295 0.843
negative regulation of feeding behavior GO:2000252 2 0.772
regulation of reactive oxygen species metabolic process GO:2000377 2 0.764
intracellular estrogen receptor signaling pathway GO:0030520 3 0.745
positive regulation of erk1 and erk2 cascade GO:0070374 2 0.650
Rat
response to ketone GO:1901654 1 0.636
positive regulation of gene expression GO:0010628 71 0.613
Human Mouse
regulation of biological quality GO:0065008 263 0.574
Mouse Rat
biosynthetic process GO:0009058 294 0.567
response to lipid GO:0033993 60 0.563
macromolecule biosynthetic process GO:0009059 227 0.552
cellular response to estradiol stimulus GO:0071392 1 0.551
Rat
cellular response to steroid hormone stimulus GO:0071383 31 0.540
enzyme linked receptor protein signaling pathway GO:0007167 106 0.526
Rat
organic cyclic compound metabolic process GO:1901360 301 0.523
heterocycle biosynthetic process GO:0018130 215 0.513
regulation of rna biosynthetic process GO:2001141 213 0.510
posterior lateral line development GO:0048916 38 0.508
maintenance of location GO:0051235 4 0.504
response to organic substance GO:0010033 153 0.485
nucleic acid metabolic process GO:0090304 244 0.484
transcription dna templated GO:0006351 181 0.482
cellular response to drug GO:0035690 1 0.468
regulation of transcription dna templated GO:0006355 213 0.462
defense response GO:0006952 47 0.451
primary amino compound metabolic process GO:1901160 1 0.441
response to stress GO:0006950 263 0.440
heterocycle metabolic process GO:0046483 290 0.436
regulation of biosynthetic process GO:0009889 250 0.436
regulation of nucleic acid templated transcription GO:1903506 213 0.425
cellular response to endogenous stimulus GO:0071495 68 0.420
regulation of macromolecule biosynthetic process GO:0010556 225 0.413
female sex differentiation GO:0046660 4 0.397
Mouse
nucleobase containing compound metabolic process GO:0006139 274 0.393
response to endogenous stimulus GO:0009719 83 0.393
regulation of primary metabolic process GO:0080090 311 0.392
positive regulation of rna metabolic process GO:0051254 59 0.384
Human Mouse
nucleobase containing compound biosynthetic process GO:0034654 205 0.381
response to dexamethasone GO:0071548 1 0.380
nitrogen compound metabolic process GO:0006807 319 0.373
positive regulation of cellular biosynthetic process GO:0031328 68 0.363
Human Mouse
circadian sleep wake cycle process GO:0022410 2 0.363
regulation of nucleobase containing compound metabolic process GO:0019219 250 0.359
aromatic compound biosynthetic process GO:0019438 217 0.356
organic cyclic compound biosynthetic process GO:1901362 223 0.348
negative regulation of cellular metabolic process GO:0031324 77 0.341
Rat
regulation of epithelial cell proliferation GO:0050678 3 0.325
organic substance biosynthetic process GO:1901576 289 0.317
ovulation cycle GO:0042698 2 0.307
Mouse
hindbrain development GO:0030902 91 0.305
female gonad development GO:0008585 4 0.304
Mouse
cellular response to lipid GO:0071396 39 0.294
cellular response to organic substance GO:0071310 105 0.290
head development GO:0060322 303 0.279
erk1 and erk2 cascade GO:0070371 4 0.276
Rat
cellular nitrogen compound metabolic process GO:0034641 290 0.270
regulation of cellular metabolic process GO:0031323 320 0.270
regulation of nitrogen compound metabolic process GO:0051171 251 0.269
positive regulation of transcription dna templated GO:0045893 57 0.269
Human Mouse
single organism metabolic process GO:0044710 217 0.267
Human Mouse Rat
positive regulation of rna biosynthetic process GO:1902680 57 0.260
Human Mouse
regulation of transmission of nerve impulse GO:0051969 1 0.258
positive regulation of camp biosynthetic process GO:0030819 2 0.244
response to steroid hormone GO:0048545 35 0.242
circadian sleep wake cycle sleep GO:0050802 1 0.239
intracellular receptor signaling pathway GO:0030522 30 0.239
response to estradiol GO:0032355 6 0.237
regulation of signaling GO:0023051 235 0.233
Human Rat
regulation of cellular macromolecule biosynthetic process GO:2000112 222 0.232
apoptotic process GO:0006915 116 0.229
Mouse Rat
response to glucocorticoid GO:0051384 1 0.226
ovulation cycle process GO:0022602 2 0.224
Mouse
intracellular signal transduction GO:0035556 85 0.221
Human Rat
cellular nitrogen compound biosynthetic process GO:0044271 218 0.218
response to estrogen GO:0043627 27 0.217
posterior lateral line neuromast primordium migration GO:0048920 12 0.212
negative regulation of cellular process GO:0048523 283 0.208
Human Rat
regulation of metabolic process GO:0019222 359 0.206
gland development GO:0048732 143 0.206
Mouse
cognition GO:0050890 1 0.202
rna biosynthetic process GO:0032774 181 0.202
lipid metabolic process GO:0006629 52 0.199
Mouse Rat
negative regulation of biosynthetic process GO:0009890 55 0.195
positive regulation of cell communication GO:0010647 56 0.195
Human Rat
cell surface receptor signaling pathway GO:0007166 325 0.193
Rat
response to hormone GO:0009725 48 0.186
nucleic acid templated transcription GO:0097659 181 0.186
cellular macromolecule metabolic process GO:0044260 391 0.184
regulation of protein complex assembly GO:0043254 3 0.184
circadian sleep wake cycle GO:0042745 2 0.180
hindbrain morphogenesis GO:0021575 22 0.180
regulation of erk1 and erk2 cascade GO:0070372 4 0.179
Rat
regulation of behavior GO:0050795 24 0.178
regulation of cell communication GO:0010646 232 0.177
Human Rat
positive regulation of biological process GO:0048518 253 0.176
Human Mouse Rat
response to corticosteroid GO:0031960 1 0.176
adrenal gland development GO:0030325 10 0.170
regulation of neurological system process GO:0031644 2 0.168
response to oxygen containing compound GO:1901700 55 0.164
otolith formation GO:0032475 2 0.162
Zebrafish
programmed cell death GO:0012501 119 0.161
Mouse Rat
cell migration GO:0016477 237 0.160
cell death GO:0008219 121 0.159
Mouse Rat
development of primary female sexual characteristics GO:0046545 4 0.158
Mouse
glucose homeostasis GO:0042593 1 0.157
locomotion GO:0040011 313 0.156
positive regulation of programmed cell death GO:0043068 29 0.155
negative regulation of gene expression GO:0010629 65 0.153
Human
cellular biosynthetic process GO:0044249 286 0.151
regulation of response to stimulus GO:0048583 269 0.149
Human Rat
serotonin metabolic process GO:0042428 1 0.145
response to xenobiotic stimulus GO:0009410 45 0.141
hormone transport GO:0009914 2 0.140
regulation of molecular function GO:0065009 70 0.137
Human Rat
cellular response to hormone stimulus GO:0032870 39 0.136
positive regulation of nucleic acid templated transcription GO:1903508 57 0.135
Human Mouse
ovarian follicle development GO:0001541 2 0.134
Mouse
response to external stimulus GO:0009605 264 0.134
response to alkaloid GO:0043279 2 0.133
steroid hormone mediated signaling pathway GO:0043401 9 0.130
negative regulation of epithelial cell proliferation GO:0050680 1 0.127
multicellular organismal response to stress GO:0033555 2 0.126
nuclear transport GO:0051169 4 0.126
positive regulation of nitrogen compound metabolic process GO:0051173 69 0.125
Human Mouse
response to drug GO:0042493 3 0.123
energy reserve metabolic process GO:0006112 2 0.122
mechanosensory lateral line system development GO:0048881 49 0.122
hemopoiesis GO:0030097 183 0.122
cellular macromolecule biosynthetic process GO:0034645 224 0.119
primary amino compound biosynthetic process GO:1901162 1 0.119
negative regulation of biological process GO:0048519 304 0.118
Human Rat
positive regulation of muscle cell differentiation GO:0051149 1 0.116
localization of cell GO:0051674 244 0.114
positive regulation of macromolecule biosynthetic process GO:0010557 59 0.112
Human Mouse
negative regulation of rna metabolic process GO:0051253 48 0.112
nucleocytoplasmic transport GO:0006913 4 0.112
signal transduction GO:0007165 455 0.110
diencephalon development GO:0021536 58 0.109
response to monosaccharide GO:0034284 3 0.108
homeostatic process GO:0042592 142 0.108
Rat
ventral spinal cord development GO:0021517 35 0.107
regulation of protein targeting GO:1903533 2 0.105
regulation of intracellular protein transport GO:0033157 3 0.105
regulation of programmed cell death GO:0043067 101 0.104
Mouse Rat
brain development GO:0007420 293 0.104
response to acid chemical GO:0001101 17 0.103
regulation of cell death GO:0010941 103 0.101
Mouse Rat
response to carbohydrate GO:0009743 3 0.101
positive regulation of nucleobase containing compound metabolic process GO:0045935 69 0.100
Human Mouse
regulation of protein import into nucleus GO:0042306 2 0.099
larval development GO:0002164 2 0.098
establishment of localization in cell GO:0051649 77 0.097
sensory system development GO:0048880 76 0.096
aging GO:0007568 2 0.096
regulation of circadian sleep wake cycle sleep GO:0045187 1 0.094
lipid storage GO:0019915 1 0.091
cell motility GO:0048870 244 0.090
peptide transport GO:0015833 1 0.090
cellular response to chemical stimulus GO:0070887 157 0.090
organic acid metabolic process GO:0006082 31 0.088
negative regulation of nucleobase containing compound metabolic process GO:0045934 59 0.087
response to organic cyclic compound GO:0014070 51 0.087
response to inorganic substance GO:0010035 38 0.086
otolith morphogenesis GO:0032474 8 0.085
Zebrafish
viral process GO:0016032 1 0.085
catechol containing compound biosynthetic process GO:0009713 2 0.084
regulation of apoptotic process GO:0042981 98 0.083
Mouse Rat
regulation of hormone secretion GO:0046883 2 0.081
positive regulation of cellular component biogenesis GO:0044089 3 0.080
regulation of multicellular organism growth GO:0040014 4 0.076
stem cell proliferation GO:0072089 4 0.076
phosphorus metabolic process GO:0006793 109 0.075
Rat
negative regulation of macromolecule metabolic process GO:0010605 76 0.075
Human
negative regulation of cellular macromolecule biosynthetic process GO:2000113 48 0.074
oxidation reduction process GO:0055114 41 0.072
Human
cellular response to organic cyclic compound GO:0071407 38 0.071
fatty acid transport GO:0015908 1 0.071
somitogenesis GO:0001756 87 0.070
positive regulation of cellular metabolic process GO:0031325 94 0.070
Human Mouse Rat
positive regulation of macromolecule metabolic process GO:0010604 93 0.069
Human Mouse
ear development GO:0043583 127 0.069
Zebrafish
phosphate containing compound metabolic process GO:0006796 108 0.069
Rat
neuroblast proliferation GO:0007405 2 0.069
ameboidal type cell migration GO:0001667 143 0.068
Zebrafish
protein localization to nucleus GO:0034504 3 0.068
blood vessel morphogenesis GO:0048514 216 0.068
response to alcohol GO:0097305 14 0.068
urogenital system development GO:0001655 97 0.068
Mouse
phospholipase c activating g protein coupled receptor signaling pathway GO:0007200 2 0.067
Rat
death GO:0016265 121 0.067
Mouse Rat
sensory perception of smell GO:0007608 2 0.066
otolith development GO:0048840 32 0.066
Zebrafish
rna metabolic process GO:0016070 219 0.065
positive regulation of signal transduction GO:0009967 56 0.065
Human Rat
endocrine system development GO:0035270 65 0.065
rhombomere 5 development GO:0021571 4 0.065
organonitrogen compound biosynthetic process GO:1901566 47 0.065
central nervous system development GO:0007417 387 0.064
regulation of circadian sleep wake cycle GO:0042749 1 0.063
multicellular organism growth GO:0035264 4 0.063
regulation of cellular biosynthetic process GO:0031326 245 0.063
response to chemical GO:0042221 320 0.062
regulation of nucleocytoplasmic transport GO:0046822 2 0.062
immune system development GO:0002520 191 0.062
regulation of signal transduction GO:0009966 225 0.061
Human Rat
regulation of camp metabolic process GO:0030814 9 0.061
positive regulation of metabolic process GO:0009893 108 0.060
Human Mouse Rat
negative regulation of cell death GO:0060548 60 0.059
Rat
hematopoietic or lymphoid organ development GO:0048534 191 0.059
secondary metabolic process GO:0019748 3 0.058
metencephalon development GO:0022037 27 0.058
negative regulation of kinase activity GO:0033673 4 0.057
hormone mediated signaling pathway GO:0009755 9 0.057
reactive oxygen species metabolic process GO:0072593 6 0.057
regulation of protein transport GO:0051223 3 0.057
hair cell differentiation GO:0035315 32 0.056
tissue remodeling GO:0048771 4 0.056
positive regulation of lipid metabolic process GO:0045834 1 0.056
negative regulation of cell proliferation GO:0008285 8 0.055
Rat
neuron death GO:0070997 21 0.054
Rat
positive regulation of transcription from rna polymerase ii promoter GO:0045944 22 0.054
Human Mouse
positive regulation of secretion by cell GO:1903532 1 0.053
androgen metabolic process GO:0008209 2 0.053
Mouse
response to transition metal nanoparticle GO:1990267 28 0.053
regulation of cytokine production GO:0001817 3 0.053
regulation of circadian rhythm GO:0042752 4 0.053
cellular component biogenesis GO:0044085 178 0.053
posterior lateral line system development GO:0048915 46 0.053
positive regulation of purine nucleotide biosynthetic process GO:1900373 8 0.053
negative regulation of macromolecule biosynthetic process GO:0010558 48 0.052
regulation of macromolecule metabolic process GO:0060255 317 0.052
system process GO:0003008 185 0.052
cyclic nucleotide biosynthetic process GO:0009190 18 0.052
dna templated transcription initiation GO:0006352 1 0.052
glucose import GO:0046323 2 0.051
Rat
protein targeting to nucleus GO:0044744 3 0.051
anterior posterior pattern specification GO:0009952 152 0.051
regulation of phosphorus metabolic process GO:0051174 43 0.050
Rat
carboxylic acid metabolic process GO:0019752 22 0.050
regulation of stem cell proliferation GO:0072091 2 0.050
cellular localization GO:0051641 97 0.049
neuromast primordium migration GO:0048883 12 0.049
embryonic organ morphogenesis GO:0048562 274 0.048
Zebrafish
multicellular organismal water homeostasis GO:0050891 1 0.048
multicellular organism reproduction GO:0032504 35 0.047
Mouse Rat
organophosphate biosynthetic process GO:0090407 23 0.046
toxin metabolic process GO:0009404 1 0.046
reproductive process GO:0022414 40 0.046
Mouse Rat
positive regulation of cell death GO:0010942 29 0.046
regulation of gene expression GO:0010468 265 0.046
regulation of establishment of protein localization GO:0070201 4 0.046
dopamine metabolic process GO:0042417 2 0.045
regulation of blood circulation GO:1903522 32 0.045
reactive nitrogen species metabolic process GO:2001057 0 0.045
long chain fatty acid metabolic process GO:0001676 1 0.045
regulation of cell migration GO:0030334 40 0.045
rhythmic process GO:0048511 21 0.045
Mouse
amine metabolic process GO:0009308 2 0.045
cellular lipid metabolic process GO:0044255 36 0.045
Rat
single organism nuclear import GO:1902593 3 0.045
monocarboxylic acid biosynthetic process GO:0072330 12 0.045
multi organism cellular process GO:0044764 2 0.044
regulation of cell projection assembly GO:0060491 4 0.044
negative regulation of protein complex assembly GO:0031333 1 0.044
regulation of organ growth GO:0046620 3 0.043
positive regulation of signaling GO:0023056 56 0.043
Human Rat
negative regulation of nitrogen compound metabolic process GO:0051172 59 0.042
regulation of protein localization to nucleus GO:1900180 2 0.042
cell projection organization GO:0030030 284 0.042
multicellular organismal homeostasis GO:0048871 29 0.042
regulation of locomotion GO:0040012 55 0.042
positive regulation of blood circulation GO:1903524 2 0.041
cellular ketone metabolic process GO:0042180 11 0.041
positive regulation of stress activated mapk cascade GO:0032874 3 0.041
positive regulation of cytosolic calcium ion concentration GO:0007204 4 0.041
Rat
negative regulation of dna metabolic process GO:0051053 4 0.041
cellular component morphogenesis GO:0032989 336 0.041
regulation of cytoplasmic transport GO:1903649 4 0.041
intracellular steroid hormone receptor signaling pathway GO:0030518 5 0.041
cell part morphogenesis GO:0032990 246 0.040
positive regulation of cytokine production GO:0001819 2 0.040
positive regulation of transport GO:0051050 2 0.040
ph reduction GO:0045851 1 0.040
indole containing compound metabolic process GO:0042430 2 0.040
cellular response to oxygen levels GO:0071453 1 0.040
meiotic nuclear division GO:0007126 4 0.040
determination of bilateral symmetry GO:0009855 204 0.039
catecholamine metabolic process GO:0006584 2 0.039
cellular component movement GO:0006928 335 0.039
cellular amine metabolic process GO:0044106 2 0.039
response to other organism GO:0051707 97 0.038
lateral line system development GO:0048925 76 0.038
cell projection morphogenesis GO:0048858 244 0.038
positive regulation of camp metabolic process GO:0030816 2 0.038
developmental growth GO:0048589 166 0.038
Mouse
fatty acid biosynthetic process GO:0006633 4 0.038
negative regulation of metabolic process GO:0009892 86 0.038
Human Rat
mapk cascade GO:0000165 18 0.038
Rat
positive regulation of secretion GO:0051047 1 0.037
regulation of multicellular organismal process GO:0051239 277 0.037
Mouse
response to wounding GO:0009611 116 0.037
monoamine transport GO:0015844 1 0.037
negative regulation of cell communication GO:0010648 96 0.037
Human
transcription from rna polymerase ii promoter GO:0006366 80 0.037
neuron development GO:0048666 262 0.036
behavior GO:0007610 74 0.036
negative regulation of protein phosphorylation GO:0001933 4 0.035
actin filament bundle organization GO:0061572 6 0.035
regulation of heart growth GO:0060420 2 0.035
epithelial cell differentiation GO:0030855 116 0.034
Mouse Rat
hypothalamus development GO:0021854 14 0.034
organonitrogen compound metabolic process GO:1901564 74 0.034
morphogenesis of an epithelium GO:0002009 333 0.034
Mouse
response to hexose GO:0009746 3 0.034
blood vessel development GO:0001568 246 0.034
response to glucose GO:0009749 3 0.033
carboxylic acid biosynthetic process GO:0046394 12 0.033
negative regulation of transcription dna templated GO:0045892 45 0.033
positive regulation of apoptotic process GO:0043065 29 0.033
catechol containing compound metabolic process GO:0009712 2 0.033
transmembrane receptor protein tyrosine kinase signaling pathway GO:0007169 42 0.033
Rat
otic vesicle development GO:0071599 42 0.033
Zebrafish
response to immobilization stress GO:0035902 1 0.033
phenol containing compound metabolic process GO:0018958 5 0.033
atrioventricular valve formation GO:0003190 3 0.032
positive regulation of response to stimulus GO:0048584 80 0.032
Human Rat
nucleotide biosynthetic process GO:0009165 21 0.032
cellular biogenic amine metabolic process GO:0006576 2 0.032
immune system process GO:0002376 241 0.031
negative regulation of cytoplasmic transport GO:1903650 2 0.031
regulation of neuron apoptotic process GO:0043523 17 0.031
Rat
extrinsic apoptotic signaling pathway GO:0097191 3 0.031
protein import GO:0017038 3 0.031
purine ribonucleotide biosynthetic process GO:0009152 20 0.030
hormone secretion GO:0046879 2 0.030
regulation of cellular component movement GO:0051270 55 0.030
establishment of protein localization to organelle GO:0072594 4 0.030
positive regulation of cell division GO:0051781 2 0.030
positive regulation of cyclic nucleotide biosynthetic process GO:0030804 8 0.030
regulation of symbiosis encompassing mutualism through parasitism GO:0043903 1 0.030
angiogenesis GO:0001525 158 0.030
cell proliferation GO:0008283 80 0.029
Mouse Rat
negative regulation of response to stimulus GO:0048585 104 0.029
Human
regulation of intracellular ph GO:0051453 1 0.029
epithelial cell development GO:0002064 42 0.029
Mouse Rat
regulation of rna metabolic process GO:0051252 224 0.029
epithelial cell proliferation GO:0050673 17 0.029
Mouse Rat
catecholamine biosynthetic process GO:0042423 2 0.029
cellular response to hypoxia GO:0071456 1 0.029
oxoacid metabolic process GO:0043436 31 0.029
protein import into nucleus GO:0006606 3 0.029
nuclear import GO:0051170 3 0.029
transmission of nerve impulse GO:0019226 19 0.029
organic substance transport GO:0071702 58 0.029
Rat
cellular response to biotic stimulus GO:0071216 3 0.028
regulation of tissue remodeling GO:0034103 2 0.028
central nervous system neuron differentiation GO:0021953 74 0.028
small molecule metabolic process GO:0044281 77 0.028
neuron projection development GO:0031175 180 0.028
somite development GO:0061053 96 0.028
er nucleus signaling pathway GO:0006984 2 0.028
response to bacterium GO:0009617 58 0.028
positive regulation of epithelial cell proliferation GO:0050679 1 0.028
zymogen activation GO:0031638 3 0.028
cell differentiation in spinal cord GO:0021515 40 0.028
cellular response to decreased oxygen levels GO:0036294 1 0.028
regulation of response to extracellular stimulus GO:0032104 1 0.028
regulation of blood vessel size GO:0050880 2 0.027
cellular carbohydrate metabolic process GO:0044262 4 0.027
digestive tract morphogenesis GO:0048546 231 0.027
Zebrafish
regulation of intracellular signal transduction GO:1902531 57 0.027
Human Rat
transmembrane receptor protein serine threonine kinase signaling pathway GO:0007178 68 0.026
negative regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090101 22 0.026
regulation of cellular ph GO:0030641 1 0.026
regulation of localization GO:0032879 104 0.026
Rat
regulation of developmental process GO:0050793 247 0.026
Mouse
negative regulation of innate immune response GO:0045824 2 0.026
carbohydrate derivative biosynthetic process GO:1901137 43 0.025
bone remodeling GO:0046849 2 0.025
lipid catabolic process GO:0016042 4 0.025
regulation of growth GO:0040008 42 0.025
growth GO:0040007 174 0.025
Mouse
interspecies interaction between organisms GO:0044419 4 0.025
segmentation GO:0035282 97 0.025
negative regulation of hormone secretion GO:0046888 2 0.025
spinal cord motor neuron differentiation GO:0021522 26 0.025
negative regulation of behavior GO:0048521 6 0.025
photoreceptor cell differentiation GO:0046530 55 0.025
positive regulation of cell cycle GO:0045787 3 0.025
erythrocyte differentiation GO:0030218 54 0.025
chemosensory behavior GO:0007635 1 0.025
negative regulation of transcription from rna polymerase ii promoter GO:0000122 16 0.025
lipid homeostasis GO:0055088 3 0.025
regulation of cyclic nucleotide biosynthetic process GO:0030802 15 0.024
regulation of transcription from rna polymerase ii promoter GO:0006357 114 0.024
pyruvate metabolic process GO:0006090 1 0.024
sensory organ morphogenesis GO:0090596 200 0.024
Zebrafish
positive regulation of striated muscle cell differentiation GO:0051155 1 0.024
apoptotic signaling pathway GO:0097190 23 0.023
connective tissue development GO:0061448 99 0.023
positive regulation of multicellular organismal process GO:0051240 52 0.023
negative regulation of protein transport GO:0051224 3 0.023
regulation of dna replication GO:0006275 3 0.023
purine containing compound biosynthetic process GO:0072522 20 0.023
lateral line development GO:0048882 66 0.023
organic anion transport GO:0015711 15 0.023
vasculature development GO:0001944 278 0.023
phenol containing compound biosynthetic process GO:0046189 4 0.023
negative regulation of cellular biosynthetic process GO:0031327 55 0.023
regulation of system process GO:0044057 40 0.022
positive regulation of cellular process GO:0048522 201 0.022
Human Mouse Rat
periodic partitioning GO:0007365 1 0.022
regulation of protein kinase b signaling GO:0051896 8 0.022
positive regulation of intracellular signal transduction GO:1902533 15 0.022
Rat
regulation of blood pressure GO:0008217 1 0.022
regulation of feeding behavior GO:0060259 5 0.022
multi organism reproductive process GO:0044703 36 0.022
Mouse Rat
pigmentation GO:0043473 85 0.022
organic hydroxy compound biosynthetic process GO:1901617 6 0.022
phagocytosis GO:0006909 3 0.022
organelle organization GO:0006996 227 0.022
muscle system process GO:0003012 20 0.022
pancreas development GO:0031016 84 0.022
regulation of cellular ketone metabolic process GO:0010565 7 0.021
nitric oxide biosynthetic process GO:0006809 2 0.021
Human
dicarboxylic acid transport GO:0006835 1 0.021
response to nicotine GO:0035094 2 0.021
single organism localization GO:1902578 225 0.021
Rat
carbohydrate metabolic process GO:0005975 12 0.021
Fly
positive regulation of catabolic process GO:0009896 4 0.021
carbohydrate homeostasis GO:0033500 1 0.021
negative regulation of apoptotic process GO:0043066 55 0.021
thermosensory behavior GO:0040040 1 0.021
regulation of cellular ph reduction GO:0032847 1 0.021
regulation of metal ion transport GO:0010959 4 0.021
multicellular organismal signaling GO:0035637 22 0.021
cellular protein complex disassembly GO:0043624 1 0.021
cellular response to oxygen containing compound GO:1901701 20 0.020
Rat
gland morphogenesis GO:0022612 13 0.020
Mouse
regulation of neurogenesis GO:0050767 87 0.020
heart valve formation GO:0003188 4 0.020
small molecule biosynthetic process GO:0044283 16 0.020
neural retina development GO:0003407 49 0.020
single organism carbohydrate metabolic process GO:0044723 12 0.020
neurological system process GO:0050877 62 0.020
regulation of lipid catabolic process GO:0050994 2 0.020
regulation of transmembrane receptor protein serine threonine kinase signaling pathway GO:0090092 50 0.020
axonal defasciculation GO:0007414 2 0.020
negative regulation of secretion GO:0051048 2 0.020
positive regulation of protein kinase b signaling GO:0051897 1 0.020
skeletal system development GO:0001501 181 0.019
Rat
positive regulation of locomotion GO:0040017 14 0.019
cellular response to growth factor stimulus GO:0071363 39 0.019
response to growth factor GO:0070848 39 0.019
single organism biosynthetic process GO:0044711 71 0.019
mitochondrion organization GO:0007005 4 0.019
calcium ion homeostasis GO:0055074 19 0.019
Rat
cellular component disassembly GO:0022411 1 0.019
regulation of carbohydrate metabolic process GO:0006109 4 0.019
developmental maturation GO:0021700 34 0.019
positive regulation of stress activated protein kinase signaling cascade GO:0070304 3 0.019
response to nutrient GO:0007584 3 0.018
signal transduction by phosphorylation GO:0023014 18 0.018
Rat
cytosolic calcium ion transport GO:0060401 3 0.018
regulation of developmental growth GO:0048638 38 0.018
limbic system development GO:0021761 16 0.018
negative regulation of rna biosynthetic process GO:1902679 45 0.018
long chain fatty acid transport GO:0015909 1 0.018
peptidyl serine modification GO:0018209 2 0.018
neuron apoptotic process GO:0051402 20 0.018
Rat
positive regulation of cell adhesion GO:0045785 1 0.018
dopamine biosynthetic process GO:0042416 2 0.018
regulation of fatty acid metabolic process GO:0019217 1 0.018
nucleoside phosphate biosynthetic process GO:1901293 21 0.017
regulation of cellular protein metabolic process GO:0032268 52 0.017
calcium ion import GO:0070509 4 0.017
blood circulation GO:0008015 87 0.017
regulation of systemic arterial blood pressure GO:0003073 1 0.017
axon development GO:0061564 166 0.017
embryonic digestive tract development GO:0048566 4 0.017
homeostasis of number of cells GO:0048872 62 0.017
cell cell signaling GO:0007267 52 0.017
regulation of receptor activity GO:0010469 2 0.017
cell migration involved in gastrulation GO:0042074 79 0.017
Zebrafish
regulation of ph GO:0006885 3 0.017
positive regulation of stem cell proliferation GO:2000648 1 0.017
spermatid development GO:0007286 2 0.016
regulation of synapse organization GO:0050807 3 0.016
regulation of synaptic plasticity GO:0048167 1 0.016
response to nutrient levels GO:0031667 10 0.016
sensory perception of pain GO:0019233 1 0.016
macromolecule modification GO:0043412 111 0.016

esr1 disease predictions

Disease predictions are made from cross-annotation of human disease genes to the identified functional analogs in zebrafish and predicted with the zebrafish functional network.

Disease DO term ID Size Probability Func Analog Org
disease of anatomical entity DOID:7 0 0.063
Human
cancer DOID:162 0 0.029
disease of cellular proliferation DOID:14566 0 0.029
organ system cancer DOID:0050686 0 0.029
cardiovascular system disease DOID:1287 0 0.021
nervous system disease DOID:863 0 0.016
Human